Giulia Pavani, PhD
Research Assistant Professor of Pathology and Laboratory MedicinePerelman School of Medicine at the University of Pennsylvania
Contact InformationChildren's Hospital of Philadelphia
3501 Civic Center Blvd.
Colket Building, Rm. 10050
Philadelphia, PA, 19104
Office: 2674261222
Email: PAVANIG@chop.edu
Education
BA (Cell and Molecular Biology), University of Ferrara, Ferrara, Italy, 2008
BS (Molecular and Cellular Biotechnologies), University Vita-Salute S.Raffaele, Milan, Italy, 2010
PhD (Molecular Biology and Biotechnology), University of Ferrara, Ferrara, Italy, 2014
Specialty Certification
Postgraduate Training
Postdoctoral Fellow, Gene Editing Research, Genethon, Evry, France, 2015-2019
Awards and Honors
Doctoral Dissertation Award, University Institute for Higher Studies - IUSS Ferrara 1391,, 2014
Nicolò Copernico thesis award, for innovative theses in sciences and technologies, 2014
Martin Villar Haemostasis Award, Basic Research, 2015
American Society of Gene and Cell Therapy, Excellence in research award, 2018
Memberships and Professional Organizations
American Society of Hematology, 2012 - 2014
American Society for Cell and Gene Therapy, 2015 - Present
International Society for Stem Cell Research, 2021 - Present
Web Links
Selected Publications
Modeling primitive and definitive erythropoiesis with induced pluripotent stem cells
Pavani G, Klein JG, Nations CC, Sussman JH, Tan K, An HH, Abdulmalik O, Thom CS, Gearhart PA, Willett CM, Maguire JA, Chou ST, French DL, Gadue P., Blood Adv, 2024, PMID:38290102
Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases
Cheng X, Barakat R, Pavani G, Usha MK, Calderon R, Snella E, Gorden A, Zhang Y, Gadue P, French DL, Dorman KS, Fidanza A, Campbell CA, Espin-Palazon R., Nat Commun 14(): 7668, 2023, PMID:37996457
Tropomyosin 1 deficiency facilitates cell state transitions to enhance hemogenic endothelial cell specification during hematopoiesis
Wilken MB, Fonar G, Nations C, Pavani G, Tsao V, Garifallou J, Tober J, Bennett L, Maguire JA, Gagne A, Okoli N, Gadue P, Chou ST, Speck NA, French DL, Thom CS., bioRxiv, 2023, PMID:37693628
In vivo hematopoietic stem cell modification by mRNA delivery
Breda L, Papp TE, Triebwasser MP, Yadegari A, Fedorky MT, Tanaka N, Abdulmalik O, Pavani G, Wang Y, Grupp SA, Chou ST, Ni H, Mui BL, Tam YK, Weissman D, Rivella S, Parhiz H., Science 381(): 436-443, 2023, PMID:37499029
The use of pluripotent stem cells to generate diagnostic tools for transfusion medicine
An HH, Gagne AL, Maguire JA, Pavani G, Abdulmalik O, Gadue P, French DL, Westhoff CM, Chou ST., Blood 140(): 1723-1734, 2022, PMID:35977098
Genome Engineering Human ESCs or iPSCs with Cytosine and Adenine Base Editors
Pavani G, Klein JG, French DL, Gadue P., Methods Mol Biol 2520(): 321-333, 2022, PMID:35579838
Modeling genetic platelet disorders with human pluripotent stem cells: mega-progress but wanting more on our plate(let)
Nations CC, Pavani G, French DL, Gadue P., Curr Opin Hematol 28(): 308-314, 2021, PMID:34397590
Study of inherited thrombocytopenia resulting from mutations in ETV6 or RUNX1 using a human pluripotent stem cell model
Borst S, Nations CC, Klein JG, Pavani G, Maguire JA, Camire RM, Drazer MW, Godley LA, French DL, Poncz M, Gadue P., Stem Cell Reports 16(): 1458-1467, 2021, PMID:34019812
Corrigendum: Targeted Gene Delivery: Where to Land
Pavani G, Amendola M., Front Genome Ed 3(): 682171, 2021, PMID:34714297
Correction of β-thalassemia by CRISPR/Cas9 editing of the α-globin locus in human hematopoietic stem cells
Pavani G, Fabiano A, Laurent M, Amor F, Cantelli E, Chalumeau A, Maule G, Tachtsidi A, Concordet JP, Cereseto A, Mavilio F, Ferrari G, Miccio A, Amendola M., Blood Adv 5(): 1137-1153, 2021, PMID:33635334
