PEOPLE

Robert B. Wilson, MD, PhD

Professor of Pathology and Laboratory Medicine in Pediatrics
Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
Children’s Hospital of Philadelphia
Room 6024, Colket Translational Research Building
3501 Civic Center Blvd.
Philadelphia, PA 19104
Office: 267-425-2201

Email: WILSONR@MAIL.MED.UPENN.EDU

Specialty Division

Precision and Computational Diagnostics, Immunobiology and Experimental Pathology

Itmat Expertise

Dr. Wilson's primary interest is in the neurodegenerative disorder Friedreich ataxia, for which he completed a high-throughput drug screen of >340,000 compounds in the fall of 2008. He is now working with medicinal chemists on the hit compounds. He is also involved in screening random shRNA expressing libraries for small RNAs to be used as therapeutics and biologic tools. The random shRNA expressing libraries and their use is described in PLoS ONE manuscripts that can be accessed openly at the following URLs: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003171
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087390

Education

Sc.B. (Biochemistry), Brown University, 1982
A.B. (Music), Brown University, 1982
M.D. University of Pennsylvania, 1989
Ph.D. (Genetics), University of Pennsylvania, 1989

Specialty Certification

Diplomate in Clinical Pathology, American Board of Pathology, 1992
Diplomate in Molecular Genetic Pathology, American Board of Pathology, 2001

Postgraduate Training

Residency in Clinical Pathology, Hospital of the University of Pennsylvania, Philadelphia, 1989-1992
Post-doctoral Research, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, 1991-1993
Fellowship in Transfusion Medicine, Hospital of the University of Pennsylvania, Philadelphia, 1992-1993

Awards and Honors

Phi Beta Kappa, Brown University, 1980
Brand Musical Premium, Brown University, 1982
Magna Cum Laude, Brown University, 1982
Honors in Music, Brown University, 1982
Honors in Biochemistry, Brown University, 1982
Sigma Xi, Brown University, 1982
Roy G. Williams Research Award, University of Pennsylvania School of Medicine, 1989
Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists, 1992
The Outstanding Group Discussion Leader Teaching Award, University of Pennsylvania School of Medicine Class of 2003, 2001
2002 Kevin E. Salhany Award for Excellence in Clinical Teaching, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 2002
John Morgan Society, University of Pennsylvania, 2002
Peter C. Nowell Teaching Award, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 2003
Leonard Berwick Memorial Teaching Award, University of Pennsylvania School of Medicine, 2004
Basic Science Teaching Award, University of Pennsylvania School of Medicine Class of 2008, 2005
Best Small Group Leader Teaching Award, University of Pennsylvania School of Medicine Class of 2012, 2009
NIH Director's Transformative Research Award, 2009
Distinguished Investigator Award, Friedreich's Ataxia Research Alliance, 2010
2011 Kevin E. Salhany Award for Excellence in Clinical Teaching, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 2011
Harrington Discovery Institute Scholar-Innovator Award, 2013
Top Doctor, Philadelphia, Castle Connolly, 2016

Memberships and Professional Organizations

Association for Molecular Pathology, 1997 - Present
Friedreich's Ataxia Research Alliance, 1998 - 2005
National Ataxia Foundation, 2002 - Present
Friedreich's Ataxia Research Alliance, 2005 - Present

Selected Publications

Open label pilot study of interferon gamma-1b in Friedreich ataxia

Seyer L., Greeley N., Foerster D., Strawser C., Gelbard S., Dong Y., Schadt K., Cotticelli M.G., Brocht A., Farmer J., Wilson R.B., Lynch D.R., Acta Neurologica Scandinavica 132(): 7-15, 2015

Frataxin levels in peripheral tissue in Friedreich ataxia

Lazaropolous, M., Dong, Y., Clark, E., Greeley, N. R., Seyer, L. A., Brigatti, K. W., Christie, C., Perlman, S. L., Wilmot, G. R., Gomez, C. M., Mathews, K. D., Yoon, G., Zesiewicz, T., Hoyle, C., Subramony, S. H., Brocht, A. F., Farmer, J. M., Wilson, R. B., Deutsch, E. C. and Lynch, D. R., Annals of Clinical and Translational Neurology 2(): 831-842, 2015

Phenotypic screening for Friedreich ataxia using random shRNA selection

Cotticelli, M. G., Acquaviva, F., Xia S., Kaur, A., Wang, Y., and Wilson, R. B., Journal of Biomolecular Screening 20(): 1084-1090, 2015

Introduction of Mismatches in a Random shRNA-encoding Library Improves Potency for Phenotypic Selection

Wang, Y., Speier, J., Engram-Pearl, J., Wilson, R. B., PLoS ONE 9(): e87390, 2014

Insights into the role of oxidative stress in the pathology of Friedreich Ataxia using peroxidation resistant polyunsaturated fatty acids

Cotticelli, M. G., Crabbe, A. M., Wilson, R. B., and Shchepinov, M. S., Redox Biology 1(): 398-404, 2013

A0001 in Friedreich ataxia: Biochemical characterization and effects in a clinical trial

Lynch, D. R., Willi, S. M., Wilson, R. B., Cotticelli, M. G., Brigatti, K., Deutsch, E. C., Kucheruk, O., Shrader, W., Rioux, P., Miller, G., Hawi, A., Sciascia, T., Movement Disorders 8(): 1026-1033, 2012, PMID:22744651

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Primary and Secondary Drug Screening Assays for Friedreich Ataxia

Cotticelli, M.G., Rasmussen ,L., Kushner, N. L., McKellip, S., Sosa, M. I., Manouvakhova, A., Feng, S., White, E. L., Maddry, J. A., Heemskerk, J., Oldt, R. J., Surrey, L. F., Ochs, R., and Wilson, R. B., J. Biomol. Screening 17(): 303-313, 2011

Urinary isoprostanes in Friedreich Ataxia: lack of correlation with disease features

Myers, L., Lynch, D. R., Farmer, J. M., Friedman, L., Lawson, J. A., Wilson, R. B., Movement Disorders 23(): 1920-1922, 2009

Alpha-Synuclein induced Aggregation of Cytoplasmic Vesicles in S. cerevisiae

Soper, J., Roy, S., Steiber, A., Lee, E., Wilson, R.B., Burd, C., Lee, V.M.-Y., Mol. Biol. Cell 19(): 1093-1103, 2008

Health related quality of life measures in Friedreich ataxia

Epstein, E., Farmer, J. M., Tsou, A., Perlman, S., Subramony, H., Gomez, C. M., Ashizawa, T., Wilmot, G. R., Mathews, K., Wilson, R. B., Balcer, L. J., Lynch, D. R., J. Neurol. Sci. 272(): 123-128, 2008, PMID:18571673

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