PEOPLE

John Q. Trojanowski, MD, PhD

William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Co-Director, Center for Neurodegenerative Disease Research
Director, Institute on Aging
Director, Alzheimer's Disease Core Center
Director, Penn Udall Center for Parkinson's Research
University of Pennsylvania Perelman School of Medicine

Contact InformationCenter for Neurodegenerative Disease Research
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building
Philadelphia, PA 19104-4283
Office: 215-662-6399
Fax: 215-349-5909

Email: TROJANOW@UPENN.EDU

Specialty Division

Neuropathology, Immunobiology and Experimental Pathology

Research Expertise

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Other Expertise

Research currently centers on molecular mechanisms of neuron dysfunction, degeneration, and death in normal aging and in neurodegenerative diseases (AD and PD, frontotemporal dementias (FTD) with and without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular, and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Graduate Groups

Neuroscience

Education

University of Vienna, Vienna, Austria, 1969
B.A. (German), King's College (1965-1967 & 1969-1970), 1970
Erasmus University Rotterdam, Rotterdam, The Netherlands, 1974
Ph.D. (Neuroanatomy), Tufts University Graduate School of Arts and Sciences, 1976
M.D. Tufts University School of Medicine, 1976

Specialty Certification

American Board of Pathology, Anatomic Pathology and Neuropathology
National Board of Medical Examiners - No. 138521, 1981

Postgraduate Training

Clinical Fellow in Medicine (Medical Intern, Mt. Auburn Hospital, Cambridge, MA), Harvard Medical School, 1976-1977
1977-79 Clinical Fellow in Pathology (Pathology and Neuropathology Resident, Massachusetts Gen. Hospital, Boston, MA) , Harvard Medical School, 1977-1979
Pathology and Neuropathology Resident, Hospital of the University of Pennsylvania, Philadelphia, PA, 1979-1980

Awards and Honors

Magna Cum Laude, King's College, 1970
Sandoz Award in Neurology, 1976
Roche Laboratories Neurosciences Research Award, 1976
Mead Johnson Excellence in Research Award, 1976
Wm. Dameshek Research Award, Tufts Univ. School of Medicine, 1976
N.I.N.C.D.S. National Research Service Award in Neuropathology, 1978-1979
N.I.N.C.D.S. Teacher Investigator Development Award (TIDA), NS-00762, 1983-1987
N.C.I. Method to Extend Research In Time (MERIT) Award, CA-36245-04-13, 1986-1995
M.A. Degree (Honoris Causa), University of Pennsylvania, 1987
Weil Award For Best Experimental Neuropathology Paper American Association of Neuropathologists, 1988
Elected Member, American Society of Clinical Investigation, 1991
Metropolitan Life Foundation Promising Investigator Award For Alzheimer's Disease Research, 1991
Established Investigator Award of the National Alliance for Research on Schizophrenia and Depression (NARSAD), 1994
Metropolitan Life Foundation Award for Medical Research in Alzheimer’s Disease, 1996
President, American Association of Neuropathology, 1997-1998
Rita Hayworth Award for Medical Research in Alzheimer’s Disease, 1998
Pioneer Award for Alzheimer’s Disease Research of the Ronald and Nancy Reagan Research Institute, Alzheimer’s Association, 1998
Potamkin Prize for Medical Research in Alzheimer’s Disease, 1998
Recognized by ISI as a an ISI "Highly Cited Researcher" (A list of the, 2000
Stanley Cohen Biomedical Research Award of the University of Pennsylvania School of Medicine, 2000
Member, Institute of Medicine of the National Academy of Sciences, Elected 2002, 2002
Irving Wright Award for Distinction of the American Federation for Aging Research, 2004-2004
Irving Wright Award of Distinction of the American Federation for Aging Research, 2004-2004
Alzheimer Research Forum Award presented at SFN meeting, 2005-2005
Alzheimer Research Forum Award presented at SFN meeting, 2005-2005
Rous-Whipple Award from the American Society for Investigative Pathology, 2005-2005
Rous-Whipple Award from the American Society for Investigative Pathology, 2005-2005
Elected, Fellow of the College of Physicians of Philadelphia, 2005
F.E. Bennet Memorial Lecture of the American Neurological Association, 133rd Meeting, 2008-2008
Khalid Iqbal Lifetime Achievement Award presented at ICAD, 2009
The Wallace H. Coulter Lectureship Award (Endowed by the Wallace H. Coulter Foundation, Miami, FL) presented at AACC in Anaheim, CA, 2010
John Scott Award (establishd by John Scott in 1822 and given for inventions that have contributed in some outstanding way to the "comfort, welfare and happiness" of mankind by the City of Philadelphia since 1822), 2012
24th Annual Robert J. and Claire Pasarow Foundation Award in Neuropsychiatry Research, Los Angeles, CA, 2012
J. Allyn Taylor International Prize in Medicine, Molecular Basis of Neurological Disorders, the Robarts Institute, London, Ontario, Canada, 2014, 2014
Award for Meritorious Contributions to Neuropathology from the American Association of Neuropathologists, 13 June, 2015, 2015

