Eitan Halper-Stromberg, MD, PhD
Penn Medicine Clinician
Hospital of the University of Pennsylvania
Contact InformationHospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
Division of Precision and Computational Diagnostics
3020 Market Street, Suite 220
Philadelphia, PA 19104
Specialty Division
Precision and Computational Diagnostics
Research Expertise
My research interests are in the areas of bioinformatics, molecular pathology, next-generation sequencing, AI, software development, digital pathology, and big data.
Clinical Expertise
Molecular pathology, genomic analytics, including large data handling, variant and CNV pipeline development, database design.
Education
BS (Mechanical Engineering), University of Maryland, 2006
PhD (Human Genetics), Johns Hopkins University, 2013
MD (Medicine, Research Track), University of Colorado, 2019
Specialty Certification
Clinical Pathology, American Board of Pathology, 2022
Molecular Genetic Pathology, American Board of Pathology, 2023
Postgraduate Training
Postdoctoral Fellow, Computational Biosciences, University of Colorado & National Jewish Health, 2013-15
Resident, Clinical Pathology, Johns Hopkins University, 2019-22
Fellow, Molecular Genetic Pathology, Johns Hopkins University, 2022-23
Awards and Honors
James M. Wallace Outstanding Gemstone Thesis Award, University of Maryland College Park, 2006
Butcher Seed Grand Award, University of Colorado BioFrontiers Institute, Boulder CO, 2014
Fred and Janet San Filippo Research Award
Johns Hopkins University, 2021
Risa B Mann Award for Education
Johns Hopkins University, 2022
Memberships and Professional Organizations
Association for Molecular Pathology, 2021-present
-------- Membership Affairs Committee, 2022-present
American Society of Clinical Pathology, 2023-present
Web Links
Selected Publications
CRISPR-Cas9 for selective targeting of somatic mutations in pancreatic cancers
Teh SSK, Bowland K, Halper-Stromberg E, Kotwal A, Bennett A, Skaist A, Tang J, Cai F, Macoretta A, Liang H, Kamiyama H, Wheelan S, Lin MT, Hruban RH, Hung CF, Goldstein M, Scharpf RB, Roberts NJ, Eshleman JR. NAR Cancer 6(2):zcae028, Jun 2024. doi: 10.1093/narcan/zcae028. PMID: 38915758; PMCID: PMC11195629.
Simultaneous CRISPR-Cas9 induced double strand breaks causes chromosomal catastrophe in pancreatic cancers: A parallel comparison with ionizing radiation
Teh SSK, Kotwal A, Halper-Stromberg E, Morsberger L, Bowland K, Bennett A, Goldstein M, Zou YS, Eshleman JR. Cancer Res 84 (7_Supplement): LB397, Apr 2024. doi: 10.1158/1538-7445.AM2024-LB397.
Druggable genomic landscapes of high-grade gliomas
Ghanem P, Fatteh M, Kamson DO, Balan A, Chang M, Tao J, Blakeley J; Johns Hopkins Molecular Tumor Board Investigators; Canzoniero J, Grossman SA, Marrone K, Schreck KC, Anagnostou V. Druggable genomic landscapes of high-grade gliomas. Front Med (Lausanne) 10:1254955, Dec 2023. doi: 10.3389/fmed.2023.1254955. PMID: 38143440; PMCID: PMC10749203.
Novel PAMs from Somatic Mutations Produce Numerous Pancreatic Cancer-Specific CRISPR-Cas9 Targets for Selective Cell Elimination: A Novel Gene Therapy Approach for Cancer
Teh SSK, Bowland K, Bennett A, Halper-Stromberg E, Skaist A, Pallavajjala A, Tang J, Cai F, Liang H, Wheelan S, Scharpf RB, Roberts NJ, Eshleman JR. Mol Cancer Ther 22 (12_Supplement): LB_B02, Dec 2023. doi: 10.1158/1535-7163.TARG-23-LB_B02.
1q Jumping Translocation in Myeloid Malignancies: Frequently Mutated Genes Are Often Associated with Worse Prognosis
Halper-Stromberg E, Zou Y, Stinnett V, Pallavajjala A, Morsberger L, Klausner M, Gocke C, Xian R, Lin M, Dudley J. J Molec Diag 25(11): S28-S29, Nov 2023.
Positive GPNMB Immunostaining Differentiates Renal Cell Carcinoma With Fibromyomatous Stroma Associated With TSC1/2/MTOR Alterations From Others
Li H, Argani P, Halper-Stromberg E, Lotan TL, Merino MJ, Reuter VE, Matoso A. Am J Surg Pathol 47(11):1267-127, Nov 2023. doi: 10.1097/PAS.0000000000002117. Epub 2023 Sep 4. PMID: 37661807; PMCID: PMC10592185.
Genomic instability delays cell death in PDAC after simultaneous double strand breaks
Teh SSK, Halper-Stromberg E, Morsberger L, Bowland K, Bennett A, Scharpf RB, Zou YS, Eshleman JR. Cancer Res 83 (7_Supplement): 6103-6103, Apr 2023. doi: 10.1158/1538-7445.AM2023-6103.
Mechanism of delayed cell death following simultaneous CRISPR-Cas9 targeting in pancreatic cancers
Teh SSK, Halper-Stromberg E, Morsberger L, Bennett A, Bowland K, Skaist A, Cai F, Liang H, Hruban RH, Roberts NJ, Scharpf RB, Zou YS, Eshleman JR. bioRxiv [Preprint] 2023.04.03.535384, Apr 2023. doi: 10.1101/2023.04.03.535384. PMID: 37066222; PMCID: PMC10103988.
Prolonged, physiologically relevant nicotine concentrations in the airways of smokers
Esther CR Jr, O'Neal WK, Alexis NE, Koch AL, Cooper CB, Barjaktarevic I, Raffield LM, Bowler RP, Comellas AP, Peters SP, Hastie AT, Curtis JL, Ronish B, Ortega VE, Wells JM, Halper-Stromberg E, Rennard SI, Boucher RC; SPIROMICS. Am J Physiol Lung Cell Mol Physiol 324(1): L32-L37, Jan 2023. doi: 10.1152/ajplung.00038.2022. Epub 2022 Nov 7. PMID: 36342131; PMCID: PMC9829458.
How to Diagnose Blood Cancer with Streamlit
Halper-Stromberg E. Advocate Posts January 25, 2022. https://blog.streamlit.io/how-to-diagnose-blood-cancer-with-streamlit/.
