Derek Alan Oldridge, M.D., Ph.D.
Assistant Professor of Pathology and Laboratory MedicinePerelman School of Medicine at the University of Pennsylvania
Contact InformationChildren's Hospital of Philadelphia
Colket Translational Research Building Rm. 9028
3501 Civic Center Boulevard
Philadelphia, PA, 19104
Research Expertise
Bioinformatics
Cancer
Genomics
Immunology
Immunotherapy
Pediatric Oncology
Statistics
Clinical Expertise
Histocompatibility
Immunogenetics
Molecular Pathology
Clinical Pathology
Education
B.A. Reed College (Interdisciplinary Chemistry/Physics), 2007
Ph.D. University of Pennsylvania (Genomics and Computational Biology), 2015
M.A. The Wharton School at the University of Pennsylvania (Statistics), 2015
M.D. Perelman School of Medicine at the University of Pennsylvania, 2017
Specialty Certification
Pathology - Clinical, American Board of Pathology, 2020
Postgraduate Training
Resident in Clinical Pathology, Hospital of the University of Pennsylvania, Philadelphia, 2017-2020
Chief Resident in Clinical Pathology, Hospital of the University of Pennsylvania, Philadelphia, 2018-2019
Postdoctoral Research Fellowship, Laboratory of E. John Wherry, University of Pennsylvania, Philadelphia, 2019-2022
Clinical Fellowship, Histocompatibility and Immunogenetics, Children’s Hospital of Philadelphia, Philadelphia, 2020-2022
Awards and Honors
Licensed Senior Reactor Operator, Reed College Research Nuclear Reactor, 2004-2007
National Barry M. Goldwater Scholar, 2006
Best Poster Award, 8th Annual APSA Meeting, Chicago IL, 2012
ASCI Joint Meeting Travel Award Recipient, Chicago IL, 2012
T32 Fellowship in Computational Genomics, 2014-2015
Tom Kadesch Prize, University of Pennsylvania Department of Genetics, 2015
Schweisguth Prize, Société Internationale d’Oncologie Pédiatrique (SIOP), 2015
F30 Fellowship Award, National Cancer Institute, 2015-2017
ITMAT Prize for Clinical/Translational Work, 2016
Saul Winegrad Award for Outstanding Dissertation, 2016
Distinguished Research Trainee Award, Children’s Hospital of Philadelphia, 2017
R38 StARR Fellowship Award; National Heart, Lung, and Blood Institute, 2019-2020
Innovation Award, Department of Pathology, Hospital of the University of Pennsylvania, 2019
Young Investigator Award, Association for Molecular Pathology Annual Meeting, 2019
Digital Innovation Award, Philadelphia Alliance for Capital and Technologies (PACT), 2020
William Pepper Award, Department of Pathology, Hospital of the University of Pennsylvania, 2020
Parker Bridge Fellow Award, Parker Institute for Cancer Immunotherapy (PICI), 2021
Sigma Xi, The Scientific Research Honor Society, Full Member, 2022
Memberships and Professional Organizations
Pennsylvania Medical Society, 2019 - Present
American Society of Clinical Pathology, 2019 - Present
College of American Pathologists, 2019 - Present
American Society for Histocompatibility and Immunogenetics, 2020 - Present
Sigma Xi, 2022 - Present
Web Links
Selected Publications
Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state
Weichert-Leahey N, Shi H, Tao T, Oldridge DA, Durbin AD, Abraham BJ, Zimmerman MW, Zhu S, Wood AC, Reyon D, Joung JK, Young RA, Diskin SJ, Maris JM, Look AT., J Clin Invest 133(10): , 2023, PMID:37183825
IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation.
Conrey PE, Denu L, O'Boyle KC, Rozich I, Green J, Maslanka J, Lubin JB, Duranova T, Haltzman BL, Gianchetti L, Oldridge DA, De Luna N, Vella LA, Allman D, Spergel JM, Tanes C, Bittinger K, Henrickson SE, Silverman MA., Sci Immunol 8(83): , 2023, PMID:37235682
Human T follicular helper clones seed the germinal center-resident regulatory pool.
