PEOPLE

Glen N. Gaulton, PhD

Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Vice Dean and Director of Global Health

Contact InformationUniversity of Pennsylvania
Perelman School of Medicine
240 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104-6055
Office: (215) 898-0848
Fax: (215) 573-7945

Email: GAULTON@MAIL.MED.UPENN.EDU

Specialty Division

Immunobiology and Experimental Pathology

Research Expertise

Research Interest
Lymphocyte development and retroviral pathology

Keywords: Lymphocyte Development, Retrovirus Pathology, HIV-1, Imaging, Diagnostics

Research Techniques:
Molecular genetics, cell biology, imaging, diagnostics, virology, immunology

Research Summary
The interests of the Gaulton laboratory focus on an increased understanding of the molecular processes that regulate the infection and pathology of retroviruses, such as HIV, the impact of these infections on the immune system, and the detection of these infections using novel imaging and diagnostic approaches.
More specifically, the laboratory has investigated the effects of human and, as experimental models, murine retroviruses during active infection of adult, pediatric and neonatal subjects. Recent results have identified the primary mechanisms whereby retroviruses induce cell destruction through cell-cell fusion, also know as syncytia formation. The laboratory has pioneered the use of magnetic resonance imaging (MRI) techniques to detect HIV infection within cells and is now applying these techniques to in vivo, whole body imaging of active infections. Lastly, using state-of-the-art engineering technology, the laboratory is developing highly sensitive yet mobile, hand-held devices to detect HIV infection in blood. These devices are critical for diagnosing new infections, and to monitor HIV levels in patients undergoing active therapy and/or participating in vaccine trials.

Lab personnel:
Tomasz Rosmyslowicz,M.D., Sr. Research Investigator

Graduate Groups

Cell and Molecular Biology
Immunology

Education

B.S. (Biology, with honors), University of California, Santa Barbara, 1974
M.S. (Biochemistry/Molecular Biology), University of California, Santa Barbara, 1977
Ph.D. (Biochemistry/Molecular Biology), University of California, Santa Barbara, 1981

Specialty Certification

Postgraduate Training

Research Fellow in Immunology, Harvard School of Public Health, Department of Cancer Biology, Boston, MA, 1980-1983
Research Fellow in Immunology, Harvard Medical School, Department of Pathology, Boston, MA, 1983-1983

Awards and Honors

University of California, E. C. Anthony Fellowship, 1977
University of California Regents Fellowship, 1979
NIH Postdoctoral Training Fellowship, 1981
NRSA Viral Oncology Fellowship, 1983
National Multiple Sclerosis Society, Harry Weaver Neuroscience Scholar, 1985
University of Pennsylvania, Dean's Award for Excellence in Basic Science Teaching, 1990
Leukemia Society of America Scholar Award, 1991
University of Pennsylvania Leonard Berwick Teaching Award, 1994
University of Pennsylvania Christian R. and Mary F. Linback Award for Distinguished Teaching, 1996

Memberships and Professional Organizations

AAMC Group on Graduate Research, Education and Training, 1997 - Present
American Association for the Advancement of Science, - Present
American Association of Immunologists, - Present

Web Links


Selected Publications

Linkage of reduced receptor affinity and superinfection to pathogenesis of TR1.3 murine leukemia virus

Murphy, SL, Landers, CM, Honczarenko, MJ and Gaulton, GN, J. Virol 80(): 4601-4609, 2006, PMID:16611920

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Modification of a viral envelope glycoprotein cell-cell fusion assay by utilizing plasmid encoded bacteriophage RNA polymerase.

Lin, G, Murphy, SL, Gaulton, GN, and Hoxie, JA, Journal of Virology Methods 128(1-2): 135-142, 2005, PMID:15941597

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The intrathymic pathogenesis of myasthenia gravis.

Levinson, Al, Song, D, Gaulton, GN, and Zheng, Clinical Development Immunology 11(): 215-220, 2005

Disparate regions of envelope protein regulate syncytium formation versus spongiform encephalopathy in neurological disease induced by murine leukemia virus TR.

Murphy, SL, Honczarenko, MJ, Dugger, NV, Hoffman, PM, Gaulton, GN, Journal of Virology 78(): 8392 - 8399, 2004, PMID:15254211

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Neuropathogenic murine leukemia virus TR1.3 induces selective syncytia formation of brain capillary endothelium.

Chung Landers, M, Dugger, N, Quadros, M, Hoffman, PM, Gaulton, GN, Virology 321(): 57-64, 2004, PMID:15033565

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Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV

Rozmyslowicz, T., Majka, M., Kijowski, J., Murphy, S.L., Conover, D.O., Poncz, M., Ratajczak, J., Gaulton, G.N. and Ratajczak, M.Z., AIDS 17(): 33-42, 2003, PMID:12478067

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Neuropathogenic murine leukemia virus TR1.3 induces selective syncytia formation of primary BALB/c brain capillary endothelium

Chung Landers, M., Dugger, N., Quadros, M., Hoffman, P. M., and Gaulton, G.N., Virology in press(): , 2003

New T-lymphocytic lines for studying cell infectability by human immunodeficiency virus

Rozmyslowicz, T., Kijowski, J., Conover, D.O., Baj-Krzyworzeka, M., Reca, R., Libura, J.J., Gaulton, G.N. and Ratajczak, M.Z., Eur. J. Haematol 67(): 142-151, 2001, PMID:11737246

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The limited infectability by R5 HIV of CD34+ cells from thymus, cord and peripheral blood and bone marrow is explained by their ability to produce chemokines.

Majka,M., Rozmyslowicz,T., Ratajczak,J., Dobrowsky,A., Pietrzowski,Z., Gaulton,G.N., Experimental Hematology 28(): 1334-1342, 2000, PMID:11146155

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Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines

Majka, M., Rozmyslowicz, T., Honczarenko, M., Ratajczak, J., Wasik, M.A., Gaulton, G.N., and Ratajczak, M.Z., Leukemia 14(): 1821-1832, 2000, PMID:11021758

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