PEOPLE

Gerard D. Schellenberg, PhD

Professor of Pathology and Laboratory Medicine, Professor of Pathology and Laboratory Medicine in Genetics
Director, Penn Neurodegeneration Genomics Center
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
University of Pennsylvania School of Medicine
Room 609B, Stellar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104

Email: gerardsc@pennmedicine.upenn.edu

Specialty Division

Neuropathology, Immunobiology and Experimental Pathology

Graduate Groups

Genomics and Computational Biology
Neuroscience

Education

B.S. (Biochemistry/minor: Cell Biology), University of California at Riverside, Riverside, CA, 1973
Ph.D. (Biochemistry/minor: Cell Biology), University of California at Riverside, Riverside, CA, 1978

Specialty Certification

Postgraduate Training

National Science Foundation Undergraduate, Summer Research Program, Department of Biochemistry, University of California at Riverside, CA, 1972-1972
National Science Foundation Undergraduate Research Fellowship, Summer Research Program, Department of Biochemistry, University of California at Riverside, California, 1972-1972
Senior Research Fellow, Department of Medical Genetics, School of Medicine, RG-20, University of Washington, Seattle, WA, 1978-1979
Senior Research Fellow, Division of Neurology, Department of Medicine, University of Washington, Seattle, WA, 1979-1982
NIH Post Doctoral Fellowship, National Institute of Health, 1980-1982
Senior Research Fellow, Department of Genetics, School of Medicine, University of Washington, Seattle, WA, 1982-1983

Awards and Honors

John Douglas French Foundation for Alzheimer's Disease, Investigator Award, 1986-1988
Potamkin Prize for Alzheimer's Disease Research
Potamkin Foundation and the American Academy of Neurology, 1994
Metropolitan Life Foundation, Awards for Medical Research, 1995
Alzheimer's Association Medical Honoree, for outstanding commitment to the research of Alzheimer's disease, 1996
National Institute on Aging, R37 Merit Award: Genomic analysis of Alzheimer’s disease, 2004

Memberships and Professional Organizations

American Society of Human Genetics, 1988 - present
Alzheimer's Association, 1990 - 1995
American Health Assistance Foundation, 1992 - 1994
University of Kansas Medical School Alzheimer's Disease Research Center, 1993 - 1995
Harvard Medical School Alzheimer's Disease Research Center, 1993 - 1997
NIH Neurology C Study Section, 1995 - 1998
Mount Sinai Alzheimer's Disease Research Center, 1998 - 1998
NIH Brain Disorders and Clinical Neuroscience 3 Study Section, 1998 - 1999
National Veterans Affairs Committee on Genetics Research, 1998 - 1998
NIH National Advisory Council for Human Genome Research, 2000 - 2008
Mayo Clinic Alzheimer's Disease Research Center, 2000 - 2004
Virtual Research Institute on Aging: Nippon Boehringer-Ingelheim, 2001 - 2004
Indiana Alzheimer's Disease Center National Cell Repository, 2001 - present
National Alzheimer's Coordinating Center, 2001 - 2004
M.I.N.D. Institute Research Program,
University of California Davis, 2002 - 2005
American Society for Biochemistry and Molecular Biology, 2002 - Present
Autism Genome Project, 2003 - Present
Society of Progressive Supranuclear Palsy, 2003 - Present
National Alliance for Autism Researsch, 2003 - Present
Alzheimer Research Consortium, 2003 - Present
Program Project "Presenilin Biology and the Mechanism of Alzheimer's Disease," Harvard Medical School, 2004 - 2007
Veteran's Affairs Dementia Prevention Study of Vitamin E and Mementine, 2005 - 2015
Texas Alzheimer Research and Care Consortium, 2008 - present
Resource Allocation Review Committee (RARC), Dominantly Inherited Alzheimer’s Disease (DIAN) Project, 2008 - present
Peebler PSP Research Foundation, 2009 - present
Alzheimer’s Association, 2009 - 2010
7th International Conference on Frontotemporal Dementia, 2009 - 2010
Barcelona Think Tank Meeting on EU-US Collaborative Research on the Prevention of Dementia, 2009 - present
NIA, 2010 - 2010
International Genomics Alzheimer Project, 2011 - present
Alzheimer's Association, 2011 - present
8th International Conference on Frontotemporal Dementias (FTD 2012), 2011 - 2012
United Kingdom Parkinson Disease Center, University College London, 2012 - present
NIA/NHGRI/NIH, 2012 - present
NIA/NHGRI/NIH, 2013 - present
Member, The Dana Alliance for Brain Initiatives, 2013 - present
University of Miami Udall Center, 2013 - present
Mayo Clinic Rochester Udall Center, 2013 - present
Oxford Parkinson’s Disease Centre, 2013 - present
NIA/NHGRI/NIH, 2014 - present

