Faculty members regularly author or co-author publications in high-tiered journals and serve in editorial board positions. Here is a selection of representative Department faculty publications that have been highlighted in the news or otherwise garnered attention.
c-Rel is a myeloid checkpoint for cancer immunotherapy
Li T, Li X, Zamani A, Wang W, Lee C, Li M, Luo G, Eiler E, Sun H, Ghosh S, Jin J, Murali R, Ruan Q, Shi W, Chen YH. Nat Cancer 1, 507–517(2020). doi: 10.1038/s43018-020-0061-3
Developmental Relationships of Four Exhausted CD8 + T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
Beltra JC, Manne S, Abdel-Hakeem MS, Kurachi M, Giles JR, Chen Z, Casella V, Ngiow SF, Khan O, Huang YJ, Yan P, Nzingha K, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Schuchter LM, Huang AC, Wherry EJ. Immunity. 2020 May 19;52(5):825-841.e8. doi: 10.1016/j.immuni.2020.04.014. Epub 2020 May 11.
Trib1 regulates T cell differentiation during chronic infection by restraining the effector program
Rome KS, Stein SJ, Kurachi M, Petrovic J, Schwartz GW, Mack EA, Uljon S, Wu WW, DeHart AG, McClory SE, Xu L, Gimotty PA, Blacklow SC, Faryabi RB, Wherry EJ, Jordan MS, Pear WS. J Exp Med. 2020 May 4;217(5):e20190888. doi: 10.1084/jem.20190888.
The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans
Johnson JL, Rosenthal RL, Knox JJ, Myles A, Naradikian MS, Madej J, Kostiv M, Rosenfeld AM, Meng W, Christensen SR, Hensley SE, Yewdell J, Canaday DH, Zhu J, McDermott AB, Dori Y, Itkin M, Wherry EJ, Pardi N, Weissman D, Naji A, Prak ETL, Betts MR, Cancro MP. Immunity. 2020 Apr 22. pii: S1074-7613(20)30133-3. doi: 10.1016/j.immuni.2020.03.020. [Epub ahead of print]
4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling
Philipson BI, O'Connor RS, May MJ, June CH, Albelda SM, Milone MC. Sci Signal. 2020 Mar 31;13(625). pii: eaay8248. doi: 10.1126/scisignal.aay8248.
Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression
Devalaraja S, To TKJ, Folkert IW, Natesan R, Alam MZ, Li M, Tada Y, Budagyan K, Dang MT, Zhai L, Lobel GP, Ciotti GE, Eisinger-Mathason TSK, Asangani IA, Weber K, Simon MC, Haldar M. Cell. 2020 Mar 19;180(6):1098-1114.e16. doi: 10.1016/j.cell.2020.02.042. Epub 2020 Mar 12.
CRISPR-engineered T cells in patients with refractory cancer
Stadtmauer EA, Fraietta JA, Davis MM, Cohen AD, Weber KL, Lancaster E, Mangan PA, Kulikovskaya I, Gupta M, Chen F, Tian L, Gonzalez VE, Xu J, Jung I, Melenhorst JJ, Plesa G, Shea J, Matlawski T, Cervini A, Gaymon AL, Desjardins S, Lamontagne A, Salas-Mckee J, Fesnak A, Siegel DL, Levine BL, Jadlowsky JK, Young RM, Chew A, Hwang WT, Hexner EO, Carreno BM, Nobles CL, Bushman FD, Parker KR, Qi Y, Satpathy AT, Chang HY, Zhao Y, Lacey SF, June CH. Science 06 Feb 2020. doi: 10.1126/science.aba7365
Clinical utility of plasma cell-free DNA in adult patients with newly diagnosed glioblastoma - a pilot prospective study
Bagley S, Nabavizadeh SA, Mays J, Till JE, Ware J, Levy S, Sarchiapone W, Hussain J, Prior TJ, Guiry S, Christensen T, Yee SS, Nasrallah M, Morrissette JJD, Zev Binder Z, O'Rourke DM, Cucchiara AJ, Brem S, Arati S, Desai AS, EL Carpenter. Clin Cancer Res. Published online October 30, 2019. doi: 10.1158/1078-0432.CCR-19-2533
Neoantigen Dissimilarity to the Self-Proteome Predicts Immunogenicity and Response to Immune Checkpoint Blockade
Richman LP, Vonderheide RH, Rech AJ. Cell Syst. 2019 Oct 8. pii: S2405-4712(19)30307-2. doi: 10.1016/j.cels.2019.08.009. [Epub ahead of print]
Nucleoside-modified mRNA encoding HSV-2 glycoproteins C, D, and E prevents clinical and subclinical genital herpes
Awasthi S, Hook LM, Pardi N, Wang F, Myles A, Cancro MP, Cohen GH, Weissman D, Friedman HM. Sci Immunol. 2019 Sep 20;4(39). pii: eaaw7083. doi: 10.1126/sciimmunol.aaw7083.
Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms
Singh BK, Lu W, Schmidt Paustian AM, Ge MQ, Koziol-White CJ, Flayer CH, Killingbeck SS, Wang N, Dong X, Riese MJ, Deshpande DA, Panettieri RA Jr, Haczku A, Kambayashi T. Sci Signal. 2019 Sep 3;12(597). pii: eaax3332. doi: 10.1126/scisignal.aax3332.
Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade
Benci JL, Johnson LR, Choa R, Xu Y, Qiu J, Zhou Z, Xu B, Ye D, Nathanson KL, June CH, Wherry EJ, Zhang NR, Ishwaran H, Hellmann MD, Wolchok JD, Kambayashi T, Minn AJ. Cell. 2019 Aug 8;178(4):933-948.e14. doi: 10.1016/j.cell.2019.07.019.
