HLA amino acid Mismatch-Based risk stratification of kidney allograft failure using a novel Machine learning algorithm
Dasariraju S, Gragert L, Wager GL, McCullough K, Brown NK, Kamoun M, Urbanowicz RJ. J Biomed Inform. 2023 Jun;142:104374. doi: 10.1016/j.jbi.2023.104374. Epub 2023 Apr 27.
Summary
Development of a novel, evolutionary algorithm - Feature Inclusion Bin Evolver for Risk Stratification (FIBERS) - and the application of the algorithm to automatically discover bins of HLA amino acid mismatches that stratify donor-recipient pairs into low versus high graft survival risk groups.
