PEOPLE

Yongping Wang, MD, PhD

Assistant Professor of Clinical Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact InformationStem Cell Lab, 5NW60 Main Building
Children's Hospital of Philadelphia
34th Street and Civic Center Blvd
Philadelphia, PA 19104
Office: 215-590-4759

Email: wangy2@email.chop.edu

Specialty Division

Immunobiology and Experimental Pathology

Research Expertise

RNAi, library screening, stem cell, erythropoiesis

Clinical Expertise

cGMP cellular therapy, stem cell, bone marrow transplant, mesenchymal stromal cell (MSC), chimeric antigen receptor T cells (CARTs)

Education

B.S. (Molecular Biophysics and Biochemistry; Economics), Yale, 1995
M.D, Ph.D. (Medicine; Pharmacology), Dartmouth Medical School, 2003

Specialty Certification

Clinical Pathology and Transfusion Medicine, 2007
Clinical Pathology and Transfusion Medicine, 2017

Postgraduate Training

Resident, Clinical Pathology, Hospital of University of Pennsylvania, 2003-2008
Fellow, Transfusion Medicine, Hospital of University of Pennsylvania, 2006-2007
Certificate, Clinical Pathology and Transfusion Medicine, University of Pennsylvania, 2007-2007
Post-doctoral Fellow, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 2008-2009

Awards and Honors

Summer Undergraduate Research Fellowship, California Institute of Technology, 1994
Max Kade Foundation Fellowship, Yale University and Universtität Heidelberg, 1994
Magna Cum Laude, Yale University, 1995
Honors in Economics, Yale University, 1995
Honors in Molecular Biophysics and Biochemistry, Yale University, 1995
Howard Hughes Medical Institute Predoctoral Fellowship, Howard Hughes Medical Institute, 1996-2000
SmithKlein Beecham Student Award, New England Pharmacologists 27th Annual Meeting, 1998
Honor Student, American Academy of Achievements, 2000
University of Pennsylvania Medical School, Basic Science Teaching Award, 2006
The Leonard Berwick Residency Teaching Award, Deptartment of Pathology and Laboratory Medicine, School of Medicine, UPenn, 2006
The William Pepper Resident Award, Dept. of Pathology and Laboratory Medicine, School of Medicine, UPenn, 2007
The Paul E. Strandjord Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists, 43rd Annual Meeting Philadelphia, Pennsylvania, 2008

Memberships and Professional Organizations

AABB - Advancing Transfusion and Cellular Therapies Worldwide, 2007 - present
International Society for Cell and Gene Therapy, 2011 - present
AABB Cellular Therapy Section, Committee on Novel Therapies and CT Product Development, 2014 - Present

Web Links


Selected Publications

Outcomes and Challenges of Manufacturing Virus-Specific Cytotoxic T-lymphocytes Using IFN-gamma Cytokine Capture System

Elena Maryamchik MD, Stephan Kadauke MD PHD, Allyson Flower, MD, Barrett, David MD PhD, Janet Ayello, MS, MT, Lauren Harrison, RN, MSN, Erin Morris, RN , Meghan Sturhahn, RN, MSN, Lynn O’Donnell, PHD, Dean Lee, MD, PHD, Rolla Abu-Arja, MD, Bryon Johnson MD PHD, Julie Talano MD, Mitchell S. Cairo, MD, Nancy Bunin, MD, Yongping Wang, MD, PHD, International Society for Cell and Gene Therapy annual meeting, Paris, France (virtual), 2020

Low CD45 Expression Predicts Poor Post-Thaw CD34 Cell Viability

Elena Maryamchik MD, Xingwu Zheng, Xiaoyong Zhang, Rene Machietto, Colleen Finn, Nicholas Giacobbe, Mario Quant, Shilpa Choudhari, Stephan Kadauke MD PhD, Yongping Wang MD PhD, International Society for Cell and Gene Therapy annual meeting, Paris, France (virtual), 2020

Partially CD3+-Depleted Unrelated and Haploidentical Donor Peripheral Stem Cell Transplantation Has Favorable Graft-versus-Host Disease and Survival Rates in Pediatric Hematologic Malignancy

