Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice
Beckerman P, Bi-Karchin J, Park AS, Qiu C, Dummer PD, Soomro I, Boustany-Kari CM, Pullen SS, Miner JH, Hu CA, Rohacs T, Inoue K, Ishibe S, Saleem MA, Palmer MB, Cuervo AM, Kopp JB, Susztak K. Nat Med. 2017 Apr;23(4):429-438. doi: 10.1038/nm.4287. Epub 2017 Feb 20.
Summary
First demonstration that the expression of APOL1 risk alleles is causal for altered podocyte function and glomerular disease in vivo.
