Off-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus

Mijušković M, Chou YF, Gigi V, Lindsay CR, Shestova O, Lewis SM, Roth DB. Cell Rep. 2015 Sep 10 [Epub ahead of print] doi: 10.1016/j.celrep.2015.08.034


The Roth Lab reports that when the enzyme key to cutting and pasting segments of DNA hits so-called “off-target” spots on a chromosome, the development of immune cells can lead to cancer in animal models. Knowing the exact nature of these editing errors will be helpful in designing therapeutic enzymes based on these molecular scissors. The findings appear online this week in Cell Reports ahead of the print issue.
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