Le Coz C, Oldridge DA, Herati RS, De Luna N, Garifallou J, Cruz Cabrera E, Belman JP, Pueschl D, Silva LV, Knox AVC, Reid W, Yoon S, Zur KB, Handler SD, Hakonarson H, Wherry EJ, Gonzalez M, Romberg N., Sci Immunol 8(82): , 2023, PMID:37027481
Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State.
Weichert-Leahey N, Shi H, Tao T, Oldridge DA, Durbin AD, Abraham BJ, Zimmerman MW, Zhu S, Wood AC, Reyon D, Joung JK, Young RA, Diskin SJ, Maris JM, Look AT., bioRxiv, 2023, PMID:36909587
Cytomegalovirus Latent Infection is Associated with an Increased Risk of COVID-19-Related Hospitalization
Alanio C, Verma A, Mathew D, Gouma S, Liang G, Dunn T, Oldridge DA, Weaver J, Kuri-Cervantes L, Pampena MB, Betts MR, Collman RG, Bushman FD, Meyer NJ, Hensley SE, Rader D, Wherry EJ; UPenn COVID Processing Unit, J Infect Dis 226(3): 463-473, 2022, PMID:35134186
Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine
Goel RR, Painter MM, Lundgreen KA, Apostolidis SA, Baxter AE, Giles JR, Mathew D, Pattekar A, Reynaldi A, Khoury DS, Gouma S, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Kc W, Oldridge DA, Erickson RI, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Dougherty J, Long S, D'Andrea K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O, Drapeau EM, Davenport MP, Hensley SE, Bates P, Greenplate AR, Wherry EJ, Cell 185(11): 1875-1887, 2022, PMID:35523182
Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers
Giles JR, Manne S, Freilich E, Oldridge DA, Baxter AE, George S, Chen Z, Huang H, Chilukuri L, Carberry M, Giles L, Weng NP, Young RM, June CH, Schuchter LM, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Huang AC, Shi J, Wherry EJ, Immunity 55(3): 557-574, 2022, PMID:35263570
Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19
Apostolidis SA, Sarkar A, Giannini HM, Goel RR, Mathew D, Suzuki A, Baxter AE, Greenplate AR, Alanio C, Abdel-Hakeem M, Oldridge DA, Giles JR, Wu JE, Chen Z, Huang YJ, Belman J, Pattekar A, Manne S, Kuthuru O, Dougherty J, Weiderhold B, Weisman AR, Ittner CAG, Gouma S, Dunbar D, Frank I, Huang AC, Vella LA; UPenn COVID Processing Unit, Reilly JP, Hensley SE, Rauova L, Zhao L, Meyer NJ, Poncz M, Abrams CS, Wherry EJ, Front Immunol 13(): 834988, 2022, PMID:35309299
Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine
Goel RR, Painter MM, Lundgreen KA, Apostolidis SA, Baxter AE, Giles JR, Mathew D, Pattekar A, Reynaldi A, Khoury DS, Gouma S, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Kc W, Oldridge DA, Erickson RI, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Dougherty J, Long S, D'Andrea K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O, Drapeau EM, Davenport MP, Hensley SE, Bates P, Greenplate AR, Wherry EJ, bioRxiv, 2022, PMID:35233575
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern
Goel RR, Painter MM, Apostolidis SA, Mathew D, Meng W, Rosenfeld AM, Lundgreen KA, Reynaldi A, Khoury DS, Pattekar A, Gouma S, Kuri-Cervantes L, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Baxter AE, Oldridge DA, Giles JR, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Drapeau EM, Dougherty J, Long S, D'Andrea K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O; UPenn COVID Processing Unit‡, Frank I, Betts MR, Vella LA, Grifoni A, Weiskopf D, Sette A, Hensley SE, Davenport MP, Bates P, Luning Prak ET, Greenplate AR, Wherry EJ, Science 374(6572): abm0829, 2021, PMID:34648302
