Spatial epigenome-transcriptome co-profiling of mammalian tissues

Zhang D, Deng Y, Kukanja P, Agirre E, Bartosovic M, Dong M, Ma C, Ma S, Su G, Bao S, Liu Y, Xiao Y, Rosoklija GB, Dwork AJ, Mann JJ, Leong KW, Boldrini M, Wang L, Haeussler M, Raphael BJ, Kluger Y, Castelo-Branco G, Fan R. Nature. 2023 Apr;616(7955):113-122. doi: 10.1038/s41586-023-05795-1. Epub 2023 Mar 15.


A new method of spatial mapping allows biologists, for the first time, to see how chromatin states within DNA structure govern gene expression in tissues and organs at near-single cell resolution. Developed by a team including co-first author Yanxiang Deng, PhD, an assistant professor of Pathology and Laboratory Medicine, the researchers believe this method has the potential to be among "the most informative tools in spatial biology" and useful across broad swaths of research.