Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer

Singhal S, Bhojnagarwala PS, O'Brien S, Moon EK, Garfall AL, Rao AS, Quatromoni JG, Stephen TL, Litzky L, Deshpande C, Feldman MD, Hancock WW, Conejo-Garcia JR, Albelda SM, Eruslanov EB. Cancer Cell. 2016 Jun 30. | doi: 10.1016/j.ccell.2016.06.001. [Epub ahead of print]


The Cancer Cell paper identifies a unique subset of tumor associated neutrophils (TANs) that exhibit hybrid characteristics of two immune cell types -- neutrophils and antigen-presenting cells -- in samples from early-stage human lung cancers. This is the first study to describe this phenomenon in a human tumor.
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