PEOPLE

Jonni S. Moore, PhD

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
University of Pennsylvania Perelman School of Medicine
Consultant, Flow Cytometry

Contact Information211 and 297 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA, 19104
Office: (215) 898-6853
Fax: (215) 898-4227

Email: moorej@pennmedicine.upenn.edu

Specialty Division

Laboratory Medicine, Hematopathology, Immunobiology and Experimental Pathology

Research Expertise

Research Summary

Research in our laboratory centers on technology development with a focus on complex technologies, in particular cytomics. We pioneered new technology in flow cytometry liquid biopsies including the detection of extracellular vesicles as a rich source of prognostic and diagnostic information and developing this technology for diagnostics/prognostics in cardiovascular disease, traumatic brian injury and relapsing breast cancer. Most recently she has focused on the development of high dimensional deep phenotyping approaches for the identification of biomarkers of cancer responses using advance cytomic technology.
Current collaborators:
Lewis Chodosh, MD, PhD, Cancer Biology
Erica Carpenter, MBA, PhD, Department of Medicine
John Wherry, Parker Institute for Cancer Immunotherapy
Mona Kumar, MD, Neurology

Flow Cytometry Expertise

As Director of the Penn Cytomics and Cell Sorting Shared Resource and founder of the Hospital of the University of Pennsylvania Clinical Flow Cytometry Laboratory as well as in my own research, I have developed and applied a variety of sophisticated flow cytometric applications with focus on translational application and computational interpretation. This includes expertise in intracellular protein detection, complex data mining, cell proliferation, rare stem cell detection as well as other functional assays. My lab has been recognized as "exceptional" by the NCI for over 20 years.

Graduate Groups

Immunology

Education

B.A. (Biology), University of Virginia, Charlottesville, 1972
Ph.D. (Microbiology), Thomas Jefferson University, Philadelphia, 1984

Specialty Certification

Becton-Dickinson FACScan Key Operator, 1990
Becton-Dickinson FACStar PLUS Key Operator, 1992

Postgraduate Training

Postdoctoral Fellow, Immunology Graduate Group, Dr. Peter C. Nowell and Dr. Richard G. Hoover, University of Pennsylvania School of Medicine, 1984-1988

Awards and Honors

Keynote Speaker Award, National Flow Cytometry Annual Course, Bowdoin College, Maine, 212
Sigma Xi Research Society (Associate Member), 1981
Sigma Xi Student Research Award, 1983
Thomas Jefferson University Fellow, 1983-1984
National Institutes of Health Postdoctoral Fellow, 1984-1987
Chapter Scholar, Arthritis Foundation, 1987, 1988, 1990, 1987-1990
Academy of Clinical Laboratory Physicians and Scientists, 2000-present
Peter C. Nowell Teaching Award, 2002
FOCUS Award for the Advancement of Women in Medicine, 2008
College of American Pathologists Outstanding Inspector, 2008
David B.P. Goodman, M.D., Ph.D. Award
Department of Pathology and Laboratory Medicine, 2009
Cyto2011 Pre-Congress Scientific Mentor, International Society for the Advancement of Cytometry, 2011
The Carleton and Sigrid Stewart Lectureship, Great Lakes International Imaging and Fluorescence Association, 2012
Wallace H. Coulter Award for Lifetime Achievement for Contributions to the Science, Education and Practice of Clinical Cytometry
International Clinical Cytometry Society, 2016
ISAC 2018 Membership Award for Advancing the Field of Cytometry, International Society for the Advancement of Cytometry, 2018
Goodman Award for University Service, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, 2018
EXCEPTIONAL SHARED RESOURCE designation by NCI in Abramson Cancer Center comprehensive cancer center competitive renewal, 2020-2025

