Nicholas K. Brown, PhD, D(ABHI)
Assistant Professor of Clinical Pathology and Laboratory MedicinePerelman School of Medicine at the University of Pennsylvania
Contact InformationFounders 7019
3400 Spruce Street
Philadelphia, PA, 19104
Office: 215-615-7789
Specialty Division
Laboratory Medicine
Education
BA (Biology), Kalamazoo College, Kalamazoo, MI, 2000
PhD (Immunology and Microbiology (incl. Research Assistant role)), Wayne State University School of Medicine, Detroit, MI, 2007
Specialty Certification
American Board of Histocompatibility and Immunogenetics, 2016
American Society for Histocompatibility and Immunogenetics, 2017
Postgraduate Training
Postdoctoral Scholar, Dept. of Pathology, The University of Chicago, 2008-2010
Fellow, Immunotherapy, The University of Michigan, 2010-2013
Fellow, Center for Cancer & Immunology Research, Children's National Medical Center, 2013-2014
Fellow, Transplant Immunology, The University of Chicago, 2014-2016
Awards and Honors
Dr. Stephen Lerman Memorial Travel Award, Wayne State University School of Medicine, 2005
Dr. Stephen Lerman Memorial Travel Award, Wayne State University School of Medicine, 2006
First Place-Oral Presentation, Graduate Student Research Day, Wayne State University School of Medicine, 2006
Graduate Student Professional Travel Award, Wayne State University School of Medicine, 2006
Academic and Research Award, Wayne State University School of Medicine, 2008
Memberships and Professional Organizations
American Association of Immunologists, 2009 - Present
American Association for the Advancement of Science, 2009 - Present
American Society for Histocompatibility and Immunogenetics, 2014 - Present
American Society of Transplantation, 2015 - Present
American Association for Clinical Chemistry, 2018 - 2019
Web Links
Selected Publications
Alloantibodies and Platelets.
Wool, G.D., and Brown, N.K., Immunologic Concepts in Transfusion Medicine, 2020
Association of HLA-B*15:02 allele with lamotrigine-induced cutaneous adverse drug reaction in an Indian patient.
Misra, M.K., Upchurch, R.L., Weidner, J.G., Pullen, B., Lee, R., Brown, N., Marino, S. R., Human Immunology Suppl(2): , 2019
A Clinician's Guide to Celiac Disease HLA Genetics.
Brown NK, Guandalini S, Semrad C, Kupfer SS., Am J Gastroenterol. 114(10): 1587-1592, 2019, PMID:31274511
Effective desensitization for a strong donor-specific HLA antibody in a case of HLA-mismatched allogeneic hematopoietic cell transplantation.
Misra MK, Xin JJ, Brown NK, Weidner JG, Upchurch RL, Bishop MR, Wool GD, Artz AS, Marino SR., HLA 94(3): 307-311, 2019, PMID:31314169
HLA Alleles and Haplotypes Observed in 263 US Families
Osoegawa, K., Mallempati, K., Gangavarapu, S., Oki, A., Gendzekhadze, K., Marino, S.R., Brown, N.K., Bettinotti, M., Weimer, E., Creary, L.E., Vayntrub, T., Chang, C.-J., Askar, M., Mack, S.J. and Fernández-Viña, M.A., Human Immunology 80(9): 644-660, 2019, PMID:31256909
Quality Control Project of NGS HLA Genotyping for the 17th International HLA and Immunogenetics Workshop.
Osoegawa K, Vayntrub TA, Wenda S, De Santis D, Barsakis K, Ivanova M, Hsu S, Barone J, Holdsworth R, Diviney M, Askar M, Willis A, Railton D, Laflin S, Gendzekhadze K, Oki A, Sacchi N, Mazzocco M, Andreani M, Ameen R, Stavropoulos-Giokas C, Dinou A, Torres M, Dos Santos Francisco R, Serra-Pages C, Goodridge D, Balladares S, Bettinotti MP, Iglehart B, Kashi Z, Martin R, Saw CL, Ragoussis J, Downing J, Navarrete C, Chong W, Saito K, Petrek M, Tokic S, Padros K, Beatriz Rodriguez M, Zakharova V, Shragina O, Marino SR, Brown NK, Shiina T, Suzuki S, Spierings E, Zhang Q, Yin Y, Morris GP, Hernandez A, Ruiz P, Khor SS, Tokunaga K, Geretz A, Thomas R, Yamamoto F, Mallempati KC, Gangavarapu S, Kanga U, Tyagi S, Marsh SGE, Bultitude WP, Liu X, Cao D, Penning M, Hurley CK, Cesbron A, Mueller C, Mytilineos J, Weimer ET, Bengtsson M, Fischer G, Hansen JA, Chang CJ, Mack SJ, Creary LE, Fernandez-Viña MA., Human Immunology 80(4): 228-236, 2019, PMID:30738112
Typing HLA by NGS: How Immunogenetics Labs Target a Complicated Genetic System (Filmed Lecture)
Brown, N.K., ASHI University (American Society for Histocompatibility and Immunogenetics), 2019
An accelerated method for reverse sequence-specific oligonucletide probe-based HLA typing.
Upchurch R.L, Xin J.J, Minarik M, West T, Weidner J.G, Brown N, Marino S. R., Human Immunology 79(Suppl): 140, 2018
Persistent detection of anti-HLA B8 by IgM and C1q testing in the posttransplant setting.
Upchurch R.L, Xin J.J, West T, Weidner J.G, Brown N, Marino S. R., Human Immunology 79(Suppl): 95, 2018
Pre-transplant Anti-nuclear Antibodies Correlate With Post-transplant Donor-specific Antibodies: A Link between Autoimmunity and Graft Failure?
McMullen P, Xin J, Brown N, Husain A, Uriel N, Marino S., J. Heart Lung Transplant 37(4): S302–S303, 2018
