Derek Alan Oldridge, MD, PhD
Assistant Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Assistant Director, Immunogenetics Laboratory,
Children's Hospital of Philadelphia
Contact InformationChildren's Hospital of Philadelphia
Department of Pathology and Laboratory Medicine
Colket Translational Research Building, Rm. 9028
3501 Civic Center Boulevard
Philadelphia, PA 19104
Email: oldridged@chop.edu
Specialty Division
Laboratory Medicine, CHOP Pathology Informatics
Research Expertise
Bioinformatics
Cancer
Genomics
Immunology
Immunotherapy
Pediatric Oncology
Statistics
Clinical Expertise
Histocompatibility
Immunogenetics
Molecular Pathology
Clinical Pathology
Graduate Groups
Genomics and Computational Biology
Immunology
Education
BA (Interdisciplinary Chemistry/Physics), Reed College, 2007
MA (Statistics), The Wharton School at the University of Pennsylvania, 2015
PhD (Genomics and Computational Biology), University of Pennsylvania, 2015
MD (Medicine), Perelman School of Medicine at the University of Pennsylvania, 2017
Specialty Certification
Clinical Pathology, American Board of Pathology, 2020
Postgraduate Training
Resident, Clinical Pathology, Hospital of the University of Pennsylvania, 2017-20
Chief Resident, Clinical Pathology, Hospital of the University of Pennsylvania, 2018-19
Postdoctoral Research Fellow, E. John Wherry Laboratory, University of Pennsylvania, 2019-22
Clinical Fellow, Histocompatibility and Immunogenetics, Children’s Hospital of Philadelphia, 2020-22
Awards and Honors
Licensed Senior Reactor Operator, Reed College Research Nuclear Reactor, 2004-07
National Barry M. Goldwater Scholar, 2006
Best Poster Award, 8th Annual APSA Meeting, Chicago IL, 2012
ASCI Joint Meeting Travel Award Recipient, Chicago IL, 2012
T32 Fellowship in Computational Genomics, 2014-15
Tom Kadesch Prize, Department of Genetics, University of Pennsylvania, 2015
Schweisguth Prize, Société Internationale d’Oncologie Pédiatrique (SIOP), 2015
F30 Fellowship Award, National Cancer Institute, 2015-17
ITMAT Prize for Clinical/Translational Work, 2016
Saul Winegrad Award for Outstanding Dissertation, 2016
Distinguished Research Trainee Award, Children’s Hospital of Philadelphia, 2017
R38 StARR Fellowship Award; National Heart, Lung, and Blood Institute, 2019-20
Innovation Award, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 2019
Young Investigator Award, Association for Molecular Pathology Annual Meeting, 2019
Digital Innovation Award, Philadelphia Alliance for Capital and Technologies (PACT), 2020
William Pepper Award, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 2020
Parker Bridge Fellow Award, Parker Institute for Cancer Immunotherapy (PICI), 2021
Sigma Xi, The Scientific Research Honor Society, Full Member, 2022
Memberships and Professional Organizations
College of American Pathologists, 2019-Present
Pennsylvania Medical Society, 2019-Present
Web Links
Selected Publications
Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours
Nabbi A, Beck P, Delaidelli A, Oldridge DA, Sudhaman S, Zhu K, Yang SYC, Mulder DT, Bruce JP, Paulson JN, Raman P, Zhu Y, Resnick AC, Sorensen PH, Sill M, Brabetz S, Lambo S, Malkin D, Johann PD, Kool M, Jones DTW, Pfister SM, Jäger N, Pugh TJ. Genome Med 15(1): Sep 2023. PMID:37679810.
Human T follicular helper clones seed the germinal center-resident regulatory pool.
Le Coz C, Oldridge DA, Herati RS, De Luna N, Garifallou J, Cruz Cabrera E, Belman JP, Pueschl D, Silva LV, Knox AVC, Reid W, Yoon S, Zur KB, Handler SD, Hakonarson H, Wherry EJ, Gonzalez M, Romberg N. Sci Immunol 8(82): Apr 2023. PMID:37027481.
