Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression

Tarangelo A, Lo N, Teng R, Kim E, Le L, Watson D, Furth EE, Raman P, Ehmer U, Viatour P. Nat Commun. 2015 Dec 7;6:10028. | doi: 10.1038/ncomms10028.


A new study, published in Nature Communications, identifies and describes an epigenetic mechanism in cancer cells that amplifies the expression of many genes and could be a central hub in cancer cell growth. Unlike most molecular cancer discoveries that advance knowledge of the disease by dividing it into narrower subtypes, this finding could directly apply to multiple cancer types.
Read more in the CHOP research communications.