PUBLICATIONS

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, V├Ása U, Whitehead KJ, Li DY, Franke L, Hart B, Schwaninger M, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn ML. Nature. 2017 May 10. doi: 10.1038/nature22075. [Epub ahead of print]

Summary

Bacteria in the gut microbiome drive the formation of cerebral cavernous malformations (CCMs), clusters of dilated, thin-walled blood vessels in the brain that can cause stroke and seizures, according to a new study published in Nature. The research suggests that altering the microbiome in CCM patients may be an effective therapy for this cerebrovascular disease.
Read the Department of Communications press release.
Coverage in the New York Times.