PEOPLE

John Q. Trojanowski, MD, PhD

William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Co-Director, Center for Neurodegenerative Disease Research
Director, Institute on Aging
Director, Alzheimer's Disease Core Center
Director, Penn Udall Center for Parkinson's Research
University of Pennsylvania Perelman School of Medicine

Contact InformationCenter for Neurodegenerative Disease Research
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building
Philadelphia, PA 19104-4283
Office: 215-662-6399
Fax: 215-349-5909

Email: TROJANOW@UPENN.EDU

Specialty Division

Neuropathology, Immunobiology and Experimental Pathology

Research Expertise

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Other Expertise

Research currently centers on molecular mechanisms of neuron dysfunction, degeneration, and death in normal aging and in neurodegenerative diseases (AD and PD, frontotemporal dementias (FTD) with and without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular, and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Graduate Groups

Neuroscience

Education

University of Vienna, Vienna, Austria, 1969
B.A. (German), King's College (1965-1967 & 1969-1970), 1970
Erasmus University Rotterdam, Rotterdam, The Netherlands, 1974
Ph.D. (Neuroanatomy), Tufts University Graduate School of Arts and Sciences, 1976
M.D. Tufts University School of Medicine, 1976

Specialty Certification

American Board of Pathology, Anatomic Pathology and Neuropathology
National Board of Medical Examiners - No. 138521, 1981

Postgraduate Training

Clinical Fellow in Medicine (Medical Intern, Mt. Auburn Hospital, Cambridge, MA), Harvard Medical School, 1976-1977
1977-79 Clinical Fellow in Pathology (Pathology and Neuropathology Resident, Massachusetts Gen. Hospital, Boston, MA) , Harvard Medical School, 1977-1979
Pathology and Neuropathology Resident, Hospital of the University of Pennsylvania, Philadelphia, PA, 1979-1980

Awards and Honors

Magna Cum Laude, King's College, 1970
Sandoz Award in Neurology, 1976
Mead Johnson Excellence in Research Award, 1976
Wm. Dameshek Research Award, Tufts Univ. School of Medicine, 1976
Roche Laboratories Neurosciences Research Award, 1976
N.I.N.C.D.S. National Research Service Award in Neuropathology, 1978-1979
N.I.N.C.D.S. Teacher Investigator Development Award (TIDA), NS-00762, 1983-1987
N.C.I. Method to Extend Research In Time (MERIT) Award, CA-36245-04-13, 1986-1995
M.A. Degree (Honoris Causa), University of Pennsylvania, 1987
Weil Award For Best Experimental Neuropathology Paper American Association of Neuropathologists, 1988
Elected Member, American Society of Clinical Investigation, 1991
Metropolitan Life Foundation Promising Investigator Award For Alzheimer's Disease Research, 1991
Established Investigator Award of the National Alliance for Research on Schizophrenia and Depression (NARSAD), 1994
Metropolitan Life Foundation Award for Medical Research in Alzheimer’s Disease, 1996
President, American Association of Neuropathology, 1997-1998
Rita Hayworth Award for Medical Research in Alzheimer’s Disease, 1998
Potamkin Prize for Medical Research in Alzheimer’s Disease, 1998
Pioneer Award for Alzheimer’s Disease Research of the Ronald and Nancy Reagan Research Institute, Alzheimer’s Association, 1998
Recognized by ISI as a an ISI "Highly Cited Researcher" (A list of the, 2000
Stanley Cohen Biomedical Research Award of the University of Pennsylvania School of Medicine, 2000
Member, Institute of Medicine of the National Academy of Sciences, Elected 2002, 2002
Irving Wright Award of Distinction of the American Federation for Aging Research, 2004-2004
Irving Wright Award for Distinction of the American Federation for Aging Research, 2004-2004
Alzheimer Research Forum Award presented at SFN meeting, 2005-2005
Elected, Fellow of the College of Physicians of Philadelphia, 2005
Alzheimer Research Forum Award presented at SFN meeting, 2005-2005
Rous-Whipple Award from the American Society for Investigative Pathology, 2005-2005
Rous-Whipple Award from the American Society for Investigative Pathology, 2005-2005
F.E. Bennet Memorial Lecture of the American Neurological Association, 133rd Meeting, 2008-2008
Khalid Iqbal Lifetime Achievement Award presented at ICAD, 2009
The Wallace H. Coulter Lectureship Award (Endowed by the Wallace H. Coulter Foundation, Miami, FL) presented at AACC in Anaheim, CA, 2010
24th Annual Robert J. and Claire Pasarow Foundation Award in Neuropsychiatry Research, Los Angeles, CA, 2012
John Scott Award (establishd by John Scott in 1822 and given for inventions that have contributed in some outstanding way to the "comfort, welfare and happiness" of mankind by the City of Philadelphia since 1822), 2012
J. Allyn Taylor International Prize in Medicine, Molecular Basis of Neurological Disorders, the Robarts Institute, London, Ontario, Canada, 2014, 2014
Award for Meritorious Contributions to Neuropathology from the American Association of Neuropathologists, 13 June, 2015, 2015
The Mayo Clinic Irving S. Cooper Professorship, “New Understanding of Disease Progression and Therapy in Neurodegenerative Tauopathies”, Mayo Clinic, Rochester, MN, 21 August, 2017, 2017
Alzheimer’s Association Lifetime Achievement Award in Alzheimer’s Disease Research, AAIC Meeting, Chicago, IL, July 24, 2018

