Ping Wang, PhD, DABCC, FAACC
Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Director of the Clinical Chemistry Section and Core Laboratory
University of Pennsylvania Perelman School of Medicine
Contact InformationChief of Clinical Chemistry
Director of Core Laboratory
Hospital of University of Pennsylvania
Professor of Pathology and Laboratory Medicine
University of Pennsylvania
3400 Spruce St.
Founders 7.103
Philadelphia, PA, 19104
Office: 215-614-6062
Email: Ping.Wang2@pennmedicine.upenn.edu
Specialty Division
Laboratory Medicine
Itmat Expertise
Innovative diagnostic technologies that enable equitable access to high-performance diagnostics, advance precision diagnosis and prognosis using bioengineering, nanotechnology, chemistry and microfluidics; clinical method development and clinical trials
Other Expertise
Dr. Wang is on Scientific Advisory Boards of major and startup diagnostics companies. She works with industry partners to translate diagnostic tools in development into clinical applications, by way of pre-submission clinical studies and clinical trials.
Clinical Expertise
Dr. Wang's clinical expertise focuses on in vitro diagnostics. She is a member of the FDA Medical Devices Advisory Committee. Her areas of clinical expertise includes Clinical Chemistry, Automation, Point-of-care Testing, Toxicology, Clinical Mass Spectrometry and Molecular Diagnostics.
Research Expertise
Seventy percent of healthcare decisions rely on in vitro diagnostics results, for disease diagnosis, prognosis and monitoring. One of the fields where diagnostics play important roles is Precision Medicine. However, high-performing diagnostics that generate highly sensitive and specific information are only available in highly resourced and specialized settings, resulting in limited clinical and societal impact. We focus on translational research by partnering with clinicians, engineers and other partners to develop, validate and translate innovative diagnostics technologies that enable wide and equitable access to diagnostics and inform rapid and efficient medical decision making in all kinds of settings. We take unmet clinical needs observed in our daily practice to research labs to develop novel technology solutions, which are then tested and validated in the intended use setting in iterations. The ultimate goal of our research is to benefit patients and improve outcomes by making these novel technologies available to a wide variety of populations.
Education
BS (Biological Sciences & Biotechnology), Tsinghua University, China, 2000
PhD (Molecular & Cellular Pharmacology), University of Wisconsin-Madison, 2005
Specialty Certification
American Board of Clinical Chemistry, Molecular Diagnostics subspecialty #47, 2008
American Board of Clinical Chemistry, Clinical Chemistry subspecialty #1032, 2008
American Board of Clinical Chemistry, Toxicological Chemistry subspecialty #127, 2011
Postgraduate Training
Clinical Chemistry Fellowship, COMACC-accredited, University of California, San Francisco, 2005-2007
Awards and Honors
Novo Nordisk Scholarship in Life Sciences, 1998
American Heart Association Predoctoral Fellowship, 2002-2004
University of Wisconsin-Madison Vilas Travel Award, 2004
Paul E Strandjord Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists, 2006
American Association of Clinical Chemistry Annual Meeting, Student Poster Contest Award, Honorable Mention, 2006
American Association of Clinical Chemistry Annual Meeting, Student Research Travel Grant, 2007
National Academy of Clinical Biochemistry Distinguished Abstract Award, 2009
