Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer

Zhang Y, He Q, Hu Z, Feng Y, Fan L, Tang Z, Yuan J, Shan W, Li C, Hu X, Tanyi JL, Fan Y, Huang Q, Montone K, Dang CV, Zhang L. Nat Struct Mol Biol. 2016 Apr 25. | doi: 10.1038/nsmb.3211


Department member Dr. Kathy Montone was part of a Basser-Center-supported study on triple-negative breast cancer (TNBC) published in Nature Structural & Molecular Biology. The paper identifies a long non-coding RNA (lncRNA) that regulates repair of DNA breaks in TNBC, an aggressive subtype of breast cancer with poor clinical outcome. Using a clinically guided genetic screening approach, researchers from the Perelman School of Medicine at the University of Pennsylvania have now identified LINP1, a lncRNA, that is overexpressed in triple-negative breast cancer cells and regulated by the tumor suppressor p53 and the activated cell surface protein, EGFR. LINP1 enhances the repair of DNA breaks by serving as a scaffold that links two other proteins in the repair machinery.
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