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19
Vella LA*, Giles JR*, Baxter AE*, Oldridge DA*, Diorio C, Kuri-Cervantes L, Alanio C, Pampena MB, Wu JE, Chen Z, Huang YJ, Anderson EM, Gouma S, McNerney KO, Chase J, Burudpakdee C, Lee JH, Apostolidis SA, Huang AC, Mathew D, Kuthuru O, Goodwin EC, Weirick ME, Bolton MJ, Arevalo CP, Ramos A, Jasen CJ, Conrey PE, Sayed S, Giannini HM, D’Andrea K; UPenn COVID Processing Unit, Meyer NJ, Behrens EM, Bassiri H, Hensley SE, Henrickson SE, Teachey DT, Betts MR, Wherry EJ. Sci Immunol 6(57): abf7570, Mar 2021. PMID:33653907.
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
Mathew D*, Giles JR*, Baxter AE*, Oldridge DA*, Greenplate AR*, Wu JE*, Alanio C*, Kuri-Cervantes L, Pampena MB, D’Andrea K, Manne S, Chen Z, Huang YJ, Reilly JP, Weisman AR, Ittner CAG, Kuthuru O, Dougherty J, Nzingha K, Han N, Kim J, Pattekar A, Goodwin EC, Anderson EM, Weirick ME, Gouma S, Arevalo CP, Bolton MJ, Chen F, Lacey SF, Ramage H, Cherry S, Hensley SE, Apostolidis SA, Huang AC, Vella LA; UPenn COVID Processing Unit, Betts MR, Meyer NJ, Wherry EJ. Science 369(6508): eabc8511, Sep 2020. PMID:32669297.
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism
Oldridge DA*, Wood AC*, Weichert-Leahey N, Crimmins I, Sussman R, Winter C, McDaniel LD, Diamond M, Hart LS, Zhu S, Durbin AD, Abraham BJ, Anders L, Tian L, Zhang S, Wei JS, Khan J, Bramlett K, Rahman N, Capasso M, Iolascon A, Gerhard DS, Guidry Auvil JM, Young RA, Hakonarson H, Diskin SJ, Look AT, Maris JM. Nature 528(7582): 418-21, Dec 2015. PMID:26560027.
Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy
Sotillo E, Barrett DM, Black KL, Bagashev A, Oldridge D, Wu G, Sussman R, Lanauze C, Ruella M, Gazzara MR, Martinez NM, Harrington CT, Chung EY, Perazzelli J, Hofmann TJ, Maude SL, Raman P, Barrera A, Gill S, Lacey SF, Melenhorst JJ, Allman D, Jacoby E, Fry T, Mackall C, Barash Y, Lynch KW, Maris JM, Grupp SA, Thomas-Tikhonenko A. Cancer Discov 5(12): 1282-95, Dec 2015. PMID:26516065.
Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations
Eleveld TF*, Oldridge DA*, Bernard V*, Koster J, Colmet Daage L, Diskin SJ, Schild L, Bentahar NB, Bellini A, Chicard M, Lapouble E, Combaret V, Legoix-Né P, Michon J, Pugh TJ, Hart LS, Rader J, Attiyeh EF, Wei JS, Zhang S, Naranjo A, Gastier-Foster JM, Hogarty MD, Asgharzadeh S, Smith MA, Guidry Auvil JM, Watkins TB, Zwijnenburg DA, Ebus ME, van Sluis P, Hakkert A, van Wezel E, van der Schoot CE, Westerhout EM, Schulte JH, Tytgat GA, Dolman ME, Janoueix-Lerosey I, Gerhard DS, Caron HN, Delattre O, Khan J, Versteeg R, Schleiermacher G, Molenaar JJ, Maris JM. Nat Genet 47(8): 864-71, Aug 2015. PMID:26121087.
