Faculty members regularly author or co-author publications in high-tiered journals and serve in editorial board positions. Here is a selection of representative Department faculty publications that have been highlighted in the news or otherwise garnered attention.
Pharmacological activation of STING blocks SARS-CoV-2 infection
Minghua Li, Max Ferretti, Baoling Ying, Hélène Descamps, Emily Lee, Mark Dittmar, Jae Seung Lee, Kanupriya Whig, Brinda Kamalia, Lenka Dohnalová, Giulia Uhr, Hoda Zarkoob, Yu-Chi Chen5, Holly Ramage, Marc Ferrer, Kristen Lynch, David C. Schultz, Christoph A. Thaiss, Michael S. Diamond, Sara Cherry. Sci Immunol. 2021 May 18;6(59):eabi9007. doi: 10.1126/sciimmunol.abi9007.
Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2
Mark Dittmar, Jae Seung Lee, Kanupriya Whig, Elisha Segrist, Minghua Li, Brinda Kamalia, Lauren Castellana, Kasirajan Ayyanathan, Fabian L Cardenas-Diaz, Edward E Morrisey, Rachel Truitt, Wenli Yang, Kellie Jurado, Kirandeep Samby, Holly Ramage, David C Schultz, Sara Cherry. Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2. Cell Rep. 2021 Mar 23;108959. doi: 10.1016/j.celrep.2021.108959. Online ahead of print.
Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection
Elizabeth M Anderson, Eileen C Goodwin, Anurag Verma, Claudia P Arevalo, Marcus J Bolton, Madison E Weirick, Sigrid Gouma, Christopher M McAllister, Shannon R Christensen, JoEllen Weaver, Phillip Hicks, Tomaz B Manzoni, Oluwatosin Oniyide, Holly Ramage, Divij Mathew, Amy E Baxter, Derek A Oldridge, Allison R Greenplate, Jennifer E Wu, Cécile Alanio, Kurt D'Andrea, Oliva Kuthuru, Jeanette Dougherty, Ajinkya Pattekar, Justin Kim, Nicholas Han, Sokratis A Apostolidis, Alex C Huang, Laura A Vella, E John Wherry, Nuala J Meyer, Sara Cherry, Paul Bates, Daniel J Rader, Scott E Hensley. Cell. Available online 9 February 2021. doi: https://doi.org/10.1016/j.cell.2021.02.010
In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics
Xu H, O'Reilly M, Gibbons GS, Changolkar L, McBride JD, Riddle DM, Zhang B, Stieber A, Nirschl J, Kim SJ, Hoxha KH, Brunden KR, Schellenberg GD, Trojanowski JQ, Lee VM. In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics. Acta Neuropathol. 2021 Feb;141(2):193-215. doi: 10.1007/s00401-020-02253-4. Epub 2021 Jan 1.
Efficacy matters: broadening complement inhibition in COVID-19
Mastellos DC, Skendros P, Calado RT, Risitano AM, Lambris JD. Efficacy matters: broadening complement inhibition in COVID-19. Lancet Rheumatol. 2021 Feb;3(2):e95. doi: 10.1016/S2665-9913(20)30423-9. Epub 2020 Dec 14.
CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
Rodriguez-Garcia A, Lynn RC, Poussin M, Eiva MA, Shaw LC, O'Connor RS, Minutolo NG, Casado-Medrano V, Lopez G, Matsuyama T, Powell DJ Jr. CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy. Nat Commun. 2021 Feb 9;12(1):877. doi: 10.1038/s41467-021-20893-2.
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells
Priyanka Verma, Yeqiao Zhou, Zhendong Cao, Peter V Deraska, Moniher Deb, Eri Arai, Weihua Li, Yue Shao, Laura Puentes, Yiwen Li, Sonali Patankar, Robert H Mach, Robert B Faryabi, Junwei Shi, Roger A Greenberg. Nat Cell Biol. 2021 Jan 18. doi: 10.1038/s41556-020-00624-3. Online ahead of print.
Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage
Jonathan B Johnnidis, Yuki Muroyama, Shin Foong Ngiow, Zeyu Chen, Sasikanth Manne, Zhangying Cai, Shufei Song, Jesse M Platt, Jason M Schenkel, Mohamed Abdel-Hakeem, Jean-Christophe Beltra, Allison R Greenplate, Mohammed-Alkhatim A Ali, Kito Nzingha, Josephine R Giles, Christelle Harly, John Attanasio, Kristen E Pauken, Bertram Bengsch, Michael A Paley, Vesselin T Tomov, Makoto Kurachi, Dario A A Vignali, Arlene H Sharpe, Steven L Reiner, Avinash Bhandoola, F Bradley Johnson, E John Wherry. Sci Immunol. 2021 Jan 15;6(55):eabe3702. doi: 10.1126/sciimmunol.abe3702.
isoCirc catalogs full-length circular RNA isoforms in human transcriptomes
Xin R, Gao Y, Gao Y, Wang R, Kadash-Edmondson KE, Liu B, Wang Y, Lin L, Xing Y. isoCirc catalogs full-length circular RNA isoforms in human transcriptomes. Nat Commun. 2021 Jan 12;12(1):266. doi: 10.1038/s41467-020-20459-8.
Real-world integration of genomic data into the electronic health record: the PennChart Genomics Initiative
Kelsey S Lau-Min, Stephanie Byers Asher, Jessica Chen, Susan M Domchek, Michael Feldman, Steven Joffe, Jeffrey Landgraf, Virginia Speare, Lisa A Varughese, Sony Tuteja, Christine VanZandbergen, Marylyn D Ritchie, Katherine L Nathanson. Genet Med. 2020 Dec 10. doi: 10.1038/s41436-020-01056-y. Online ahead of print.
Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo
Wu Q, Shaikh MA, Meymand ES, Zhang B, Luk KC, Trojanowski JQ, Lee VM. Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo. Acta Neuropathol. 2020 Dec;140(6):831-849. doi: 10.1007/s00401-020-02227-6. Epub 2020 Oct 6.
Targeted massively parallel sequencing of mature lymphoid neoplasms: assessment of empirical application and diagnostic utility in routine clinical practice
Davis AR, Stone SL, Oran AR, Sussman RT, Bhattacharyya S, Morrissette JJD, Bagg A. Targeted massively parallel sequencing of mature lymphoid neoplasms: assessment of empirical application and diagnostic utility in routine clinical practice. Mod Pathol. 2020 Dec 12. doi: 10.1038/s41379-020-00720-7. Online ahead of print.
Cytokine storm
Fajgenbaum DC, June CH. Cytokine storm. N Engl J Med. 2020 Dec 3;38(23):2255-2273.
Acquired Cystic Kidney Disease-associated Renal Cell Carcinoma (ACKD-RCC) Harbor Recurrent Mutations in KMT2C and TSC2 Genes
Shah A, Lal P, Toorens E, Palmer MB, Schwartz L, Vergara N, Guzzo T, Nayak A. Acquired Cystic Kidney Disease-associated Renal Cell Carcinoma (ACKD-RCC) Harbor Recurrent Mutations in KMT2C and TSC2 Genes. Am J Surg Pathol. 2020 Nov;44(11):1479-1486. doi: 10.1097/PAS.0000000000001530.
Helicobacter pylori Antigen But Not the Organism Is Occasionally Present Within Germinal Centers: Implications for Patient Management and Biology
Nelson ND, Tondon R, Fortuna D, Westerhoff M, Swanson PE, Furth E. Helicobacter pylori Antigen But Not the Organism Is Occasionally Present Within Germinal Centers: Implications for Patient Management and Biology. Am J Surg Pathol. 2020 Nov;44(11):1528-1534. doi: 10.1097/PAS.0000000000001542.
