Yuk Yee Leung, PhD
Research Assistant Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Contact Information3700 Hamilton Walk
D101 Richards Medical Research Building
Perelman School of Medicine, University of Pennsylvania
Philadelphia, PA, 19104
Email: yyee@pennmedicine.upenn.edu
Clinical Expertise
Small RNA biomarkers for Alzheimer's disease and other neurodegenerative diseases
Translational bioinformatics in Alzheimer's disease and other neurodegenerative diseases
Research Expertise
Machine Learning
Data Mining
Statistics
Biomarker Discovery
RNA-Seq analysis
Microarray data analysis
Proteomics data analysis
Itmat Expertise
Biomarker Discovery
RNAs
Small RNAs
Bioinformatics
Education
BEng (Medical Engineering ), University of Hong Kong, 2005
PhD (Electrical and Electronic Engineering (Bioinformatics)), University of Hong Kong, 2010
Specialty Certification
Postgraduate Training
Postdoctoral Researcher , Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, 2010-2015
Awards and Honors
Reviewers’ Choice Abstracts Award, American Society of Human Genetics Annual Meeting—ASHG, 2017
Reviewers’ Choice Abstracts Award, American Society of Human Genetics Annual Meeting—ASHG, 2022
Memberships and Professional Organizations
Institute of Electrical and Electronics Engineers (IEEE) Engineering in Medicine & Biology Society, 2005 - 2009
Emerging Information and Technology Conference (EITC.org), Emerging
Information and Technology Association-Bio Conference, Annual
EITA Young Investigator Conference, 2011 - 2013
American Society of Human Genetics, 2014 - Present
Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART), 2018 - Present
International Conference on
Computational Advances in Bio and medical Sciences (ICCABS), 2019 - Present
Web Links
Selected Publications
Alzheimer's disease variant portal (ADVP): a catalog of genetic findings for Alzheimer's disease
Kuksa P.P., Liu C.-L., Fu W., Qu L., Zhao Y., Katanic Z., Kuzma A.B., Ho P.-C., Tzeng K.-T., Valladares O., Chou S.-Y, Naj A.C, Schellenberg G.D., Wang L.-S., Leung Y.Y, Journal of Alzheimer's disease 86(1): 461-477, 2022, PMID:35068457
FILER: a framework for harmonizing and querying large-scale functional genomics knowledge
Kuksa P.P, Gangadharan P., Katanic Z., Kleidermacher L., Amlie-Wolf A., Lee C.-Y., Qu L., Greenfest-Allen E., Valladares O., Leung Y.Y., Wang L.-S., NAR Genomics and Bioinformatics 4(1): , 2022, PMID:35047815
Inferring the molecular mechanisms of noncoding Alzheimer's disease-associated genetic variants
Alexandre Amlie-Wolf, Mitchell Tang, Jessica Way, Beth Dombroski, Ming Jiang, Nicholas Vrettos, Yi-Fan Chou, Yi Zhao, Amanda Kuzma, Elisabeth E. Mlynarski, Yuk Yee Leung, Christopher D. Brown, Li-San Wang, Gerard D. Schellenberg, Journal of Alzheimer's Disease 72(1): 301-318, 2019, PMID:31561366
Functional Annotation of genomic variants in studies of Late-Onset Alzheimer’s Disease.
Butkiewicz M, Blue E, Leung YY, Jian X, Marcora E, Renton A, Kuzma A, Wang L-S, Koboldt D, Haines JL, Bush WS, Bioinformatics 34(16): 2724-2731, 2018, PMID:29590295
VCPA: genomic variant calling pipeline and data management tool for Alzheimer's Disease Sequencing Project.
Leung YY, Valladares O, Chou Y-F, Lin H-J, Kuzma A, Cantwell L, Qu L, Gangadharan P, Alzheimers Disease Sequencing Project (ADSP), Salerno W.J., Schellenberg G.D., Wang L-S., Bioinformatics 35(10): 1768-1770, 2019, PMID:30351394
SPAR: Small RNA-seq Portal for Analysis of sequencing expeRiments
Kuksa PP, Amlie-Wolf A, Katanic Z, Valladares O, Wang LS, Leung YY, Nucleic Acids Research WebServer Issue 46(W1): W36-W42, 2018, PMID:29733404
DASHR 2.0: integrated database of human small non-coding RNA genes and mature products
Pavel P Kuksa, Alexandre Amlie-Wolf, Živadin Katanić, Otto Valladares, Li-San Wang, Yuk Yee Leung, Bioinformatics 35(6): 1033-1039, 2018, PMID:30668832
Identifying amyloid pathology-related CSF biomarkers for Alzheimer’s disease in a multicohort study.
Leung Y.Y., Toledo J.B, Nefedov A., Polikar R., Raghavan N., Xie S.X., Farnum M., Schultz T., Baek Y., Deerlin V., Hu W.T., Holtzman D.M., Fagan A.M., Perrin R.J., Grossman M., Soares H.D., Kling M.A., Mailman M., Arnold S.E., Narayan V.A., Lee V.M.-Y., Shaw L.M., Baker D., Wittenberg G.M., Trojanowski J.Q., Wang L.S., for the Alzheimer's Disease Neuroimaging Initiative., Alzheimer’s and Dementia: Diagnosis, Assessment and Disease Monitoring 1(3): 339-348, 2015, PMID:26693175
Changes in the transcriptome of human astrocytes accompanying oxidative stress-induced senescence.
Crowe E.P., Tuzer F., Gregory B.D., Donahue G., Gosai S.J., Leung Y.Y., Yetkin E., Cohen J., Nativio R., Wang L.-S., Sell C., Bonini N.M., Berger S.L., Johnson F.B. and Torres C., Frontiers in Aging Neuroscience 8(): 208, 2016, PMID:27630559
CoRAL: Predicting non-coding RNAs from small RNA-sequencing data.
Leung Y.Y.*, Ryvkin P.*, Gregory B. and Wang L.S., Nucleic Acids Research 41(14): e137, 2013, PMID:23700308
