Olga Pozdnyakova, MD, PhD
Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania
Director, Division of Hematopathology
Department of Pathology and Laboratory Medicine
Contact InformationHospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
7 Gates Building
3400 Spruce Street
Philadelphia, PA 19104
Tel: 215-662-3640
Fax: 215-615-3931
Email: Olga.Pozdnyakova@pennmedicine.upenn.edu
Specialty Division
Hematopathology
Clinical Expertise
Laboratory Hematology, Flow Cytometry, Diagnostic approach to hematologic disorders, Leukemias, Lymphomas, Myelomas, Mast cell disorders
Research & Itmat Expertise
1. The diagnostic approach to hematologic neoplasms with the development of new testing algorithms and modalities;
2. Discovery of new morphologic, immunophenotypic and physical characteristics of hematopoietic cells for diagnosing and predictive models
Education
MD (Internal Medicine), Russian State Medical University, Moscow, Russia, 1993
PhD (Pediatric Hematology), Federal Clinical Research Center, Moscow, Russia, 1997
Specialty Certification
Anatomic and Clinical Pathology, American Board of Pathology
Hematopathology, American Board of Pathology
Postgraduate Training
Resident, Pediatrics, Central Children’s Hospital of Russia, Moscow, 1993-95
Fellow, Hematology & Oncology, Clinical Research Ctr for Pediatric Hematology, Oncology & Immunology, Russia, 1995-98
Postdoctoral Fellow, Immunology, Dr. Michael Carroll Lab, CBR Institute for Biomedical Research, Boston, MA, 1998-2003
Research Fellow, Pathology, Harvard Medical School, 1998-2003
Resident, Pathology, UMass Memorial Medical Center, 2004-08
Clinical Fellow, Pathology, Brigham and Women’s Hospital, 2008-09
Awards and Honors
Excellence in Urologic Pathology Research Award, United States and Canadian Academy of Pathology (USCAP) Annual Meeting, 2007
Partners in Excellence Award, Brigham & Women’s Hospital, 2010
Poster of Distinction, Department of Pathology, Brigham & Women’s Hospital, 2012
Partners in Excellence Award, Brigham & Women’s Hospital, 2013
Certificate of Recognition, Department of Pathology, Brigham & Women’s Hospital, 2014
Clinical Pathology Residents’ Teaching Award, Department of Pathology, Brigham & Women’s Hospital, 2015
Poster of Distinction, Pathology Retreat, Harvard Medical School, 2016
Poster of Distinction, Pathology Retreat, Brigham & Women’s Hospital, 2017
BWH Leadership Program VII, Harvard Business School, 2018
Partners in Excellence Award, Team Leader, Brigham & Women’s Hospital and Harbor Medical Associates, 2018
BWH COVID Response Team Award, Brigham & Women’s Hospital and Harbor Medial Associates, 2021
Pillars of Excellence Award, Team Leader, Brigham & Women’s Hospital and Harbor Medical Associates, 2022
HMS Career Advancement & Leadership Skills for Women in Healthcare 2022 Scholarship, Brigham & Women’s Hospital, 2022
Pillars of Excellence Award, Team Leader, Mass General Brigham, 2023
Memberships and Professional Organizations
United States and Canadian Academy of Pathology (USCAP), 2005-present
-------- 2019 Annual Meeting, Interactive Microscopy Session, Director, 2018-19
-------- 2023 Annual Meeting, Short Course, Director, 2022-23
-------- 2024 Annual Meeting, 3-Day Interactive Center Course, Director, 2023-24
American Society for Clinical Pathology (ASCP), 2005-present
-------- Fellow In-Service Hematopathology Examination (FISHE) Question Writer, 2014
-------- Pathologist Recertification Individualized Self-Assessment Examination (PRISE) Question Writer, 2016
-------- 2016 Annual Meeting, Short Course, Co-Director, 2015-16
-------- 2017 Annual Meeting, Short Course, Co-Director, 2016-17
-------- 2018 Annual Meeting, Short Course, Co-Director, 2017-18
-------- 2019 Annual Meeting, Short Course, Co-Director, 2018-19
-------- 2020 Annual Meeting, Short Course, Co-Director, 2019-20
-------- Resident In-Service Examination (RISE), Hematology/Hematopathology Subcommittee, 2021-present (Chair, 2023)
International Society of Laboratory Hematology, 2017-present
-------- “Laboratory Testing for Hematological Malignancies” Session, Co-Chair, 2019
International Clinical Cytometry Society, Education Committee, 2022-present
Society for Hematopathology, 2010-present
-------- SH Workshop, Co-Chair, 2019
-------- Education Committee, 2023-present
College of American Pathologists (CAP), 2011-present
-------- Hematology & Clinical Microscopy Committee, 2019-present (Vice Chair, 2022-23; Chair, 2024-present)
-------- 2020 Annual Meeting, Short Course, Co-Director, 2019-20
-------- 2021 Annual Meeting, Short Course, Co-Director, 2020-21
-------- 2024 Annual Meeting, Short Course, Co-Director, 2023-24
Web Links
Selected Publications
A randomized, double-blind study of zinpentraxin alfa in patients with myelofibrosis who were previously treated with or ineligible for ruxolitinib: Stage 2 of a phase II trial
Verstovsek S, Talpaz M, Wadleigh M, Isidori A, Te Boekhorst P, Savona MR, Bose P, Pozdnyakova O, Mesa R, El-Galaly TC, O'Sullivan J, Gamel K, Higgins B, Katakam S, Todorov B, Trunzer K, Harrison CN. Haematologica 2024 Jan 25. doi: 10.3324/haematol.2023.284410. Epub ahead of print. PMID: 38268448.
