Tatiana Akimova (nee: Tikhomirova), MD, PhD
Research Assistant Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact InformationThe Children's Hospital of Philadelphia
Division of Transplant Immunology, Department of Pathology and Laboratory Medicine
914G Abramson Research Center
3615 Civic Center Blvd, Philadelphia, PA 19104,USA
Philadelphia, PA 19104
Office: 267-426-9644
Fax: 215-426-1880
Email: akimovat@email.chop.edu
Research Expertise
Cancer immunology, transplant immunology, inflammation and tolerance, autoimmune diseases, obesity.
My main interest is biology of human FOXP3+ regulatory T cells (Treg) and T cells.
18 years of medical, clinical and research experience.
Education
MD (Internal Medicine), St. Petersburg State Pavlov Medical University, St. Petersburg, Russia, 2001
PhD (Immunology and Allergy), Center for Molecular Medicine, St. Petersburg State Pavlov Medical University, 2006
Certific. (2 years program in Analytics and Statistical Studies, Biostatistics certificate), The Institute for Statistics Education, VA, USA, 2022
Specialty Certification
Postgraduate Training
Internship in Internal Medicine, including Endocrinology, Department of Therapy and Endocrine Diseases, St. Petersburg State Pavlov Medical University, 2001-2002
PhD Fellowship in Immunology and Allergy, Center for Molecular medicine, St. Petersburg State Pavlov Medical University., 2003-2006
Residency in Immunology and Allergy , Center for Molecular Medicine and Department of Therapy and Allergic Diseases,
St. Petersburg State Pavlov Medical University, 2005-2007
Awards and Honors
National Science Forum
1st & 2nd award winner of young scientist competition (for the best scientific work) at 7th, 8th and 9th National Science Forum with international participation “Days of Immunology in St. Petersburg” in 2003, 2004, 2005, 2003
Young Scientist Award 3rd award winner for the best scientific work, at St. Petersburg State Pavlov Medical University Young Scientist Society’s Russian National Conference with international participation, in 2004, 2004
Clinical Immunology
The paper “Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs” listed in Top 25 hottest articles, 2010
Molecular Cell Biology
The paper “Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3+ T-regulatory cells” listed in “Articles of significant interest selected from this issue., 2011
PLoS One
The paper "Helios expression is a marker of T cell activation and proliferation" was ranked as one of the top 2% of published articles in these fields by F1000., 2011
PLoS One
The paper "Helios expression is a marker of T cell activation and proliferation" was listed as in the top1% most cited papers at PLoS One., 2017
Memberships and Professional Organizations
American Association of Immunologists, 2012 - Present
American Thoracic Society, 2020 - Present
Web Links
Selected Publications
Antisense targeting of FOXP3+ Tregs to boost anti-tumor immunity.
Akimova T, Wang L, Bartosh Z, Christensen LM, Eruslanov E, Singhal S, Aishwarya V, Hancock WW., Front Immunol. 15(1426657): , 2024, PMID:39234236
T-regulatory cells require Sin3a for stable expression of Foxp3
Christensen LM, Akimova T, Wang L, Han R, Samanta A, Di Giorgio E, Hancock WW., Front Immunol. 15(1444937): , 2024, PMID:39156895
FOXP3+ regulatory T cells are associated with the severity and prognosis of sarcoidosis.
Patterson KC, Miller WT, Hancock WW, Akimova T., Front Immunol. 14(1301991): , 2023, PMID:38173720
The poly (C)-binding protein Pcbp2 is essential for CD4+ T cell activation and proliferation
Massimo Martinelli, Gabrielle Aguilar, David SM Lee, Andrew Kromer, Nhu Nguyen, Benjamin J Wilkins, Tatiana Akimova, Ulf H Beier, Louis R Ghanem, Iscience 26(1): 105860, 2023, PMID:36632062
Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury
Tatiana Akimova, Tianyi Zhang, Lanette M Christensen, Zhonglin Wang, Rongxiang Han, Dmitry Negorev, Arabinda Samanta, Isaac E Sasson, Trivikram Gaddapara, Jing Jiao, Liqing Wang, Tricia R Bhatti, Matthew H Levine, Joshua M Diamond, Ulf H Beier, Rebecca A Simmons, Edward Cantu, David S Wilkes, David J Lederer, Michaela Anderson, Jason D Christie, Wayne W Hancock, American Journal of Respiratory and Critical Care Medicine 204(9): 1060-1074, 2021, PMID:34346860
A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+ Foxp3+ T-Regulatory Cells
Eros Di Giorgio, Liqing Wang, Yan Xiong, Lanette M Christensen, Tatiana Akimova, Rongxiang Han, Arabinda Samanta, Matteo Trevisanut, Claudio Brancolini, Ulf H Beier, Wayne W Hancock, Frontiers in Immunology 5(12): 703632, 2021, PMID:34290714
Mef2d sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity
Di Giorgio E, Wang L, Xiong Y, Akimova T, Christensen LM, Han R, Samanta A, Trevisanut M, Bhatti TR, Beier UH, Hancock WW, The Journal of Clinical Investigation 12(130): , 2020, PMID:32790649
The CCR2/MCP-1 Chemokine Pathway and Lung Adenocarcinoma
Mittal P, Wang L, Akimova T, Leach CA, Clemente JC, Sender MR, Chen Y, Turunen BJ, Hancock WW., Cancers (Basel) 11(12): 3723, 2020, PMID:33322474
HDAC10 deletion promotes Foxp3(+) T-regulatory cell function
Dahiya S, Beier UH, Wang L, Han R, Jiao J, Akimova T, Angelin, A., Wallace, D. C., Hancock, W. W., Scientific Reports 1(10): 424, 2020, PMID:31949209
Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity
Xiong Y, Wang L, Di Giorgio E, Akimova T, Beier UH, Han R, Trevisanut M, Kalin JH, Cole PA, Hancock WW, The Journal of Clinical Investigation 130(4): 1830-42, 2020, PMID:31917688
