More than half of human cancers have abnormally upregulated chemical signals related to lipid metabolism, yet how the phospholipid signals are controlled during tumorigenesis is not fully understood. The Chen Lab now reports that TIPE3, a newly described oncogenic protein, promotes cancer by targeting these pathways. The study "TIPE3 Is the Transfer Protein of Lipid Second Messengers that Promote Cancer" was published in Cancer Cell.
Read the Department of Communications news release.