PEOPLE

Gerard D. Schellenberg, PhD

Professor of Pathology and Laboratory Medicine, Professor of Pathology and Laboratory Medicine in Genetics
Director, Penn Neurodegeneration Genomics Center
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
University of Pennsylvania School of Medicine
Room 609B, Stellar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104

Specialty Division

Neuropathology, Immunobiology and Experimental Pathology

Graduate Groups

Genomics and Computational Biology
Neuroscience

Education

B.S. (Biochemistry/minor: Cell Biology), University of California at Riverside, Riverside, CA, 1973
Ph.D. (Biochemistry/minor: Cell Biology), University of California at Riverside, Riverside, CA, 1978

Specialty Certification

Postgraduate Training

National Science Foundation Undergraduate, Summer Research Program, Department of Biochemistry, University of California at Riverside, CA, 1972-1972
National Science Foundation Undergraduate Research Fellowship, Summer Research Program, Department of Biochemistry, University of California at Riverside, California, 1972-1972
Senior Research Fellow, Department of Medical Genetics, School of Medicine, RG-20, University of Washington, Seattle, WA, 1978-1979
Senior Research Fellow, Division of Neurology, Department of Medicine, University of Washington, Seattle, WA, 1979-1982
NIH Post Doctoral Fellowship, National Institute of Health, 1980-1982
Senior Research Fellow, Department of Genetics, School of Medicine, University of Washington, Seattle, WA, 1982-1983

Awards and Honors

John Douglas French Foundation for Alzheimer's Disease, Investigator Award, 1986-1988
Potamkin Prize for Alzheimer's Disease Research
Potamkin Foundation and the American Academy of Neurology, 1994
Metropolitan Life Foundation, Awards for Medical Research, 1995
Alzheimer's Association Medical Honoree, for outstanding commitment to the research of Alzheimer's disease, 1996
National Institute on Aging, R37 Merit Award: Genomic analysis of Alzheimer’s disease, 2004

Memberships and Professional Organizations

American Society of Human Genetics, 1988 - present
Alzheimer's Association, 1990 - 1995
American Health Assistance Foundation, 1992 - 1994
University of Kansas Medical School Alzheimer's Disease Research Center, 1993 - 1995
Harvard Medical School Alzheimer's Disease Research Center, 1993 - 1997
NIH Neurology C Study Section, 1995 - 1998
Mount Sinai Alzheimer's Disease Research Center, 1998 - 1998
NIH Brain Disorders and Clinical Neuroscience 3 Study Section, 1998 - 1999
National Veterans Affairs Committee on Genetics Research, 1998 - 1998
NIH National Advisory Council for Human Genome Research, 2000 - 2008
Mayo Clinic Alzheimer's Disease Research Center, 2000 - 2004
Indiana Alzheimer's Disease Center National Cell Repository, 2001 - present
Virtual Research Institute on Aging: Nippon Boehringer-Ingelheim, 2001 - 2004
National Alzheimer's Coordinating Center, 2001 - 2004
M.I.N.D. Institute Research Program,
University of California Davis, 2002 - 2005
American Society for Biochemistry and Molecular Biology, 2002 - Present
Autism Genome Project, 2003 - Present
Society of Progressive Supranuclear Palsy, 2003 - Present
National Alliance for Autism Researsch, 2003 - Present
Alzheimer Research Consortium, 2003 - Present
Program Project "Presenilin Biology and the Mechanism of Alzheimer's Disease," Harvard Medical School, 2004 - 2007
Veteran's Affairs Dementia Prevention Study of Vitamin E and Mementine, 2005 - 2015
Texas Alzheimer Research and Care Consortium, 2008 - present
Resource Allocation Review Committee (RARC), Dominantly Inherited Alzheimer’s Disease (DIAN) Project, 2008 - present
Peebler PSP Research Foundation, 2009 - present
Alzheimer’s Association, 2009 - 2010
7th International Conference on Frontotemporal Dementia, 2009 - 2010
Barcelona Think Tank Meeting on EU-US Collaborative Research on the Prevention of Dementia, 2009 - present
NIA, 2010 - 2010
International Genomics Alzheimer Project, 2011 - present
Alzheimer's Association, 2011 - present
8th International Conference on Frontotemporal Dementias (FTD 2012), 2011 - 2012
United Kingdom Parkinson Disease Center, University College London, 2012 - present
NIA/NHGRI/NIH, 2012 - present
NIA/NHGRI/NIH, 2013 - present
Member, The Dana Alliance for Brain Initiatives, 2013 - present
University of Miami Udall Center, 2013 - present
Mayo Clinic Rochester Udall Center, 2013 - present
Oxford Parkinson’s Disease Centre, 2013 - present
NIA/NHGRI/NIH, 2014 - present