Automated Deep Learning-Based Diagnosis and Molecular Characterization of Acute Myeloid Leukemia Using Flow Cytometry
Lewis JE, Cooper LAD, Jaye DL, Pozdnyakova O. Mod Pathol 37(1):100373, Jan 2024. doi: 10.1016/j.modpat.2023.100373. Epub 2023 Nov 3. PMID: 37925056.
Cutaneous Manifestations of Myeloid Neoplasms Exhibit Broad and Divergent Morphologic and Immunophenotypic Features but Share Ancestral Clonal Mutations With Bone Marrow
Sadigh S, DeAngelo DJ, Garcia JS, Hasserjian RP, Hergott CB, Lane AA, Lovitch SB, Lucas F, Luskin MR, Morgan EA, Pinkus GS, Pozdnyakova O, Rodig SJ, Shanmugam V, Tsai HK, Winer ES, Zemmour D, Kim AS. Mod Pathol 37(1):100352, Jan 2024. doi: 10.1016/j.modpat.2023.100352. Epub 2023 Oct 13. PMID: 37839675.
Low-frequency inherited complement receptor variants are associated with purpura fulminans
Bendapudi PK, Nazeen S, Ryu J, Soylemez O, Robbins AK, Rouaisnel B, O'Neil JK, Pokhriyal R, Yang M, Colling M, Pasko B, Bouzinier M, Tomczak L, Collier L, Barrios DA, Ram S, Toth-Petroczy A, Krier J, Fieg E, Dzik W', Hudspeth J, Pozdnyakova O, Nardi V, Knight J, Maas R, Sunyaev S, Losman JA. Blood 2023 Dec 14:blood.2023021231. doi: 10.1182/blood.2023021231. Epub ahead of print. PMID: 38096369.
Safety and efficacy of zinpentraxin alfa as monotherapy or in combination with ruxolitinib in myelofibrosis: stage I of a phase II trial
Verstovsek S, Foltz L, Gupta V, Hasserjian R, Manshouri T, Mascarenhas J, Mesa R, Pozdnyakova O, Ritchie E, Veletic I, Gamel K, Hamidi H, Han L, Higgins B, Trunzer K, Uguen M, Wang D, El-Galaly TC, Todorov B, Gotlib J. Haematologica 108(10):2730-2742, Oct 2023. doi: 10.3324/haematol.2022.282411. PMID: 37165840; PMCID: PMC10543197.
Optimization of Advanced Molecular Genetic Testing Utilization in Hematopathology: A Goldilocks Approach to Bone Marrow Testing
AlJabban A, Paik H, Aster JC, Berliner N, Brouillard J, Brown JR, Burns KH, Castillo JJ, Card J, Dal Cin P, DeAngelo DJ, Dorfman DM, Ebert BL, Garcia JS, Jacobson CA, Lakhani H, Laubach JP, Ligon AH, Lindeman NI, Lindsley RC, Lovitch SB, Luskin MR, Morgan EA, Nowak A, Petrides A, Pinkus GS, Pozdnyakova O, Steensma DP, Stone RM, Weinberg OK, Winer ES, Kim AS. JCO Oncol Pract OP2300217, Sep 2023. doi: 10.1200/OP.23.00217. Epub ahead of print. PMID: 37683132.
Significant Variability in the Identification and Reporting of Band Neutrophils by Participants Enrolled in the College of American Pathologists Proficiency Testing Program: Time for a Change
Vergara-Lluri M, Kovach AE, Nakashima MO, Bradley KT, Mahe E, Tsao L, Savage NM, Salansky SA, Long T, Perkins SL, Hsi ED, Pozdnyakova O, Bhargava P. Arch Pathol Lab Med 2023 Aug 28. doi: 10.5858/arpa.2023-0015-CP. Epub ahead of print. PMID: 37638547.
Standardising acute myeloid leukaemia classification systems: a perspective from a panel of international experts
Shallis RM, Daver N, Altman JK, Komrokji RS, Pollyea DA, Badar T, Bewersdorf JP, Bhatt VR, de Botton S, de la Fuente Burguera A, Carraway HE, Desai P, Dillon R, Duployez N, El Chaer F, Fathi AT, Freeman SD, Gojo I, Grunwald MR, Jonas BA, Konopleva M, Lin TL, Mannis GN, Mascarenhas J, Michaelis LC, Mims AS, Montesinos P, Pozdnyakova O, Pratz KW, Schuh AC, Sekeres MA, Smith CC, Stahl M, Subklewe M, Uy GL, Voso MT, Walter RB, Wang ES, Zeidner JF, Žučenka A, Zeidan AM. Lancet Haematol 10(9):e767-e776, Sep 2023. doi: 10.1016/S2352-3026(23)00159-X. Epub 2023 Aug 9. PMID: 37572683.
Autopsy findings from patients diagnosed with COVID-19 demonstrate unique morphological patterns in bone marrow and lymph node
AlJabban A, Evans MG, Fell GG, Guccione JP, Edwards RA, Pinkus GS, Padera RF, Pozdnyakova O, Kim AS. J Clin Pathol 2023 Jun 8:jcp-2023-208875. doi: 10.1136/jcp-2023-208875. Epub ahead of print. PMID: 37290912.
Digital assessment of peripheral blood and bone marrow aspirate smears
Lewis JE, Pozdnyakova O. Int J Lab Hematol 45 Suppl 2:50-58, Jun 2023. doi: 10.1111/ijlh.14082. Epub 2023 May 21. PMID: 37211430.
