PEOPLE

Wayne William Hancock, MB.BS, PhD, FRCPA

Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact Information916B Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104-4318
Office: (215) 590-8709
Fax: (215) 590-7384

Email: whancock@pennmedicine.upenn.edu

Research Expertise

Research Interests

Transplant immunobiology, inflammation and mechanisms of disease

Research Summary

New Co-Stimulation Molecules And Their Function In Vivo
The world is currently awash with costimulation molecules. Individual labs tout this or that molecule as being key to T cell activation under specific (often ludicrously specific) conditions, but none of these "insights" have yet led to actual therapeutic agents in clinical use. This reflects several factors. Drug companies make drugs and then try and find an application for them, ideally rheumatoid arthritis, multiple sclerosis, asthma or some other widespread disease involving long-term therapy, but certainly not any of the indications subject to the "too small a market (e.g.

CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention
Myocyte Biology / Heart Failure
Biotechnology / Nanomedicine / Imaging
Thrombosis / Hemostasis

CVI Research Description:
I am interested in immunologic and inflammatory events affecting the cardiovascular system, with particular interest in replacement therapies, whether by manipulation of stem cells or through cardiac transplantation. Optimizing outcomes of cardiac transplantation is another special interest.

Itmat Expertise

Transplantation
Autoimmunity
Tolerance
Epigenetics
Therapeutics
HDAC inhibitors
HAT inhibitors
DNMT inhibitors

Graduate Groups

Immunology

Education

M.B.B.S. (Medicine), Monash University, Clayton, Victoria, Australia, 1977
Ph.D. (Medicine), Monash University, Clayton, Victoria, Australia, 1984
F.R.C.P.A. (Pathology), Royal College of Pathologists of Australasia, 1989

Specialty Certification

Fellow of the Royal College of Pathologists of Australasia, 1989

Postgraduate Training

Intern in Medicine , Alfred Hospital, Mebourne, Australia, 1977-1978
Resident in Medicine, Alfred Hospital , Mebourne, Australia, 1978-1979
Pathology Fellow , Prince Henry's Hospital, Melbourne, Australia, 1980-1983
Research Fellowship, Pathology, Brigham and Women's Hospital, Boston, MA, 1984-1986

Awards and Honors

Australian Kidney Foundation Medical Research Scholarship, 1981
Neil Hamilton Fairley Fellowship, National Health and Medical Research Council of Australia, 1984-1985
Australasian Society of Nephrology Travelling Fellowship, 1984
Fogarty International Research Fellowship (NIH), 1985
Inaugural NIH Basic Science Award for Best Basic Science Abstract, American Society for Transplant Physicians, 1996

Memberships and Professional Organizations

International Society of Nephrology, 1983 - Present
The Transplantation Society, 1983 - Present
American Society of Nephrology, 1984 - Present
The Histochemical Society, 1985 - 1994
American Association of Immunologists, 1986 - Present
Transplantation Society of Australia and New Zealand, 1990 - present
American Society of Transplant Physicians, 1993 - 2001
American Society of Transplant Physicians, 1993 - 2001
American Society for Investigative Pathology, 1994 - 2004
NIH Surgery, Anesthesiology and Trauma (SAT) Study Section, 1995 - 2003
American Society for Hematology, 1997 - Present
National Kidney Foundation, 1997 - 2001
American Society of Transplantation, 2001 - Present
NIH Surgery, Anesthesiology and Trauma (SAT) Study Section, 2003 - 2004
NIH Transplantation, Tolerance & Tumors (TTT) Study Section, 2004 - 2006
National Institutes of Health, 2007 - 2007
British Heart Foundation, 2007 - 2007
National Institutes of Health, 2008 - 2008
Wessex Medical Research, 2008 - 2008
The Wellcome Trust, 2008 - 2009
University of Pennsylvania, 2008 - Present
National Health and Medical Research Council of Australia, 2008 - 2008
National Institutes of Health, 2008 - 2008
National Institutes of Health, 2009 - 2009
Australian National University, 2009 - 2010
National Institutes of Health, 2009 - 2009
International Pancreas and Islet Transplant Association, 2009 - Present
Swiss National Science Foundation, 2010 - 2010
Arthritis Research UK, 2010 - 2010
Australian National University, 2010 - 2010
National Institutes of Health, 2010 - 2010
National Institutes of Health, 2010 - 2010
American Chemical Society, 2011 - Present
American Association for Cancer Research, 2011 - Present
National Institutes of health, 2011 - 2011
National Institutes of Health, 2011 - 2011
Transplant Research Foundation of British Columbia, Canada, 2011 - 2011
American Society for Microbiology, 2011 - Present
National Institutes of Health, 2012 - 2019
National Institutes of Health, 2012 - 2012
Broad Medical Research Program, 2012 - 2012
National Institutes of Health, 2012 - 2012
Department of Defense, 2013 - 2013
Medical Research Council (UK), 2013 - 2013
National Institutes of Health, 2013 - 2014
National Institutes of Health, 2013 - 2013
National Institutes of Health, 2013 - 2013
Austrian Science Fund, 2013 - 2013
Leukaemia & Lymphoma Research, 2013 - 2013
Children's Hospital of Philadelphia, 2013 - 2013
Israel Science Foundation, 2014 - 2014
National Institutes of Health, 2014 - 2014
International Hand and Composite Tissue Allotransplantation Society, 2014 - present
Department of Defense, 2014 - 2014
National Institutes of Health, 2014 - 2014
National Institutes off Health, 2015 - 2015
National Institutes of Health, 2015 - 2015
National Institutes of Heath, 2016 - 2016
Veterans Administration, 2016 - 2016
National Institutes of Health, 2016 - 2016
National Institutes of Health, 2016 - 2016
National Institutes of Health, 2016 - 2016
American Thoracic Society, 2017 - present
Society for Immunotherapy of Cancer, 2017 - Present
National Institutes of Health, 2017 - 2017
National Institutes of Health, 2017 - 2017
Trisomy 21 Research Society, 2017 - present
National Institute so fHealth, 2017 - 2017
American Society for Biochemistry and Molecular Biology, 2017 - present
Children's Hospital of Philadelphia, 2017 - 2017
International Chemical Biology Society, 2017 - Present
Oligonucleotide Therapeutics Society, 2018 - present
National Institutes of Health, 2018 - 2018
National Institutes of Health, 2018 - 2018
National Institutes of Health, 2018 - 2018
National Institutes of Health, 2018 - 2018
National Institutes of Health, 2018 - 2018
National Institutes of Health, 2019 - 2019
National Institutes of Health, 2019 - 2019
American Society of Gene & Cell Therapy, 2019 - present
National Institutes of Health, 2019 - 2019
National Institutes of Health, 2019 - 2019
National Institutes of Health, 2019 - 2019
National Institutes of Health, 2019 - 2019
National Institutes of Health, 2020 - 2020
National Institutes of Health, 2020 - 2020

