Annapurna Saksena, MBBS, MD

Assistant Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania

Contact InformationHospital of the University of Pennsylvania
7.010 Gates Building
3400 Spruce Street
Philadelphia, PA 19104
Tel: 215-615-3938

Specialty Division


Clinical Expertise

Lymphomas, Histiocytic and dendritic neoplasms, Leukemias, Flow cytometry

Research Expertise

DNA methylation in Hematolymphoid neoplasms and development of a methylation based classifier, Molecular genetics and pathology of lymphomas, Molecular basis of FDC sarcomas

Itmat Expertise

(1) DNA methylation in hematolymphoid neoplasms and its use to facilitate diagnosis
(2) Molecular genetics of lymphomas and FDC sarcomas


MBBS (Medicine & Surgery) Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, India, 2008

Specialty Certification

ECFMG (Education Commission for Foreign Medical Graduates) Certification, 2015
American Board of Pathology, Anatomic Pathology and Clinical Pathology, 2020
American Board of Pathology, Hematopathology, 2021

Postgraduate Training

Intern in Medicine and Surgery, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, India, 2009-10
Junior Assistant, Complete Detailed Diagnostic Center, Delhi, India, 2010-11
Resident in Pathology, Maulana Azad Medical College, New Delhi, Delhi, India, 2011-14
Research Associate, All India Institute of Medical Sciences, Delhi, India, 2014
Junior Pathologist, Guru Nanak Trust Hospital, Surat, India, 2014-16
Hematopathology Observer, MD Anderson Cancer Center, Houston, TX, 2015
Resident in Anatomic and Clinical Pathology, University of Texas Health San Antonio, 2016-19
Resident in Anatomic and Clinical Pathology, National Cancer Institute (NCI), National Institutes of Health, 2019-20
Fellow, Hematopathology, National Cancer Institute (NCI), National Institutes of Health, 2020-22
Hematopathology Research (Rabson) Fellow, National Cancer Institute (NCI), National Institutes of Health, 2022-23

Awards and Honors

Second Position (Bronze Medal) in Pathology, Second Proficiency University Examinations in Medical School, Rohtak, India, 2006
Best Poster Award, Indian Association of Pathologists and Microbiologists, Delhi Chapter, India, 2012
Second Prize in Quiz held in Delhi Society of Hematology, Safdarjung Hospital, Delhi, India, 2013
Second Prize in Quiz held in Indian Association of Pathologist and Microbiologists, New Delhi, India, 2014
Best Dissertation/Thesis Award (Gold Medal) in Pre- and Para-Clinical Subjects, Maulana Azad Medical College, Delhi, India, 2014
Best Gross Photo Award, Department of Pathology, UT Health San Antonio, 2017
Society for Hematopathology Pathologist-in-Training Award Finalist, United States and Canadian Academy of Pathology, Los Angeles, 2022

Memberships and Professional Organizations

American Society of Hematology, 2016-17
College of American Pathologists, 2016-Present
United States and Canadian Academy of Pathology, 2016-Present
Society of Hematopathology, 2020-Present

Web Links

Selected Publications

A novel case of peripheral T-cell lymphoma, not otherwise specified, with rhabdoid morphology and INI1 loss

Saksena A, Rajgariah A. Blood 142(7): 675, Aug 2023. doi: 10.1182/blood.2023021106. PMID: 37590025. 

Severe Autoimmune intravascular hemolytic anemia in patients receiving Alemtuzumab for Multiple Sclerosis   

Sharma P, Saksena A, Diaz AE, Pang Y, Desai P. Blood Advances 7(11): 2534-2537, June 2023. doi: 10.1182/bloodadvances.2022008968.  

Follicle Center Lymphoma (FCL) of the Lower Female Genital Tract (LFGT): A Novel Variant of Primary Cutaneous Follicle Center Lymphoma (PCFCL)  

Saksena A, Jain A, Pack SD, Kim J, Lee I, Tyagi M, Xi L, Pittaluga S, Raffeld M, Jaffe ES. Am J Surg Pathol 47(3): 409-419, March 2023. doi: 10.1097/PAS.0000000000002003.

Cyclic-AMP signalling, MYC and hypoxia-inducible factor 1α intersect to regulate angiogenesis in B-cell lymphoma

Ethiraj P, Sasi B, Holder KN, Lin AP, Qiu Z, Jaafar C, Elkhalili A, Desai P, Saksena A, Ritter JP, Aguiar RCT. Br J Haematol 198(2): 349-359, July 2022. doi: 10.1111/bjh.18196. 

Epstein-Barr Virus-negative Marginal Zone Lymphoma as an Uncommon Form of Monomorphic Posttransplant Lymphoproliferative Disorder

Galera P, Flavin R, Savage NM, Saksena A, Gong S, Wang HY, Swan N, Xi L, Raffeld M, Pittaluga S, Jaffe ES. American Journal of Surgical Pathology 44((10)): 1340-1352, October 2020. doi: 10.1097/PAS.0000000000001514. 

CD5-negative Mantle Cell Lymphoma: Clinicopathologic Correlations and Outcome in 58 Patients

Miao Y, Lin P, Saksena A, Xu J, Wang M, Romaguera J, Yin CC, Medeiros LJ, Li S. Am J Surg Pathol. 43(8): 1052-1060, August 2019. doi: 10.1097/PAS.0000000000001278. 

CD23 expression in mantle cell lymphoma is associated with CD200 expression, leukemic non-nodal form, and a better prognosis 

Saksena A, Yin CC, Xu J, Li J, Zhou J, Wang SA, Lin P, Tang G, Wang L, Wang M, Miranda RN, Medeiros LJ, Li S. Human Pathology 89: 71-80, July 2019. doi: 10.1016/j.humpath.2019.04.010. 

SOX11-negative Mantle Cell Lymphoma: Clinicopathologic and Prognostic Features of 75 Patients 

Xu J, Wang L, Li J, Saksena A, Wang SA, Shen J, Hu Z, Lin P, Tang G, Yin CC, Wang M, Medeiros LJ, Li S. Am J Surg Pathol. 43(5): 710-716, May 2019. doi: 10.1097/PAS.0000000000001233.

CD10-positive mantle cell lymphoma: clinicopathologic and prognostic study of 30 cases

Xu J, Medeiros LJ, Saksena A, Wang M, Zhou J, Li J, Yin CC, Tang G, Wang L, Lin P, Li S. Oncotarget 9(14): 11441-11450, Dec 2017. doi: 10.18632/oncotarget.23571. PMID: 29545910

CD30 expression and prognostic significance in R- EPOCH-treated patients with diffuse large B-cell lymphoma

Xu J, Oki Y, Saksena A, Desai P, Lin P, Tang G, Yin CC, You MJ, Thakral B, Medeiros LJ, Li S. Hum Pathol 60: 160-166, Feb 2017. doi: 10.1016/j.humpath.2016.10.009. Epub 2016 Nov 2. PMID: 27816715.

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