Wan-Ping Lee, PhD
Research Assistant Professor of Pathology and Laboratory MedicinePerelman School of Medicine at the University of Pennsylvania
Contact InformationD103, Richards Medical Research Laboratories
3700 Hamilton Walk
Philadelphia, PA, 19104
Specialty Division
Neuropathology
Research Expertise
My group focuses on discovering human genomic variations, especially structural variations such as copy number variations (deletions and duplications), insertions, tandem duplications, inversions, and translocations. They are substantial contributors to genetic diversity and are usually associated with human diseases. We are closely working on the Alzheimer’s Disease genomics data analysis and participating in the Alzheimer’s Disease Sequencing Project (ADSP) and Alzheimer’s Disease Genetics Consortium (ADGC).
Education
B.B.A. (Management Information System), Chung Yuan Christian University, 2001
M.S. (Computer Science and Engineering), National Sun Yat-Sen University, 2004
Ph.D. (Electrical Engineering), National Taiwan University, 2009
Specialty Certification
Postgraduate Training
Postdoctoral associate, Department of Biology, Boston College, 2009-2013
Awards and Honors
1st Place, FPGA Design Contest, Ministry of Education, Taiwan, 2003
Honorable Mention, Semiconductor Design and Application Competition, Macronix Education Foundation, 2005
2nd Prize, IC/CAD Contest, Ministry of Education, Taiwan, 2005
EDA Scholarship for DAC and ICCAD regular papers, and UBooth poster, SpringSoft Education Foundation, 2006
Honorable Mention, IC/CAD Contest, Ministry of Education, Taiwan, 2007
Outstanding Research Award, Graduate Institute of Electronic Engineering, National Taiwan University, Taiwan, 2007
EDA Scholarship for DAC and ICCAD regular papers, and UBooth poster, SpringSoft Education Foundation, 2007
Scholarship for Graduate Students Study Abroad Program, National Science Council, Taiwan, 2007
Honorable Mention, IC/CAD Contest, Ministry of Education, Taiwan, 2008
The 2018 Albert Nelson Marquis Lifetime Achievement, 2018
Merit Award, Jackson Laboratory for Genomic Medicine, 2018
Memberships and Professional Organizations
Swiss National Science Foundation study section, 2023 - Present
NIH/NHGRI RFA-HG-23-026 Study Section, 2024 - Present
Web Links
Selected Publications
Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells
Hui Wang, Timothy S Change, Beth A Dombroski, Po-Liang Cheng, Ya-Qin Si, Albert Tucci, Vishakha Patil, Leopoldo Valiente-Banuet, Chong Li, Kurt Farrell, Catriona Mclean, Laura Molina-Porcel, Alex Rajput, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C Van Swieten, Elise Dopper, Bernardino F Ghetti, Kathy L Newell, Claire Troakes, Justo G de Yébenes, Alberto Rábano-Gutierrez, Tina Meller, Wolfgang H Oertel, Gesine Respondek, Maria Stamelou, Thomas Arzberger, Sigrun Roeber, Ulrich Müller, Franziska Hopfner, Pau Pastor, Alexis Brice, Alexandra Durr, Isabelle Le Ber, Thomas G Beach, Geidy E Serrano, Lili-Naz Hazrati, Irene Litvan, Rosa Rademakers, Owen A Ross, Douglas Galasko, Adam L Boxer, Bruce L Miller, Willian W Seeley, Vivianna M Van Deerlin, Edward B Lee, Charles L White III, Huw R Morris, Rohan de Silva, John F Crary, Alison M Goate, Jeffrey S Friedman, Yaroslau Compta, Yuk Yee Leung, Giovanni Coppola, Adam C Naj, Li-San Wang, PSP genetics study group, Clifton Dalgard, Dennis W Dickson, Günter U Höglinger, Jung-Ying Tzeng, Daniel H Geschwind, Gerard D Schellenberg, Wan-Ping Lee, Movement Disorders, 2025