Memberships and Professional Organizations

The Anne and Howard Gottlieb/Institute for the Study of Aging Award for Alzheimer’s Disease Drug Discovery, 2003 - Present
The Gerontological Society of America (GSA), Task Force on Research Committee, 2004 - 2007
Organizing Committee, 8th International Conference On Progress In
Alzheimer’s And Parkinson’s Disease, Salzburg, Austria, 2005 - 2007
Coins for Alzheimer’s Research Trust (CART), The CART Fund, in partnership with the American Federation for Aging Research, Grant Review, 2005 - Present
8th International Conference on Progress in Alzheimer's and Parkinson's Disease, 2005 - 2007
Member, Alzheimer 100 Scientific Advisory Board on the centennial of the presentation by Alois Alzheimer of the Auguste D. case in Tubingen on November 3, 1906, 2005 - 2006
Neuroscience Interest Group of the Institute of Medicine, 2007 - Present
Neuroscience Intrerest Group of the Institue of Medicine, Neuroscience,Behavior, Brain Function and Disorders, 2007 - Present
Member, NINDS Morris K. Udall Parkinson’s Disease Center Coordinating Committee, 2008 - 2011
EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration), 2008 - Present
Alzheimer's Disease Neuroimaging Initiative Targeted Proteonomics Project Team, of the NIH Biomarkers Consortium and Foundation of the NIH, 2008 - Present
National Advisory Panel for the Surgery, Anesthesia, and Dementia Study, 2008 - Present
MetLife Foundation Awards for Medical Research in Alzheimer's Disease Advisory Committee, 2008 - Present
NIA Division of Aging Biology Review Subcommittee on the Nathan Shock Centers, 2009 - Present
Alliance for Aging Research Working Group on the Uses of Biomarkers in Alzheimer's Disease, 2010 - Present
American Society for Clinical Investigators, - Present
American Academy of Neurology (Consultant, Potamkin Award Subcommittee), - Present
American Academy of Neurology (Consultant, Potamkin Award), - Present
Association of American Physicians, - Present
Killam Research Fellowship Program, The Canada Council, - Present
International Academy of Pathology, Abstract Review Board member, - Present
National Institutes of Health Neurology A Study Section, - Present
Elwyn Institute, Elwyn, PA, - Present
National Sleep Foundation, - Present
National Institutes of Health Grant Study Section Reviewers Reserve, - Present
National Institutes of Health, - Present
American Board of Pathology, - Present
Harvard Brain Tissue Resource Center, - Present
University of Pittsburgh Alzheimer’s Disease Research Center, - Present
National Campaign to End Neurological Disorders (END)), - Present
Amyotrophic Lateral Sclerosis Association Grant Review Committee, - Present
American Federation for Aging Research National Scientific Advisory Council, - Present
Dystonia Medical Research Foundation, - Present
Society for Neuroscience, - Present
Paul Beeson Physician Faculty Scholar in Aging Research Grant Review Committee, - Present
National Institutes of Neurologic Disorders and Stroke Parkinson’s Disease Center Grant Review Committee, - Present
National Institute on Aging, - Present
The Institute for the Study of Aging, - Present
National Institute on Aging, - Present
University of Washington Alzheimer's Disease Research Center, - Present
American Academy of Neurology, - Present
Alzheimer's Disease and Related Disorders Association of Greater Philadelphia, - Present
Institute on Aging, - Present
National Sleep Foundation, - Present
National Institutes on Aging, Neuroscience, Behavior and Sociology of Aging Review Committee (Sub-committee A) Study Section, - Present
National Cancer Institute, - Present
National Institutes of Health Pathology A Study Section, - Present
National Institutes of Child Health and Human Development, - Present
American Society for Investigative Pathology, - Present
American Association of Neuropathologists, - Present
American Association of Pathologists, - Present
American Society for Cell Biology, - Present
Society for Neuroscience, - Present
Institute of Medicine Class of 2002, - Present
National Institute on Aging, Board of Scientific Councilors, - Present
National Institute on Aging, National Advisory Council on Aging (NACA), - Present
National Institute on Aging, - Present
American Brain Tumor Association, - Present
National Institutes of Neurologic Disorders and Stroke, - Present
National Instutitues on Aging Leadership and Excellence In Alzheimer's Disease (LEAD) Award, - Present
American Health Assistance Foundation Alzheimer's Disease Research Review Committee, - Present
Alzheimer's Association, - Present
Alzheimer's Association, Ad Hoc Grant Reviewer; Medical and Scientific Advisory Board, - Present
Rush-Presbyterian-St. Luke's Medical Center, Alzheimer's Disease Center, Chicago IL, - Present