Thorn-shaped astrocytes in the depth of cortical sulci in Western Pacific ALS/Parkinsonism-Dementia complex
Kovacs GG, Robinson JL, Perl DP, Lee VM, Trojanowski JQ. Thorn-shaped astrocytes in the depth of cortical sulci in Western Pacific ALS/Parkinsonism-Dementia complex. Acta Neuropathol. 2020 Oct;140(4):591-593. doi: 10.1007/s00401-020-02192-0. Epub 2020 Jul 13.
Transdifferentiation of lymphoma into sarcoma associated with profound reprogramming of the epigenome
Zhang Q, Orlando EJ, Wang HY, Bogusz AM, Liu X, Lacey SF, Strauser HT, Nunez-Cruz S, Nejati R, Zhang P, Brooks S, Watt C, Melenhorst JJ, June CH, Schuster SJ, Wasik MA. Transdifferentiation of lymphoma into sarcoma associated with profound reprogramming of the epigenome. Blood. 2020 Oct 22;136(17):1980-1983. doi: 10.1182/blood.2020005123.
APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease
Nguyen AT, Wang K, Hu G, Wang X, Miao Z, Azevedo JA, Suh E, Van Deerlin VM, Choi D, Roeder K, Li M, Lee EB. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta Neuropathol. 2020 Oct;140(4):477-493. doi: 10.1007/s00401-020-02200-3. Epub 2020 Aug 25.
Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau
Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies
Kevin R Parker, Denis Migliorini, Eric Perkey 3, Kathryn E Yost, Aparna Bhaduri, Puneet Bagga, Mohammad Haris, Neil E Wilson, Fang Liu, Khatuna Gabunia, John Scholler, Thomas J Montine, Vijay G Bhoj, Ravinder Reddy, Suyash Mohan, Ivan Maillard, Arnold R Kriegstein, Carl H June, Howard Y Chang, Avery D Posey Jr, Ansuman T Satpathy. Cell. 2020 Oct 1;183(1):126-142.e17. doi: 10.1016/j.cell.2020.08.022. Epub 2020 Sep 21.
An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease
Stable HLA antibodies following sustained CD19+ cell depletion implicate a long-lived plasma cell source
Zhang Z, Schuster SJ, Lacey SF, Milone MC, Monos D, Bhoj VG. Stable HLA antibodies following sustained CD19+ cell depletion implicate a long-lived plasma cell source. Blood Adv. 2020 Sep 22;4(18):4292-4295. doi: 10.1182/bloodadvances.2020002435.
Memory Sequencing Reveals Heritable Single-Cell Gene Expression Programs Associated with Distinct Cellular Behaviors
Shaffer SM, Emert BL, Reyes Hueros RA, Cote C, Harmange G, Schaff DL, Sizemore AE, Gupte R, Torre E, Singh A, Bassett DS, Raj A. Memory Sequencing Reveals Heritable Single-Cell Gene Expression Programs Associated with Distinct Cellular Behaviors. Cell. 2020 Aug 20;182(4):947-959.e17. doi: 10.1016/j.cell.2020.07.003. Epub 2020 Jul 30.
Developing an interactive and illustrative laboratory management curriculum for cytopathology trainees
Marcos Lepe, Christopher Preciado, Sharon J Song, Zubair W Baloch. Diagn Cytopathol. 2020 Jul 22. doi: 10.1002/dc.24448. Online ahead of print.
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
Mathew D, Giles JR, Baxter AE, Oldridge DA, Greenplate AR, Wu JE, Alanio C, Kuri-Cervantes L, Pampena MB, D'Andrea K, Manne S, Chen Z, Huang YJ, Reilly JP, Weisman AR, Ittner CAG, Kuthuru O, Dougherty J, Nzingha K, Han N, Kim J, Pattekar A, Goodwin EC, Anderson EM, Weirick ME, Gouma S, Arevalo CP, Bolton MJ, Chen F, Lacey SF, Ramage H, Cherry S, Hensley SE, Apostolidis SA, Huang AC, Vella LA; UPenn COVID Processing Unit, Betts MR, Meyer NJ, Wherry EJ. Science. 2020 Jul 15;eabc8511. doi: 10.1126/science.abc8511. Online ahead of print.
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