Nicholas K. Brown, PhD, F(ACHI)

Associate Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania

Associate Director, Histocompatibility Testing Laboratory

Contact InformationHospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
7.019 Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104
Tel: 215-615-7789

Specialty Division

Laboratory Medicine


BA (Biology), Kalamazoo College, Kalamazoo, MI, 2000
PhD (Immunology and Microbiology), Wayne State University School of Medicine, Detroit, MI, 2007

Specialty Certification

American College of Histocompatibility and Immunogenetics, 2016

Postgraduate Training

Postdoctoral Scholar, Department of Pathology, University of Chicago, 2008-10
Fellow, Immunotherapy, University of Michigan, 2010-13
Fellow, Center for Cancer & Immunology Research, Children's National Medical Center, 2013-14
Fellow, Transplant Immunology, University of Chicago, 2014-16

Awards and Honors

Dr. Stephen Lerman Memorial Travel Award, Wayne State University School of Medicine, 2005, 2006
Graduate Student Professional Travel Award, Wayne State University School of Medicine, 2006
First Place-Oral Presentation, Graduate Student Research Day, Wayne State University School of Medicine, 2006
Academic and Research Award, Wayne State University School of Medicine, 2008
People's Choice Award - Poster Presentation, 47th Annual American Society for Histocompatibility and Immunogenetics Meeting, 2021
Innovation Scholarship Award, American Society for Histocompatibility & Immunogenetics, 2022
Best Written Lay Summary, 48th Annual American Society for Histocompatibility and Immunogenetics Meeting, 2022
Poster of Distinction, American Transplant Congress 2023, San Diego, CA, 2023

Memberships and Professional Organizations

American Association of Immunologists, 2009-present
American Association for the Advancement of Science, 2009-present
American Society for Histocompatibility and Immunogenetics, 2014-present
American Society of Transplantation, 2015-present
American Association for Clinical Chemistry, 2018-19
American Society for Transplantation and Cellular Therapy, 2022-present

Web Links

Selected Publications

Longer-Term Clinical Outcomes From the THINKER and EXPANDER Trials of Transplantation of HCV-RNA+ Donor Kidneys Into Hepatitis C Virus-Negative Recipients

Potluri V, Naqvi F, Goldberg DS, Shah M, Loupy A, Abt P, Blumberg E, Trofe-Clark J, Bloom R, Sawinski D, Chattergoon M, Segev DL, Bair-Marcantoni N, Durand CM, Reddy R, Levine M, Brown N, Mapchan S, Aubert O, Desai N, Reese PP. Kidney Int Rep 8,1460–1463, Jul 2023.  doi:10.1016/j.ekir.2023.04.018. PMID:37441470.

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HLA Amino Acid Mismatch-Based Risk Stratification of Kidney Allograft Failure Using a Novel Machine Learning Algorithm

Dasariraju S, Gragert L, Wager GL, McCullough K, Brown NK, Kamoun M, Urbanowicz RJ. J Biomed Inform 142:104374, Jun 2023. doi: 10.1016/j.jbi.2023.104374. Epub 2023 Apr 27. PMID: 37120046; PMCID: PMC10286565.

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Carving your path through ASHI: An interview with Dr. Nicholas Brown

Brown NK. Coffee & Compatibility Podcast, American Society for Histocompatability & Immunogenetics, Apr 2023. 

An unusually well HLA-matched pairing between a homozygous HLA-A*03:02 deceased donor kidney and a highly sensitized patient carrying HLA-A*03:02 and having antibodies to HLA-A*03:01 (abs # P33)

Johnson FB, Mateu S, Vo E, Kearns J, Bui TM, Brown N, Kamoun M. In “ASHI 48th Annual Meeting, Poster Abstracts.” Human Immunology 83(S1): 73, Oct 2022.

An open-source program to gather relevant data for virtual crossmatch (abs # P145)

Brown N, Bui TM. In “ASHI 48th Annual Meeting, Poster Abstracts.” Human Immunology 83(S1): 184-185, Oct 2022.

CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder

Wang X, Liu M, Zhang J, Brown NK, Zhang P, Zhang Y, Liu H, Du X, Wu W, Devenport M, Tao W, Mao-Draayer Y, Chen GY, Chen YE, Zheng P, Liu Y. Cell Metab 34(8):1088-1103e6, Aug 2022. doi: 10.1016/j.cmet.2022.07.005. PMID: 35921817; PMCID: PMC9393047. 

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Immunogenetics of heteroclitic recognition of HLA-DQB1 55R eplet specificity by human alloantibody

Kamoun M, Askar M, Kearns JD, Bui TM, Nguyen M, Brown NK, Duquesnoy RJ. Hum Immunol 83(2):99-106, Feb 2022. doi: 10.1016/j.humimm.2021.11.001. Epub 2021 Nov 20. PMID: 34815108.

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R for HLA Data: A Suite of Tools for Managing and Analyzing Data from Clinical HLA Laboratory Information Systems (abs # B1)

Brown NK, Peyster EG, Bui T. In “American Transplant Congress 2023, Poster Abstracts.” American Journal of Transplantation 23(6, Suppl 1): S756-S757, Jun 2023. doi: 10.1016/j.ajt.2023.05.014.

Reduced PCR-generated errors from a hybrid capture-based NGS assay for HLA typing

Brown NK, Merkens H, Rozemuller EH, Bell D, Bui TM, Kearns J. Hum Immunol 82(4):296-301, Apr 2021. doi: 10.1016/j.humimm.2021.02.010. Epub 2021 Mar 4. PMID: 33676750.

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Effective desensitization for a strong donor-specific HLA antibody in a case of HLA-mismatched allogeneic hematopoietic cell transplantation

Misra MK, Xin JJ, Brown NK, Weidner JG, Upchurch RL, Bishop MR, Wool GD, Artz AS, Marino SR. HLA 94(3):307-311, Sep 2019. doi: 10.1111/tan.13627. Epub 2019 Aug 6. PMID: 31314169. 

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