Anupma Nayak, MBBS, MD
Associate Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania
Associate Vice Chair for Translational and Clinical Research
​Department of Pathology and Laboratory Medicine
Contact InformationHospital of the University of Pennsylvania
6 Founders Building
3400 Spruce Street
Philadelphia, PA 19104
Office: 215.662.4899
Email: anupma.nayak@pennmedicine.upenn.edu
Specialty Division
Anatomic Pathology
Research Expertise
Breast Cancer
Itmat Expertise
Breast Cancer
Clinical Expertise
Breast Pathology
Education
MBBS (Medicine), King George Medical College, Lucknow, India, 1997
Specialty Certification
Anatomic Pathology, American Board of Pathology, 2010
Postgraduate Training
Intern, Dr. Shyama Prasad Mukherjee Hospital (Civil Hospital), Lucknow, India, 1997-1998
Pathology, All India Institute of Medical Sciences, New Delhi, India, 1999-2001
Senior Resident, Pathology, All India Institute of Medical Sciences, New Delhi, India, 2002-2005
Resident, Pathology, NSLIJHS-Albert Einstein College of Medicine at Long Island Jewish Medical Center, NY, USA, 2007-2010
Chief Resident, Department of Pathology and Lab Medicine, NSLIJHS-Albert Einstein College of Medicine at Long Island Jewish Medical Center, NY, 2009-2010
Fellow, Selective Breast Pathology, University of Texas- MD Anderson Cancer Center, Houston, Texas, USA, 2010-2011
Awards and Honors
Honors in Anatomy and Biochemistry in First MBBS examination, 1994
Honors in Pathology and Pharmacology in Second MBBS examination, 1996
Honors in Surgery and Orthopedics in Final MBBS examination, 1997
2nd Prize, Telepathology Quiz, Annual Conference of Indian Association of Pathologists and Microbiologists, Kolkata, India, 2002
1st Prize, 43rd Annual Academic Competition, NSLIJHS-Albert Einstein College of Medicine at Long Island Jewish Medical Center, New York, 2008
2nd Prize, 43rd Annual Academic Competition, NSLIJHS-Albert Einstein College of Medicine at Long Island Jewish Medical Center, New York, 2008
Donald West King Fellowship in Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, D.C., 2009
Pathology Faculty Recognition Award for Exceptional Teaching in Pathology, Mount Sinai Medical Center, NY, 2013
Listed in top abstracts in Anatomic Pathology by College of American Pathologists(CAP). Hanna MG, Jaffer S, Bleiweiss IJ, Nayak A. Re-evaluating the role of sentinel lymph node biopsy in microinvasive breast carcinoma. Mod Pathol. 2014;27(11):1489-98, 2015
AAPath (Association of Academic Pathology) Pathology Leadership Fellow (APLF), 2024
Memberships and Professional Organizations
Medical Council of India (MCI), 1999 - Present
College of American Pathologists (CAP), 2007 - 2010
American Society of Clinical Pathology (ASCP), 2007 - 2010
United States and Canadian Academy of Pathology (USCAP), 2012 - Present
American Society of Breast Diseases (ASBD), 2013 - 2015
New York Path Society (NYSP), 2013 - 2016
International Society of Breast Pathologists, 2017 - Present
Pennsylvania Association of Pathologists, 2019 - Present
Pathology Society of Philadelphia, 2019 - Present
ISPY2 Pathology Working Group, 2023 - Present
National Mesothelioma Virtual Bank (NMVB) Steering Committee, 2023 - Present
Web Links
Selected Publications
Designing Smart Spatial Omics Experiments with S2Omics
Musu Yuan, Kaitian Jin, Hanying Yan, Amelia Schroeder, Chunyu Luo, Sicong Yao, Bernhard Domoulin, Jonathan Levinsohn, Tianhao Luo, Jean R. Clemenceau, Inyeop Jang, Minji Kim, Yunhe Liu, Minghua Deng, Emma E. Furth, Parker Wilson, Anupma Nayak, Idania Lubo, Luisa Maren Solis Soto, Linghua Wang, Jeong Hwan Park, Katalin Susztak, Tae Hyun Hwang, Mingyao Li, bioRxiv [Preprint]; Accepted in Nature Cell Biology, 2025
Targeting Dormant Tumor Cells to Prevent Recurrent Breast Cancer: a randomized phase 2 trial.
