PEOPLE

John Q. Trojanowski, MD, PhD

William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Co-Director, Center for Neurodegenerative Disease Research
Director, Institute on Aging
Director, Alzheimer's Disease Core Center
Director, Penn Udall Center for Parkinson's Research
University of Pennsylvania Perelman School of Medicine

Contact InformationCenter for Neurodegenerative Disease Research
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building
Philadelphia, PA 19104-4283
Office: 215-662-6399
Fax: 215-349-5909

Email: TROJANOW@MAIL.MED.UPENN.EDU

Specialty Division

Neuropathology, Immunobiology and Experimental Pathology

Research Expertise

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Other Expertise

Research currently centers on molecular mechanisms of neuron dysfunction, degeneration, and death in normal aging and in neurodegenerative diseases (AD and PD, frontotemporal dementias (FTD) with and without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular, and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Graduate Groups

Neuroscience

Education

University of Vienna, Vienna, Austria, 1969
B.A. (German), King's College (1965-1967 & 1969-1970), 1970
Erasmus University Rotterdam, Rotterdam, The Netherlands, 1974
M.D. Tufts University School of Medicine, 1976
Ph.D. (Neuroanatomy), Tufts University Graduate School of Arts and Sciences, 1976

Specialty Certification

American Board of Pathology, Anatomic Pathology and Neuropathology
National Board of Medical Examiners - No. 138521, 1981

Postgraduate Training

Clinical Fellow in Medicine (Medical Intern, Mt. Auburn Hospital, Cambridge, MA), Harvard Medical School, 1976-1977
1977-79 Clinical Fellow in Pathology (Pathology and Neuropathology Resident, Massachusetts Gen. Hospital, Boston, MA) , Harvard Medical School, 1977-1979
Pathology and Neuropathology Resident, Hospital of the University of Pennsylvania, Philadelphia, PA, 1979-1980

Awards and Honors

Magna Cum Laude, King's College, 1970
Mead Johnson Excellence in Research Award, 1976
Roche Laboratories Neurosciences Research Award, 1976
Wm. Dameshek Research Award, Tufts Univ. School of Medicine, 1976
Sandoz Award in Neurology, 1976
N.I.N.C.D.S. National Research Service Award in Neuropathology, 1978-1979
N.I.N.C.D.S. Teacher Investigator Development Award (TIDA), NS-00762, 1983-1987
N.C.I. Method to Extend Research In Time (MERIT) Award, CA-36245-04-13, 1986-1995
M.A. Degree (Honoris Causa), University of Pennsylvania, 1987
Weil Award For Best Experimental Neuropathology Paper American Association of Neuropathologists, 1988
Elected Member, American Society of Clinical Investigation, 1991
Metropolitan Life Foundation Promising Investigator Award For Alzheimer's Disease Research, 1991
Established Investigator Award of the National Alliance for Research on Schizophrenia and Depression (NARSAD), 1994
Metropolitan Life Foundation Award for Medical Research in Alzheimer’s Disease, 1996
President, American Association of Neuropathology, 1997-1998
Rita Hayworth Award for Medical Research in Alzheimer’s Disease, 1998
Pioneer Award for Alzheimer’s Disease Research of the Ronald and Nancy Reagan Research Institute, Alzheimer’s Association, 1998
Potamkin Prize for Medical Research in Alzheimer’s Disease, 1998
Stanley Cohen Biomedical Research Award of the University of Pennsylvania School of Medicine, 2000
Recognized by ISI as a an ISI "Highly Cited Researcher" (A list of the, 2000
Member, Institute of Medicine of the National Academy of Sciences, Elected 2002, 2002
Irving Wright Award of Distinction of the American Federation for Aging Research, 2004-2004
Irving Wright Award for Distinction of the American Federation for Aging Research, 2004-2004
Rous-Whipple Award from the American Society for Investigative Pathology, 2005-2005
Alzheimer Research Forum Award presented at SFN meeting, 2005-2005
Alzheimer Research Forum Award presented at SFN meeting, 2005-2005
Elected, Fellow of the College of Physicians of Philadelphia, 2005
Rous-Whipple Award from the American Society for Investigative Pathology, 2005-2005
F.E. Bennet Memorial Lecture of the American Neurological Association, 133rd Meeting, 2008-2008
Khalid Iqbal Lifetime Achievement Award presented at ICAD, 2009
The Wallace H. Coulter Lectureship Award (Endowed by the Wallace H. Coulter Foundation, Miami, FL) presented at AACC in Anaheim, CA, 2010
John Scott Award (establishd by John Scott in 1822 and given for inventions that have contributed in some outstanding way to the "comfort, welfare and happiness" of mankind by the City of Philadelphia since 1822), 2012
24th Annual Robert J. and Claire Pasarow Foundation Award in Neuropsychiatry Research, Los Angeles, CA, 2012
J. Allyn Taylor International Prize in Medicine, Molecular Basis of Neurological Disorders, the Robarts Institute, London, Ontario, Canada, 2014, 2014
Award for Meritorious Contributions to Neuropathology from the American Association of Neuropathologists, 13 June, 2015, 2015

