Elizabeth M. Margolskee, MD, MPH

Assistant Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania

Contact Information3401 Civic Center Boulevard
Philadelphia, PA, 19104
Office: 6316808643

Specialty Division


Other Expertise

On my first day as a lab director, I learned that our entire dayshift staff had been exposed to COVID-19 in the workplace and had to quarantine. Although no one became seriously ill, this experience framed my relationship with laboratory professionals, and highlighted their role as front line workers.

I work closely with Surabhi Mulchandani, Vice Chair for Laboratory Administration, and other leadership in the department, to develop sustainable, ongoing strategies to develop and strengthen the pathology workforce.

Clinical Expertise

I am a hematopathologist and Director of the hematology laboratory at Children's Hospital of Philadelphia. I came to hematopathology originally because I wanted to care for critically ill patients alongside intelligent, curious clinicians in a collaborative fashion. I also enjoy interacting with our strong flow cytometrists, medical technologists, molecular pathologists, cytogeneticists, histotechs and pathology assistants, who make my work possible.

I am interested in quality and process improvement in the lab, and I am particularly fascinated by pediatric myeloid neoplasms.


AB Harvard University, Cambridge, MA, 2006
MD Mount Sinai School of Medicine, New York, NY, 2010
MPH (Epidemiology), Columbia University Mailman School of Public Health, 2014

Specialty Certification

American Board of Pathology, Anatomic and Clinical Pathology, 2015
American Board of Pathology, Hematopathology, 2016

Postgraduate Training

Resident, Anatomic/Clinical Pathology, NYPH-Columbia University Medical Center, New York, NY, 2010-2015
Chief Resident, Anatomic/Clinical Pathology NYPH-Columbia University Medical Center, New York, NY, 2012-2013
Fellow, Hematopathology, NYPH Weill Cornell, New York, NY, 2015-2016

Awards and Honors

Vermeule Prize for excellence in Archaeological Scholarship, 2006
Hoopes Prize for Senior thesis, 2006
Honorable Mention: Gold Foundation Humanism in Medicine Essay Contest, 2009
American Society of Hematology Abstract Achievement Award, 2013
Wyman Scholar at Mailman School of Public Health, 2013
American Society of Hematology Abstract Achievement Award, 2015

Memberships and Professional Organizations

United States & Canadian Academy of Pathology, 2012 - Present
College of American Pathologists, 2016 - Present
AIDS Malignancies Consortium, 2017 - 2019
Society for Hematopathology, 2018 - Present

Web Links

Selected Publications

Haematology Laboratory Parameters to Assess Efficacy of CD19-, CD22-, CD33-, and CD123-directed Chimeric Antigen Receptor T-cell Therapy in Haematological Malignancies

Drumheller B, Gebre K, Lockhart B, Margolskee E, Obstfeld A, Paessler M, Pillai V, International Journal of Laboratory Hematology, 2022, PMID:35419923

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An Erythematous Indurated Plaque on the Neck of a 12-year-old Girl

Xu Z, Wat M, Pillai V, Margolskee E, Rubin AI, Khurana MC, Pediatr Dermatol, 2022, PMID:35188291

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A Healthy 16-year-old Boy Presenting with Multifocal Asymptomatic Subcutaneous Nodules

Xu Z, Margolskee E, Villasenor-Park J, Rubin AI, Khurana MC, Pediatr Dermatol 39(1): , 2022, PMID:35106821

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Pediatric Myeloproliferative Neoplasms

El-Sharkawy F, Margolskee E, Clinics in Laboratory Medicine 41(3): 529-540, 2021, PMID:34304780

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NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation

Papachristodoulou A, Rodriguez-Calero A, Panja S, Margolskee E, Virk RK, Milner TA, Martina LP, Kim JY, Di Bernardo M, Williams AB, Maliza EA, Caputo JM, Haas C, Wang V, De Castro GJ, Wenske S, Hibshoosh H, McKiernan JM, Shen MM, Rubin MA, Mitrofanova A, Dutta A, Abate-Shen C, Cancer Discovery 11(9): 2316-2333, 2021, PMID:33893149

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Pathology and Molecular Diagnosis of Leukemias and Lymphomas

Margolskee E, Wertheim GBW, Harvey RC, Pizzo and Poplack's Pediatric Oncology 8th Edition, 2021

Genomic Characterization of 747 Pediatric Hematological Malignancies

Zhong Y, Wu, J, Lin F, Luo M, Surrey L, Schubert J, Patel M, Xu F, Pechter K, Cao K, Gallo D, Denenberg E, Fanning E, Chen J, Fan Z, MacFarland S, Paessler M, Margolskee M, Pillau V, Aplenc R, Bernt K, Rheingold S, Tasian S, Hunger S, Wertheim G, Li M, 2021 ACMG Annual Clinical Genetics Meeting, 2021

Interobserver Variability Between Cytopathologists and Cytotechnologists Upon Application and Characterization of the Indeterminate Category in the Milan System for Reporting Salivary Gland Cytopathology

Viswanathan K, Patel A, Abdelsayed M, Rosado L, Soong L, Margolskee E, Heymann JJ, Goyal A, Rao RA, Cancer Cytopathology 128(11): 828-839, 2020, PMID:32573971

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Loss of Surface CD3 Expression in Allogeneic CAR T-cells.

Margolskee E, Pillai V, American Journal of Hematology 95(9): 1115-1116, 2020, PMID:32129509

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