PEOPLE

Wayne William Hancock, MB.BS, PhD, FRCPA

Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact Information916B Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104-4318
Office: (215) 590-8709
Fax: (215) 590-7384

Email: whancock@mail.med.upenn.edu

Specialty Division

Immunobiology and Experimental Pathology

Research Expertise

Research Interests

Transplant immunobiology, inflammation and mechanisms of disease

Research Summary

New Co-Stimulation Molecules And Their Function In Vivo
The world is currently awash with costimulation molecules. Individual labs tout this or that molecule as being key to T cell activation under specific (often ludicrously specific) conditions, but none of these "insights" have yet led to actual therapeutic agents in clinical use. This reflects several factors. Drug companies make drugs and then try and find an application for them, ideally rheumatoid arthritis, multiple sclerosis, asthma or some other widespread disease involving long-term therapy, but certainly not any of the indications subject to the "too small a market (e.g.

CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention
Myocyte Biology / Heart Failure
Biotechnology / Nanomedicine / Imaging
Thrombosis / Hemostasis

CVI Research Description:
I am interested in immunologic and inflammatory events affecting the cardiovascular system, with particular interest in replacement therapies, whether by manipulation of stem cells or through cardiac transplantation. Optimizing outcomes of cardiac transplantation is another special interest.

Itmat Expertise

Transplantation
Autoimmunity
Tolerance
Epigenetics
Therapeutics
HDAC inhibitors
HAT inhibitors
DNMT inhibitors

Graduate Groups

Immunology

Education

M.B.B.S. (Medicine), Monash University, Clayton, Victoria, Australia, 1977
Ph.D. (Medicine), Monash University, Clayton, Victoria, Australia, 1984
F.R.C.P.A. (Pathology), Royal College o fPathologists of Australasia, 1989

Specialty Certification

Fellow of the Royal College of Pathologists of Australasia, 1989

Postgraduate Training

Intern in Medicine , Alfred Hospital, Mebourne, Australia, 1977-1978
Resident in Medicine, Alfred Hospital , Mebourne, Australia, 1978-1979
Pathology Fellow , Prince Henry's Hospital, Melbourne, Australia, 1980-1983
Research Fellowship, Pathology, Brigham and Women's Hospital, Boston, MA, 1984-1986

Awards and Honors

Australian Kidney Foundation Medical Research Scholarship, 1981
Neil Hamilton Fairley Fellowship, National Health and Medical Research Council of Australia, 1984-1985
Australasian Society of Nephrology Travelling Fellowship, 1984
Fogarty International Research Fellowship (NIH), 1985
Inaugural NIH Basic Science Award for Best Basic Science Abstract, American Society for Transplant Physicians, 1996

Memberships and Professional Organizations

International Society of Nephrology, 1983 - Present
The Transplantation Society, 1983 - Present
American Society of Nephrology, 1984 - Present
The Histochemical Society, 1985 - Present
American Association of Immunologists, 1986 - Present
American Society of Transplant Physicians, 1993 - 2001
American Society of Transplant Physicians, 1993 - Present
American Society for Investigative Pathology, 1994 - Present
NIH Surgery, Anesthesiology and Trauma (SAT) Study Section, 1995 - 2003
American Society for Hematology, 1997 - Present
National Kidney Foundation, 1997 - 2001
American Society of Transplantation, 2001 - Present
NIH Surgery, Anesthesiology and Trauma (SAT) Study Section, 2003 - 2004
NIH Transplantation, Tolerance & Tumors (TTT) Study Section, 2004 - 2006
National Institutes of Health, 2007 - 2007
British Heart Foundation, 2007 - 2007
The Wellcome Trust, 2008 - 2009
National Health and Medical Research Council of Australia, 2008 - 2008
National Institutes of Health, 2008 - 2008
Wessex Medical Research, 2008 - 2008
National Institutes of Health, 2008 - 2008
UPenn, 2008 - Present
Australian National University, 2009 - 2010
National Institutes of Health, 2009 - 2009
National Institutes of Health, 2009 - 2009
International Pancreas and Islet Transplant Association, 2009 - Present
National Institutes of Health, 2010 - 2010
National Institutes of Health, 2010 - 2010
Australian National University, 2010 - 2010
Swiss National Science Foundation, 2010 - 2010
Arthritis Research UK, 2010 - 2010
American Society for Microbiology, 2011 - Present
American Association for Cancer Research, 2011 - Present
Transplant Research Foundation of British Columbia, Canada, 2011 - 2011
National Institutes of health, 2011 - 2011
American Chemical Society, 2011 - Present
National Institutes of Health, 2011 - 2011
National Institutes of Health, 2012 - 2017
National Institutes of Health, 2012 - 2012
National Institutes of Health, 2012 - 2012
Broad Medical Research Program, 2012 - 2012
Department of Defense, 2013 - Present
National Institutes of Health, 2013 - 2014
National Institutes of Health, 2013 - 2013
National Institutes of Health, 2013 - 2013
Medical Research Council (UK), 2013 - Present
Leukaemia & Lymphoma Research, 2013 - Present
Austrian Science Fund, 2013 - 2013
Children's Hospital of Philadelphia, 2013 - 2013
Israel Science Foundation, 2014 - Present
National Institutes of Health, 2014 - Present
National Institutes of Health, 2014 - Present
Department of Defense, 2014 - Present
National Institutes of Health, 2015 - Present
National Institutes off Health, 2015 - Present
Veterans Administration, 2016 - Present
National Institutes of Health, 2016 - Present
National Institutes of Health, 2016 - Present
National Institutes of Heath, 2016 - Present
National Institutes of Health, 2016 - Present
National Institutes of Health, 2017 - Present

