Douglas C. Wallace, PhD

Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Michael and Charles Barnett Endowed Chair in Pediatric Mitochondrial Medicine and Metabolic Disease
Children's Hospital of Philadelphia

Contact InformationThe Center for Mitochondrial and Epigenomic Medicine at The Children's Hospital of Philadelphia Research Institute
The Colket Translational Research Building, Rm 6060
3501 Civic Center Boulevard
Philadelphia, PA 19104-4302
Office: 267-425-3034
Fax: 267-303-3615

Specialty Division

Immunobiology and Experimental Pathology

Itmat Expertise

Mitochondrial and Epigenomic Medicine

Graduate Groups

Cell and Molecular Biology


B.S. (Genetics, Developmental Biology), Cornell University, Ithaca, NY, 1968
M. Phil. (Microbiology and Human Genetics), Yale University, New Haven CT, 1972
PhD (Microbiology and Human Genetics), Yale University, New Haven CT, 1975

Specialty Certification

American Board of Medical Genetics Diplomate, Ph.D. Medical Genetics, 1989
American Board of Medical Genetics Diplomate, Clinical Molecular Genetics, 1993

Postgraduate Training

Predoctoral Research, Woods Hole Marine Biological Laboratory, 1971-1971
Predoctoral Research, Department of Microbiology, Yale University, 1971-1975
NIH Postdoctoral Fellowship, Department of Human Genetics, Yale University, 1975-1976

Awards and Honors

Mellon Foundation Fellow, Stanford University, 1978-1979
Hume Faculty Scholar, Stanford University, 1981-1982
Most Valuable Professor, Emory University School of Medicine, Class of 1988, 1988
Most Animated Instructor, Emory University School of Medicine, Class of 1990, 1990
Robert W. Woodruff Professor of Molecular Genetics, 1991-2002
William Allan Award, American Society of Human Genetics, 1994
Member of National Academy of Sciences, 1995
Member of American Academy for Microbiology, 1995
Passano Award 2000 for mitochondrial genetics, with G. Attardi, 2000
Metropolitan Life Foundation Award for Medical Research in Alzheimer’s Disease, 2000
Docteur Honoris Causa, Universite Victor Segalen Bordeaux 2, 2000
Donald Bren Professor of Biological Sciences and Molecular Medicine, University of California, Irvine, 2002-2010
Fellow, American College of Medical Genetics, 2004
Member American Academy of Arts and Sciences, 2004
Excellence in Teaching Award, University of California, Irvine, School of Medicine, 2005
Albert Einstein Visiting Professorship, Chinese Academy of Sciences, 2006
Excellence in Teaching Award, University of California, Irvine, School of Medicine, 2006
Faculty Achievement Award, University of California, Irvine Alumni Association, 2006
Lauds & Laurels, University of California, Irvine, 2006
Robert J. & Claire Pasarow Award for contributions to Cardiovascular Disease, 2006
Member of Institute of Medicine of the National Academies, 2009
Michael and Charles Barnett Endowed Chair of Pediatric Mitochondrial Medicine and Metabolic Disease, Children's Hospital of Philadelphia, University of Pennsylvania, 2010
Gruber Foundation Genetics Prize, 2012
American College of Physicians Award for Outstanding Work in Science as Related to Medicine, 2013
Foreign Member of The Accademia Nazionale Delle Sceince Detta Dei XL, Rome, Italy, 2016

Memberships and Professional Organizations

American Society for Microbiology, 1968 - present
Sigma Xi, 1972 - present
The American Association for the Advancement of Science, 1972 - present
Society for Inherited Metabolic Disorders, 1989 - present
Human Gene Mapping Consortium, 1993 - 2002
American Society of Human Genetics, 1993 - present
United Mitochondrial Disease Foundation, 1996 - 2008
International Human Genome Organization, 1999 - present
National Institute of Aging, 2002 - 2005
Autism Speaks, 2009 - present
National Heart Lung and Blood Institute, 2010 - present

Web Links

Selected Publications

Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction

Kokoszka JE, Waymire KG, Flierl A, Sweeney KM, Angelin A, MacGregor GR, Wallace DC, Biochimica et Biophysica Acta 1857(8): 1203-12, 2016

High throughput gene complementation screening permits identification of a mammalian mitochondrial protein synthesis (ρ-) mutant

Potluri P, Procaccio V, Scheffler IE, Wallace DC, Biochimica et Biophysica Acta 1857(8): 1336-43, 2016

Genetics: Mitochondrial DNA in evolution and disease

Wallace DC, Nature 535(7613): 498-500, 2016, PMID:27383787

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The rise of mitochondria in medicine

Picard M, Wallace DC, Burelle Y, Mitochondrion 30(): 105-116, 2016, PMID:27423788

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MSeqDR: A Centralized Knowledge Repository and Bioinformatics Web Resource to Facilitate Genomic Investigations in Mitochondrial Disease

Shen L, Diroma MA, Gonzalez M, Navarro-Gomez D, Leipzig J, Lott MT, van Oven M, Wallace DC, Muraresku CC, Zolkipli-Cunningham Z, Chinnery PF, Attimonelli M, Zuchner S, Falk MJ, Gai X, Human Mutation 37(6): 540-08, 2016

Differential Mitochondrial Requirements for Radially and Non-radially Migrating Cortical Neurons: Implications for Mitochondrial Disorders

Lin-Hendel EG, McManus MJ, Wallace DC, Anderson SA, Golden JA, Cell Reports 15(2): 229-37, 2016

Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress.

Picard M, McManus MJ, Gray JD, Nasca C, Moffat C, Kopinski P, Seifert E, McEwen BS, Wallace DC., Proceedings of the National Academy of Sciences 112(48): , 2015, PMID:26627253

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Mitochondrial DNA Variation in Human Radiation and Disease.

Wallace DC, Cell 163(1): 33-38, 2015, PMID:26406369

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Mitochondrial DNA variants can mediate methylation sttus of inflammation, angiogenesis and signaling genes.

Atilano SR, Malik D, Chwa M, Cáceres-Del-Carpio J, Nesburn AB, Boyer DS, Kuppermann BD, Jazwinski SM, Miceli MV, Wallace DC, Udar N, Kenney MC., Human Molecular Genetics, 2015, PMID:25964427

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Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion.

Rivadeneira DB, Caino MC, Seo JH, Angelin A, Wallace DC, Languino LR, Altieri DC., Sci Signal 8(389): , 2015, PMID:26268608

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