Brian Harding, DPhil, BMBCh

Professor of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia
University of Pennsylvania Perelman School of Medicine

Contact InformationThe Children's Hospital of Philadelphia
Department of Pathology
S 34th St & Civic Center Blvd
Main Building, Suite 5NW15
Philadelphia, PA 19104
Office: 2967-426-5504
Fax: 267-426-7783

Itmat Expertise

Developmental neuropathology
Malformations and peditatric degenerative disorders of the nervous sytem


B.A. (Animal Physiology), Worcester College, University of Oxford, 1969
B.M. B.Ch. University of Oxford ( & St George’s Hospital Medical School London), 1976
M.A. (Animal Physiology), Worcester College, University of Oxford, 1976
D.Phil. (Thesis: A Study of certain nuclei of the thalamus), Dept of Anatomy University of Oxford, 1976

Specialty Certification

MRCPath Royal College of Pathologists (Neuropathology), 1982
FRCPath Royal College of Pathologists (Neuropathology), 1994

Postgraduate Training

House officer in Surgery, St George’s Hospital, Hyde Park Corner, London SW1, 1976-1977
House officer in Medicine, St James Hospital Balham SW12, 1976-1976
Senior House officer/Registrar, Pathology St George’s Hospital, London SW1 & SW17, 1977-1979
Senior Registrar in Histopathology, St George’s Hospital, London SW17, 1979-1980
Senior Registrar in Neuropathology, National Hospital for Neurology and Neurosurgery, Queens Square, London WC1, 1980-1983

Awards and Honors

Memberships and Professional Organizations

British Neuropathology Society, 1981 - Present
British Paediatric Neurology Association, 1985 - 2008
British Neuropathology Society, 1986 - 1989
American Association of Neuropathologists, 1989 - Present
Royal College of Pathologists (UK) scheme, 1990 - Present
Societe Francaise de Neuropathologie, 1990 - 2008
Clinical Pathology Accreditation Ltd (UK), 2004 - 2008
Royal College of Pathologists (UK) scheme, 2005 - 2008
Royal College of Pathologists (UK) scheme, 2007 - 2008
The College of Physicians of Philadelphia, 2010 - Present

Web Links

Selected Publications

Deregulated expression of EZH2 in congenital brainstem disconnection

Barth PG, Aronica E, Fox S, Fluiter K, Weterman MA, Poretti A, Miller DC, Boltshauser E, Harding B, Santi M, Baas F, Neuropathol Appl Neurobiol, 2016, PMID:27886392

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Mutations in Citron Kinase Cause Recessive Microlissencephaly with Multinucleated Neurons.

Harding BN, Moccia A, Drunat S, Soukarieh O, Tubeuf H, Chitty LS, Verloes A, Gressens P, El Ghouzzi V, Joriot S, Di Cunto F, Martins A, Passemard S, Bielas SL, Am J Hum Genet. 99(2): 511-20, 2016, PMID:27453579

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Pontine tegmental cap dysplasia: neuropathological confirmation of a rare clinical/radiological syndrome.

Harding B, Vossough A, Goldberg E, Santi M, Neuropathology and Applied Neurobiology 42(3): 301-6, 2016, PMID:26331236

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Degos disease mimicking primary vasculitis of the CNS

Gmuca S, Boos MD, Treece A, Narula S, Billinghurst L, Bhatti T, Laje P, Perman MJ, Vossough A, Harding B, Burnham J, Banwell B., Neurol Neuroimmunol Neuroinflamm 3(2): E206, 2016, PMID:26894208

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A Clinical, Neuropathological and Genetic Study of Homozygous A467T POLG-Related Mitochondrial Disease

Rajakulendran S, Pitceathly RD, Taanman JW, Costello H, Sweeney MG, Woodward CE, Jaunmuktane Z, Holton JL, Jacques TS, Harding BN, Fratter C9, Hanna MG, Rahman S, PLoS One 11(1): e0145500, 2016, PMID:26735972

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Microlissencephaly with multinucleated neurons results from failed cytokinesis due to truncating mutations in Citron kinase

Harding BN, Moccia A, Chtty L and Bielas S, Clin Neuropath 35(): , 2016

Truncating mutations in Citron-Kinase: a cause of micro-lissencephaly with multinucleated neurons

Harding B, Moccia A, Chitty L, Bielas S, JNEN 75(): , 2016

Clinical and histopathological outcomes in patients with SCN1A mutations undergoing surgery for epilepsy

Skjei KL, Church EW, Harding BN, Santi M, Holland-Bouley KD, Clancy RR, Porter BE, Heuer GG, Marsh ED, J Neurosurg Pediatr 16(6): 668-74, 2015, PMID:26339958

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Recessive nephrocerebellar syndrome on the Galloway-Mowat syndrome spectrum is caused by homozygous protein-truncating mutations of WDR73.

Jinks RN, Puffenberger EG, Baple E, Harding B, Crino P, Fogo AB, Wenger O, Xin B, Koehler AE, McGlincy MH, Provencher MM, Smith JD, Tran L, Al Turki S, Chioza BA11, Cross H, Harlalka GV, Hurles ME, Maroofian R, Heaps AD, Morton MC, Stempak L, Hildebrandt F, Sadowski CE, Zaritsky J, Campellone K, Morton DH, Wang H, Crosby A, Strauss KA., Brain 138(): 2173-90, 2015, PMID:26070982

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Diagnostic accuracy and limitations of post-mortem MRI for neurological abnormalities in fetuses and children.

Arthurs OJ, Thayyil S, Pauliah SS, Jacques TS, Chong WK, Gunny R, Saunders D, Addison S, Lally P, Cady E, Jones R, Norman W, Scott R, Robertson NJ, Wade A, Chitty L, Taylor AM, Sebire NJ; Magnetic Resonance Imaging Autopsy Study (MaRIAS) Collaborative Group., Clin Radiol. 70(8): 872-80, 2015, PMID:26050535

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