PEOPLE

Wayne William Hancock, MD, PhD, FRCPA

Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact Information916B Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104-4318
Office: (215) 590-8709
Fax: (215) 590-7384

Email: whancock@mail.med.upenn.edu

Specialty Division

Immunobiology and Experimental Pathology

Research Expertise

Research Interests

Transplant immunobiology, inflammation and mechanisms of disease

Research Summary

New Co-Stimulation Molecules And Their Function In Vivo
The world is currently awash with costimulation molecules. Individual labs tout this or that molecule as being key to T cell activation under specific (often ludicrously specific) conditions, but none of these "insights" have yet led to actual therapeutic agents in clinical use. This reflects several factors. Drug companies make drugs and then try and find an application for them, ideally rheumatoid arthritis, multiple sclerosis, asthma or some other widespread disease involving long-term therapy, but certainly not any of the indications subject to the "too small a market (e.g.

CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention
Myocyte Biology / Heart Failure
Biotechnology / Nanomedicine / Imaging
Thrombosis / Hemostasis

CVI Research Description:
I am interested in immunologic and inflammatory events affecting the cardiovascular system, with particular interest in replacement therapies, whether by manipulation of stem cells or through cardiac transplantation. Optimizing outcomes of cardiac transplantation is another special interest.

Itmat Expertise

Transplantation
Autoimmunity
Tolerance
Epigenetics
Therapeutics
HDAC inhibitors
HAT inhibitors
DNMT inhibitors

Graduate Groups

Immunology

Education

M.B.B.S. (Medicine), Monash University, Clayton, Victoria, Australia, 1977
Ph.D. (Medicine), Monash University, Clayton, Victoria, Australia, 1984
F.R.C.P.A. (Pathology), Royal College o fPathologists of Australasia, 1989

Specialty Certification

Fellow of the Royal College of Pathologists of Australasia, 1989

Postgraduate Training

Intern in Medicine , Alfred Hospital, Mebourne, Australia, 1977-1978
Resident in Medicine, Alfred Hospital , Mebourne, Australia, 1978-1979
Pathology Fellow , Prince Henry's Hospital, Melbourne, Australia, 1980-1983
Research Fellowship, Pathology, Brigham and Women's Hospital, Boston, MA, 1984-1986

Awards and Honors

Australian Kidney Foundation Medical Research Scholarship, 1981
Neil Hamilton Fairley Fellowship, National Health and Medical Research Council of Australia, 1984-1985
Australasian Society of Nephrology Travelling Fellowship, 1984
Fogarty International Research Fellowship (NIH), 1985
Inaugural NIH Basic Science Award for Best Basic Science Abstract, American Society for Transplant Physicians, 1996

Memberships and Professional Organizations

International Society of Nephrology, 1983 - Present
The Transplantation Society, 1983 - Present
American Society of Nephrology, 1984 - Present
The Histochemical Society, 1985 - Present
American Association of Immunologists, 1986 - Present
American Society of Transplant Physicians, 1993 - 2001
American Society of Transplant Physicians, 1993 - Present
American Society for Investigative Pathology, 1994 - Present
NIH Surgery, Anesthesiology and Trauma (SAT) Study Section, 1995 - 2003
American Society for Hematology, 1997 - Present
National Kidney Foundation, 1997 - 2001
American Society of Transplantation, 2001 - Present
NIH Surgery, Anesthesiology and Trauma (SAT) Study Section, 2003 - 2004
NIH Transplantation, Tolerance & Tumors (TTT) Study Section, 2004 - 2006
National Institutes of Health, 2007 - 2007
British Heart Foundation, 2007 - 2007
Wessex Medical Research, 2008 - 2008
National Health and Medical Research Council of Australia, 2008 - 2008
UPenn, 2008 - Present
National Institutes of Health, 2008 - 2008
National Institutes of Health, 2008 - 2008
The Wellcome Trust, 2008 - 2009
National Institutes of Health, 2009 - 2009
International Pancreas and Islet Transplant Association, 2009 - Present
Australian National University, 2009 - 2010
National Institutes of Health, 2009 - 2009
Australian National University, 2010 - 2010
National Institutes of Health, 2010 - 2010
Arthritis Research UK, 2010 - 2010
National Institutes of Health, 2010 - 2010
Swiss National Science Foundation, 2010 - 2010
National Institutes of health, 2011 - 2011
American Society for Microbiology, 2011 - Present
American Association for Cancer Research, 2011 - Present
Transplant Research Foundation of British Columbia, Canada, 2011 - 2011
National Institutes of Health, 2011 - 2011
American Chemical Society, 2011 - Present
National Institutes of Health, 2012 - 2012
Broad Medical Research Program, 2012 - 2012
National Institutes of Health, 2012 - Present
National Institutes of Health, 2012 - 2012
National Institutes of Health, 2013 - 2014
Medical Research Council (UK), 2013 - Present
Department of Defense, 2013 - Present
Children's Hospital of Philadelphia, 2013 - 2013
Austrian Science Fund, 2013 - 2013
National Institutes of Health, 2013 - 2013
National Institutes of Health, 2013 - 2013
Leukaemia & Lymphoma Research, 2013 - Present
National Institutes of Health, 2014 - Present
National Institutes of Health, 2014 - Present
Israel Science Foundation, 2014 - Present
Department of Defense, 2014 - Present
National Institutes of Health, 2015 - Present
National Institutes off Health, 2015 - Present
National Institutes of Heath, 2016 - Present

