PEOPLE

Zissimos Mourelatos, MD

Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
Division of Neuropathology
613B Stellar Chance Labs
422 Curie Boulevard
Philadelphia, PA 19104-6100
Office: 215-746-0014
Fax: 215-746-0285

Email: mourelaz@uphs.upenn.edu

Specialty Division

Neuropathology, Immunobiology and Experimental Pathology

Research Expertise

Biochemical and genetic studies of Ribonucleoproteins (RNPs) with emphasis on
small regulatory RNPs such as microRNAs (miRNAs) and piRNAs (Piwi-associated RNAs).
Biochemical and genetic studies of mRNA translation and mRNA decay.
Biochemical and genetic studies of RNA dysregulation in the pathogenesis of neurodegeneration.

Clinical Expertise

Neuropathology
Surgical Neuropathology (Brain tumors; Brain biopsies; Muscle biopsies; Nerve biopsies)
Medical Neuropathology

Other Expertise

Director, Division of Neuropathology
Fellowship Director, Neuropathology

Itmat Expertise

Biochemical and genetic studies of Ribonucleoproteins (RNPs) with emphasis on
small regulatory RNPs such as microRNAs (miRNAs) and piRNAs (Piwi-associated RNAs).
Biochemical and genetic studies of mRNA translation and mRNA decay.
Biochemical and genetic studies of RNA dysregulation in the pathogenesis of neurodegeneration.

Graduate Groups

Cell and Molecular Biology

Education

M.D. Aristotelian University of Thessaloniki - School of Medicine, Thessaloniki, Greece, 1991

Specialty Certification

American Board of Pathology (Board Certified in Anatomic Pathology and Neuropathology), 1999

Postgraduate Training

Clinical Student Fellowship, A.U.TH, A' Neurology Clinic, Thessaloniki, Greece., 1988-1989
Research Student Fellowship, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, U.S.A., 1989-1989
ERASMUS-E.C.T.S. Clinical Student Scholarship: , Universite Libre de Bruxelles, School of Medicine, Brussels, Belgium, 1990-1990
Resident in Anatomic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 1995-1997
Fellow in Neuropathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 1997-1999

Awards and Honors

ERASMUS Scholar (The "ERASMUS-European Credit Transfer System" program is sponsored by the Educational Council of the European Union), 1990
Michael S. Brown New Investigator Research Award, 2006
Elected Member of the American Association of University Pathologists “Pluto Society”, 2012-current

Memberships and Professional Organizations

American Association for the Advancement in Science, 2004 - Present
Ad Hoc Member, Grant reviews, Wellcome Trust, London, UK, 2004 - Present
Ad Hoc Member, Grant Reviews, Netherlands Organization for Health Research and Development, The Netherlands, 2005 - Present
Ad Hoc Member, NCF Study Section CSR/NIH, 2005 - Present
Member, Grant Reviews, European Union Commission on Framework Grants; Brussels, EU, 2005 - Present
Ad Hoc Member, ZRG1 Study Section, CSR/NIH/NINDS, 2005 - 2005
Ad Hoc Member, ZMH1 ERB-L Study Section, CSR/NIH/NIMH, 2006 - Present
Ad Hoc Member, ZCA1 GRB-S P01 Study Section, NCI/NIH, 2007 - Present
Reviewer, Austrian Science Fund, Vienna, Austria, 2009 - Present
Reviewer, Swedish Research Council, 2009 - Present
Reviewer, Hellenic Ministry of Education Research Council, Athens, Greece, 2011 - Present
Reviewer, Israel Science Foundation, 2011 - Present
American Association of Neuropathologists, 2011 - Present
Ad Hoc Member, MGB Study Section CSR/NIH, 2012 - 2013
Reviewer, Agence Nationale de la Recerche, France (ANR), 2012 - present
Permanent Member, MGB Study Section CSR/NIH, 2013 - 2019
Human Frontier Science Program (HFSP), 2016 - present

Web Links


Selected Publications

Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis

Couthouis J., Hart M.P., Erion R., King O.D., Diaz Z., Nakaya T., Ibrahim F., Kim H.J., Mojsilovic-Petrovic J., Panossian S., Kim C.E., Frackelton E.C., Solski J.A., Williams K.L., Clay-Falcone D., Elman L., McCluskey L., Greene R., Hakonarson H., Kalb R.G., Lee V-MY, Trojanowski J.Q., Nicholson G.A., Blair I.P., Bonini N.M., Van Deerlin V.M., Mourelatos Z. ,Shorter J and A.D. Gitler, Human Molecular Genetics 21(): 2899-911, 2012, PMID:22454397

Read article

Precursor MicroRNA-Programmed Silencing Complex Assembly Pathways in Mammals

Liu X., Jin D-Y, McManus M.T. and Z. Mourelatos, Molecular Cell 46(): 507-17, 2012, PMID:22503104

Read article

Target RNA repertoire of Mili and Miwi reveals piRNA biogenesis and function of Miwi in spermiogenesis

Vourekas, A, Zheng Q., Kirino Y., Alexiou P., Maragkakis, M., Gregory B.D. and Z. Mourelatos, Nature Structural & Molecular Biology 19(): 773-81, 2012

Asymmetric bilateral demyelinating optic neuropathy from tacrolimus toxicity

Venneti S, Moss HE, Levin MH, Vagefi MR, Brozena CS, Pruitt AA, Mourelatos Z, Trojanowski JQ, Galetta SL, Balcer LJ, Journal of the Neurological Sciences 301(1-2): 112-5, 2011, PMID:21112060

Read article

A yeast functional screen predicts new candidate ALS disease genes.

Couthouis J., Erion R., Hart M.P., Oristano R.E., Liu X.A., Ramos D., Jethava N., Hosangadi D., Epstein J., Chiang A., Diaz Z., Nakaya T., Ibrahim F., King O.D., , Kim H.J., Panossian S., Kim C.E., Frackelton E.C., Geser F., Clay-Falcone D., Elman L., McCluskey L., Greene R., Lee V-MY, Trojanowski J.Q., Hakonarson H., Bonini N.M., Shorter J., Van Deerlin V.M., Mourelatos Z. and A.D. Gitler, PNAS 108(): 20881-90, 2011, PMID:22065782

Read article

MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS.

Venneti S., Boateng L.A., Friedman J.R, Baldwin D.A., Tobias J.W., Judkins A.R., Mourelatos Z. and L. Priti., Brain Pathology 22(4): 522-9, 2012

Immunoprecipitation of piRNPs and directional, next generation sequencing of piRNAs

Kirino Y, Vourekas A, Khandros E, Mourelatos Z, Methods Molecular Biology 725(): 281-93, 2011, PMID:21528460

Read article

Arginine methylation of vasa protein is conserved across phyla

Kirino Y, Vourekas A, Kim N, de Lima Alves F, Rappsilber J, Klein PS, Jongens TA, Mourelatos Z, J Biol Chem 285(11): 8148-54, 2010, PMID:20080973

Read article

Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization

Kirino A, Vourekas A, Sayed N, de Lima Alves F, Thomson T, Lasko P, Rappsilber J, Jongens TA, and Mourelatos Z, RNA 16(1): 70-8, 2010, PMID:19926723

Read article

Search PubMed for articles