Selected Publications

Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases

Ferrari R, Wang Y, Vandrovcova J, Guelfi S, Witeolar A, Karch CM, Schork AJ, Fan CC, Brewer JB; International FTD-Genomics Consortium (IFGC); International Parkinson's Disease Genomics Consortium (IPDGC); International Genomics of Alzheimer's Project (IGAP), Momeni P, Schellenberg GD, Dillon WP, Sugrue LP, Hess CP, Yokoyama JS, Bonham LW, Rabinovici GD, Miller BL, Andreassen OA, Dale AM, Hardy J, Desikan RS, J Neurol Neurosurg Psychiatry 88(2): 152-164, 2017, PMID:27899424

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The Alzheimer's Disease Sequencing Project: Study design and sample selection

Beecham GW, Bis JC, Martin ER, Choi, SH, DeStefano AL, van Duijn CM, Fornage M, Gabriel SB, Koboldt DC, Larson DE, Naj AC, Psaty BM, Salerno W, Bush WS, Foroud TM, Wijsman E, Farrer LA, Goate A, Haines JL, Pericak-Vance MA, Boerwinkle E, Mayeux R, Seshadri S, Schellenberg G, Neurol Genet 3(5): , 2017

Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants

Rehker J, Rodhe J, Nesbitt RR, Boyle EA, Martin BK, Lord J, Ramirez A, Karaca I, Scherer M, Jessen F, Helisalmi S, Soininen H, Hiltunen M, Naj A, Shendure J, Raskind WH, Cruchaga C, Schellenberg GD, Bertrand Joseph, Brkanac Z, PLoS One 12(10): , 2017, PMID:28985224

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Genetic Influences on Cognition in Progressive Supranuclear Palsy

Gerstenecker A, Roberson ED, Schellenberg GD, Standaert DG, Shprecher DR, Kluger BM, Litvan I, Movement Dis, 2017, PMID:29076559

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Polygenic hazard scores in preclinical Alzheimer’s disease

Tan CH, Hyman BT, Tan JJX, Hess CP, Dillon WP, Schellenberg GD, Besser LM, Kukull WA, Kauppi K, McEvoy LK, Andreassen OA, Dale AM, Fan CC, Desikan RS, Ann Neurol 82(3): 484-488, 2017, PMID:28940650

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A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

Huang K-L, Marcora E, Pimenova AM, Di Narzo AF, Kapoor M, Jin SC, Harari O, Bertelsen S, Fairfax BF, Czajkowski J, Chouraki V, Grenier-Boley B, Bellenguez C, Deming Y, McKenzie A, Raj T, Renton AE, Budde J, Smith A, Fitzpatrick A, Bis JC, DeStefano A, Adams HHH, Ikram MA, van der Lee S, Del-Aguila JL, Fernande MV, Ibañez L, International Genomics of Alzheimer's Project, Alzheimer's Disease Neuroimaging Initiative, Sims R, Escott-Price V, Mayeux R, Haines JL, Farrer LA, Pericak-Vance MA, Lambert JC, van Duijn C, Launer L, Seshadri S, Williams J, Amouyel P, Schellenberg GD, Zhang B, Boreck I, Kauwe JSK, Cruchaga C, Hao K, Goate AM, Nat Neurosci 20(8): 1052-1061, 2017, PMID:28628103

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Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism

Chapuis J, Flaig A, Grenier-Boley B, Eysert F, Pottiez V, Deloison G, Vandeputte A, Ayral AM, Mendes T, Desai S, Goate AM, Kauwe JSK, Leroux F, Herledan A, Demiautte F, Bauer C, Checler F, Petersen RC, Blennow K, Zetterberg H, Minthon L, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Albert M, Moghekar A, O'Brien R, Peskind ER, Malmanche N, Schellenberg GD, Dourlen P, Song OR, Cruchaga C, Amouyel P, Deprez B, Brodin P, Lambert JC; ADGC, Alzheimer’s Disease Neuroimaging Initiative, Acta Neuropathol 133(6): 955-966, 2017, PMID:27933404

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Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia

Yokoyama JS, Karch CM, Fan CC, Bonham LW, Kouri N, Ross OA, Rademakers R, Kim J, Wang Y, Höglinger GU, Müller U, Ferrari R, Hardy J; International FTD-Genomics Consortium (IFGC)., Momeni P, Sugrue LP, Hess CP, James Barkovich A, Boxer AL, Seeley WW, Rabinovici GD, Rosen HJ, Miller BL, Schmansky NJ, Fischl B, Hyman BT, Dickson DW, Schellenberg GD, Andreassen OA, Dale AM, Desikan RS, Acta Neuropathol 133(5): 825-837, 2017, PMID:28271184

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Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers

Deming Y, Li Z, Kapoor M, Harari O, Del-Aguila JL, Black K, Carrell D, Cai Y, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Huang KL, Bertelsen S, Fagan AM, Holtzman DM, Morris JC, Kim S, Saykin AJ, De Jager PL, Albert M, Moghekar A, O'Brien R, Riemenschneider M, Petersen RC, Blennow K, Zetterberg H, Minthon L, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Schellenberg G, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Peskind ER, Li G, Di Narzo AF; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer Disease Genetic Consortium (ADGC), Kauwe JS, Goate AM, Cruchaga C, Acta Neuropathol 133(5): 839-856, 2017, PMID:28247064

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