Yuk Yee Leung, PhD
Research Assistant Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Contact Information3700 Hamilton Walk
D101 Richards Medical Research Building
Perelman School of Medicine, University of Pennsylvania
Philadelphia, PA, 19104
Email: yyee@pennmedicine.upenn.edu
Clinical Expertise
Small RNA biomarkers for Alzheimer's disease and other neurodegenerative diseases
Translational bioinformatics in Alzheimer's disease and other neurodegenerative diseases
Research Expertise
Machine Learning
Data Mining
Statistics
Biomarker Discovery
RNA-Seq analysis
Microarray data analysis
Proteomics data analysis
Itmat Expertise
Biomarker Discovery
RNAs
Small RNAs
Bioinformatics
Education
BEng (Medical Engineering ), University of Hong Kong, 2005
PhD (Electrical and Electronic Engineering (Bioinformatics)), University of Hong Kong, 2010
Specialty Certification
Postgraduate Training
Postdoctoral Researcher , Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, 2010-2015
Awards and Honors
Reviewers’ Choice Abstracts Award, American Society of Human Genetics Annual Meeting—ASHG, 2017
Reviewers’ Choice Abstracts Award, American Society of Human Genetics Annual Meeting—ASHG, 2022
Reviewers’ Choice Abstracts Award, American Society of Human Genetics Annual Meeting—ASHG 2024, 2024
Memberships and Professional Organizations
Institute of Electrical and Electronics Engineers (IEEE) Engineering in Medicine & Biology Society, 2005 - 2009
Emerging Information and Technology Conference (EITC.org), Emerging
Information and Technology Association-Bio Conference, Annual
EITA Young Investigator Conference, 2011 - 2013
American Society of Human Genetics, 2014 - Present
Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART), 2018 - Present
International Conference on
Computational Advances in Bio and medical Sciences (ICCABS), 2019 - Present
Web Links
Selected Publications
Human whole-exome genotype data for Alzheimer’s disease
Yuk Yee Leung, Adam C Naj, Yi-Fan Chou, Otto Valladares, Michael Schmidt, Kara Hamilton-Nelson, Nicholas Wheeler, Honghuang Lin, Prabhakaran Gangadharan, Liming Qu, Kaylyn Clark, Amanda B Kuzma, Wan-Ping Lee, Laura Cantwell, Heather Nicaretta, Jonathan Haines, Lindsay Farrer, Sudha Seshadri, Zoran Brkanac, Carlos Cruchaga, Margaret Pericak-Vance, Richard P Mayeux, William S Bush, Anita Destefano, Eden Martin, Gerard D Schellenberg, Li-San Wang, Nature Communication, 2024, PMID:38263370
NIAGADS Alzheimer's GenomicsDB: A resource for exploring Alzheimer's disease genetic and genomic knowledge
Emily Greenfest‐Allen, Otto Valladares, Pavel P Kuksa, Prabhakaran Gangadharan, Wan‐Ping Lee, Jeffrey Cifello, Zivadin Katanic, Amanda B Kuzma, Nicholas Wheeler, William S Bush, Yuk Yee Leung, Gerard Schellenberg, Christian J Stoeckert Jr, Li‐San Wang, Alzheimers Dement, 2024, PMID:37881831
hipFG: high-throughput harmonization and integration pipeline for functional genomics data
Jeffrey Cifello, Pavel P Kuksa, Naveensri Saravanan, Otto Valladares, Li-San Wang, Yuk Yee Leung, Bioinformatics, 2023, PMID:37947320
Alzheimer's disease variant portal (ADVP): a catalog of genetic findings for Alzheimer's disease
Kuksa P.P., Liu C.-L., Fu W., Qu L., Zhao Y., Katanic Z., Kuzma A.B., Ho P.-C., Tzeng K.-T., Valladares O., Chou S.-Y, Naj A.C, Schellenberg G.D., Wang L.-S., Leung Y.Y, Journal of Alzheimer's disease 86(1): 461-477, 2022, PMID:35068457
FILER: a framework for harmonizing and querying large-scale functional genomics knowledge
Kuksa P.P, Gangadharan P., Katanic Z., Kleidermacher L., Amlie-Wolf A., Lee C.-Y., Qu L., Greenfest-Allen E., Valladares O., Leung Y.Y., Wang L.-S., NAR Genomics and Bioinformatics 4(1): , 2022, PMID:35047815
Inferring the molecular mechanisms of noncoding Alzheimer's disease-associated genetic variants
Alexandre Amlie-Wolf, Mitchell Tang, Jessica Way, Beth Dombroski, Ming Jiang, Nicholas Vrettos, Yi-Fan Chou, Yi Zhao, Amanda Kuzma, Elisabeth E. Mlynarski, Yuk Yee Leung, Christopher D. Brown, Li-San Wang, Gerard D. Schellenberg, Journal of Alzheimer's Disease 72(1): 301-318, 2019, PMID:31561366
VCPA: genomic variant calling pipeline and data management tool for Alzheimer's Disease Sequencing Project
Leung YY, Valladares O, Chou Y-F, Lin H-J, Kuzma A, Cantwell L, Qu L, Gangadharan P, Alzheimers Disease Sequencing Project (ADSP), Salerno W.J., Schellenberg G.D., Wang L-S., Bioinformatics 35(10): 1768-1770, 2019, PMID:30351394
DASHR 2.0: integrated database of human small non-coding RNA genes and mature products
Pavel P Kuksa, Alexandre Amlie-Wolf, Živadin Katanić, Otto Valladares, Li-San Wang, Yuk Yee Leung, Bioinformatics 35(6): 1033-1039, 2018, PMID:30668832
SPAR: Small RNA-seq Portal for Analysis of sequencing expeRiments
Kuksa PP, Amlie-Wolf A, Katanic Z, Valladares O, Wang LS, Leung YY, Nucleic Acids Research WebServer Issue 46(W1): W36-W42, 2018, PMID:29733404
Identifying amyloid pathology-related CSF biomarkers for Alzheimer’s disease in a multicohort study
Leung Y.Y., Toledo J.B, Nefedov A., Polikar R., Raghavan N., Xie S.X., Farnum M., Schultz T., Baek Y., Deerlin V., Hu W.T., Holtzman D.M., Fagan A.M., Perrin R.J., Grossman M., Soares H.D., Kling M.A., Mailman M., Arnold S.E., Narayan V.A., Lee V.M.-Y., Shaw L.M., Baker D., Wittenberg G.M., Trojanowski J.Q., Wang L.S., for the Alzheimer's Disease Neuroimaging Initiative., Alzheimer’s and Dementia: Diagnosis, Assessment and Disease Monitoring 1(3): 339-348, 2015, PMID:26693175