Finalist, Outstanding Research Award in Molecular Pathology/Pharmacogenomics, AACC Molecular Pathology Division, 2009
Finalist, Outstanding Research Award in Molecular Pathology/Pharmacogenomics, AACC Molecular Pathology Division, 2012
National Academy of Clinical Biochemistry Distinguished Abstract Award, 2012
Career Cornerstone Award, 2013
Pathology Leadership Academy, Association of Pathology Chairs, 2016
Emerging Inventor of the Year, University of Pennsylvania, 2022
Memberships and Professional Organizations
American Association of Clinical Chemistry, 2005 - Present
Northern California Section, American Association of Clinical Chemistry, 2006 - 2006
Academy of Clinical Laboratory Physicians and Scientists, 2006 - Present
National Academy of Clinical Biochemistry, 2008 - Present
American Association of Clinical Chemistry, Therapeutic Drug Monitoring and Toxicology Division, 2010 - 2012
North American Chinese Clinical Chemists Association, 2010 - 2012
Association of Molecular Pathology, 2011 - Present
Immunosuppressant Scientific Committee, International Association of Therapeutic Drug Monitoring and Clinical Toxicology, 2013 - Present
American Association of Clinical Chemistry, Lipoproteins and Vascular Diseases, 2014 - 2015
American Board of Clinical Chemistry, 2014 - 2016
Electronic Testing Task Force, American Board of Clinical Chemistry, 2014 - 2016
North American Chinese Clinical Chemists Association, 2015 - 2017
Unitegen, 2015 - 2016
Commission on Accreditation of Clinical Chemistry, 2016 - 2016
NIH Center for Scientific Review, Surgical Sciences, Biomedical Imaging and Bioengineering, ZRG1 SBIB-Q 57, Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment (R01), 2017 - present
Personalized Medicine Division, American Association of Clinical Chemistry, 2017 - 2018
Roche Diagnostics US Infectious Disease Scientific Advisory Board, 2017 - 2017
American Board of Clinical Chemistry, 2017 - 2018
Dr. Edward S. Cooper Leadership Training Program, Perelman School of Medicine and Wharton School of University of Pennsylvania, 2017 - 2017
FOCUS Mid-career Series/University of Pennsylvania, 2017 - 2017
Genome BC Canada, 2017 - 2017
Association of American Medical Colleges Mid-Career Women Faculty Leadership Development Seminar, 2017 - 2017
Committee for Omics Translation, Emerging Technologies Division, International Federation of Clinical Chemistry and Laboratory Medicine, 2019 - Present
NIH Bioengineering Sciences and Technologies IRG (BST) Center for Scientific Review Instrumentation and Systems Development (ISD) Study Section, 2019 - Present
Personalized Medicine Division, American Association of Clinical Chemistry, 2019 - 2020
Science and Practice Core Committee, American Association of Clinical Chemistry, 2019 - 2020
American Association of Clinical Chemistry Research Prize Competition Organizing Taskforce, 2019 - Present
NIH Center for Scientific Review Panel for Emergency Awards: Rapid Investigation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19), 2020 - Present
NIH Center for Scientific Review Special Emphasis Panel Interdisciplinary Molecular Science and Training (ZRG1 IMST-J) Small Business: Biological Chemistry, Biophysics, and Assay Development, 2020 - Present
American Chemical Society-Division of Biochemicl Technology/European Society of Biochemical Engineering SCiences COVID19 Working Group, 2020 - Present
Societal Responses to and Preparedness for Emerging Viral Infections – 2020, The Novo Nordisk Foundation (NNF), Denmark, 2020 - Present
NIH Center for Scientific Review, Bioengineering Sciences and Technologies IRG, Instrumentation and Systems Development Study Section (ISD), 2021 - Present