Web Links


Selected Publications

Proximity ligation assay to quantify Foxp3 acetylation in regulatory T cells.

Jiao J, Han R, Hancock WW, Beier UH., Methods in Molecular Biology 1510(): 287-293, 2017

Histone deacetylase 11 is an epigenetic regulator of Eomes and Tbet expression in T-cells.

Woods DM, Woan K, Wang D, Sodré AL, Cheng F, Wang Z, Chen J, Powers J, Pinilla-Ibarz J, Yu Y, Weber J, Hancock WW, Seto E, Villagra A, Yu XZ, Sotomayor EM., Blood In press(): , 2017

Foxp3 reprograms T cell metabolism to function in low glucose high lactate environments.

Angelin A, De Gomez LG, Dahiya S, Jiao J, Guo L, Wang L, Akimova T, Liu Y, Bhatti TR, Han R, Wang W, Laskin BL, Blair IA, Wallace DC, Hancock WW, Beier UH., Cell Metabolism In press(): , 2017

NHLBI Workshop Report: Animal Models of Lung Transplant Research

Lama VN, Belperio JA, Christie JD, El-Chemaly S, Fishbein MC, Gelman AE, Hancock WW, Keshavjee S, Kreisel D, Laubach VE, Looney MR, McDyer JF, Mohanakumar T, Shilling RA, Panoskaltsis-Mortari A, Wilkes DS, Eu JP, Nicolls MR., JCI Insight In press(): , 2017

Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity.

Wang L, Kumar S, Dahiya S, Wang F, Wu J, Newick K, Han R, Samanta A, Beier UH, Akimova T, Bhatti TR, Nicholson B, Kodrasov MP, Agarwal S, Sterner DE, Gu W, Weinstock J, Butt TR, Albelda SM, Hancock WW., EBioMedicine 13(): 99-112, 2016

Isoform-selective HDAC inhibitor therapy for transplantation: Are we ready for HDAC6?

Hancock WW., Transplantation 100(8): 1597-98, 2016

Standardization, evaluation and area-under-curve analysis of human and murine Treg suppressive function.

Akimova T, Levine MH, Beier UH, Hancock WW., Methods in Molecular Biology 1371(): 43-78, 2016

Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer.

Singhal S, Bhojnagarwala PS, O'Brien S, Moon EK, Garfall AL, Rao AS, Quatromoni JG, Stephen TL, Litzky L, Deshpande C, Feldman MD, Hancock WW, Conejo-Garcia JR, Albelda SM, Eruslanov EB., Cancer Cell 30(1): 120-135, 2016

Targeting Sirtuin-1 prolongs murine renal allograft survival and function.

Levine MH, Wang Z, Xiao H, Jiao J, Wang L, Bhatti TR, Hancock WW, Beier UH.., Kidney International 89(5): 1016-1026, 2016

Improved renal ischemia tolerance in females influences kidney transplantation outcomes.

Aufhauser DA, Wang Z, Bhatti TR, Wang Y, Ge G, Redfield RR, Abt PL, Wang L, Thomasson A, Reese P, Hancock WW, Levine MH., Journal of Clinical Investigation 126(5): 1968-1977, 2016

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