Polygenic burden of short tandem repeat expansions promotes risk for Alzheimer’s disease
Michael H Guo, Wan-Ping Lee, Badri Vardarajan, Gerard D Schellenberg, Jennifer Phillips-Cremins, Nature Communications 16(1126): , 2025, PMID:39875385
Association of Common and Rare Variants with Alzheimer’s Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer’s Disease Sequencing Project
Wan-Ping Lee, Seung Hoan Choi, Margaret G Shea, Po-Liang Cheng, Beth A Dombroski, Achilleas N Pitsillides, Nancy L Heard-Costa, Hui Wang, Katia Bulekova, Amanda B Kuzma, Yuk Yee Leung, John J Farrell, Honghuang Lin, Adam Naj, Elizabeth E Blue11, Frederick Nusetor, Dongyu Wang, Eric Boerwinkle1, William S Bush, Xiaoling Zhang, Philip L De Jager, Josée Dupuis, Lindsay A Farrer, Myriam Fornage, Eden Martin, Margaret Pericak-Vance, Sudha Seshadri, Ellen M Wijsman, Li-San Wang, The Alzheimer’s Disease Sequencing Project, Gerard D Schellenberg, Anita L Destefano, Jonathan L Haines, Gina M Peloso, Alzheimer's & dementia 20(): , 2024, PMID:39428839
Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes
Kurt Farrell, Jack Humphrey, Timothy Chang, Yi Zhao, Yuk Yee Leung, Pavel P. Kuksa, Vishakha Patil, Wan-Ping Lee, Amanda B. Kuzma, Otto Valladares, Laura B. Cantwell, Hui Wang, Ashvin Ravi, Claudia De Sanctis, Natalia Han, Thomas D. Christie, Robina Afzal, Shrishtee Kandoi, Kristen Whitney, Margaret M. Krassner, Hadley Ressler, SoongHo Kim, Diana Dangoor, Megan A. Iida, Alicia Casella, Ruth H. Walker, Melissa J. Nirenberg, Alan E. Renton, Bergan Babrowicz, Giovanni Coppola, Towfique Raj, Günter U. Höglinger, Ulrich Müller, Lawrence I. Golbe, Huw R. Morris, John Hardy, Tamas Revesz, Tom T. Warner, Zane Jaunmuktane, Kin Y. Mok, Rosa Rademakers, Dennis W. Dickson, Owen A. Ross, Li-San Wang, Alison Goate, Gerard Schellenberg, Daniel H. Geschwind, PSP Genetics Study Group, John F. Crary, Adam Naj, Nature Communications 15(7880): , 2024, PMID:39251599
Whole genome sequencing analysis reveals new susceptibility loci and structural variants associated with Progressive Supranuclear Palsy
Hui Wang, Timothy S. Chang, Beth A. Dombroski, Po-Liang Cheng, Vishakha Patil, Leopoldo Valiente-Banuet, Kurt Farrell, Catriona Mclean, Laura Molina-Porcel, Alex Rajput, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C. Van Swieten, Elise Dopper, Bernardino F. Ghetti, Kathy L. Newell, Claire Troakes, Justo G. de Yébenes, Alberto Rábano-Gutierrez, Tina Meller, Wolfgang H. Oertel, Gesine Respondek, Maria Stamelou, Thomas Arzberger, Sigrun Roeber, Ulrich Müller, Franziska Hopfner, Pau Pastor, Alexis Brice, Alexandra Durr, Isabelle Le Ber, Thomas G. Beach, Geidy E. Serrano, Lili-Naz Hazrati, Irene Litvan, Rosa Rademakers, Owen A. Ross, Douglas Galasko, Adam L. Boxer, Bruce L. Miller, Willian W. Seeley, Vivanna M. Van Deerlin, Edward B. Lee, Charles L. White III, Huw Morris, Rohan de Silva, John F. Crary, Alison M. Goate, Jeffrey S. Friedman, Yuk Yee Leung, Giovanni Coppola, Adam C. Naj, Li-San Wang, P. S. P. genetics study group, Clifton Dalgard, Dennis W. Dickson, Günter U. Höglinger, Gerard D. Schellenberg, Daniel H. Geschwind, Wan-Ping Lee, Molecular Neurodegeneration 19(61): , 2024, PMID:39152475
Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry
