mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern
Goel RR, Painter MM, Apostolidis SA, Mathew D, Meng W, Rosenfeld AM, Lundgreen KA, Reynaldi A, Khoury DS, Pattekar A, Gouma S, Kuri-Cervantes L, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Baxter AE, Oldridge DA, Giles JR, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Drapeau EM, Dougherty J, Long S, D'Andrea K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O; UPenn COVID Processing Unit, Frank I, Betts MR, Vella LA, Grifoni A, Weiskopf D, Sette A, Hensley SE, Davenport MP, Bates P, Luning Prak ET, Greenplate AR, Wherry EJ. Science. 2021 Dec 3;374(6572):abm0829. doi: 10.1126/science.abm0829. Epub 2021 Dec 3.
Summary
The Human Immunology Core (HIC) facility has provided expertise and generated immune repertoire profiling data (sequencing of antibody gene rearrangements) in support of multiple high-profile studies in recent months. In collaboration with the Wherry lab, the HIC performed an analysis of over 500,000 B cell clones and tracked clonal lineages in SARS-CoV-2 mRNA vaccinated and recovered individuals. This study revealed that antibodies that can bind to different variants of the spike protein accumulate somatic mutations, providing new insights into the mechanisms of generating cross-protective immunity to SARS-CoV-2 variants. Authors in bold font are members of the HIC or the Department.
