Yanxiang Deng, PhD

Assistant Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania

Contact InformationDepartment of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Stellar-Chance Laboratories
422 Curie Boulevard, Room 713A
Philadelphia, PA 19104

Specialty Division

Cancer and Immunobiology

Research Expertise

Spatial omics, Single-cell analysis, Microfluidics

Graduate Groups

Cell and Molecular Biology
Genomics and Computational Biology


PhD, Rensselaer Polytechnic Institute (RPI), 2018

Specialty Certification

Postgraduate Training

Postdoctoral Associate, Yale University, 2018-2022

Awards and Honors

National Scholarship, 2008
Founders Award of Excellence, Rensselaer Polytechnic Institute, 2015
Blavatnik Awards for Young Scientists, Regional Awards Laureate in Life Sciences, 2023

Memberships and Professional Organizations

Web Links

Selected Publications

Spatial profiling of chromatin accessibility in mouse and human tissues

Deng Y, Bartosovic M, Ma S, Zhang D, Liu Y, Qin X, Su G, Xu ML, Halene S, Craft JE, Castelo-Branco G, Fan R. Nature 609: 375-383, 2022. (Highlight in Nature Structural & Molecular Biology)

Spatial-CUT&Tag: spatially resolved chromatin modification profiling at the cellular level

Deng Y, Bartosovic M, Kukanja P, Zhang D, Liu Y, Su G, Enninful A, Bai Z, Castelo-Branco G, Fan R. Science 375: 681-686, 2022.

High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue

Liu Y#, Yang M#, Deng Y#, Su G, Enninful A, Guo C, Tebaldi T, Zhang D, Kim D, Bai Z, Norris E, Pan A, Li J, Xiao Y, Halene S, Fan R. Cell 183: 1–17, 2020. (# Co-first author) (Highlight in Nature Methods) (Method of the Year by Nature Methods)

Single-cell omics analyses enabled by microchip technologies 

Deng Y, Finck A, Fan R. Annual Review of Biomedical Engineering 21: 365–393, 2019.

Hydroporator: A hydrodynamic cell membrane perforator for high-throughput vector-free nanomaterial intracellular delivery and DNA origami biostability evaluation

Kizer M#, Deng Y#, Kang G-Y, Paiyz M, Wang X, Chung AJ. Lab on a Chip 19: 1747–1754, 2019.  (# Co-first author) (Featured as cover image) 

Microfluidics-enabled orientation and microstructure control of macroscopic graphene fibres

Xin G, Zhu W, Deng Y, Chung AJ, De S, Lian J. Nature Nanotechnology 14, 168–175, 2019.

Intracellular delivery of nanomaterials via an inertial microfluidic cell hydroporator

Deng Y, Kizer M, Rada M, Sage J, Wang X, Cheon DJ, Chung AJ. Nano Letters 18, 2705-2710, 2018.

Inertial microfluidic cell stretcher (iMCS): Fully automated, high-throughput, and near real-time cell mechanotyping

Deng Y, Davis SP, Yang F, Paulsen KS, Kumar M, Sinnott-DeVaux R, Wang X, Conklin DS, Oberai A, Herschkowitz JI, Chung AJ. Small 13, 1700705, 2017. (Featured as cover image) 

Sub-100 micron 3D-shaped particles from next generation-optofluidic fabrication

Paulsen K, Deng Y, Chung AJ. Advanced Science 5:1800252, 2018.