Memberships and Professional Organizations

The Anne and Howard Gottlieb/Institute for the Study of Aging Award for Alzheimer’s Disease Drug Discovery, 2003 - Present
The Gerontological Society of America (GSA), Task Force on Research Committee, 2004 - 2007
Coins for Alzheimer’s Research Trust (CART), The CART Fund, in partnership with the American Federation for Aging Research, Grant Review, 2005 - Present
Member, Alzheimer 100 Scientific Advisory Board on the centennial of the presentation by Alois Alzheimer of the Auguste D. case in Tubingen on November 3, 1906, 2005 - 2006
8th International Conference on Progress in Alzheimer's and Parkinson's Disease, 2005 - 2007
Organizing Committee, 8th International Conference On Progress In
Alzheimer’s And Parkinson’s Disease, Salzburg, Austria, 2005 - 2007
Neuroscience Intrerest Group of the Institue of Medicine, Neuroscience,Behavior, Brain Function and Disorders, 2007 - Present
Neuroscience Interest Group of the Institute of Medicine, 2007 - Present
MetLife Foundation Awards for Medical Research in Alzheimer's Disease Advisory Committee, 2008 - Present
Member, NINDS Morris K. Udall Parkinson’s Disease Center Coordinating Committee, 2008 - 2011
National Advisory Panel for the Surgery, Anesthesia, and Dementia Study, 2008 - Present
Alzheimer's Disease Neuroimaging Initiative Targeted Proteonomics Project Team, of the NIH Biomarkers Consortium and Foundation of the NIH, 2008 - Present
EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration), 2008 - Present
NIA Division of Aging Biology Review Subcommittee on the Nathan Shock Centers, 2009 - Present
Alliance for Aging Research Working Group on the Uses of Biomarkers in Alzheimer's Disease, 2010 - Present
American Brain Tumor Association, - Present
National Institute on Aging, - Present
National Institute on Aging, National Advisory Council on Aging (NACA), - Present
National Institute on Aging, Board of Scientific Councilors, - Present
Institute of Medicine Class of 2002, - Present
Society for Neuroscience, - Present
American Society for Cell Biology, - Present
American Association of Pathologists, - Present
American Association of Neuropathologists, - Present
American Society for Investigative Pathology, - Present
American Society for Clinical Investigators, - Present
American Academy of Neurology (Consultant, Potamkin Award Subcommittee), - Present
American Academy of Neurology (Consultant, Potamkin Award), - Present
Association of American Physicians, - Present
Killam Research Fellowship Program, The Canada Council, - Present
International Academy of Pathology, Abstract Review Board member, - Present
National Institutes of Health Neurology A Study Section, - Present
Elwyn Institute, Elwyn, PA, - Present
National Sleep Foundation, - Present
National Institutes of Health Grant Study Section Reviewers Reserve, - Present
National Institutes of Health, - Present
American Board of Pathology, - Present
Harvard Brain Tissue Resource Center, - Present
University of Pittsburgh Alzheimer’s Disease Research Center, - Present
National Campaign to End Neurological Disorders (END)), - Present
Amyotrophic Lateral Sclerosis Association Grant Review Committee, - Present
American Federation for Aging Research National Scientific Advisory Council, - Present
Dystonia Medical Research Foundation, - Present
Society for Neuroscience, - Present
Paul Beeson Physician Faculty Scholar in Aging Research Grant Review Committee, - Present
National Institutes of Neurologic Disorders and Stroke Parkinson’s Disease Center Grant Review Committee, - Present
National Institute on Aging, - Present
The Institute for the Study of Aging, - Present
National Institute on Aging, - Present
University of Washington Alzheimer's Disease Research Center, - Present
American Academy of Neurology, - Present
Alzheimer's Disease and Related Disorders Association of Greater Philadelphia, - Present
Institute on Aging, - Present
National Sleep Foundation, - Present
National Institutes on Aging, Neuroscience, Behavior and Sociology of Aging Review Committee (Sub-committee A) Study Section, - Present
National Cancer Institute, - Present
National Institutes of Health Pathology A Study Section, - Present
National Institutes of Child Health and Human Development, - Present
Alzheimer's Association, Ad Hoc Grant Reviewer; Medical and Scientific Advisory Board, - Present
Rush-Presbyterian-St. Luke's Medical Center, Alzheimer's Disease Center, Chicago IL, - Present
Alzheimer's Association, - Present
American Health Assistance Foundation Alzheimer's Disease Research Review Committee, - Present
National Instutitues on Aging Leadership and Excellence In Alzheimer's Disease (LEAD) Award, - Present
National Institutes of Neurologic Disorders and Stroke, - Present