Alix E. Seif, Yimei Li, Dimitri S. Monos, Stephanie C. Heideman, nRichard Aplenc, David M. Barrett, James T. Casper, Jason L. Freedman, Stephan A. Grupp, David A. Margolis, Timothy S. Olson, David T. Teachey, Carolyn A. Keever-Taylor, Yongping Wang, Julie-An M. Talano, Nancy J. Bunin, Biology of Blood and Marrow Transplantation 26(): 493-501, 2020

The Safety and Efficacy of Targeted Virus Specific Cytotoxic T-lymphocytes Manufactured by the IFN-g Cytokine Capture System (CCS) for the Treatment of Refractory Adenovirus (ADV), cytomegalovirus (CMV), Epstein Barr Virus (EBV) and BK Virus (BKV) in Children, Adolescents and Young Adults after Allogenic Hematopoietic Stem Cell Transplantation (Allo-HSCT), Solid Organ Transplantation (SOT), or with Primary Immunodeficiency (PID).

Allyson Flower, Janet Ayello, Lauren Harrison, Erin Morris, Meghan Sturhan, Elena Maryamchik, Yongping Wang, Lynn O’Donnell, Dean Lee, Julie Talano, Bryon Jonson, Mitchell S. Cairo, Nancy Bunin., American Society of Transplantation & Cellular Therapy annual meeting. Orlando, FL., 2020

Safety and Efficacy of Related Donor Viral (CMV, ADV, EBV, BK) Cytotoxic T-Lymphocytes (vCTLs) Manufactured by a Cytokine Capture System (CCS) in Children, Adolescents and Young Adults with Medically Refractory Systemic Viral Infections: A Report from the Viral CTL Consortium (VIRCTLC) (IND 17449)

Mitchell S. Cairo, Allyson Flower, Julie-An Talano, Janet Ayello, Yongping Wang, Bryon Johnson, Lynn O’Donnell, Lauren Harrison, Rosemarie Shaw, Meghan Sturhahn, Elena Maryamchik, Rollo Abu-Arja, Dean Lee, and Nancy Bunin, European Society for Blood and Marrow Transplantation annual meeting, Madrid, Spain, 2019

CD3+/CD19+ depleted matched and mismatched unrelated donor hematopoietic stem cell transplant with targeted T cell addback is associated with excellent outcomes in pediatric patients with non-malignant hematologic disorders

Joseph H. Oved, Yongping Wang, David M. Barrett, Ellen M. Levy, Yanping Huang, Dimitrios S. Monos, Stephan A. Grupp, Nancy J. Bunin, and Timothy S. Olson, Biology of Blood and Marrow Transplantation 25(3): 549-555, 2019

Rapid Manufacture and Isolation of Highly Viable Interferon-γ Expressing Virus Specific T Cells: Validation Results for the Virus Specific Cytotoxic T Lymphocyte Consortium for Refractory EBV, CMV, and Adenovirus Infections

Stephan Kadauke, MD, PhD, Bryon D. Johnson, PhD, Lauren Harrison, RN, MSN, Lynn C. O'Donnell, PhD, Youwei Wang, MD, Janet Ayello, MS, MT(ASCP), JulieAn M. Talano, MD, Dean Lee, MD, PhD, Nancy J. Bunin, MD, Yongping Wang, MD, PhD and Mitchell S. Cairo, MD,, Transplantation & Cellular Therapy Meetings of ASBMT and CIBMTR, Houston, TX, 2019

Unrelated or Partially Matched Related Donor Hematopoietic Stem Cell Transplant (HSCT) with TCRab/CD19 Depletion for Children and Young Adults (CAYA) with Acute Leukemias.

Sarah Lo, Yongping Wang, Dimitrios Monos, David Barrett, Farah Contractor, Stephan Grupp, Nancy Bunin, Pediatric Blood and Marrow Transplant Consortium (PBMTC) Meeting, 2018

Identification of p38 MAPK as a novel therapeutic target for Friedreich’s ataxia

Cotticelli, M. G., Xia, S., Kaur, A., Lin, D., Wang, Y., Ruff, E., Tobias, J. W., and Wilson, R. B., Scientific Reports 8(1): 5007, 2018

Two Partial T cell Depletion Strategies for Unrelated Donor Peripheral Stem Cell Trans-plantation are associated with excellent outcomes for pediatric patients with bone mar-row failure

Oved JH, Wang Y, Huang Y, Monos D, Barrett DM, Grupp SA, Bunin NJ, and Olson TS, ASBMT Tandem Mtg, Salt Lake City, UT, 2018