Shefali Setia Verma, PhD
Assistant Professor of Pathology and Laboratory MedicinePerelman School of Medicine at the University of Pennsylvania
Contact InformationPerelman School of Medicine at the University of Pennsylvania
Department of Pathology and Laboratory Medicine
Richards Medical Research Laboratories, D202
3700 Hamilton Walk
Philadelphia, PA 19104
Email: Shefali.SetiaVerma@pennmedicine.upenn.edu
Specialty Division
Diagnostic Innovation
Graduate Groups
Cell and Molecular Biology
Genomics and Computational Biology
Education
B.Tech (Biotechnology), Jaipur National University, 2008
MS (Bioinformatics), New Jersey Institute of Technology, 2011
PhD (Bioinformatics and Genomics), Penn State University, 2018
Specialty Certification
Awards and Honors
Pacific Symposium on Biocomputing Travel Award, 2016
American Medical Informatics Association, Translational Bioinformatics (TBI) Year in Review, Altman Award, “Identifying gene-gene interactions that are highly associated with Body Mass Index using Quantitative Multifactor Dimensionality Reduction (QMDR)," 2016
American Society of Human Genetics, Reviewer's Choice Award at Annual Meeting for abstract titled "Identifying genetic associations with variability in metabolic health and blood count laboratory values: Diving into the quantitative traits in an HER," 2016
Pacific Symposium of Biocomputing Travel Award, 2017
American Medical Informatics Association, Translational Bioinformatics (TBI) Year in Review, Altman Award, "Using knowledge-driven genomic interactions for multi-omics data analysis: meta-dimensional models for predicting clinical outcomes in ovarian carcinoma," 2017
COVID Dream Team Award, University of Pennsylvania, 2021
Keystone Award, PSOM Center for Global Genome Health Equity, 2022
Memberships and Professional Organizations
American Society of Human Genetics, 2018-present
Web Links
Selected Publications
A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma
Verma SS, Gudiseva HV, Chavali VRM, Salowe RJ, Bradford Y, Guare L, Lucas A, Collins DW, Vrathasha V, Nair RM, Rathi S, Zhao B, He J, Lee R, Zenebe-Gete S, Bowman AS, McHugh CP, Zody MC, Pistilli M, Khachatryan N, Daniel E, Murphy W, Henderer J; Regeneron Genetics Center; Kinzy TG, Iyengar SK, Peachey NS; VA Million Veteran Program; Taylor KD, Guo X, Chen YI, Zangwill L, Girkin C, Ayyagari R, Liebmann J, Chuka-Okosa CM, Williams SE, Akafo S, Budenz DL, Olawoye OO, Ramsay M, Ashaye A, Akpa OM, Aung T, Wiggs JL, Ross AG, Cui QN, Addis V, Lehman A, Miller-Ellis E, Sankar PS, Williams SM, Ying GS, Cooke Bailey J, Rotter JI, Weinreb R, Khor CC, Hauser MA, Ritchie MD, O'Brien JM. Cell 187(2):464-480.e10, Jan 2024. doi: 10.1016/j.cell.2023.12.006. PMID: 38242088.
Polygenic risk scores for cardiometabolic traits demonstrate importance of ancestry for predictive precision medicine
Kember RL, Verma SS, Verma A, Xiao B, Lucas A, Kripke CM, Judy R, Chen J, Damrauer SM, Rader DJ, Ritchie MD. Pac Symp Biocomput 29:611-626, 2024. PMID: 38160310.
Uncovering myocardial infarction genetic signatures using GWAS exploration in Saudi and European cohorts
Al-Ali AK, Al-Rubaish AM, Alali RA, Almansori MS, Al-Jumaan MA, Alshehri AM, Al-Madan MS, Vatte C, Cherlin T, Young S, Verma SS, Morahan G, Koeleman BPC, Keating BJ. Sci Rep 13(1):21866, Dec 2023. doi: 10.1038/s41598-023-49105-1. PMID: 38072966; PMCID: PMC10711020.
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target
Roychowdhury T, Klarin D, Levin MG, Spin JM, Rhee YH, Deng A, Headley CA, Tsao NL, Gellatly C, Zuber V, Shen F, Hornsby WE, Laursen IH, Verma SS, Locke AE, Einarsson G, Thorleifsson G, Graham SE, et al. Nat Genet 55(11):1831-1842, Nov 2023. doi: 10.1038/s41588-023-01510-y. Epub 2023 Oct 16. PMID: 37845353; PMCID: PMC10632148.
Quantitative traits associated with primary open-angle glaucoma in African ancestry individuals
Verma SS, Gudiseva HV, Chavali, VRM, Bradford Y, Salowe R, He J, Lee R, Zenebe-Gete S, Daniel E, Ying GS, Miller-Ellis EG. Investigative Ophthalmology & Visual Science, New Orleans, LO - Poster Presentation 63(7): 4013 – A0355, 2023.
Gene Interactions in Human Disease Studies-Evidence Is Mounting
Singhal P, Verma SS, Ritchie MD. Annu Rev Biomed Data Sci 6:377-395, Aug 2023. doi: 10.1146/annurev-biodatasci-102022-120818. Epub 2023 May 17. PMID: 37196359.
Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program
Klarin D, Devineni P, Sendamarai AK, Angueira AR, Graham SE, Shen YH, Levin MG, Pirruccello JP, Surakka I, Karnam PR, Roychowdhury T, Li Y, Wang M, Aragam KG, Paruchuri K, Zuber V, Shakt GE, Tsao NL, Judy RL, Vy HMT, Verma SS, Rader DJ, Do R, Bavaria JE, Nadkarni GN, Ritchie MD; VA Million Veteran Program; Burgess S, Guo DC, Ellinor PT, LeMaire SA, Milewicz DM, Willer CJ, Natarajan P, Tsao PS, Pyarajan S, Damrauer SM. Nat Genet 55(7):1106-1115, Jul 2023. doi: 10.1038/s41588-023-01420-z. Epub 2023 Jun 12. PMID: 37308786; PMCID: PMC10335930.
Leveraging electronic health record data for endometriosis research
Penrod N, Okeh C, Velez Edwards DR, Barnhart K, Senapati S, Verma SS. Front Digit Health 5:1150687, Jun 2023. doi: 10.3389/fdgth.2023.1150687. PMID: 37342866; PMCID: PMC10278662.
How to Run the Pharmacogenomics Clinical Annotation Tool (PharmCAT)
Li B, Sangkuhl K, Keat K, Whaley RM, Woon M, Verma S, Dudek S, Tuteja S, Verma A, Whirl-Carrillo M, Ritchie MD, Klein TE. Clin Pharmacol Ther 113(5):1036-1047, May 2023. doi: 10.1002/cpt.2790. Epub 2022 Dec 23. PMID: 36350094; PMCID: PMC10121724.
Genome-Wide Association Study of Breast Density Among Women of African Ancestry
Verma SS, Guare L, Ehsan S, Gastounioti A, Scales G, Ritchie MD, Kontos D, McCarthy AM, Penn Medicine Biobank. Cancers (Basel) 15(10):2776, May 2023. doi: 10.3390/cancers15102776. PMID: 37345113; PMCID: PMC10216271.
