Nicholas K. Brown, PhD, F(ACHI)

Assistant Professor of Clinical Pathology and Laboratory Medicine
Associate Director, Histocompatibility Testing Laboratory
Perelman School of Medicine at the University of Pennsylvania

Contact InformationFounders 7019
3400 Spruce Street

Philadelphia, PA, 19104
Office: 215-615-7789

Specialty Division

Laboratory Medicine


BA (Biology), Kalamazoo College, Kalamazoo, MI, 2000
PhD (Immunology and Microbiology (incl. Research Assistant role)), Wayne State University School of Medicine, Detroit, MI, 2007

Specialty Certification

American Board of Histocompatibility and Immunogenetics, 2016

Postgraduate Training

Postdoctoral Scholar, Dept. of Pathology, The University of Chicago, 2008-2010
Fellow, Immunotherapy, The University of Michigan, 2010-2013
Fellow, Center for Cancer & Immunology Research, Children's National Medical Center, 2013-2014
Fellow, Transplant Immunology, The University of Chicago, 2014-2016

Awards and Honors

Dr. Stephen Lerman Memorial Travel Award, Wayne State University School of Medicine, 2005
Dr. Stephen Lerman Memorial Travel Award, Wayne State University School of Medicine, 2006
First Place-Oral Presentation, Graduate Student Research Day, Wayne State University School of Medicine, 2006
Graduate Student Professional Travel Award, Wayne State University School of Medicine, 2006
Academic and Research Award, Wayne State University School of Medicine, 2008
People's Choice Award - Poster Presentation, 47th Annual American Society for Histocompatibility and Immunogenetics Meeting, 2021
Innovation Scholarship Award, American Society for Histocompatibility & Immunogenetics, 2022
Best written lay summary, 48th Annual American Society for Histocompatibility and Immunogenetics Meeting, 2022

Memberships and Professional Organizations

American Association for the Advancement of Science, 2009 - Present
American Association of Immunologists, 2009 - Present
American Society for Histocompatibility and Immunogenetics, 2014 - Present
American Society of Transplantation, 2015 - Present
American Association for Clinical Chemistry, 2018 - 2019
American Society for Transplantation and Cellular Therapy, 2022 - Present

Web Links

Selected Publications

Applying modern data science tools to aid virtual crossmatch

Nicholas Brown, ASHI Quarterly Q3 2022(): 32-35, 2022

CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder

Wang X, Liu M, Zhang J, Brown NK, Zhang P, Zhang Y, Liu H, Du X, Wu W, Devenport M, Tao W, Mao-Draayer Y, Chen GY, Chen YE, Zheng P, Liu Y., Cell Metab 34(): 1088-1103, 2022, PMID:35921817

Read article

Immunogenetics of heteroclitic recognition of HLA-DQB1 55R eplet specificity by human alloantibody

Kamoun M, Askar M, Kearns JD, Bui TM, Nguyen M, Brown NK, Duquesnoy RJ., Human Immunology, 2021, PMID:34815108

Read article

An HLA-identical child as a donor for hematopoietic cell transplantation: is this a haploidentical or matched-“sibling” transplant?

Nicholas Brown, David Porter, Alison Loren, Malek Kamoun, F.Brad Johnson, Human Immunology 82(S1): P05, 2021

From zero to hero: use of the statistical programming language R to manage clinical HLA laboratory data by a lab with little programming experience

Nicholas Brown , Hui Gao , Thanh-Mai Bui, Human Immunology 82(S1): P109, 2021

Logicle scaling for flow cytometric crossmatching increases events of scarce B cells

Nicholas Brown, Bao Ngo, Than-Mai Bui, Human Immunology 82(S1): P86, 2021

Reduced PCR-generated errors from a hybrid capture-based NGS assay for HLA typing.

#Brown NK, Merkens H, Rozemuller EH, Bell D, Bui TM, Kearns J, Human Immunology 82(4): 296-301, 2021, PMID:33676750

Read article

R for HLA data

Nicholas Brown,, 2021

High-Resolution Analysis of a Common Ancestral Haplotype Including Classical and Non-Classical HLA Loci Reveals Significant Haplotype Diversity

Nicholas K. Brown, Derrick Bell, Thanh-Mai Bui, Jane Kearns, F. Brad Johnson, Malek Kamoun, Human Immunology 81(Supplement 1): P47, 2020

Alloantibodies and Platelets.

Wool, G.D., and Brown, N.K., Immunologic Concepts in Transfusion Medicine, 2020