Gerard D. Schellenberg, PhD

Professor of Pathology and Laboratory Medicine, Professor of Pathology and Laboratory Medicine in Genetics
Director, Penn Neurodegeneration Genomics Center
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
University of Pennsylvania School of Medicine
Room 609B, Stellar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104


Specialty Division

Neuropathology, Immunobiology and Experimental Pathology

Graduate Groups

Genomics and Computational Biology


B.S. (Biochemistry/minor: Cell Biology), University of California at Riverside, Riverside, CA, 1973
Ph.D. (Biochemistry/minor: Cell Biology), University of California at Riverside, Riverside, CA, 1978

Specialty Certification

Postgraduate Training

National Science Foundation Undergraduate, Summer Research Program, Department of Biochemistry, University of California at Riverside, CA, 1972-1972
National Science Foundation Undergraduate Research Fellowship, Summer Research Program, Department of Biochemistry, University of California at Riverside, California, 1972-1972
Senior Research Fellow, Department of Medical Genetics, School of Medicine, RG-20, University of Washington, Seattle, WA, 1978-1979
Senior Research Fellow, Division of Neurology, Department of Medicine, University of Washington, Seattle, WA, 1979-1982
NIH Post Doctoral Fellowship, National Institute of Health, 1980-1982
Senior Research Fellow, Department of Genetics, School of Medicine, University of Washington, Seattle, WA, 1982-1983

Awards and Honors

John Douglas French Foundation for Alzheimer's Disease, Investigator Award, 1986-1988
Potamkin Prize for Alzheimer's Disease Research
Potamkin Foundation and the American Academy of Neurology, 1994
Metropolitan Life Foundation, Awards for Medical Research, 1995
Alzheimer's Association Medical Honoree, for outstanding commitment to the research of Alzheimer's disease, 1996
National Institute on Aging, R37 Merit Award: Genomic analysis of Alzheimer’s disease, 2004

Memberships and Professional Organizations

American Society of Human Genetics, 1988 - present
Alzheimer's Association, 1990 - 1995
American Health Assistance Foundation, 1992 - 1994
Harvard Medical School Alzheimer's Disease Research Center, 1993 - 1997
University of Kansas Medical School Alzheimer's Disease Research Center, 1993 - 1995
NIH Neurology C Study Section, 1995 - 1998
Mount Sinai Alzheimer's Disease Research Center, 1998 - 1998
NIH Brain Disorders and Clinical Neuroscience 3 Study Section, 1998 - 1999
National Veterans Affairs Committee on Genetics Research, 1998 - 1998
NIH National Advisory Council for Human Genome Research, 2000 - 2008
Mayo Clinic Alzheimer's Disease Research Center, 2000 - 2004
National Alzheimer's Coordinating Center, 2001 - 2004
Indiana Alzheimer's Disease Center National Cell Repository, 2001 - present
Virtual Research Institute on Aging: Nippon Boehringer-Ingelheim, 2001 - 2004
M.I.N.D. Institute Research Program,
University of California Davis, 2002 - 2005
American Society for Biochemistry and Molecular Biology, 2002 - Present
Autism Genome Project, 2003 - Present
Alzheimer Research Consortium, 2003 - Present
National Alliance for Autism Researsch, 2003 - Present
Society of Progressive Supranuclear Palsy, 2003 - Present
Program Project "Presenilin Biology and the Mechanism of Alzheimer's Disease," Harvard Medical School, 2004 - 2007
Veteran's Affairs Dementia Prevention Study of Vitamin E and Mementine, 2005 - 2015
Resource Allocation Review Committee (RARC), Dominantly Inherited Alzheimer’s Disease (DIAN) Project, 2008 - present
Texas Alzheimer Research and Care Consortium, 2008 - present
Peebler PSP Research Foundation, 2009 - present
Alzheimer’s Association, 2009 - 2010
7th International Conference on Frontotemporal Dementia, 2009 - 2010
Barcelona Think Tank Meeting on EU-US Collaborative Research on the Prevention of Dementia, 2009 - present
NIA, 2010 - 2010
8th International Conference on Frontotemporal Dementias (FTD 2012), 2011 - 2012
Alzheimer's Association, 2011 - present
International Genomics Alzheimer Project, 2011 - present
NIA/NHGRI/NIH, 2012 - present
United Kingdom Parkinson Disease Center, University College London, 2012 - present
NIA/NHGRI/NIH, 2013 - present
University of Miami Udall Center, 2013 - present
Mayo Clinic Rochester Udall Center, 2013 - present
Oxford Parkinson’s Disease Centre, 2013 - present
Member, The Dana Alliance for Brain Initiatives, 2013 - present
NIA/NHGRI/NIH, 2014 - present

Selected Publications

CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease

Ma Y, Jun GR, Chung J, Zhang X, Kunkle BW, Naj AC, White CC, Bennett DA, De Jager PL; Alzheimer’s Disease Genetics Consortium, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, Farrer LA, Lunetta KL, Aging Cell 18(4): , 2019, PMID:31144443

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C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy

Cali CP, Patino M, Tai YK, Ho WY, McLean CA, Morris CM, Seeley WW, Miller BL, Gaig C, Vonsattel JPG, White CL 3rd, Roeber S, Kretzschmar H, Troncoso JC, Troakes C, Gearing M, Ghetti B, Van Deerlin VM, Lee VM, Trojanowski JQ, Mok KY, Ling H, Dickson DW, Schellenberg GD, Ling SC, Lee EB, Acta Neuropathol, 2019, PMID:313277044

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Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

Ma Y, Jun GR, Zhang X, Chung J, Naj AC, Chen Y, Bellenguez C, Hamilton-Nelson K, Martin ER, Kunkle BW, Bis JC, Debette S, DeStefano AL, Fornage M, Nicolas G, van Duijn C, Bennett DA, De Jager PL, Mayeux R, Haines JL, Pericak-Vance MA, Seshadri S, Lambert JC, Schellenberg GD, Lunetta KL, Farrer LA; Alzheimer’s Disease Sequencing Project and Alzheimer’s Disease Exome Sequencing–France Project, JAMA Neurol, 2019, PMID:31180460

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VCPA: genomic variant calling pipeline and data management tool for Alzheimer's Disease Sequencing Project

Leung YY, Valladares O, Chou YF, Lin HJ, Kuzma AB, Cantwell L, Qu L, Gangadharan P, Salerno WJ, Schellenberg GD, Wang LS, Bioinformatics 35(10): 1768-1770, 2019, PMID:30351394

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A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease

Zhang X, Zhu C, Beecham G, Vardarajan BN, Ma Y, Lancour D, Farrell JJ, Chung J; Alzheimer's Disease Sequencing Project, Mayeux R, Haines JL, Schellenberg GD, Pericak-Vance MA, Lunetta KL, Farrer LA, Alzheimers Dement 15(3): 441-452, 2019, PMID:30503768

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Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration

Tan CH, Bonham LW, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Yokoyama JS, Rabinovici GD, Miller BL, Yaffe K, Schellenberg GD, Kauppi K, Holland D, McEvoy LK, Kukull WA, Tosun D, Weiner MW, Sperling RA, Bennett DA, Hyman BT, Andreassen OA, Dale AM, Desikan RS; Alzheimer’s Disease Neuroimaging Initiative, Brain 142(2): 460-470, 2019, PMID:30689776

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Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease

Broce IJ, Tan CH, Fan CC, et al., Acta Neuropathol 137(2): 209-226, 2019, PMID:30413934

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