PEOPLE

Michele E. Paessler, DO

Associate Professor of Clinical Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact Information3401 Civic Center Boulevard
Suite 5199D
Philadelphia, PA 19104
Office: 267-426-7309
Fax: 215-590-2130

Email: paessler@email.chop.edu

Education

B.S. Muhlenberg College (with honors), Allentown, PA, 1993
D.O. Philadelphia College of Osteopathic Medicine, Philadelphia, PA, 1997

Specialty Certification

Hematology/Hematopathology, 2004
Anatomic Pathology and Clinical Pathology, 2004
Molecular Genetic Pathology, 2005

Postgraduate Training

Intern in Medicine, Philadelphia College of Osteopathic Medicine (PCOM)/Allegheny University Hospitals, Philadelphia, PA, 1997-1998
Resident in Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, 1998-2001
Chief Resident, Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, 2000-2001
Fellow, Molecular Pathology, University of Pennsylvania Medical Center, Philadelphia, PA, 2001-2003
Fellow, Hematopathology, University of Pennsylvania Medical Center, Philadelphia, PA, 2002-2003
Fellow, Molecular Genetic Pathology, University of Pennsylvania Medical Center, Philadelphia, PA, 2003-2004

Awards and Honors

Deans List, Muhlenberg College, Allentown, PA, 1990-1993
Philadelphia College of Osteopathic Medicine Academic Scholarship, Philadelphia College of Osteopathic Medicine (PCOM)/Allegheny University Hospitals, Philadelphia, PA, 1994-1997
Sigma Xi Research Award, Philadelphia College of Osteopathic Medicine (PCOM)/Allegheny University Hospitals, Philadelphia, PA, -1997
William F. Daiber, D.O. Memorial Cardiology Award, Philadelphia College of Osteopathic Medicine (PCOM)/Allegheny University Hospitals, Philadelphia, PA, -1997
Internship Cardiology/Critical Care Award, Philadelphia College of Osteopathic Medicine (PCOM)/Allegheny University Hospitals, Philadelphia, PA, -1998
William Pepper Clinical Laboratory Fellow, University of Pennsylvania Medical Center, Philadelphia PA, -2001
2001 Resident Teaching Award, Dept of Pathology, University of Pennsylvania Medical Center, Philadelphia PA, -2001

Memberships and Professional Organizations

Pennsylvania Osteopathic Medical Association, 1997 - Present
United States and Canadian Academy of Pathology, 2000 - Present
Association of Molecular Pathology, 2001 - 2004
American Society of Hematology, 2002 - Present
International Clinical Cytometry Society, 2005 - Present
Society for Pediatric Pathology, 2005 - Present
College of American Pathologists - Instrumentation Resource Committee, 2007 - Present
NAPAAC Aplastic Anemia Retrospective Analysis
Hematopathology Working Group Study, 2013 - present
Society of Hematopathology, 2015 - Present
International Society for Laboratory Hematology (ISLH), 2016 - Present

Web Links


Selected Publications

Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2

Diorio C, Henrickson SE, Vella LA, McNerney KO, Chase JM, Burudpakdee C, Lee JH, Jasen C, Balamuth F, Barrett DM, Banwell B, Bernt KM, Blatz AM, Chiotos K, Fisher BT, Fitzgerald JC, Gerber JS, Gollomp K, Gray C, Grupp SA, Harris RM, Kilbaugh TJ, Odom John AR, Lambert MP, Liebling EJ, Paessler M, Petrosa W, Phillips CA, Reilly AF, Romberg N, Seif AE, Sesok-Pizzini D, Sullivan K, Vardaro J, Behrens EM, Teachey DT, Bassiri H, The Journal of Clinical Investigation, 2020, PMID:32730233

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Evidence of Thrombotic Microangiopathy in Children with SARS-CoV-2 Across the Spectrum of Clinical Presentations

Dorio C, Paessler MP, Blood Advances, 2020

CAR T-cell therapy is effective for CD 19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy.

Pillai V, Muralidharan K, Meng W, Bagashev A, Oldridge DA, Rosenthal J, Van Arnam J, Melenhorst JJ, Mohan D, DiNofia AM, Luo M, Cherian S, Fromm JR, Wertheim G, Thomas-Tikhonenko A, Paessler M, June CH, Luning Prak ET, Bhoj VG, Grupp SA, Maude SL, Rheingold SR, Blood Advances 3(22): 3539-3549, 2019, PMID:31738832

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Rhabdomyosarcoma and Wilms tumors contain a subpopulation of noggin producing, myogenic cells immunoreactive for lens beaded filament proteins

Gerhart J, Behling K, Paessler M, Milton L, Bramblett G, Garcia D, Pitts M, Hurtt R, Crawford M, Lackman R, Nguyen D, Infanti J, FitzGerald P, George-Weinstein M, PLoS One 14(4): e0214758, 2019, PMID:30973903

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Patients with common variable immunodeficiency with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses

Romberg N, Le Coz C, Glauzy S, Schickel JN, Trofa M, Nolan BE, Paessler M, Xu ML, Lambert MP, Lakhani SA, Khokha MK, Jyonouchi S, Heimall J, Takach P, Maglione PJ, Catanzaro J, Hsu FI, Sullivan KE, Cunningham-Rundles C, Meffre E, The Journal of Allergy and Clinical Immunology 143(1): 258-265, 2019, PMID:29935219

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Heterogeneity of surface CD19 and CD22 expression in B lymphoblastic leukemia

Rosenthal J, Naqvi AS, Luo M, Wertheim G, Paessler M, Thomas-Tikhonenko A, Rheingold SR, Pillai V, American Journal of Hematology 93(11): E352-E355, 2018, PMID:30058145

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International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease

Fajgenbaum DC1, Uldrick TS2, Bagg A3, Frank D3, Wu D4, Srkalovic G5, Simpson D6, Liu AY7, Menke D8, Chandrakasan S9, Lechowicz MJ9, Wong RS10, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KS, Lim MS, Blood 129(12): 1646-1657, 2017, PMID:28087540

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Repeated loss of target surface antigen after immunotherapy in primary mediastinal large B cell lymphoma

Yu H, Sotillo E, Harrington C, Wertheim G, Paessler M, Maude SL, Rheingold SR, Grupp SA, Thomas-Tikhonenko A, Pillai V, Am J Hematol 92(1): E11-E13, 2017, PMID:27779774

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Marked eosinophilia masking B lymphoblastic leukemia

Yu H, Wertheim G, Shankar S, Paessler M, Aplenc R, Pillai V, Am J Hematol 91(5): 543-4, 2016, PMID:26662494

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