Quantitation of Femtomolar‐Level Protein Biomarkers Using a Simple Microbubbling Digital Assay and Bright‐Field Smartphone Imaging
Chen H, Li Z, Zhang L, Sawaya P, Shi J, Wang P. Angew Chem Int Ed Engl. 2019 Jul 25. doi: 10.1002/anie.201906856. [Epub ahead of print]
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
Khan O, Giles JR, McDonald S, Manne S, Ngiow SF, Patel KP, Werner MT, Huang AC, Alexander KA, Wu JE, Attanasio J, Yan P, George SM, Bengsch B, Staupe RP, Donahue G, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Schuchter LM, Kaye J, Berger SL, Wherry EJ. Nature. 2019 Jun 17. doi: 10.1038/s41586-019-1325-x. [Epub ahead of print]
Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors
Dangaj D, Bruand M, Grimm AJ, Ronet C, Barras D, Duttagupta PA, Lanitis E, Duraiswamy J, Tanyi JL, Benencia F, Conejo-Garcia J, Ramay HR, Montone KT, Powell Jr DJ, Gimotty PA, Facciabene A, Jackson DG, Weber JS, Rodig SJ, Hodi SF, Kandalaft LE, Irving M, Zhang L, Foukas P, Rusakiewicz S, Delorenzi M, Coukos G. Cancer Cell. 2019 Jun 10; 35(6):885-900.e10. doi: 10.1016/j.ccell.2019.05.004
Computational staining of unlabelled tissue
Bakas S, Feldman MD. Nat Biomed Eng. 2019 June; 3(6):425-426. doi: 10.1038/s41551-019-0414-3.
Gilteritinib induces differentiation in relapsed and refractory FLT3-mutated acute myeloid leukemia
McMahon CM, Canaani J, Rea B, Sargent RL, Qualtieri JN, Watt CD, Morrissette JJD, Carroll M, Perl AE. Blood Adv. 2019 May 28;3(10):1581-1585. doi: 10.1182/bloodadvances.2018029496
Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques
Petrovic J, Zhou Y, Fasolino M, Goldman N, Schwartz GW, Mumbach MR, Nguyen SC, Rome KS, Sela Y, Zapataro Z, Blacklow SC, Kruhlak MJ, Shi J, Aster JC, Joyce EF, Little SC, Vahedi G, Pear WS, Faryabi RB. Mol Cell. 2019 Mar 21;73(6): 1174-1190.e12. doi: 10.1016/j.molcel.2019.01.006
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Kunkle BW, Benjamin Grenier-Boley B, […] Trojanowski JQ, Van Deerlin VM, […] Wang LS, Schellenberg GD, Lambert JC, Pericak-Vance MA. Nat Genet. 2019 Mar;51(3):414-430. doi: 10.1038/s41588-019-0358-2. [Epub 2019 Feb 28]
Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion
Pinzone MR, VanBelzen DJ, Weissman S, Bertuccio MP, Cannon L, Venanzi-Rullo E, Migueles S, Jones RB, Mota T, Joseph SB, Groen K, Pasternak AO, Hwang WT, Sherman B, Vourekas A, Nunnari G, O'Doherty U. Nat Commun. 2019 Feb 13;10(1):728. doi: 10.1038/s41467-019-08431-7.
Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't-eat-me' signal
Liu M, O'Connor RS, Trefely S, Graham K, Snyder N, Beatty GL. Nat Immunol. 2019 Jan 21. doi: 10.1038/s41590-018-0292-y. [Epub ahead of print]
Loss of Phd2 cooperates with BRAF(V600E) to drive melanomagenesis
Liu S, Zhang G, Guo J, Chen X, Lei J, Ze K, Dong L, Dai X, Gao Y, Song D, Ecker BL, Yang R, Feltcher C, Peng K, Feng C, Chen H, Lee RX, Kerestes H, Niu J, Kumar S, Xu W, Zhang J, Wei Z, Martin JS, Liu X, Mills G, Lu Y, Guo W, Sun L, Zhang L, Weeraratna A, Herlyn M, Wei W, Lee FS, Xu X. Nat Commun. 2018 Dec 21;9(1):5426. doi: 10.1038/s41467-018-07126-9.
Clinical Implications of Plasma-Based Genotyping With the Delivery of Personalized Therapy in Metastatic Non-Small Cell Lung Cancer
Aggarwal C, Thompson JC, Black TA, Katz SI, Fan R, Yee SS, Chien AL, Evans TL, Bauml JM, Alley EW, Ciunci CA, Berman AT, Cohen RB, Lieberman DB, Majmundar KS, Savitch SL, Morrissette JJD, Hwang WT, Elenitoba-Johnson KSJ, Langer CJ, Carpenter EL. JAMA Oncol. 2018 Oct 11. doi: 10.1001/jamaoncol.2018.4305.
Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W.
Nature. 2018 Aug 8. doi: 10.1038/s41586-018-0392-8. [Epub ahead of print]
Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
Fraietta JA, Lacey SF, Orlando EJ, Pruteanu-Malinici I, Gohil M, Lundh S, Boesteanu AC, Wang Y, O'Connor RS, Hwang WT, Pequignot E, Ambrose DE, Zhang C, Wilcox N, Bedoya F, Dorfmeier C, Chen F, Tian L, Parakandi H, Gupta M, Young RM, Johnson FB, Kulikovskaya I, Liu L, Xu J, Kassim SH, Davis MM, Levine BL, Frey NV, Siegel DL, Huang AC, Wherry EJ, Bitter H, Brogdon JL, Porter DL, June CH, Melenhorst JJ. Nat Med. 2018 May;24(5):563-571. doi: 10.1038/s41591-018-0010-1.
