PUBLICATIONS

Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis

Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SX, Lee EB, Van Deerlin VM, Lopez OL, Kofler JK, Nelson PT, Jicha GA, Woltjer R, Quinn JF, Kaye J, Leverenz JB, Tsuang D, Longfellow K, Yearout D, Kukull W, Keene CD, Montine TJ, Zabetian CP, Trojanowski JQ. Lancet Neurol. 2017 Jan;16(1):55-65. doi: 10.1016/S1474-4422(16)30291-5.

Summary

A post-mortem brain tissue study shows that patients who had a diagnosis of Parkinson’s disease with dementia or dementia with Lewy bodies and had higher levels of Alzheimer’s disease (AD) pathology in their donated post-mortem brains also had more severe symptoms of these Lewy body diseases during their lives, compared to those whose brains had less AD pathology.
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