PEOPLE

Jonni S. Moore, PhD

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
University of Pennsylvania Perelman School of Medicine
Consultant, Flow Cytometry

Contact Information211 and 297 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA, 19104
Office: (215) 898-6853
Fax: (215) 898-4227

Email: moorej@pennmedicine.upenn.edu

Specialty Division

Laboratory Medicine, Hematopathology, Immunobiology and Experimental Pathology

Research Expertise

Research Summary

Research in our laboratory centers on technology development with a focus on complex technologies, in particular cytomics. We pioneered new technology in flow cytometry liquid biopsies including the detection of extracellular vesicles as a rich source of prognostic and diagnostic information and developing this technology for diagnostics/prognostics in cardiovascular disease, traumatic brian injury and relapsing breast cancer. Most recently she has focused on the development of high dimensional deep phenotyping approaches for the identification of biomarkers of cancer responses using advance cytomic technology.
Current collaborators:
Lewis Chodosh, MD, PhD, Cancer Biology
Erica Carpenter, MBA, PhD, Department of Medicine
John Wherry, Parker Institute for Cancer Immunotherapy
Mona Kumar, MD, Neurology

Flow Cytometry Expertise

As Director of the Flow Cytometry and Cell Sorting Shared Resource and the Clinical Flow Cytometry Laboratory as well as in my own research, I have developed and applied a variety of sophisticated flow cytometric applications. This includes expertise in intracellular protein detection, complex data mining, cell proliferation, rare stem cell detection as well as other functional assays.

Graduate Groups

Immunology

Education

B.A. (Biology), University of Virginia, Charlottesville, 1972
Ph.D. (Microbiology), Thomas Jefferson University, Philadelphia, 1984

Specialty Certification

Becton-Dickinson FACScan Key Operator, 1990
Becton-Dickinson FACStar PLUS Key Operator, 1992

Postgraduate Training

Postdoctoral Fellow, Immunology Graduate Group, Dr. Peter C. Nowell and Dr. Richard G. Hoover, University of Pennsylvania School of Medicine, 1984-1988

Awards and Honors

Keynote Speaker Award, National Flow Cytometry Annual Course, Bowdoin College, Maine, 212
Sigma Xi Research Society (Associate Member), 1981
Sigma Xi Student Research Award, 1983
Thomas Jefferson University Fellow, 1983-1984
National Institutes of Health Postdoctoral Fellow, 1984-1987
Chapter Scholar, Arthritis Foundation, 1987, 1988, 1990, 1987-1990
Academy of Clinical Laboratory Physicians and Scientists, 2000-present
Peter C. Nowell Teaching Award, 2002
FOCUS Award for the Advancement of Women in Medicine, 2008
College of American Pathologists Outstanding Inspector, 2008
David B.P. Goodman, M.D., Ph.D. Award
Department of Pathology and Laboratory Medicine, 2009
Cyto2011 Pre-Congress Scientific Mentor, International Society for the Advancement of Cytometry, 2011
The Carleton and Sigrid Stewart Lectureship, Great Lakes International Imaging and Fluorescence Association, 2012
Wallace H. Coulter Award for Lifetime Achievement for Contributions to the Science, Education and Practice of Clinical Cytometry
International Clinical Cytometry Society, 2016
ISAC 2018 Membership Award for Advancing the Field of Cytometry, International Society for the Advancement of Cytometry, 2018
Goodman Award for University Service, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, 2018

Memberships and Professional Organizations

Penn Professional Women, 1991 - Present
International Society for Advancement of Cytometry, 1992 - Present
Great Lakes International Imaging and Flow Cytometry Association, 1996 - Present
International Clinical Cytometry Society, 1996 - Present
National Institutes of Health Special Emphasis Panel (SBIR), Hematology 1,2 Study Section, 1998 - 2005
University of Rochester School of Medicine, 2003 - 2003
Center for Human Cell Therapy, CBR Institute for Biomedical Research, Harvard University Medical School, 2004 - 2007
University of California at San Diego, Department of Pathology and Cancer Center, 2004 - 2004
College of Graduate Studies, Thomas Jefferson University, 2005 - 2019
University of Alabama at Birmingham, Arthritis and Musculoskelatal Disease Center, 2005 - 2005
University of Michigan, Department of Pathology, 2006 - 2006
American Society for Investigative Pathology, 2006 - Present
International Society for Hematopathology and Graft Engineering, - Present
American Association of Immunologists, - Present
American College of Laboratory Physicians and Scientists, - Present
Association of Biomolecular Resource Facilities, - Present

Web Links


Selected Publications

Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia.

Urtishak KA, Wang L, Culikovic-Krajiacic B, Davenport J, Porazzi P, Vincent T, Teachey D, Tasian S, Moore J, Seif A, Jin S, Barrett J, Robinson B, Chen I-M, Harvey R, Carroll M, Carroll A, Herrera N, Devidas M, Dryer Z, Hilden J, Hunger S, Willman C, Borden K, Felix C., Oncogene 38(): 2241, 2019

An integrated enrichment system to facilitate isolation and mononuclear characterization of single cancer cells from whole blood.

Yu L, Silin S, Wang L, Dulmage K, Bhagwat N, Yee S, Sen M, Pletcher C, Moore J, Saksena S, Dixon E,Carpenter E., Cytometry A 93(12): 1226, 2018

An integrated flow cytometry-based platform for isolation and molecular characterization of circulating tumor single cells and clusters

Bhagwat N, Dulmage K, Pletcher CH, Wang L, DeMuth W, Sen M, Balli D, Yee S, Sa S, Tong F, Yu L, Moore JS, Stanger BZ, Dixon EP, Carpenter EL, Scientific Reports 8(): 5035, 2018

"Peter C. Nowell (1928-2016)"

Mark I. Greene, Jonni S. Moore, Science 355(Issue 6328): 913, 2017

Vascular Health Profile Predicts Cardiovascular Outcomes in Patients with Diabetes

WT Rogers, L Zhang, S Welden, B Krieger, M Rickels, JS Moore, ER Mohler, III, Cytometry Part B 92B(): , 2017

Extracellular Vesicles: Great Potential, Many Challenges

Nolan, JP and Moore, J, Cytometry Part B 90B(): 324-325, 2016

Endothelial Cell-, Platelet-, and Monocyte/Macrophage-Derived Microparticles are Elevated in Psoriasis Beyond Cardiometabolic Risk Factors.

Takeshita J, Mohler E, Krishnamoorthy P, Moore J, Rogers W, Zhang L, Gelfand J, Mehta N., J Am Heart Association, 2014

Personalized cytomic assessment of vascular health: Evaluation of the vascular health profile in diabetes mellitus.

Kurtzman N, Zhang L, French B, Jonas R, Bantly A, Rogers WT, Moore JS, Rickels M, Mohler ER III, Cytometry Part B: Clinical Cytometry in press(): , 2013

Endothelial Microparticles; Sophisticated Vesicles Modulating Vascular Function

Curtis A.M., Edelberg J., Jonas R., Rogers W.T., Moore J.S., Wajihuddin S., Mohler E.R. III, Vascular Medicine in press(): , 2013

Potent Obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia. Blood 121(14): 2689-2703

Urtishak KA, Edwards AY, Wang LS, Hudome A, Robinson BW, Barrett JS, Cao K, Cory L, Moore JS, Bantly AD, Yu QC, Chen IM, Atlas SR, Willman CL, Kundu M, Carroll AJ, Heerema NA, Devidas M, Hilden JM, Dreyer ZE, Hunger SP, Reaman GH, Felix CA, Blood 121(14): 2689-2703, 2013

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