PEOPLE

Gerard D. Schellenberg, PhD

Professor of Pathology and Laboratory Medicine, Professor of Pathology and Laboratory Medicine in Genetics
Director, Penn Neurodegeneration Genomics Center
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
University of Pennsylvania School of Medicine
Room 609B, Stellar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104

Specialty Division

Neuropathology, Immunobiology and Experimental Pathology

Graduate Groups

Genomics and Computational Biology
Neuroscience

Education

B.S. (Biochemistry/minor: Cell Biology), University of California at Riverside, Riverside, California, 1973
Ph.D. (Biochemistry/minor: Cell Biology), University of California at Riverside, Riverside, California, 1978

Specialty Certification

Postgraduate Training

National Science Foundation Undergraduate Research Fellowship, Summer Research Program, Department of Biochemistry, University of California at Riverside, California, 1972-1972
National Science Foundation Undergraduate, Summer Research Program, Department of Biochemistry, University of California at Riverside, California, 1972-1972
Senior Research Fellow, Department of Medical Genetics, School of Medicine, RG-20, University of Washington, 1978-1979
Senior Research Fellow, Division of Neurology, Department of Medicine, University of Washington, Seattle, Washington, 1979-1982
NIH Post Doctoral Fellowship, National Institute of Health, 1980-1982
Senior Research Fellow, Department of Genetics, School of Medicine, University of Washington, Seattle, Washington, 1982-1983

Awards and Honors

John Douglas French Foundation for Alzheimer's Disease, Investigator Award, 1986-1988
Potamkin Prize for Alzheimer's Disease Research
Potamkin Foundation and the American Academy of Neurology, 1994
Metropolitan Life Foundation, Awards for Medical Research, 1995
Alzheimer's Association Medical Honoree, for outstanding commitment to the research of Alzheimer's disease, 1996
National Institute on Aging, R37 Merit Award: Genomic analysis of Alzheimer’s disease, 2004

Memberships and Professional Organizations

American Society of Human Genetics, 1988 - present
Alzheimer's Association, 1990 - 1995
American Health Assistance Foundation, 1992 - 1994
Harvard Medical School Alzheimer's Disease Research Center, 1993 - 1997
University of Kansas Medical School Alzheimer's Disease Research Center, 1993 - 1995
NIH Neurology C Study Section, 1995 - 1998
Mount Sinai Alzheimer's Disease Research Center, 1998 - 1998
NIH Brain Disorders and Clinical Neuroscience 3 Study Section, 1998 - 1999
National Veterans Affairs Committee on Genetics Research, 1998 - 1998
Mayo Clinic Alzheimer's Disease Research Center, 2000 - 2004
NIH National Advisory Council for Human Genome Research, 2000 - 2008
Indiana Alzheimer's Disease Center National Cell Repository, 2001 - present
Virtual Research Institute on Aging: Nippon Boehringer-Ingelheim, 2001 - 2004
National Alzheimer's Coordinating Center, 2001 - 2004
M.I.N.D. Institute Research Program,
University of California Davis, 2002 - 2005
American Society for Biochemistry and Molecular Biology, 2002 - Present
Autism Genome Project, 2003 - Present
Society of Progressive Supranuclear Palsy, 2003 - Present
National Alliance for Autism Researsch, 2003 - Present
Alzheimer Research Consortium, 2003 - Present
Program Project "Presenilin Biology and the Mechanism of Alzheimer's Disease," Harvard Medical School, 2004 - 2007
Veteran's Affairs Dementia Prevention Study of Vitamin E and Mementine, 2005 - 2015
Texas Alzheimer Research and Care Consortium, 2008 - present
Resource Allocation Review Committee (RARC), Dominantly Inherited Alzheimer’s Disease (DIAN) Project, 2008 - present
Peebler PSP Research Foundation, 2009 - present
Barcelona Think Tank Meeting on EU-US Collaborative Research on the Prevention of Dementia, 2009 - present
Alzheimer’s Association, 2009 - 2010
7th International Conference on Frontotemporal Dementia, 2009 - 2010
NIA, 2010 - 2010
8th International Conference on Frontotemporal Dementias (FTD 2012), 2011 - 2012
International Genomics Alzheimer Project, 2011 - present
Alzheimer's Association, 2011 - present
NIA/NHGRI/NIH, 2012 - present
United Kingdom Parkinson Disease Center, University College London, 2012 - present
NIA/NHGRI/NIH, 2013 - present
Member, The Dana Alliance for Brain Initiatives, 2013 - present
Oxford Parkinson’s Disease Centre, 2013 - present
University of Miami Udall Center, 2013 - present
Mayo Clinic Rochester Udall Center, 2013 - present
NIA/NHGRI/NIH, 2014 - present

Selected Publications

Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy.

Kouri N, Ross OA, Dombroski B, Younkin CS, Serie DJ, Soto-Ortolaza A, Baker M, Finch NC, Yoon H, Kim J, Fujioka S, McLean CA, Ghetti B, Spina S, Cantwell LB, Farlow MR, Grafman J, Huey ED, Ryung Han M, Beecher S, Geller ET, Kretzschmar HA, Roeber S, Gearing M, Juncos JL, Vonsattel JP, Van Deerlin VM, Grossman M, Hurtig HI, Gross RG, Arnold SE, Trojanowski JQ, Lee VM, Wenning GK, White CL, Höglinger GU, Müller U, Devlin B, Golbe LI, Crook J, Parisi JE, Boeve BF, Josephs KA, Wszolek ZK, Uitti RJ, Graff-Radford NR, Litvan I, Younkin SG, Wang LS, Ertekin-Taner N, Rademakers R, Hakonarsen H, Schellenberg GD, Dickson DW., Nat Commun. 6(): 7247, 2015, PMID:26077951

Read article

Polygenic overlap between C-reactive protein, plasma lipids, and Alzheimer disease.

Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen CH, Karow DS, Brewer JB, Hess CP, Williams J, Sims R, O'Donovan MC, Choi SH, Bis JC, Ikram MA, Gudnason V, DeStefano AL, van der Lee SJ, Psaty BM, van Duijn CM, Launer L, Seshadri S, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Hardy J, Ulstein ID, Aarsland D, Fladby T, White LR, Sando SB, Rongve A, Witoelar A, Djurovic S, Hyman BT, Snaedal J, Steinberg S, Stefansson H, Stefansson K, Schellenberg GD, Andreassen OA, Dale AM; Inflammation Working Group and International Genomics of Alzheimer’s Disease Project (IGAP) and DemGene Investigators., Circulation 131(23): , 2015, PMID:25862742

Read article

High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration.

Wheeler JM, McMillan PJ, Hawk M, Iba M, Robinson L, Xu GJ, Dombroski BA, Jeong D, Dichter MA, Juul H, Loomis E, Raskind M, Leverenz JB, Trojanowski JQ, Lee VM, Schellenberg GD, Kraemer BC., Acta Neuropathol Commun 3(): 33, 2015, PMID:26041339

Read article

Convergent genetic and expression data implicate immunity in Alzheimer's disease.

International Genomics of Alzheimer's Disease Consortium IGAP., Alzheimers Dement 11(6): 658-71, 2015, PMID:25533204

Read article

Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk.

Hohman TJ, Cooke-Bailey JN, Reitz C, Jun G, Naj A, Beecham GW, Liu Z, Carney RM, Vance JM, Cuccaro ML, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue MW, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hardy J, Hendrie HC, Hall KS, Goate AM, Lang R, Byrd GS, Kukull WA, Foroud TM, Farrer LA, Martin ER, Pericak-Vance MA, Schellenberg GD, Mayeux R, Haines JL, Thornton-Wells TA; Alzheimer Disease Genetics Consortium., Alzheimers Dement. S1552-5260(15)00190-9(): , 2015

PARK10 is a major locus for sporadic neuropathologically confirmed parkinson disease.

Beecham GW, Dickson DW, Scott WK, Martin ER, Schellenberg G, Nuytemans K, Larson EB, Buxbaum JD, Trojanowski JQ, Van Deerlin VM, Hurtig HI, Mash DC, Beach TG, Troncoso JC, Pletnikova O, Frosch MP, Ghetti B, Foroud TM, Honig LS, Marder K, Vonsattel JP, Goldman SM, Vinters HV, Ross OA, Wszolek ZK, Wang L, Dykxhoorn DM, Pericak-Vance MA, Montine TJ, Leverenz JB, Dawson TM, Vance JM., Neurology 84(10): 972-80, 2015, PMID:25663231

Read article

A novel Alzheimer disease locus located near the gene encoding tau protein.

Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, Beecham GW, Smith AV, Chouraki V, Hamilton-Nelson KL, Ikram MA, Fievet N, Denning N, Martin ER, Schmidt H, Kamatani Y, Dunstan ML, Valladares O, Laza AR, Zelenika D, Ramirez A, Foroud TM, Choi SH, Boland A, Becker T, Kukull WA, van der Lee SJ, Pasquier F, Cruchaga C, Beekly D, Fitzpatrick AL, Hanon O, Gill M, Barber R, Gudnason V, Campion D, Love S, Bennett DA, Amin N, Berr C, Tsolaki M, Buxbaum JD, Lopez OL, Deramecourt V, Fox NC, Cantwell LB, Tárraga L, Dufouil C, Hardy J, Crane PK, Eiriksdottir G, Hannequin D, Clarke R, Evans D, Mosley TH Jr, Letenneur L, Brayne C, Maier W, De Jager P, Emilsson V, Dartigues JF, Hampel H, Kamboh MI, de Bruijn RF, Tzourio C, Pastor P, Larson EB, Rotter JI, O'Donovan MC, Montine TJ, Nalls MA, Mead S, Reiman EM, Jonsson PV, Holmes C, St George-Hyslop PH, Boada M, Passmore P, Wendland JR, Schmidt R, Morgan K, Winslow AR, Powell JF, Carasquillo M, Younkin SG, Jakobsdóttir J, Kauwe JS, Wilhelmsen KC, Rujescu D, Nöthen MM, Hofman A, Jones L; IGAP Consortium, Haines JL, Psaty BM, Van Broeckhoven C, Holmans P, Launer LJ, Mayeux R, Lathrop M, Goate AM, Escott-Price V, Seshadri S, Pericak-Vance MA, Amouyel P, Williams J, van Duijn CM, Schellenberg GD, Farrer LA., Mol Psychiatry, 2015, PMID:25778476

Read article

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways.

Network and Pathway Analysis Subgroup of Psychiatric Genomics Consortium, Nat Neurosci 18(2): 199-209, 2015, PMID:25599223

Read article

Rarity of the Alzheimer disease-protective APP A673T variant in the United States.

Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E; Alzheimer's Disease Genetics Consortium, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD; National Institute on Aging-Late-Onset Alzheimer’s Disease (NIA-LOAD) Family Study, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada M, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam WM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L., JAMA Neurol 72(2): 209-16, 2015, PMID:25531812

Read article

Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder.

Maier R, Moser G, Chen GB, Ripke S; Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Coryell W, Potash JB, Scheftner WA, Shi J, Weissman MM, Hultman CM, Landén M, Levinson DF, Kendler KS, Smoller JW, Wray NR, Lee SH., Am J Hum Genet 96(2): 283-94, 2015, PMID:25640677

Read article