Web Links


Selected Publications

Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology.

Portelius Erik, Olsson Bob, Höglund Kina, Cullen Nicholas C, Kvartsberg Hlin, Andreasson Ulf, Zetterberg Henrik, Sandelius Åsa, Shaw Leslie M, Lee Virginia M Y, Irwin David J, Grossman Murray, Weintraub Daniel, Chen-Plotkin Alice, Wolk David A, McCluskey Leo, Elman Lauren, McBride Jennifer, Toledo Jon B, Trojanowski John Q, Blennow Kaj, Acta neuropathologica 136(3): 363-376, 2018, PMID:29700597

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TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading.

Martini-Stoica Heidi, Cole Allysa L, Swartzlander Daniel B, Chen Fading, Wan Ying-Wooi, Bajaj Lakshya, Bader David A, Lee Virginia M Y, Trojanowski John Q, Liu Zhandong, Sardiello Marco, Zheng Hui, The Journal of experimental medicine, 2018, PMID:30108137

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Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease.

Shi Min, Tang Lu, Toledo Jon B, Ginghina Carmen, Wang Hua, Aro Patrick, Jensen Poul H, Weintraub Daniel, Chen-Plotkin Alice S, Irwin David J, Grossman Murray, McCluskey Leo, Elman Lauren B, Wolk David A, Lee Edward B, Shaw Leslie M, Trojanowski John Q, Zhang Jing, Alzheimer's & dementia : the journal of the Alzheimer's Association 14(8): 1052-1062, 2018, PMID:29604263

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Cerebrospinal Fluid Total and Phosphorylated α-Synuclein in Patients with Creutzfeldt-Jakob Disease and Synucleinopathy.