Web Links


Selected Publications

Large-scale exploratory genetic analysis of cognitive impairment in Parkinson's disease.

Mata Ignacio F, Johnson Catherine O, Leverenz James B, Weintraub Daniel, Trojanowski John Q, Van Deerlin Vivianna M, Ritz Beate, Rausch Rebecca, Factor Stewart A, Wood-Siverio Cathy, Quinn Joseph F, Chung Kathryn A, Peterson-Hiller Amie L, Espay Alberto J, Revilla Fredy J, Devoto Johnna, Yearout Dora, Hu Shu-Ching, Cholerton Brenna A, Montine Thomas J, Edwards Karen L, Zabetian Cyrus P, Neurobiology of aging 56(): 211.e1-211.e7, 2017, PMID:28526295

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Ante mortem CSF tau levels correlate with post mortem tau pathology in FTLD.

Irwin D J, Lleó A, Xie S X, McMillan C T, Wolk D, Lee E B, Van Deerlin V M, Shaw L M, Trojanowski J Q, Grossman M, Annals of neurology, 2017, PMID:28719018

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Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium.

McKeith Ian G, Boeve Bradley F, Dickson Dennis W, Halliday Glenda, Taylor John-Paul, Weintraub Daniel, Aarsland Dag, Galvin James, Attems Johannes, Ballard Clive G, Bayston Ashley, Beach Thomas G, Blanc Frédéric, Bohnen Nicolaas, Bonanni Laura, Bras Jose, Brundin Patrik, Burn David, Chen-Plotkin Alice, Duda John E, El-Agnaf Omar, Feldman Howard, Ferman Tanis J, Ffytche Dominic, Fujishiro Hiroshige, Galasko Douglas, Goldman Jennifer G, Gomperts Stephen N, Graff-Radford Neill R, Honig Lawrence S, Iranzo Alex, Kantarci Kejal, Kaufer Daniel, Kukull Walter, Lee Virginia M Y, Leverenz James B, Lewis Simon, Lippa Carol, Lunde Angela, Masellis Mario, Masliah Eliezer, McLean Pamela, Mollenhauer Brit, Montine Thomas J, Moreno Emilio, Mori Etsuro, Murray Melissa, O'Brien John T, Orimo Sotoshi, Postuma Ronald B, Ramaswamy Shankar, Ross Owen A, Salmon David P, Singleton Andrew, Taylor Angela, Thomas Alan, Tiraboschi Pietro, Toledo Jon B, Trojanowski John Q, Tsuang Debby, Walker Zuzana, Yamada Masahito, Kosaka Kenji, Neurology 89(1): 88-100, 2017, PMID:28592453