Memberships and Professional Organizations

The Anne and Howard Gottlieb/Institute for the Study of Aging Award for Alzheimer’s Disease Drug Discovery, 2003 - Present
The Gerontological Society of America (GSA), Task Force on Research Committee, 2004 - 2007
Organizing Committee, 8th International Conference On Progress In
Alzheimer’s And Parkinson’s Disease, Salzburg, Austria, 2005 - 2007
Coins for Alzheimer’s Research Trust (CART), The CART Fund, in partnership with the American Federation for Aging Research, Grant Review, 2005 - Present
8th International Conference on Progress in Alzheimer's and Parkinson's Disease, 2005 - 2007
Member, Alzheimer 100 Scientific Advisory Board on the centennial of the presentation by Alois Alzheimer of the Auguste D. case in Tubingen on November 3, 1906, 2005 - 2006
Neuroscience Interest Group of the Institute of Medicine, 2007 - Present
Neuroscience Intrerest Group of the Institue of Medicine, Neuroscience,Behavior, Brain Function and Disorders, 2007 - Present
Member, NINDS Morris K. Udall Parkinson’s Disease Center Coordinating Committee, 2008 - 2011
EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration), 2008 - Present
Alzheimer's Disease Neuroimaging Initiative Targeted Proteonomics Project Team, of the NIH Biomarkers Consortium and Foundation of the NIH, 2008 - Present
National Advisory Panel for the Surgery, Anesthesia, and Dementia Study, 2008 - Present
MetLife Foundation Awards for Medical Research in Alzheimer's Disease Advisory Committee, 2008 - Present
NIA Division of Aging Biology Review Subcommittee on the Nathan Shock Centers, 2009 - Present
Alliance for Aging Research Working Group on the Uses of Biomarkers in Alzheimer's Disease, 2010 - Present
American Society for Clinical Investigators, - Present
American Academy of Neurology (Consultant, Potamkin Award Subcommittee), - Present
American Academy of Neurology (Consultant, Potamkin Award), - Present
Association of American Physicians, - Present
Killam Research Fellowship Program, The Canada Council, - Present
International Academy of Pathology, Abstract Review Board member, - Present
National Institutes of Health Neurology A Study Section, - Present
Elwyn Institute, Elwyn, PA, - Present
National Sleep Foundation, - Present
National Institutes of Health Grant Study Section Reviewers Reserve, - Present
National Institutes of Health, - Present
American Board of Pathology, - Present
Harvard Brain Tissue Resource Center, - Present
University of Pittsburgh Alzheimer’s Disease Research Center, - Present
National Campaign to End Neurological Disorders (END)), - Present
Amyotrophic Lateral Sclerosis Association Grant Review Committee, - Present
American Federation for Aging Research National Scientific Advisory Council, - Present
Dystonia Medical Research Foundation, - Present
Society for Neuroscience, - Present
Paul Beeson Physician Faculty Scholar in Aging Research Grant Review Committee, - Present
National Institutes of Neurologic Disorders and Stroke Parkinson’s Disease Center Grant Review Committee, - Present
National Institute on Aging, - Present
The Institute for the Study of Aging, - Present
National Institute on Aging, - Present
University of Washington Alzheimer's Disease Research Center, - Present
American Academy of Neurology, - Present
Alzheimer's Disease and Related Disorders Association of Greater Philadelphia, - Present
Institute on Aging, - Present
National Sleep Foundation, - Present
National Institutes on Aging, Neuroscience, Behavior and Sociology of Aging Review Committee (Sub-committee A) Study Section, - Present
National Cancer Institute, - Present
National Institutes of Health Pathology A Study Section, - Present
National Institutes of Child Health and Human Development, - Present
American Society for Investigative Pathology, - Present
American Association of Neuropathologists, - Present
American Association of Pathologists, - Present
American Society for Cell Biology, - Present
Society for Neuroscience, - Present
Institute of Medicine Class of 2002, - Present
National Institute on Aging, Board of Scientific Councilors, - Present
National Institute on Aging, National Advisory Council on Aging (NACA), - Present
National Institute on Aging, - Present
American Brain Tumor Association, - Present
National Institutes of Neurologic Disorders and Stroke, - Present
National Instutitues on Aging Leadership and Excellence In Alzheimer's Disease (LEAD) Award, - Present
American Health Assistance Foundation Alzheimer's Disease Research Review Committee, - Present
Alzheimer's Association, - Present
Alzheimer's Association, Ad Hoc Grant Reviewer; Medical and Scientific Advisory Board, - Present
Rush-Presbyterian-St. Luke's Medical Center, Alzheimer's Disease Center, Chicago IL, - Present

