PEOPLE

Nicholas K. Brown, PhD, D(ABHI)

Assistant Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania

Contact InformationFounders 7019
3400 Spruce Street

Philadelphia, PA, 19104
Office: 215-615-7789

Specialty Division

Laboratory Medicine

Education

BA (Biology), Kalamazoo College, Kalamazoo, MI, 2000
PhD (Immunology and Microbiology (incl. Research Assistant role)), Wayne State University School of Medicine, Detroit, MI, 2007

Specialty Certification

American Board of Histocompatibility and Immunogenetics, 2016
American Society for Histocompatibility and Immunogenetics, 2017

Postgraduate Training

Postdoctoral Scholar, Dept. of Pathology, The University of Chicago, 2008-2010
Fellow, Immunotherapy, The University of Michigan, 2010-2013
Fellow, Center for Cancer & Immunology Research, Children's National Medical Center, 2013-2014
Fellow, Transplant Immunology, The University of Chicago, 2014-2016

Awards and Honors

Dr. Stephen Lerman Memorial Travel Award, Wayne State University School of Medicine, 2005
Dr. Stephen Lerman Memorial Travel Award, Wayne State University School of Medicine, 2006
First Place-Oral Presentation, Graduate Student Research Day, Wayne State University School of Medicine, 2006
Graduate Student Professional Travel Award, Wayne State University School of Medicine, 2006
Academic and Research Award, Wayne State University School of Medicine, 2008

Memberships and Professional Organizations

American Association of Immunologists, 2009 - Present
American Association for the Advancement of Science, 2009 - Present
American Society for Histocompatibility and Immunogenetics, 2014 - Present
American Society of Transplantation, 2015 - Present
American Association for Clinical Chemistry, 2018 - 2019

Web Links


Selected Publications

Alloantibodies and Platelets.

Wool, G.D., and Brown, N.K., Immunologic Concepts in Transfusion Medicine, 2020

Association of HLA-B*15:02 allele with lamotrigine-induced cutaneous adverse drug reaction in an Indian patient.

Misra, M.K., Upchurch, R.L., Weidner, J.G., Pullen, B., Lee, R., Brown, N., Marino, S. R., Human Immunology Suppl(2): , 2019

A Clinician's Guide to Celiac Disease HLA Genetics.

Brown NK, Guandalini S, Semrad C, Kupfer SS., Am J Gastroenterol. 114(10): 1587-1592, 2019, PMID:31274511

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Effective desensitization for a strong donor-specific HLA antibody in a case of HLA-mismatched allogeneic hematopoietic cell transplantation.

Misra MK, Xin JJ, Brown NK, Weidner JG, Upchurch RL, Bishop MR, Wool GD, Artz AS, Marino SR., HLA 94(3): 307-311, 2019, PMID:31314169

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HLA Alleles and Haplotypes Observed in 263 US Families

Osoegawa, K., Mallempati, K., Gangavarapu, S., Oki, A., Gendzekhadze, K., Marino, S.R., Brown, N.K., Bettinotti, M., Weimer, E., Creary, L.E., Vayntrub, T., Chang, C.-J., Askar, M., Mack, S.J. and Fernández-Viña, M.A., Human Immunology 80(9): 644-660, 2019, PMID:31256909

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Quality Control Project of NGS HLA Genotyping for the 17th International HLA and Immunogenetics Workshop.

Osoegawa K, Vayntrub TA, Wenda S, De Santis D, Barsakis K, Ivanova M, Hsu S, Barone J, Holdsworth R, Diviney M, Askar M, Willis A, Railton D, Laflin S, Gendzekhadze K, Oki A, Sacchi N, Mazzocco M, Andreani M, Ameen R, Stavropoulos-Giokas C, Dinou A, Torres M, Dos Santos Francisco R, Serra-Pages C, Goodridge D, Balladares S, Bettinotti MP, Iglehart B, Kashi Z, Martin R, Saw CL, Ragoussis J, Downing J, Navarrete C, Chong W, Saito K, Petrek M, Tokic S, Padros K, Beatriz Rodriguez M, Zakharova V, Shragina O, Marino SR, Brown NK, Shiina T, Suzuki S, Spierings E, Zhang Q, Yin Y, Morris GP, Hernandez A, Ruiz P, Khor SS, Tokunaga K, Geretz A, Thomas R, Yamamoto F, Mallempati KC, Gangavarapu S, Kanga U, Tyagi S, Marsh SGE, Bultitude WP, Liu X, Cao D, Penning M, Hurley CK, Cesbron A, Mueller C, Mytilineos J, Weimer ET, Bengtsson M, Fischer G, Hansen JA, Chang CJ, Mack SJ, Creary LE, Fernandez-Viña MA., Human Immunology 80(4): 228-236, 2019, PMID:30738112

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Typing HLA by NGS: How Immunogenetics Labs Target a Complicated Genetic System (Filmed Lecture)

Brown, N.K., ASHI University (American Society for Histocompatibility and Immunogenetics), 2019

An accelerated method for reverse sequence-specific oligonucletide probe-based HLA typing.

Upchurch R.L, Xin J.J, Minarik M, West T, Weidner J.G, Brown N, Marino S. R., Human Immunology 79(Suppl): 140, 2018

Persistent detection of anti-HLA B8 by IgM and C1q testing in the posttransplant setting.

Upchurch R.L, Xin J.J, West T, Weidner J.G, Brown N, Marino S. R., Human Immunology 79(Suppl): 95, 2018

Pre-transplant Anti-nuclear Antibodies Correlate With Post-transplant Donor-specific Antibodies: A Link between Autoimmunity and Graft Failure?

McMullen P, Xin J, Brown N, Husain A, Uriel N, Marino S., J. Heart Lung Transplant 37(4): S302–S303, 2018