Web Links


Selected Publications

Targeting Sirtuin-1 prolongs murine renal allograft survival and function.

Levine MH, Wang Z, Xiao H, Jiao J, Wang L, Bhatti TR, Hancock WW, Beier UH.., Kidney International, 2016

Proximity ligation assay to quantify Foxp3 acetylation in regulatory T cells.

Jiao J, Han R, Hancock WW, Beier UH., Methods in Molecular Biology, 2016

Improved renal ischemia tolerance in females influences kidney transplantation outcomes.

Aufhauser DA, Wang Z, Bhatti TR, Wang Y, Ge G, Redfield RR, Abt PL, Wang L, Thomasson A, Reese P, Hancock WW, Levine MH., Journal of Clinical Investigation, 2016

Isoform-selective HDAC inhibitor therapy for transplantation: Are we ready for HDAC6?

Hancock WW., Transplantation, 2016

HDAC5 controls the functions of Foxp3+ T-regulatory and CD8+ T cells.

Xiao H, Jiao J, Wang L, O'Brien S, Newick K, Wang LS, Falkensammer E, Liu Y, Han R, Kapoor V, Hansen FK, Kurz T, Hancock WW, Beier UH., Int J Cancer., 2015

Thiol-based potent and selective HDAC6 inhibitors promote tubulin acetylation and T‑regulatory cell suppressive function.

Segretti MCF, Vallerini GP, Brochier C, Langley B, Wang L, Hancock WW, Kozikowski AP., ACS Medicinal Chemistry Letters 5(): 1156-1161, 2015

Pim-2 kinase influences T-regulatory cell function and stability by mediating Foxp3 N-terminal phosphorylation.

Deng G, Nagai Y, Xiao Y, Li Z, Dai S, Ohtani T, Banham AH, Li B, Wu SL, Hancock W, Samanta A, Zhang H, Greene MI., Journal of Biological Chemistry 290(): 20211-20220, 2015

Mesenchymal stromal cell-derived factors promote tissue repair in a small-for-size ischemic liver model but do not protect against early effects of ischemia and reperfusion injury.

Fouraschen SM, Wolf JH, van der Laan LJ, de Ruiter PE, Hancock WW, van Kooten JP, Verstegen MM, Olthoff KM, de Jonge J., Journal of Immunologic Research 2015(): 202975, 2015

Standardization, evaluation and area-under-curve analysis of human and murine Treg suppressive function.

Akimova T, Levine MH, Beier UH, Hancock WW., Methods in Molecular Biology In press(): , 2015

Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival.

Beier UH, Angelin A, Akimova T, Wang L, Liu Y, Xiao H, Koike MA, Hancock SA, Bhatti TR, Han R, Jiao J, Veasey SC, Sims CA, Baur JA, Wallace DC, Hancock WW., FASEB Journal In press(): , 2015

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