Memberships and Professional Organizations

American Association of Immunologists, 1985 - present
Penn Professional Women, 1991 - Present
International Society for Advancement of Cytometry, 1992 - Present
International Clinical Cytometry Society, 1996 - Present
Great Lakes International Imaging and Flow Cytometry Association, 1996 - Present
National Institutes of Health Special Emphasis Panel (SBIR), Hematology 1,2 Study Section, 1998 - 2005
International Society for Hematopathology and Graft Engineering, 1999 - 2019
University of Rochester School of Medicine, 2003 - 2003
University of California at San Diego, Department of Pathology and Cancer Center, 2004 - 2004
Center for Human Cell Therapy, CBR Institute for Biomedical Research, Harvard University Medical School, 2004 - 2007
University of Alabama at Birmingham, Arthritis and Musculoskelatal Disease Center, 2005 - 2005
College of Graduate Studies, Thomas Jefferson University, 2005 - 2019
American Society for Investigative Pathology, 2006 - present
University of Michigan, Department of Pathology, 2006 - 2006
New York University Grossman School of Medicine, Flow Cytometry and Cell Sorting Shared Resource, 2011 - present
Association of Biomolecular Resource Facilities, - Present
American College of Laboratory Physicians and Scientists, - Present

Web Links


Selected Publications

PanoplyCF: A New R Package for Manifold Learning Clustering via Binning.

Rogers W, Ionita M, Moore J, CYTO Virtual 2020 https://learning.isac-net.org/cytovirtual2020, 2020

Reduction in non-classical monocytes suggest recruitment to CNS after Acute Traumatic Brain Injury

Kumar M, Schmierer M, Silverman E, Kulkarni N, Silvestro E, Schretzenmair R, Sandsmark D, Diaz-Arrastia R, Rogers W, Moore J, CYTO Virtual 2020 https://learning.isac-net.org/cytovirtual2020, 2020

Tailor: Targeting heavy tails in flow cytometry data with fast mixture modeling

Ionita M, Jones D, Moore J, Schretenmair R, Wang L-S, Rogers W., CYTO Virtual 2020 https://learning.isac-net.org/cytovirtual2020, 2020

Fluster: A New R Package for Fingerprint-based Clustering

Rogers W, Ionita M, Moore J., CYTO Virtual 2020 https://learning.isac-net.org/cytovirtual2020, 2020

FACSymphony A5 Harmonization and Validation for Computational Population Discovery

Schretzenmair RD, Jones DD, Brake-Silla G, Balderas R, Stall A, Moore JS, CYTO Virtual 2020 https://learning.isac-net.org/cytovirtual2020, 2020

Robust Measurement of CD279 on Patients Receiving anti-PD-1 Therapy

Schretzenmair RD, Brake-Silla G, Jakubowski J, Jones DD, Moore JS., CYTO Virtual 2020 https://learning.isac-net.org/cytovirtual2020, 2020

Development of a Flow Cytometry-Based Assay for Clinical Detection and Molecular Characterization of Breast Cancer Disseminated Tumor Cells in Bone Marrow

Chislock E, Woodfield G, Graves J, Pan T-C, Pant D, Chen Y, Shih N, Bayne L, Blanchard T, Smith M, Murphy W, Morchauser A, DeMuth W, Pletcher C, Moore J, Yu L, Bornheimer S, , Feldman M, Nayak A, DeMichele A, Chodosh L., CYTO Virtual 2020 https://learning.isac-net.org/cytovirtual2020, 2020

Expression of Extracellular Vesicles after acute Traumatic Brian Injury: A Pilot Flow Cytometry Study

Kumar M, Schmierer M , Silverman E, Kulkarni N, Ballestar S, Silvestro E, Schretzenmair R, Diaz-Arrastia R, Rogers W, Moore JS., International Society for Extracellular Vesicles (ISEV Virtual) https://www.eventscribe.com/2020/ISEV/posterspeakers.asp?pfp=PresentingAuthor, 2020

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

Cossarizza A, Chang HD, Radbruch A, et al, European Journal of Immunology 49(10): 1457-1973, 2019

Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia.

Urtishak KA, Wang L, Culikovic-Krajiacic B, Davenport J, Porazzi P, Vincent T, Teachey D, Tasian S, Moore J, Seif A, Jin S, Barrett J, Robinson B, Chen I-M, Harvey R, Carroll M, Carroll A, Herrera N, Devidas M, Dryer Z, Hilden J, Hunger S, Willman C, Borden K, Felix C., Oncogene 38(): 2241, 2019

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