Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy

Flingai S, Plummer EM, Patel A, Shresta S, Mendoza JM, Broderick KE, Sardesai NY, Muthumani K, Weiner DB. Sci Rep. 2015 Jul 29;5:12616. doi: 10.1038/srep12616.


The study, published in Scientific Reports by the Weiner Lab, demonstrated that animals injected with synthetic DNA engineered to encode a specific neutralizing antibody against the dengue virus were capable of producing the exact antibodies necessary to protect against disease, without the need for standard antigen-based vaccination. Importantly, this approach, termed DMAb, was rapid, protecting animals within a week of administration. Dengue virus is the most important mosquito-borne viral infection in humans. In recent years, the number of cases and outbreaks has dramatically increased worldwide.
Read more in the Department of Communications news release.