Selected Publications

C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy

Cali CP, Patino M, Tai YK, Ho WY, McLean CA, Morris CM, Seeley WW, Miller BL, Gaig C, Vonsattel JPG, White III, CL, Roeber S, Kretzschmar H, Troncoso JC, Troakes C, Gearing M, Ghetti B, Van Deerlin VM, Lee VM-Y, Trojanowski JQ, Mok KY, Ling H, Dickson DW, Schellenberg GD, Ling S-C, Lee EB, Acta Neuropathologica 138(5): 795-811, 2019, PMID:31327044

Read article

Sex differences in the genetic predictors of Alzheimer’s pathology

Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Bush WS, Gifford KA, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Deming Y, Chao MJ, Huentelman M, Martin ER, Hamilton-Nelson K, Shaw LM, Trojanowski JQ, Peskind ER, Cruchaga C, Pericak-Vance MA, Goate AM, Cox NJ, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M for the Alzheimer’s Disease Genetics Consortium and the Alzheimer Disease Neuroimaging Initiative, Bennett DA, Schneider JA, Jefferson AL, Hohman TJ, Brain 42(9): 2581-2589, 2019, PMID:31497858

Read article

APOE promoter polymorphism -219T/G is an effect modifier of the influence of APOE ε4 with Alzheimer’s disease risk in a multiracial sample

Choi KY, Lee JJ, Gunasekaran TI, Kang S, Lee W, Jeong J, Lim HJ, Zhang X, Zhu C, Won S-Y, Choi YY, Seo EH, Lee SC, Gim J, Chung JY, Chong A, Byun MS, Seo S, Ko P-W, Han JW, McLean C, Farrell J, Lunetta KL, Miyashita A, Hara N, Won S, Choi S-M, Ha J-M, Jeong JH, Kuwano R, Song MK, An SSA, Lee YM, Park KW, Lee H-W, Choi SH, Rhee S, Song WK, Lee JS, Mayeux R, Haines JL, Pericak-Vance MA, Choo IH, Nho K, Kim K-W, Lee DY, Kim SY, Kim BC, Kim H, Jun GR, Schellenberg GD, Ikeuchi T, Farrer LA, Lee KH, J Clinical Medicine 8(8): , 2019, PMID:31426376

Read article

CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease

Ma Y, Jun GR, Chung J, Zhang X, Kunkle BW, Naj AC, White CC, Bennett DA, De Jager PL; Alzheimer’s Disease Genetics Consortium, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, Farrer LA, Lunetta KL, Aging Cell 18(4): , 2019, PMID:31144443

Read article

C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy

Cali CP, Patino M, Tai YK, Ho WY, McLean CA, Morris CM, Seeley WW, Miller BL, Gaig C, Vonsattel JPG, White CL 3rd, Roeber S, Kretzschmar H, Troncoso JC, Troakes C, Gearing M, Ghetti B, Van Deerlin VM, Lee VM, Trojanowski JQ, Mok KY, Ling H, Dickson DW, Schellenberg GD, Ling SC, Lee EB, Acta Neuropathol, 2019, PMID:313277044

Read article

Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

Ma Y, Jun GR, Zhang X, Chung J, Naj AC, Chen Y, Bellenguez C, Hamilton-Nelson K, Martin ER, Kunkle BW, Bis JC, Debette S, DeStefano AL, Fornage M, Nicolas G, van Duijn C, Bennett DA, De Jager PL, Mayeux R, Haines JL, Pericak-Vance MA, Seshadri S, Lambert JC, Schellenberg GD, Lunetta KL, Farrer LA; Alzheimer’s Disease Sequencing Project and Alzheimer’s Disease Exome Sequencing–France Project, JAMA Neurol, 2019, PMID:31180460

Read article

VCPA: genomic variant calling pipeline and data management tool for Alzheimer's Disease Sequencing Project

Leung YY, Valladares O, Chou YF, Lin HJ, Kuzma AB, Cantwell L, Qu L, Gangadharan P, Salerno WJ, Schellenberg GD, Wang LS, Bioinformatics 35(10): 1768-1770, 2019, PMID:30351394

Read article

Association of rare coding mutations with Alzheimer disease and other dementias among adults of European ancestry

Patel D, Mez J, Vardarajan BV, Staley L, Chung J, Zhang X, Farrell JJ, Rynkiewicz MJ, Cannon-Albright LA, Teerlink CC, Stevens J, Corcoran C, Murcia JDG, Lopez SOL, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, Kauwe JSK, Lunetta KL, Farrer LA for the Alzheimer’s Disease Sequencing Project, JAMA 2(3): , 2019, PMID:30924900

Read article