DeMichele A, Clark A, Shea E, Bayne L, Sterner C, Rohn K, Eberle-Dwyer S, Pan T-C, Nivar I, Chen Y, Wileyto EP, Berry L, DeLuca S, Savage J, Makhlin I, Pant D, Egunsola A, Mears N, Goodspeed B, Chislock E, Graves J, Wang J, Shih N, Belka G, Berry D, Nayak A, Feldman M, Martin H, Chodosh L., Nature Medicine, 2025, PMID:40897974
miRNA Panel from HER2+ and CD24+ Plasma Extracellular Vesicle Subpopulations as Biomarkers of Early-stage Breast Cancer
Griffin B. Spychalski1, Andrew A. Lin, Stephanie J. Yang, Hanfei Shen, Jean Rosario, Kyle Tien, Kate French, Miriyam Ghali, Stephanie Yee, Melinda Yin, Michael D. Feldman, Emily F. Conant, Susan P. Weinstein, Erica L. Carpenter, David Issadore, Anupma Nayak, Breast Cancer Res. 27(1): 90, 2025, PMID:40405296
Mucinous Cystadenocarcinomas of the Breast Exhibit Heterogeneous Genomic Profile as Triple Negative Breast Cancer, Harbor Alterations in PIK3CA, PTEN, AKT1, and GNAS Genes, and May Not Be Indolent.
Tondi Resta I, Nelson ND, Toorens E, Bleiweiss IJ, Nayak A., Int J Surg Pathol., 2025, PMID:40221995
Clinicopathologic Features of Breast Tumors in Germline TP53 Variant-Associated Li-Fraumeni Syndrome.
Narasimhamurthy M, Le A, Boruah N, Moses R, Kelly G, Bleiweiss I, Maxwell KN, Nayak A., Am J Surg Pathol. 49(3): 195-205, 2025, PMID:39629784
Pathogenic Germline Variants in Patients with Metaplastic Breast Cancer
Kaitlin Demarest, Arravinth Anantharajah, Kara N. Maxwell1, Mersedeh Rohanizadegan, Angela Bradbury, Katherine L Nathanson, Susan Domchek, Anupma Nayak, Payal D. Shah, JAMA Network Open 8(2): , 2025, PMID:39964682
Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted 18F-Fluorthanatrace PET in Breast Cancer.
Young AJ, Pantel AR, Kiani M, Doot RK, Bagheri S, Pryma DA, Farwell MD, Li S, Lee H, Schubert EK, Secreto A, Zuckerman SP, Nayak A, Choi H, Carlin S, DeMichele A, Mankoff DA, Zhou R, Mach RH, McDonald ES., J Nucl Med. 65((12)): 1862-68, 2024, PMID:39477499
Change in Biomarker Profile after neoadjuvant chemotherapy is prognostic and is especially common in patients with HER2+ breast cancer.
Tchou J, Gottipati S, Goldbach M, Baxter M, Venters S, Chen Y, Gonzalves D, Ahmad Z, Nayak A, Mukhtar R, Boughey J., Ann Surg Oncol. 31(12): 8093-8101, 2024, PMID:39117925
Validation Study of the Newly Proposed Refined Diagnostic Criteria for Malignant Phyllodes Tumor With 136 Borderline and Malignant Phyllodes Tumor Cases
Li X, Nguyen TTA, Zhang J, Nayak A, Liu Y, Duckworth LA, Zhang G, Bakkar R, Agarwal I, Hou Y, Guo H, Huang X, Wei S, Yasmeen S, Thaer K, Huang H, Zhang H, Smith GH, Turashvili G, Peng L, Liu Y, Yang W, Siziopikou KP., Am J Surg Pathol. 48(9): 1146-1153, 2024, PMID:38934254
Distinct genomic and immunologic tumor evolution in germline TP53-driven breast cancers.
Boruah N, Hoyos D, Moses R, Hausler R, Desai H, Le AN, Good M, Kelly G, Raghavakaimal A, Tayeb M, Narasimhamurthy M, Doucette A, Gabriel P, Feldman MJ, Park J, de Rodas ML, Schalper KA, Goldfarb SB, Nayak A, Levine AJ, Greenbaum BD, Maxwell KN., bioRxiv [Preprint]., 2024, PMID:38617260