Schmitz Matthias, Villar-Piqué Anna, Llorens Franc, Gmitterová Karin, Hermann Peter, Varges Daniela, Zafar Saima, Lingor Paul, Vanderstichele Hugo, Demeyer Leentje, Stoops Erik, Trojanowski John Q, Lee Virginia M-Y, Zerr Inga, Molecular neurobiology, 2018, PMID:30136097

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Alzheimer's genetic risk is reduced in primary age-related tauopathy: a potential model of resistance?

McMillan Corey T, Lee Edward B, Jefferson-George Kyra, Naj Adam, Van Deerlin Vivianna M, Trojanowski John Q, Wolk David A, Annals of clinical and translational neurology 5(8): 927-934, 2018, PMID:30128317

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Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration.

Alosco Michael L, Tripodis Yorghos, Fritts Nathan G, Heslegrave Amanda, Baugh Christine M, Conneely Shannon, Mariani Megan, Martin Brett M, Frank Samuel, Mez Jesse, Stein Thor D, Cantu Robert C, McKee Ann C, Shaw Leslie M, Trojanowski John Q, Blennow Kaj, Zetterberg Henrik, Stern Robert A, Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018, PMID:30049650

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Publisher Correction: Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease.

Nativio Raffaella, Donahue Greg, Berson Amit, Lan Yemin, Amlie-Wolf Alexandre, Tuzer Ferit, Toledo Jon B, Gosai Sager J, Gregory Brian D, Torres Claudio, Trojanowski John Q, Wang Li-San, Johnson F Brad, Bonini Nancy M, Berger Shelley L, Nature neuroscience 21(7): 1018, 2018, PMID:29556027

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Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines.

Oukoloff Killian, Kovalevich Jane, Cornec Anne-Sophie, Yao Yuemang, Owyang Zachary A, James Michael, Trojanowski John Q, Lee Virginia M-Y, Smith Amos B, Brunden Kurt R, Ballatore Carlo, Bioorganic & medicinal chemistry letters 28(12): 2180-2183, 2018, PMID:29764743

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Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.

Robinson John L, Lee Edward B, Xie Sharon X, Rennert Lior, Suh EunRan, Bredenberg Colin, Caswell Carrie, Van Deerlin Vivianna M, Yan Ning, Yousef Ahmed, Hurtig Howard I, Siderowf Andrew, Grossman Murray, McMillan Corey T, Miller Bruce, Duda John E, Irwin David J, Wolk David, Elman Lauren, McCluskey Leo, Chen-Plotkin Alice, Weintraub Daniel, Arnold Steven E, Brettschneider Johannes, Lee Virginia M-Y, Trojanowski John Q, Brain : a journal of neurology 141(7): 2181-2193, 2018, PMID:29878075

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Sex-specific genetic predictors of Alzheimer's disease biomarkers.

Deming Yuetiva, Dumitrescu Logan, Barnes Lisa L, Thambisetty Madhav, Kunkle Brian, Gifford Katherine A, Bush William S, Chibnik Lori B, Mukherjee Shubhabrata, De Jager Philip L, Kukull Walter, Huentelman Matt, Crane Paul K, Resnick Susan M, Keene C Dirk, Montine Thomas J, Schellenberg Gerard D, Haines Jonathan L, Zetterberg Henrik, Blennow Kaj, Larson Eric B, Johnson Sterling C, Albert Marilyn, Moghekar Abhay, Del Aguila Jorge L, Fernandez Maria Victoria, Budde John, Hassenstab Jason, Fagan Anne M, Riemenschneider Matthias, Petersen Ronald C, Minthon Lennart, Chao Michael J, Van Deerlin Vivianna M, Lee Virginia M-Y, Shaw Leslie M, Trojanowski John Q, Peskind Elaine R, Li Gail, Davis Lea K, Sealock Julia M, Cox Nancy J, Goate Alison M, Bennett David A, Schneider Julie A, Jefferson Angela L, Cruchaga Carlos, Hohman Timothy J, Acta neuropathologica, 2018, PMID:29967939

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