Nicholas R. Ray, Brian W. Kunkle, Kara Hamilton-Nelson, Jiji T. Kurup, Farid Rajabli, Min Qiao, Badri N. Vardarajan, Mehmet I. Cosacak, Caghan Kizil, Melissa Jean-Francois, Michael Cuccaro, Dolly Reyes-Dumeyer, Laura Cantwell, Amanda Kuzma, Jeffery M. Vance, Sujuan Gao, Hugh C. Hendrie, Olusegun Baiyewu, Adesola Ogunniyi, Rufus O. Akinyemi, Alzheimer's Disease Genetics Consortium, Wan-Ping Lee, Eden R. Martin, Li-San Wang, Gary W. Beecham, William S. Bush, Wanying Xu, Fulai Jin, Liyong Wang, Lindsay A. Farrer, Jonathan L. Haines, Goldie S. Byrd, Gerard D. Schellenberg, Richard Mayeux, Margaret A. Pericak-Vance, Christiane Reitz, Alzheimer's & Dementia 20(8): , 2024, PMID:38958117
A comparative study of structural variant calling in WGS from Alzheimer's disease families
John S Malamon, John J Farrell, Li Charlie Xia, Beth A Dombroski, Rueben G Das, Jessica Way, Amanda B Kuzma, Otto Valladares, Yuk Yee Leung, Allison J Scanlon, Irving Antonio Barrera Lopez, Jack Brehony, Kim C Worley, Nancy R Zhang, Li-San Wang, Lindsay A Farrer, Gerard D Schellenberg, Wan-Ping Lee, Badri N Vardarajan, Life Science Alliance 7(5): , 2024, PMID:38418088
Human whole-exome genotype data for Alzheimer's disease
Yuk Yee Leung, Adam C. Naj, Yi-Fan Chou, Otto Valladares, Michael Schmidt, Kara Hamilton-Nelson, Nicholas Wheeler, Honghuang Lin, Prabhakaran Gangadharan, Liming Qu, Kaylyn Clark, Amanda B. Kuzma, Wan-Ping Lee, Laura Cantwell, Heather Nicaretta, Alzheimer’s Disease Sequencing Project, Jonathan Haines, Lindsay Farrer, Sudha Seshadri, Zoran Brkanac, Carlos Cruchaga, Margaret Pericak-Vance, Richard P. Mayeux, William S. Bush, Anita Destefano, Eden Martin, Gerard D. Schellenberg, Li-San Wang, Nature Communications 15(684): , 2024, PMID:38263370
LUSTR: a new customizable tool for calling genome-wide germline and somatic short tandem repeat variants
Jinfeng Lu, Camilo Toro, David R. Adams, Undiagnosed Diseases Network, Cristiane Araujo Martins Moreno, Wan-Ping Lee, Yuk Yee Leung, Mathew B. Harms, Badri Vardarajan, Erin L. Heinzen, BMC Genomics 25(115): , 2024, PMID:38279154
Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians
Pei-Chuan Ho, Wai Haung Yu, Boon Lead Tee, Wan-Ping Lee, Clara Li, Yian Gu, Jennifer S. Yokoyama, Dolly Reyes-Dumeyer, Yun-Beom Choi, Hyun-Sik Yang, Badri N. Vardarajan, Marian Tzuang, Kevin Lieu, Anna Lu, Kelley M. Faber, Zoë D. Potter, Carolyn Revta, Maureen Kirsch, Jake McCallum, Diana Mei, Briana Booth, Laura B. Cantwell, Fangcong Chen, Sephera Chou, Dewi Clark, Michelle Deng, Ting Hei Hong, Ling-Jen Hwang, Lilly Jiang, Yoonmee Joo, Younhee Kang, Ellen S. Kim, Hoowon Kim, Kyungmin Kim, Amanda B. Kuzma, Eleanor Lam, Serggio C. Lanata, Kunho Lee, Donghe Li, Mingyao Li, Xiang Li, Chia-Lun Liu, Collin Liu, Linghsi Liu, Jody-Lynn Lupo, Khai Nguyen, Shannon E. Pfleuger, James Qian, Winnie Qian, Veronica Ramirez, Kristen A. Russ, Eun Hyun Seo, Yeunjoo E. Song, Maria Carmela Tartaglia, Lu Tian, Mina Torres, Namkhue Vo, Ellen C. Wong, Yuan Xie, Eugene B. Yau, Isabelle Yi, Victoria Yu, Xiaoyi Zeng, Peter St George-Hyslop, Rhoda Au, Gerard D. Schellenberg, Jeffrey L. Dage, Rohit Varma, Ging-Yuek R. Hsiung, Howard Rosen, Victor W. Henderson, Tatiana Foroud, Walter A. Kukull, Guerry M. Peavy, Haeok Lee, Howard H. Feldman, Richard Mayeux, Helena Chui, Gyungah R. Jun, Van M. Ta Park, Tiffany W. Chow, Li-San Wang, Alzheimer's & Dementia 20(3): , 2024, PMID:38215053
