PEOPLE

Qian Zhang, MD, PhD

Research Associate Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact InformationUniversity of Pennsylvania School of Medicine
Department of Pathology & Laboratory Medicine
Stellar Chance Laboratories Building
422 Curie Blvd.
413A/Stellar Chance
Philadelphia, PA 19104
Office: 215-573-5468

Email: qian2@mail.med.upenn.edu

Specialty Division

Immunobiology and Experimental Pathology

Research Expertise

Lymphomas and other hematologic malignancies

The pathogenesis of lymphomas and, more specifically, on the role of aberrant signal transduction in malignant transformation of lymphocytes. The area of signal transduction in lymphomas and other hematopoietic and non-hematopoietic malignancies has far reaching basic, diagnostic, and therapeutic implications.



 

Education

M.D. Xi'an Medical University, Xian, China, 1986
Ph.D. Institute for Medical Microbiology and Immunology University of Copenhagen, Copenhagen, Denmark, 2000

Specialty Certification

Postgraduate Training

Resident Physician, Internal Medicine , The 5th Hospital of Xi'an, Xi'an, China, 1986-1989
Postdoctoral Research Fellow, Department of Medicine, Pulmonary and Critical Care Division , University of Pennsylvania School of Medicine, Philadelphia, PA, 1993-1994
Postdoctoral Research Fellow, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 1994-1997

Awards and Honors

Award of Excellent Student in Xi'an Medical University, 1981-1982
Award of Foundation of Chinese Medical Association, 1990-1990

Memberships and Professional Organizations

American Association for Cancer Research, 2010 - Present
American Society of Hematology, 2011 - Present

Selected Publications

STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes.

Zhang, Q.*, Wang, H.Y., Woetmann, A., Raghunath, P.N., Odum, N., Wasik, M.A.*, Blood. 108(3): 1058-1064, 2006, PMID:16861352

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Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.

Kasprzycka, M., Majewski, M., Wang, Z.J., Ptasznik, A., Wysocka, M., Zhang, Q., Marzec, M., Gimotty, P., Crompton, M.R., Wasik, M.A., Am. J. Pathol. 168(5): 1631-1641, 2006, PMID:16651629

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Chromatin Modification Pathways.

Zhang, Q., Wang, HY., Marzec, M., Raghunath, PN., Nagasawa, T., Wasik, MA, Keystone Symposium, 2005

Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3.

Marzec, M., Kasprzycka, M., Ptasznik, A., Wlodarski, P., Zhang, Q., Odum, N., Wasik, M.A., Lab. Invest. 85(12): 1544-1554, 2005, PMID:16170336

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Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma.

Zhang, Q., Raghunath, P.N., Majewski, M., Carpentieri, D.F., Xuen, L., Odum, N., Morrise, S., Skorski, T., Wasik, M.A., J. Immunol. 168(1): 466-474, 2002, PMID:11751994

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Diminished expression of the type II receptor for TGFbeta (TGFbetaRII) in T lymphocytes from patients with Sezary syndrome is not due to mutations in the receptor's poly-A tract: limitations of the standard RT-PCR in cDNA sequence analysis of homopolymeric base stretches.

Zhang, Q., Capocasale, R., Fox, F.E., Bedian, V., Vonderheid, E.C., Moore, J.S., Nowell, P.C., Haines, D.S., Wasik, M.A., Arch. Immunol. Ther. Exp. (Warsz) 50(6): 419-427, 2002, PMID:12546068

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Role of signal transducer and activator of transcription 5 in nucleophosmin/ anaplastic lymphoma kinase-mediated malignant transformation of lymphoid cells.

Nieborowska-Skorska, M., Slupianek, A., Xue, L., Zhang, Q., Raghunath, P.N., Hoser, G., Wasik, M.A., Morris, S.W., Skorski, T., Cancer Res. 61(17): 6517-6523, 2001, PMID:11522649

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Expression of SHP-1 phosphatase indicates post-germinal center cell derivation of B-cell posttransplant lymphoproliferative disorders.

Paessler, M., Kossev, P., Tsai, D., Raghunath, P.N., Majewski, M., Zhang, Q., Ramalingam, P., Schuster, S., Tomaszewski, J., Arber, D., Hsi, E., Wasik, M.A., Lab. Invest. 82(11): 1599-1606, 2002, PMID:12429820

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SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells.

Brockdorff, J.L., Woetmann, A., Mustelin, T., Kaltoft, K., Zhang, Q., Wasik, M.A., Ropke, C., Odum, N., Cytokine 20(4): 141-147, 2002, PMID:12543077

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Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.

Zhang, Q., Nowak, I., Vonderheid, E.C., Rook, A.H., Kadin, M.E., Nowell, P.C., Shaw, L.M., Wasik., M.A., Proc Natl Acad Sci USA. 93(17): 9148-9153, 1996, PMID:8799169

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