PEOPLE

Yongping Wang, MD, PhD

Assistant Professor of Clinical Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact InformationStem Cell Lab, 5NW60 Main Building
Children's Hospital of Philadelphia
34th Street and Civic Center Blvd
Philadelphia, PA 19104
Office: 215-590-4759

Email: wangy2@email.chop.edu

Specialty Division

Immunobiology and Experimental Pathology

Research Expertise

RNAi, library screening, stem cell, erythropoiesis

Clinical Expertise

cGMP cellular therapy, stem cell, bone marrow transplant, mesenchymal stromal cell (MSC), chimeric antigen receptor T cells (CARTs)

Education

B.S. (Molecular Biophysics and Biochemistry; Economics), Yale, 1995
M.D, Ph.D. (Medicine; Pharmacology), Dartmouth Medical School, 2003

Specialty Certification

Clinical Pathology and Transfusion Medicine, 2007

Postgraduate Training

Resident, Clinical Pathology, Hospital of University of Pennsylvania, 2003-2008
Fellow, Transfusion Medicine, Hospital of University of Pennsylvania, 2006-2007
Certificate, Clinical Pathology and Transfusion Medicine, University of Pennsylvania, 2007-2007
Post-doctoral Fellow, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 2008-2009

Awards and Honors

Summer Undergraduate Research Fellowship, California Institute of Technology, 1994
Max Kade Foundation Fellowship, Yale University and Universtität Heidelberg, 1994
Magna Cum Laude, Yale University, 1995
Honors in Economics, Yale University, 1995
Honors in Molecular Biophysics and Biochemistry, Yale University, 1995
Howard Hughes Medical Institute Predoctoral Fellowship, Howard Hughes Medical Institute, 1996-2000
SmithKlein Beecham Student Award, New England Pharmacologists 27th Annual Meeting, 1998
Honor Student, American Academy of Achievements, 2000
The Leonard Berwick Residency Teaching Award, Deptartment of Pathology and Laboratory Medicine, School of Medicine, UPenn, 2006
University of Pennsylvania Medical School, Basic Science Teaching Award, 2006
The William Pepper Resident Award, Dept. of Pathology and Laboratory Medicine, School of Medicine, UPenn, 2007
The Paul E. Strandjord Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists, 43rd Annual Meeting Philadelphia, Pennsylvania, 2008

Memberships and Professional Organizations

AABB - Advancing Transfusion and Cellular Therapies Worldwide, 2007 - Present
International Society for Cellular Therapy, 2011 - present

Web Links


Selected Publications

CD3/CD19 Depletion with Targeted T Cell Add-Back Results in Stable Engraftment and Minimal GVHD in Pediatric Patients with Bone Marrow Failure Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplantation.

Mala Kiran Talekar, Yongping Wang, Dimitri S. Monos, Stephan A. Grupp, Nancy Bunin and Timothy Olson., BMT Tandem Meeting, Honolulu, HI, 2016

Unrelated and Haploidentical Hematopoietic Stem Cell Transplantation (HSCT) using TCR-αβ+CD3+ Depletion in Pediatric Patients with Hematologic Malignancies.

Jason L. Freedman, Yongping Wang, Yimei Li, Dmitri Monos, David Barrett, Alix Seif, David T. Teachey, Timothy Olson, Stephan Grupp, and Nancy Bunin., BMT Tandem Meeting, Honolulu, HI, 2016

Favorable chronic graft-versus-host-disease (GVHD), event-free (EFS), and overall survival (OS) rates following partially CD3-depleted alternative donor peripheral stem cell transplantation (PSCT) for pediatric hematologic malignancies.

Alix E. Seif, Yimei Li, Richard Aplenc, David M. Barrett, James T. Casper, Jason L. Freedman, Stephan A. Grupp, David A. Margolis, Timothy S. Olson, David T. Teachey, Yongping Wang, Julie-An M. Talano, and Nancy J. Bunin., BMT Tandem Meeting, Honolulu, HI, 2016

Phenotypic screening for Friedreich ataxia using random shRNA selection.

Cotticelli, M.G., Acquaviva, F., Xia S., Kaur, A., Wang, Y., and Wilson, R.B, Journal of Biomolecular Screening 20(9): 1084, 2015

Academia and Industry Collaborate in Cellular Therapy Partnerships

Yongping Wang and Deborah Sesok-Pizzini, AABB News, 2015

Introduction of Mismatches in a Random shRNA-encoding Library Improves Potency for Phenotypic Selection

Wang Y, Speier JS, Engram-Pearl J, Wilson RB, PLoS One 9(2): e87390, 2014

Manufacturing Mesenchymal Stromal Cells for Phase I Clinical Trials

Hanley PJ, Mei Z, da Cabreira-Hansen M, Klis M, Li W, Zhao Y, Durett AG, Zheng X, Wang Y, Gee AP, and Horwitz EM, Cytotherapy 15(4): 416-422, 2013

A Random shRNA-Encoding Library for Phenotypic Selection and Hit-Optimization

Wang Y, Wang YE, Cotticelli MG and Wilson RB, Cambridge Healthtech Institute’s 8th International Discovery On Target Meeting, Boston, MA, 2010

A random shRNA-encoding library for phenotypic selection and hit-optimization

Wang Y, Wang YE, Cotticelli MG, Wilson RB, PLoS One 3(9): e3171, 2008, PMID:18779859

Read article

Synthesis of a Random shRNA-encoding Library for Phenotypic Selection and Hit-optimization

Wang Y, Wang YE, Cotticelli MG and Wilson RB, Academy of Clinical Laboratory Physicians and Scientists 43rd Annual Meeting, Philadelphia, PA, 2008