FDA Medical Devices Advisory Committee, Clinical Chemistry and Clinical Toxicology Devices Panel, 2021 - Present
Web Links
Wang Lab website
360Dx Report on the Microbubbling Technology
My Diagnostics World News Interview
360Dx Report on the Fentanyl Lateral Flow Assay
Penn Medicine Q&A on the microbubbling SARS-CoV-2 antigen test
Penn Coronavirus Symposium presentation
New COVID-19 Testing Technology at Penn
Selected Publications
Point-of-care Testing
Wang P. and O'Kane M., Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 7th Edition, 2022
Deadly Pathogens, Transformative Technologies, and Protracted Pandemics: Challenges and Opportunities in Laboratory Medicine
Pritt BS, Wang P, Nuzzo J, Zimmermann S and Burnham CA, Clin Chem 68(1): 1-3, 2022
Point-of-care Testing
Wang P., Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 9th Edition, 2022
Pretreatment Methods for Human Nasopharyngeal Swabs to Increase Signal to Noise Ratio of High Sensitivity Immunoassays
Chen H, Feng S, Zhou W, Li Z, Richard-Greenblatt M and Wang P, ACS Measurement Science Au 2(5): 414, 2022
Debulking different Corona (SARS-COV-2 delta, omicron, OC43) and Influenza (H1N1, H3N2) virus strains by plant viral trap proteins in chewing gums to decrease infection and transmission
Daniell H, Nair SK, Guan H, Guo Y, Kulchar RJ, Torres MDT, Shahed-Al-Mahmud, Liu Y,Graham-Wooten J,Zhou W, Wang P,Mante F, Fuente-Nunez C, Ma C, Ricciardi R, Collman R,Wolff MS, Biomaterials 288(): 121671, 2022
Performance of Two Fentanyl Immunoassays Against a Liquid Chromatography-Tandem Mass Spectrometry Method
Feng S, Rutledge TJ, Manzoni M, Le T, Gardiner J, Milone M, Shaw L, Wang P, J Anal Tox 45(2): 117-123, 2021
The SARS-CoV-2 Outbreak: Diagnosis, Infection Prevention, and Public Perception
Wang P, Anderson N, Pan Y, Poon L, Charlton C, Zelyas N, Persing D, Rhoads D and Babcock H, Clinical Chemistry, 2020
Femtomolar SARS-CoV-2 Antigen Detection Using the Microbubbling Digital Assay with Smartphone Readout Enables Antigen Burden Quantitation and Tracking
Chen H, Li Z, Feng S, Richard-Greenblatt M, Hutson E, Andrianus S, Glaser LJ, Rodino KG, Qian J, Jayaraman D, Collman RG, Glascock A, Bushman FD, Lee JS, Cherry S, Fausto A, Weiss SR, Koo H, Corby PM, O’Doherty U, Garfall AL, Vogl DT, Stadtmauer EA, Wang P, Clin Chem 68(1): 230, 2021
A Biomarker for Concussion: The Good, the Bad and the Unknown
Reece JT, Milone MC, Wang P, Herman D and Shaw LM, The Journal of Applied Laboratory Medicine 5(1): 170-82, 2020
Point of Care Drugs of Abuse Testing in the Opioid Epidemic
Li Z and Wang P, Arch Pathol Lab Med 144(11): 1325-34, 2020
Debulking SARS-COV-2 in Saliva using Angiotensin Converting Enzyme 2 in the Chewing Gum to Decrease Oral Virus Transmission and Infection
Daniell1 H, Nair1 S, Esmaeili1 N, Wakade1 G, Schad D, Gerbrick K, Kulp J, Shepley-McTaggart A, Feng S,Islam R, Nuth M, Nunez Cruz S, Graham-Wooten J, Streatfield S, Lopez RM, Kaznica P, Mawson M, Green B, Gurdon C, R. Ricciardi,1 Milone M,Harty R,Wang P and Collman R, Molecular Therapy 30(): 1-13, 2022
Falsely Increased Plasma Lactate Dehydrogenase without Hemolysis following Transport through Pneumatic Tube System
Herman D., Cobani E., Baraban E., Bagg A., and Wang P., Journal of Applied Laboratory Medicine 4(3): 433-438, 2019
Quantitation of Femtomolar Protein Biomarkers Using a Simple Microbubbling Digital Assay via Bright-field Smartphone Imaging
Chen H., Li Z., Zhang L., Sawaya P., Shi J., Wang P., Angewandte Chemie International Edition 58(39): 2-9, 2019
Point-of-care Testing
