Nicholas K. Brown, PhD, F(ACHI)
Assistant Professor of Clinical Pathology and Laboratory Medicine
Associate Director, Histocompatibility Testing Laboratory
Perelman School of Medicine at the University of Pennsylvania
Contact InformationFounders 7019
3400 Spruce Street
Philadelphia, PA, 19104
Office: 215-615-7789
Specialty Division
Laboratory Medicine
Education
BA (Biology), Kalamazoo College, Kalamazoo, MI, 2000
PhD (Immunology and Microbiology (incl. Research Assistant role)), Wayne State University School of Medicine, Detroit, MI, 2007
Specialty Certification
American Board of Histocompatibility and Immunogenetics, 2016
Postgraduate Training
Postdoctoral Scholar, Dept. of Pathology, The University of Chicago, 2008-2010
Fellow, Immunotherapy, The University of Michigan, 2010-2013
Fellow, Center for Cancer & Immunology Research, Children's National Medical Center, 2013-2014
Fellow, Transplant Immunology, The University of Chicago, 2014-2016
Awards and Honors
Dr. Stephen Lerman Memorial Travel Award, Wayne State University School of Medicine, 2005
Dr. Stephen Lerman Memorial Travel Award, Wayne State University School of Medicine, 2006
First Place-Oral Presentation, Graduate Student Research Day, Wayne State University School of Medicine, 2006
Graduate Student Professional Travel Award, Wayne State University School of Medicine, 2006
Academic and Research Award, Wayne State University School of Medicine, 2008
People's Choice Award - Poster Presentation, 47th Annual American Society for Histocompatibility and Immunogenetics Meeting, 2021
Innovation Scholarship Award, American Society for Histocompatibility & Immunogenetics, 2022
Best written lay summary, 48th Annual American Society for Histocompatibility and Immunogenetics Meeting, 2022
Memberships and Professional Organizations
American Association for the Advancement of Science, 2009 - Present
American Association of Immunologists, 2009 - Present
American Society for Histocompatibility and Immunogenetics, 2014 - Present
American Society of Transplantation, 2015 - Present
American Association for Clinical Chemistry, 2018 - 2019
American Society for Transplantation and Cellular Therapy, 2022 - Present
Web Links
Selected Publications
Applying modern data science tools to aid virtual crossmatch
Nicholas Brown, ASHI Quarterly Q3 2022(): 32-35, 2022
CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder
Wang X, Liu M, Zhang J, Brown NK, Zhang P, Zhang Y, Liu H, Du X, Wu W, Devenport M, Tao W, Mao-Draayer Y, Chen GY, Chen YE, Zheng P, Liu Y., Cell Metab 34(): 1088-1103, 2022, PMID:35921817
Immunogenetics of heteroclitic recognition of HLA-DQB1 55R eplet specificity by human alloantibody
Kamoun M, Askar M, Kearns JD, Bui TM, Nguyen M, Brown NK, Duquesnoy RJ., Human Immunology, 2021, PMID:34815108
An HLA-identical child as a donor for hematopoietic cell transplantation: is this a haploidentical or matched-“sibling” transplant?
Nicholas Brown, David Porter, Alison Loren, Malek Kamoun, F.Brad Johnson, Human Immunology 82(S1): P05, 2021
From zero to hero: use of the statistical programming language R to manage clinical HLA laboratory data by a lab with little programming experience
Nicholas Brown , Hui Gao , Thanh-Mai Bui, Human Immunology 82(S1): P109, 2021
Logicle scaling for flow cytometric crossmatching increases events of scarce B cells
Nicholas Brown, Bao Ngo, Than-Mai Bui, Human Immunology 82(S1): P86, 2021
Reduced PCR-generated errors from a hybrid capture-based NGS assay for HLA typing.
#Brown NK, Merkens H, Rozemuller EH, Bell D, Bui TM, Kearns J, Human Immunology 82(4): 296-301, 2021, PMID:33676750
R for HLA data
Nicholas Brown, https://github.com/users/k96nb01/projects/1, 2021
High-Resolution Analysis of a Common Ancestral Haplotype Including Classical and Non-Classical HLA Loci Reveals Significant Haplotype Diversity
Nicholas K. Brown, Derrick Bell, Thanh-Mai Bui, Jane Kearns, F. Brad Johnson, Malek Kamoun, Human Immunology 81(Supplement 1): P47, 2020
Alloantibodies and Platelets.
Wool, G.D., and Brown, N.K., Immunologic Concepts in Transfusion Medicine, 2020