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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Sims Rebecca, van der Lee Sven J, Naj Adam C, Bellenguez Céline, Badarinarayan Nandini, Jakobsdottir Johanna, Kunkle Brian W, Boland Anne, Raybould Rachel, Bis Joshua C, Martin Eden R, Grenier-Boley Benjamin, Heilmann-Heimbach Stefanie, Chouraki Vincent, Kuzma Amanda B, Sleegers Kristel, Vronskaya Maria, Ruiz Agustin, Graham Robert R, Olaso Robert, Hoffmann Per, Grove Megan L, Vardarajan Badri N, Hiltunen Mikko, Nöthen Markus M, White Charles C, Hamilton-Nelson Kara L, Epelbaum Jacques, Maier Wolfgang, Choi Seung-Hoan, Beecham Gary W, Dulary Cécile, Herms Stefan, Smith Albert V, Funk Cory C, Derbois Céline, Forstner Andreas J, Ahmad Shahzad, Li Hongdong, Bacq Delphine, Harold Denise, Satizabal Claudia L, Valladares Otto, Squassina Alessio, Thomas Rhodri, Brody Jennifer A, Qu Liming, Sánchez-Juan Pascual, Morgan Taniesha, Wolters Frank J, Zhao Yi, Garcia Florentino Sanchez, Denning Nicola, Fornage Myriam, Malamon John, Naranjo Maria Candida Deniz, Majounie Elisa, Mosley Thomas H, Dombroski Beth, Wallon David, Lupton Michelle K, Dupuis Josée, Whitehead Patrice, Fratiglioni Laura, Medway Christopher, Jian Xueqiu, Mukherjee Shubhabrata, Keller Lina, Brown Kristelle, Lin Honghuang, Cantwell Laura B, Panza Francesco, McGuinness Bernadette, Moreno-Grau Sonia, Burgess Jeremy D, Solfrizzi Vincenzo, Proitsi Petra, Adams Hieab H, Allen Mariet, Seripa Davide, Pastor Pau, Cupples L Adrienne, Price Nathan D, Hannequin Didier, Frank-García Ana, Levy Daniel, Chakrabarty Paramita, Caffarra Paolo, Giegling Ina, Beiser Alexa S, Giedraitis Vilmantas, Hampel Harald, Garcia Melissa E, Wang Xue, Lannfelt Lars, Mecocci Patrizia, Eiriksdottir Gudny, Crane Paul K, Pasquier Florence, Boccardi Virginia, Henández Isabel, Barber Robert C, Scherer Martin, Tarraga Lluis, Adams Perrie M, Leber Markus, Chen Yuning, Albert Marilyn S, Riedel-Heller Steffi, Emilsson Valur, Beekly Duane, Braae Anne, Schmidt Reinhold, Blacker Deborah, Masullo Carlo, Schmidt Helena, Doody Rachelle S, Spalletta Gianfranco, Jr W T Longstreth, Fairchild Thomas J, Bossù Paola, Lopez Oscar L, Frosch Matthew P, Sacchinelli Eleonora, Ghetti Bernardino, Yang Qiong, Huebinger Ryan M, Jessen Frank, Li Shuo, Kamboh M Ilyas, Morris John, Sotolongo-Grau Oscar, Katz Mindy J, Corcoran Chris, Dunstan Melanie, Braddel Amy, Thomas Charlene, Meggy Alun, Marshall Rachel, Gerrish Amy, Chapman Jade, Aguilar Miquel, Taylor Sarah, Hill Matt, Fairén Mònica Díez, Hodges Angela, Vellas Bruno, Soininen Hilkka, Kloszewska Iwona, Daniilidou Makrina, Uphill James, Patel Yogen, Hughes Joseph T, Lord Jenny, Turton James, Hartmann Annette M, Cecchetti Roberta, Fenoglio Chiara, Serpente Maria, Arcaro Marina, Caltagirone Carlo, Orfei Maria Donata, Ciaramella Antonio, Pichler Sabrina, Mayhaus Manuel, Gu Wei, Lleó Alberto, Fortea Juan, Blesa Rafael, Barber Imelda S, Brookes Keeley, Cupidi Chiara, Maletta Raffaele Giovanni, Carrell David, Sorbi Sandro, Moebus Susanne, Urbano Maria, Pilotto Alberto, Kornhuber Johannes, Bosco Paolo, Todd Stephen, Craig David, Johnston Janet, Gill Michael, Lawlor Brian, Lynch Aoibhinn, Fox Nick C, Hardy John, Albin Roger L, Apostolova Liana G, Arnold Steven E, Asthana Sanjay, Atwood Craig S, Baldwin Clinton T, Barnes Lisa L, Barral Sandra, Beach Thomas G, Becker James T, Bigio Eileen H, Bird Thomas D, Boeve Bradley F, Bowen James D, Boxer Adam, Burke James R, Burns Jeffrey M, Buxbaum Joseph D, Cairns Nigel J, Cao Chuanhai, Carlson Chris S, Carlsson Cynthia M, Carney Regina M, Carrasquillo Minerva M, Carroll Steven L, Diaz Carolina Ceballos, Chui Helena C, Clark David G, Cribbs David H, Crocco Elizabeth A, DeCarli Charles, Dick Malcolm, Duara Ranjan, Evans Denis A, Faber Kelley M, Fallon Kenneth B, Fardo David W, Farlow Martin R, Ferris Steven, Foroud Tatiana