Web Links


Selected Publications

Neuropsychological Subgroups in Non-Demented Parkinson's Disease: A Latent Class Analysis.

Brennan Laura, Devlin Kathryn M, Xie Sharon X, Mechanic-Hamilton Dawn, Tran Baochan, Hurtig Howard H, Chen-Plotkin Alice, Chahine Lama M, Morley James F, Duda John E, Roalf David R, Dahodwala Nabila, Rick Jacqueline, Trojanowski John Q, Moberg Paul J, Weintraub Daniel, Journal of Parkinson's disease, 2017, PMID:28387684

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Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease.

Covell Dustin J, Robinson John L, Akhtar Rizwan S, Grossman Murray, Weintraub Daniel, Bucklin Hannah M, Pitkin Rose M, Riddle Dawn, Yousef Ahmed, Trojanowski John Q, Lee Virginia M-Y, Neuropathology and applied neurobiology, 2017, PMID:28386933

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Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis.

Gendron Tania F, Chew Jeannie, Stankowski Jeannette N, Hayes Lindsey R, Zhang Yong-Jie, Prudencio Mercedes, Carlomagno Yari, Daughrity Lillian M, Jansen-West Karen, Perkerson Emilie A, O'Raw Aliesha, Cook Casey, Pregent Luc, Belzil Veronique, van Blitterswijk Marka, Tabassian Lilia J, Lee Chris W, Yue Mei, Tong Jimei, Song Yuping, Castanedes-Casey Monica, Rousseau Linda, Phillips Virginia, Dickson Dennis W, Rademakers Rosa, Fryer John D, Rush Beth K, Pedraza Otto, Caputo Ana M, Desaro Pamela, Palmucci Carla, Robertson Amelia, Heckman Michael G, Diehl Nancy N, Wiggs Edythe, Tierney Michael, Braun Laura, Farren Jennifer, Lacomis David, Ladha Shafeeq, Fournier Christina N, McCluskey Leo F, Elman Lauren B, Toledo Jon B, McBride Jennifer D, Tiloca Cinzia, Morelli Claudia, Poletti Barbara, Solca Federica, Prelle Alessandro, Wuu Joanne, Jockel-Balsarotti Jennifer, Rigo Frank, Ambrose Christine, Datta Abhishek, Yang Weixing, Raitcheva Denitza, Antognetti Giovanna, McCampbell Alexander, Van Swieten John C, Miller Bruce L, Boxer Adam L, Brown Robert H, Bowser Robert, Miller Timothy M, Trojanowski John Q, Grossman Murray, Berry James D, Hu William T, Ratti Antonia, Traynor Bryan J, Disney Matthew D, Benatar Michael, Silani Vincenzo, Glass Jonathan D, Floeter Mary Kay, Rothstein Jeffrey D, Boylan Kevin B, Petrucelli Leonard, Science translational medicine 9(383): , 2017, PMID:28356511

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Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies.

Ono Maiko, Sahara Naruhiko, Kumata Katsushi, Ji Bin, Ni Ruiqing, Koga Shunsuke, Dickson Dennis W, Trojanowski John Q, Lee Virginia M-Y, Yoshida Mari, Hozumi Isao, Yoshiyama Yasumasa, van Swieten John C, Nordberg Agneta, Suhara Tetsuya, Zhang Ming-Rong, Higuchi Makoto, Brain : a journal of neurology 140(3): 764-780, 2017, PMID:28087578

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Typical and atypical pathology in primary progressive aphasia variants.

