PEOPLE

Deborah French, PhD

Research Associate Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact InformationChildren's Hospital of Philadelphia
3501 Civic Center Blvd
Colket Translational Research Building 5014

Philadelphia, PA, 19104
Office: 267-426-9673

Email: frenchd@email.chop.edu

Specialty Division

Immunobiology and Experimental Pathology

Research Expertise

As Director of the human induced pluripotent stem cell (iPSC) core facility within the Center for Cellular and Molecular Therapeutics at The Children’s Hospital of Philadelphia, our mission is to provide expertise and quality-control reagents for culture and differentiation of iPSCs and human embryonic stem cells (hESC) to the research communities. We have established standardized protocols to: 1) Propagate human ESC and iPSC lines, monitor for maintenance of the pluripotent state and distribute these lines to investigators; 2) Differentiate hESCs and iPSCs into the various germ layers and their derivative tissues under controlled, serum-free conditions with defined cytokines; and 3) Generate iPSCs from fibroblasts and blood cells obtained from human subjects using integrating and non-integrating reprogramming systems. We have generated over 60 normal and disease-specific iPSC lines in which the normal reference lines are available for distribution to the research community. In addition to working with investigators to design new protocols tailored for their individualized research, we provide a hands on training course to gain expertise in the growth, maintenance, expansion, and cryopreservation of hESCs and iPSCs. Technologies for creating and manipulating ESCs/iPSCs are evolving rapidly and we are dedicated to incorporating the latest technologies and protocols to the research community.

Education

BS (Microbiology), Purdue University, W Lafayette, IN, 1974
PhD (Immunology), Rush University, Chicago, IL, 1984

Specialty Certification

Postgraduate Training

Post-doctoral fellow, Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, 1984-1989

Awards and Honors

Established Fellow of the New York Heart Association, 1984-1986
Catacosinos Young Investigator Award for Cancer Research, 1990
Ilma F. Kern Foundation of the New York Heart Association, 1997-2003
The Charles Slaughter Foundation, 1999-2002

Memberships and Professional Organizations

International Society of Thrombosis and Haemostasis, 2000 - 2010
International Society of Stem Cell Research, 2000 - Present
American Society of Hematology, 2000 - Present
American Heart Association, 2002 - 2005

Web Links


Selected Publications