M, Galasko Douglas R, Gearing Marla, Geschwind Daniel H, Gilbert John R, Graff-Radford Neill R, Green Robert C, Growdon John H, Hamilton Ronald L, Harrell Lindy E, Honig Lawrence S, Huentelman Matthew J, Hulette Christine M, Hyman Bradley T, Jarvik Gail P, Abner Erin, Jin Lee-Way, Jun Gyungah, Karydas Anna, Kaye Jeffrey A, Kim Ronald, Kowall Neil W, Kramer Joel H, LaFerla Frank M, Lah James J, Leverenz James B, Levey Allan I, Li Ge, Lieberman Andrew P, Lunetta Kathryn L, Lyketsos Constantine G, Marson Daniel C, Martiniuk Frank, Mash Deborah C, Masliah Eliezer, McCormick Wayne C, McCurry Susan M, McDavid Andrew N, McKee Ann C, Mesulam Marsel, Miller Bruce L, Miller Carol A, Miller Joshua W, Morris John C, Murrell Jill R, Myers Amanda J, O'Bryant Sid, Olichney John M, Pankratz Vernon S, Parisi Joseph E, Paulson Henry L, Perry William, Peskind Elaine, Pierce Aimee, Poon Wayne W, Potter Huntington, Quinn Joseph F, Raj Ashok, Raskind Murray, Reisberg Barry, Reitz Christiane, Ringman John M, Roberson Erik D, Rogaeva Ekaterina, Rosen Howard J, Rosenberg Roger N, Sager Mark A, Saykin Andrew J, Schneider Julie A, Schneider Lon S, Seeley William W, Smith Amanda G, Sonnen Joshua A, Spina Salvatore, Stern Robert A, Swerdlow Russell H, Tanzi Rudolph E, Thornton-Wells Tricia A, Trojanowski John Q, Troncoso Juan C, Van Deerlin Vivianna M, Van Eldik Linda J, Vinters Harry V, Vonsattel Jean Paul, Weintraub Sandra, Welsh-Bohmer Kathleen A, Wilhelmsen Kirk C, Williamson Jennifer, Wingo Thomas S, Woltjer Randall L, Wright Clinton B, Yu Chang-En, Yu Lei, Garzia Fabienne, Golamaully Feroze, Septier Gislain, Engelborghs Sebastien, Vandenberghe Rik, De Deyn Peter P, Fernadez Carmen Muñoz, Benito Yoland Aladro, Thonberg Hakan, Forsell Charlotte, Lilius Lena, Kinhult-Stählbom Anne, Kilander Lena, Brundin RoseMarie, Concari Letizia, Helisalmi Seppo, Koivisto Anne Maria, Haapasalo Annakaisa, Dermecourt Vincent, Fievet Nathalie, Hanon Olivier, Dufouil Carole, Brice Alexis, Ritchie Karen, Dubois Bruno, Himali Jayanadra J, Keene C Dirk, Tschanz JoAnn, Fitzpatrick Annette L, Kukull Walter A, Norton Maria, Aspelund Thor, Larson Eric B, Munger Ron, Rotter Jerome I, Lipton Richard B, Bullido María J, Hofman Albert, Montine Thomas J, Coto Eliecer, Boerwinkle Eric, Petersen Ronald C, Alvarez Victoria, Rivadeneira Fernando, Reiman Eric M, Gallo Maura, O'Donnell Christopher J, Reisch Joan S, Bruni Amalia Cecilia, Royall Donald R, Dichgans Martin, Sano Mary, Galimberti Daniela, St George-Hyslop Peter, Scarpini Elio, Tsuang Debby W, Mancuso Michelangelo, Bonuccelli Ubaldo, Winslow Ashley R, Daniele Antonio, Wu Chuang-Kuo, Peters Oliver, Nacmias Benedetta, Riemenschneider Matthias, Heun Reinhard, Brayne Carol, Rubinsztein David C, Bras Jose, Guerreiro Rita, Al-Chalabi Ammar, Shaw Christopher E, Collinge John, Mann David, Tsolaki Magda, Clarimón Jordi, Sussams Rebecca, Lovestone Simon, O'Donovan Michael C, Owen Michael J, Behrens Timothy W, Mead Simon, Goate Alison M, Uitterlinden Andre G, Holmes Clive, Cruchaga Carlos, Ingelsson Martin, Bennett David A, Powell John, Golde Todd E, Graff Caroline, De Jager Philip L, Morgan Kevin, Ertekin-Taner Nilufer, Combarros Onofre, Psaty Bruce M, Passmore Peter, Younkin Steven G, Berr Claudine, Gudnason Vilmundur, Rujescu Dan, Dickson Dennis W, Dartigues Jean-François, DeStefano Anita L, Ortega-Cubero Sara, Hakonarson Hakon, Campion Dominique, Boada Merce, Kauwe John Keoni, Farrer Lindsay A, Van Broeckhoven Christine, Ikram M Arfan, Jones Lesley, Haines Jonathan L, Tzourio Christophe, Launer Lenore J, Escott-Price Valentina, Mayeux Richard, Deleuze Jean-François, Amin Najaf, Holmans Peter A, Pericak-Vance Margaret A, Amouyel Philippe, van Duijn Cornelia M, Ramirez Alfredo, Wang Li-San, Lambert Jean-Charles, Seshadri Sudha, Williams Julie, Schellenberg Gerard D, Nature genetics, 2017, PMID:28714976

