Aggressive triple negative breast cancers have unique molecular signature on the basis of mitochondrial genetic and functional defects
Guha M, Srinivasan S, Raman P, Jiang Y, Kaufman BA, Taylor D, Dong D, Chakrabarti R, Picard M, Carstens RP, Kijima Y, Feldman M, Avadhani NG. Biochim Biophys Acta. 2018 Jan 5. pii: S0925-4439(18)30003-6. doi: 10.1016/j.bbadis.2018.01.002. [Epub ahead of print]
Summary
New findings from a study led by researchers at the University of Pennsylvania have made inroads into a strategy to identify triple-negative cancer (TNBC) tumors at risk for metastasis, and eventually target these cancers with drugs. The work, which compared the metabolic profiles of different cancer sub-types, identified patterns associated with aggressive triple-negative breast cancers that point to the possibility for more accurate risk assessment and personalized treatment.
Link to Penn news release