Wang P., NEJM/AACC Learning Lab, 2019
Lateral Flow Assay Ruler for Quantitative and Rapid Point-of-care Testing
Li Z., Chen H. and Wang P., Analyst 144(10): 3314-22, 2019
Development and Clinical Validation of a Sensitive Lateral Flow Assay for Rapid Urine Fentanyl Screening in the Emergency Department
Li Z., Chen H., Feng S., Liu K. and Wang P., Clinical Chemistry 66(2): 324-32, 2020
Point-of-care Testing for Infectious Diseases
Chen H., Liu K., Li Z. and Wang P., Clinica Chimica Acta 493(): 138-147, 2019
Wearable Knitted Bands For Sweat Glucose Sensing and Quantitation in Telemedicine
Wang P, Panatdasirisuk W, Zhang M, Stoltzfus A, Dion G, Yang S, 27th Critical and Point of Care Testing International Symposium, Anaheim, CA, 2018
A Ultra-low Cost Smartphone Octochannel Spectrometer for Mobile Health Diagnostics
Wang L, Naudé N, Chang Y, Crivaro A, Kamoun M, Wang P*, and Li L*, Journal of Biophotonics 11(8): doi:10.1002/jbio.201700382, 2018, PMID:29603674
Analytical Validation of an Ultra Low-cost Mobile Phone Microplate Reader for Infectious Disease Testing
Wang L, Naudé N, Demissie M, Crivaro A, Kamoun M, Wang P*, Li L*, Clinica Chimica Acta 482(): 21-26, 2018, PMID:29580858
Integrated microfluidic chip for efficient isolation and deformability analysis of circulating tumor cells
Liu Z, Chen R; Li Y; Liu J; Wang P*; Xia X* and Qin L*, Advanced Biosystems 2(10): https://doi.org/10.1002/adbi.201800200, 2018
Current and Emerging Trends in Point-of-care Technology and Strategies for Clinical Validation and Implementation
Wang P* and Kricka LJ, Clinical Chemistry 64(10): 1439-52, 2018, PMID:29884677
Efficient homology-directed gene editing by CRISPR/Cas9 in human stem and primary cells using tube electroporation
Xu X, Gao D, Wang P, Chen J, Ruan J, Xu J, and Xia X, Nature Scientific Reports 8(1): 11649, 2018
Quality Control Practices for Chemistry and Immunochemistry in a Cohort of 21 Large Academic Medical Centers
Rosenbaum MW, Flood JG, Melanson SEF, Baumann NA, Marzinke MA, Rai AJ, Hayden J, Wu A, Ladror M, Lifshitz MS, Palmer SM, Bowen R, Babic N, Sobhani K, Giacherio D, Bocsi G, Herman DS, Wang P, Toffaletti J, Handel E, Kelly KA, Albeiroti S, Wang S, Zimmer M, Driver B, Yi X, Wilburn C, Lewandowski KB, American Journal of Clinical Pathology 150(2): 1-9, 2018
The Prevalence and Role of Hemoglobin Variants in Biometric Screening of a Multiethnic Population: One Large Health System’s experience
Wilburn C.R., Bernard D.W., Zieske A.W, Andrieni J., Miller T. and Wang P., American Journal of Clinical Pathology 147(6): 589-95, 2017, PMID:28575177
Fast, Sensitive and Quantitative Point-of-care Platform for the Assessment of Drugs of Abuse in Urine, Serum and Whole Blood
Li Y, Uddayasankar U, He B, Wang P* and Qin L*, Analytical Chemistry 89(16): 8273-8281, 2017, PMID:28700829
Nanoporous Glass Integrated in Volumetric Bar-chart Chip for Point-of-care Diagnostics of Non-small Cell Lung Cancer
Li Y, Xuan J, Song Y, Qi W, Wang P*, Qin L*, ACS Nano 10(1): 1640-47, 2016
Integrative volumetric bar-chart chip for rapid and quantitative point-of-care detection of myocardial infarction biomarker
Song Y., Wang Y., Qi W., Li Y., Xuan J., Wang P*., Qin L*, Lab on a Chip 16(15): 2955-62, 2016
A Microfluidic Platform with Digital Readout and Ultra-Low Detection Limit for Quantitative Point-of-Care Diagnostics
Li Y, Xuan J, Song Y, Li Y, Wang P*, Qin L*, Lab on a Chip 15(16): 3300-06, 2015
High Throughput, Label-free Isolation of Cancer Stem Cells on the Basis of Cell Adhesion Capacity
Zhang Y, Wu M, Han X, Wang P*, and Qin L*, Angewandte Chemie International Edition 127(37): 1-6, 2015