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Clinically silent Alzheimer's and vascular pathologies influence brain networks supporting executive function in healthy older adults.

Gold Brian T, Brown Christopher A, Hakun Jonathan G, Shaw Leslie M, Trojanowski John Q, Smith Charles D, Neurobiology of aging 58(): 102-111, 2017, PMID:28719854

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Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies.

Henderson Michael X, Chung Charlotte Hiu-Yan, Riddle Dawn M, Zhang Bin, Gathagan Ronald J, Seeholzer Steven H, Trojanowski John Q, Lee Virginia M Y, The Journal of neuroscience : the official journal of the Society for Neuroscience 37(24): 5870-5884, 2017, PMID:28522732

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Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases.

Cornec Anne-Sophie, Monti Ludovica, Kovalevich Jane, Makani Vishruti, James Michael J, Vijayendran Krishna G, Oukoloff Killian, Yao Yuemang, Lee Virginia M-Y, Trojanowski John Q, Smith Amos B, Brunden Kurt R, Ballatore Carlo, Journal of medicinal chemistry 60(12): 5120-5145, 2017, PMID:28530811

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Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).

Kovacs Gabor G, Xie Sharon X, Lee Edward B, Robinson John L, Caswell Carrie, Irwin David J, Toledo Jon B, Johnson Victoria E, Smith Douglas H, Alafuzoff Irina, Attems Johannes, Bencze Janos, Bieniek Kevin F, Bigio Eileen H, Bodi Istvan, Budka Herbert, Dickson Dennis W, Dugger Brittany N, Duyckaerts Charles, Ferrer Isidro, Forrest Shelley L, Gelpi Ellen, Gentleman Stephen M, Giaccone Giorgio, Grinberg Lea T, Halliday Glenda M, Hatanpaa Kimmo J, Hof Patrick R, Hofer Monika, Hortobágyi Tibor, Ironside James W, King Andrew, Kofler Julia, Kövari Enikö, Kril Jillian J, Love Seth, Mackenzie Ian R, Mao Qinwen, Matej Radoslav, McLean Catriona, Munoz David G, Murray Melissa E, Neltner Janna, Nelson Peter T, Ritchie Diane, Rodriguez Roberta D, Rohan Zdenek, Rozemuller Annemieke, Sakai Kenji, Schultz Christian, Seilhean Danielle, Smith Vanessa, Tacik Pawel, Takahashi Hitoshi, Takao Masaki, Rudolf Thal Dietmar, Weis Serge, Wharton Stephen B, White Charles L, Woulfe John M, Yamada Masahito, Trojanowski John Q, Journal of neuropathology and experimental neurology, 2017, PMID:28591867

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Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis.

Gendron Tania F, Daughrity Lillian M, Heckman Michael G, Diehl Nancy N, Wuu Joanne, Miller Timothy M, Pastor Pau, Trojanowski John Q, Grossman Murray, Berry James D, Hu William T, Ratti Antonia, Benatar Michael, Silani Vincenzo, Glass Jonathan D, Floeter Mary Kay, Jeromin Andreas, Boylan Kevin B, Petrucelli Leonard, Annals of neurology, 2017, PMID:28628244

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TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.

Paolicelli Rosa C, Jawaid Ali, Henstridge Christopher M, Valeri Andrea, Merlini Mario, Robinson John L, Lee Edward B, Rose Jamie, Appel Stanley, Lee Virginia M-Y, Trojanowski John Q, Spires-Jones Tara, Schulz Paul E, Rajendran Lawrence, Neuron, 2017, PMID:28669544

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