PEOPLE

Douglas C. Wallace, PhD

Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Michael and Charles Barnett Endowed Chair in Pediatric Mitochondrial Medicine and Metabolic Disease
Children's Hospital of Philadelphia

Contact InformationThe Center for Mitochondrial and Epigenomic Medicine at The Children's Hospital of Philadelphia Research Institute
The Colket Translational Research Building, Rm 6060
3501 Civic Center Boulevard

Philadelphia, PA, 19104-4302
Office: 267-425-3034

Specialty Division

Immunobiology and Experimental Pathology

Itmat Expertise

Mitochondrial and Epigenomic Medicine

Graduate Groups

Cell and Molecular Biology

Education

B.S. (Genetics, Developmental Biology), Cornell University, Ithaca, NY, 1968
M. Phil. (Microbiology and Human Genetics), Yale University, New Haven CT, 1972
PhD (Microbiology and Human Genetics), Yale University, New Haven CT, 1975

Specialty Certification

American Board of Medical Genetics Diplomate, Ph.D. Medical Genetics, 1989
American Board of Medical Genetics Diplomate, Clinical Molecular Genetics, 1993

Postgraduate Training

Predoctoral Research, Department of Microbiology, Yale University, 1971-1975
Predoctoral Research, Woods Hole Marine Biological Laboratory, 1971-1971
NIH Postdoctoral Fellowship, Department of Human Genetics, Yale University, 1975-1976

Awards and Honors

Mellon Foundation Fellow, Stanford University, 1978-1979
Hume Faculty Scholar, Stanford University, 1981-1982
Most Valuable Professor, Emory University School of Medicine, Class of 1988, 1988
Most Animated Instructor, Emory University School of Medicine, Class of 1990, 1990
Robert W. Woodruff Professor of Molecular Genetics, 1991-2002
William Allan Award, American Society of Human Genetics, 1994
Member of National Academy of Sciences, 1995
Member of American Academy for Microbiology, 1995
Docteur Honoris Causa, Universite Victor Segalen Bordeaux 2, 2000
Metropolitan Life Foundation Award for Medical Research in Alzheimer’s Disease, 2000
Passano Award 2000 for mitochondrial genetics, with G. Attardi, 2000
Donald Bren Professor of Biological Sciences and Molecular Medicine, University of California, Irvine, 2002-2010
Fellow, American College of Medical Genetics, 2004
Member American Academy of Arts and Sciences, 2004
Excellence in Teaching Award, University of California, Irvine, School of Medicine, 2005
Faculty Achievement Award, University of California, Irvine Alumni Association, 2006
Lauds & Laurels, University of California, Irvine, 2006
Albert Einstein Visiting Professorship, Chinese Academy of Sciences, 2006
Excellence in Teaching Award, University of California, Irvine, School of Medicine, 2006
Robert J. & Claire Pasarow Award for contributions to Cardiovascular Disease, 2006
Member of Institute of Medicine of the National Academies, 2009
Michael and Charles Barnett Endowed Chair of Pediatric Mitochondrial Medicine and Metabolic Disease, Children's Hospital of Philadelphia, University of Pennsylvania, 2010
Gruber Foundation Genetics Prize, 2012
American College of Physicians Award for Outstanding Work in Science as Related to Medicine, 2013
Foreign Member of The Accademia Nazionale Delle Sceince Detta Dei XL, Rome, Italy, 2016
The Franklin Institute's "2017 Benjamin Franklin Medal in Life Science Laureate", Philadelphia, PA, 2017
Johnson & Johnson, "2017 Dr. Paul Janssen Award for Biomedical Research", Beerse Award Ceremony, Belgium; and Scientific Symposium & Luncheon, New York, 2017

Memberships and Professional Organizations

American Society for Microbiology, 1968 - present
Sigma Xi, 1972 - present
The American Association for the Advancement of Science, 1972 - present
Society for Inherited Metabolic Disorders, 1989 - present
American Society of Human Genetics, 1993 - present
Human Gene Mapping Consortium, 1993 - 2002
United Mitochondrial Disease Foundation, 1996 - 2008
International Human Genome Organization, 1999 - present
National Institute of Aging, 2002 - 2005
Autism Speaks, 2009 - present
National Heart Lung and Blood Institute, 2010 - present

Web Links


Selected Publications

Mitochondrial respiration is sensitive to cytoarchitectural breakdown

Kandel J, Angelin AA, Wallace DC, Eckmann DM, Integr Biol (Camb) 8(11): 1170-1182, 2016, PMID:27734042

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Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction

Kokoszka JE, Waymire KG, Flierl A, Sweeney KM, Angelin A, MacGregor GR, Wallace DC, Biochimica et Biophysica Acta 1857(8): 1203-12, 2016

High throughput gene complementation screening permits identification of a mammalian mitochondrial protein synthesis (ρ-) mutant

Potluri P, Procaccio V, Scheffler IE, Wallace DC, Biochimica et Biophysica Acta 1857(8): 1336-43, 2016

Genetics: Mitochondrial DNA in evolution and disease

Wallace DC, Nature 535(7613): 498-500, 2016, PMID:27383787

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Microchambers with Solid-State Phosphorescent Sensor for Measuring Single Mitochondrial Respiration

Pham TD, Wallace DC, Burke PJ, Sensors (Basel) 7(): 1065, 2016

Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK feedback mechanism.

Shah S, Carriveau WJ, Li J, Campbell SL, Kopinski PK, Lim HW, Daurio N, Trefely S, Won KJ, Wallace DC, Koumenis C, Mancuso A, Wellen KE., Oncotarget. 7(28): 43713-43730, 2016

The rise of mitochondria in medicine

Picard M, Wallace DC, Burelle Y, Mitochondrion 30(): 105-116, 2016, PMID:27423788

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Genetics: Mitochondrial DNA in evolution and disease

Wallace, DC, Nature 535(7613): 498-500, 2016, PMID:27383787

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MSeqDR: A Centralized Knowledge Repository and Bioinformatics Web Resource to Facilitate Genomic Investigations in Mitochondrial Disease

Shen L, Diroma MA, Gonzalez M, Navarro-Gomez D, Leipzig J, Lott MT, van Oven M, Wallace DC, Muraresku CC, Zolkipli-Cunningham Z, Chinnery PF, Attimonelli M, Zuchner S, Falk MJ, Gai X, Human Mutation 37(6): 540-08, 2016