Web Links


Selected Publications

Inhibiting the coregulator CoREST impairs Foxp3+ Treg cell function and promotes antitumor immunity.

Xiong Y, Wang L, Di Giorgio E, Akimova T, Beier UH, Han R, Trevisanut M, Kalin JH, Cole PA, Hancock WW., Journal of Clinical Investigation, 2020

Donor-host lymphatic anastomosis after murine lung transplantation.

Outtz-Reed H, Wang L, Kahn ML, Hancock WW., Transplantation 104(): 511-515, 2020

HDAC10 deletion promotes Foxp3+ T-regulatory cell function.

Dahiya S, Beier UH, Wang L, Han R, Jiao J, Akimova T, Angelin A, Wallace DC, Hancock WW., Scientific Reports 10(): 424, 2020, PMID:31949209

Read article

Adipose tissue quantification and primary graft dysfunction after lung transplantation: The Lung Transplant Body Composition Study.

Anderson MR, Udupa JK, Edwin EA, Diamond JM, Singer JP, Kukreja J, Hays SR, Greenland JR, Ferrante AW, Lippel M, Blue T, McBurnie A, Oyster M, Kalman L, Rushefski M, Wu C, Pednekar G, Liu W, Arcasoy S, Sonett J, D’Ovidio F, Bacchetta M, Newell JD, Torigian D, Cantu E, Farber DL, Giles JT, Tong Y, Palmer S, Ware LB, Hancock WW, Christie JD, Lederer DJ., Journal of Heart and Lung Transplantation 38(): , 2019

Sirtuin-1 in immunotherapy: A Janus-headed target.

Chadha S, Wang L, Hancock WW, Beier UH., Journal of Leukocyte Biology 2019, 2019

GCN5 and PCAF have complementary roles in Foxp3+ T-regulatory cells and their dual loss leads to lethal autoimmunity.

Liu Y, Bao C, Wang L, Han R, Beier UH, Cole PA, Dent SYR, Hancock WW., Cancers, 2019

Impaired pulmonary lymphatic function leads to tertiary lymphoid organ formation and lung injury.

Reed HO, Wang L, Sonett J, Chen M, Yang J, Li L, D’Armiento J, Hancock WW, Kahn ML., Journal of Clinical Investigation, 2019

Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer.

Singhal S, Stadanlick J, Annunziata MJ, Rao AS, Bhojnagarwala PS, O’Brien S, Moon EK, Cantu E, Danet-Desnoyers G, Ra HJ, Litzky L, Akimova T, Beier UH, Hancock WW, Albelda SM, Eruslanov EB., Science Translational Medicine 11(): pii: eaat1500. doi: 10.1126/scitranslmed.aat1500, 2019

Loss of HDAC6 alters gut microbiota and worsens obesity.

Lieber AD, Beier UH, Xiao H, Jiao J, Bokulich NA, Ruggles K, Akimova T, Hancock WW, Blaser MJ., FASEB Journal 33(): , 2019

Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms.

Negorev D, Beier UH, Zhang T, Quatromoni JG, Bhojnagarwala P, Albelda SM, Singhal S, Eruslanov E, Lohoff FW, Levine MH, Diamond JM, Christie JD, Hancock WW, Akimova T., Scientific Reports 8(1): 3135, 2018

Search PubMed for articles