Spinelli Edoardo G, Mandelli Maria Luisa, Miller Zachary A, Santos-Santos Miguel A, Wilson Stephen M, Agosta Federica, Grinberg Lea T, Huang Eric J, Trojanowski John Q, Meyer Marita, Henry Maya L, Comi Giancarlo, Rabinovici Gil, Rosen Howard J, Filippi Massimo, Miller Bruce L, Seeley William W, Gorno-Tempini Maria Luisa, Annals of neurology 81(3): 430-443, 2017, PMID:28133816

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Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases.

Kovacs Gabor G, Robinson John L, Xie Sharon X, Lee Edward B, Grossman Murray, Wolk David A, Irwin David J, Weintraub Dan, Kim Christopher F, Schuck Theresa, Yousef Ahmed, Wagner Stephanie T, Suh Eunran, Van Deerlin Vivianna M, Lee Virginia M-Y, Trojanowski John Q, Journal of neuropathology and experimental neurology, 2017, PMID:28340083

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Metabolic network failures in Alzheimer's disease-A biochemical road map.

Toledo Jon B, Arnold Matthias, Kastenmüller Gabi, Chang Rui, Baillie Rebecca A, Han Xianlin, Thambisetty Madhav, Tenenbaum Jessica D, Suhre Karsten, Thompson J Will, John-Williams Lisa St, MahmoudianDehkordi Siamak, Rotroff Daniel M, Jack John R, Motsinger-Reif Alison, Risacher Shannon L, Blach Colette, Lucas Joseph E, Massaro Tyler, Louie Gregory, Zhu Hongjie, Dallmann Guido, Klavins Kristaps, Koal Therese, Kim Sungeun, Nho Kwangsik, Shen Li, Casanova Ramon, Varma Sudhir, Legido-Quigley Cristina, Moseley M Arthur, Zhu Kuixi, Henrion Marc Y R, van der Lee Sven J, Harms Amy C, Demirkan Ayse, Hankemeier Thomas, van Duijn Cornelia M, Trojanowski John Q, Shaw Leslie M, Saykin Andrew J, Weiner Michael W, Doraiswamy P Murali, Kaddurah-Daouk Rima, Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017, PMID:28341160

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Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials.

Weiner Michael W, Veitch Dallas P, Aisen Paul S, Beckett Laurel A, Cairns Nigel J, Green Robert C, Harvey Danielle, Jack Clifford R, Jagust William, Morris John C, Petersen Ronald C, Saykin Andrew J, Shaw Leslie M, Toga Arthur W, Trojanowski John Q, Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017, PMID:28342697

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Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers.

Deming Yuetiva, Li Zeran, Kapoor Manav, Harari Oscar, Del-Aguila Jorge L, Black Kathleen, Carrell David, Cai Yefei, Fernandez Maria Victoria, Budde John, Ma Shengmei, Saef Benjamin, Howells Bill, Huang Kuan-Lin, Bertelsen Sarah, Fagan Anne M, Holtzman David M, Morris John C, Kim Sungeun, Saykin Andrew J, De Jager Philip L, Albert Marilyn, Moghekar Abhay, O'Brien Richard, Riemenschneider Matthias, Petersen Ronald C, Blennow Kaj, Zetterberg Henrik, Minthon Lennart, Van Deerlin Vivianna M, Lee Virginia Man-Yee, Shaw Leslie M, Trojanowski John Q, Schellenberg Gerard, Haines Jonathan L, Mayeux Richard, Pericak-Vance Margaret A, Farrer Lindsay A, Peskind Elaine R, Li Ge, Di Narzo Antonio F, Kauwe John S K, Goate Alison M, Cruchaga Carlos, Acta neuropathologica, 2017, PMID:28247064

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Milder Alzheimer's disease pathology in heart failure and atrial fibrillation.

Sposato Luciano A, Ruíz Vargas Estefanía, Riccio Patricia M, Toledo Jon B, Trojanowski John Q, Kukull Walter A, Cipriano Lauren E, Nucera Antonia, Whitehead Shawn N, Hachinski Vladimir, Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017, PMID:28174071

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