Yang Li, MD, PhD
Assistant Professor of Pathology and Laboratory Medicine at the Children's Hospital of PhiladelphiaPerelman School of Medicine at the University of Pennsylvania
Contact InformationAbramson Research Bldg. 707C
The Children's Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA, 19104
Office: 2105354249
Research Expertise
Antigenicity and immunogenicity of HLAs, Chromatin interactions and gene regulation within the major histocompatibility complex (MHC), CAR T for transplantation desensitization
Clinical Expertise
Immunogenetics/histocompatibility: HLA typing, anti-HLA antibody screening, alloimmune risk assessment, virtual and physical crossmatching, chimerism evaluation, NGS and nanopore sequencing, HLA-disease association, desensitization; Transfusion Medicine
Education
B.A. (Biophysics), Johns Hopkins University, 2007
M.A. (Biophysics), Johns Hopkins University, 2008
Ph.D. (Cell and Molecular Biology), University of Pennsylvania, 2013
M.D. University of Pennsylvania, 2015
Specialty Certification
American Board of Pathology - Clinical Pathology, 2018
Postgraduate Training
Clinical Pathology Residency, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 2015-2018
Transfusion Medicine Fellowship, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 2018-2019
Postdoctoral Fellowship, Children's Hospital of Philadelphia, 2019-2022
Immunogenetics Fellowship, Children's Hospital of Philadelphia, 2022-2024
Awards and Honors
NCIIA BMEidea competition, first place national, 2007
Phi Beta Kappa, 2007
Training in Virology T32 grant, 2011-2013
Richard K. Root Prize for Infectious Disease Research, 2014
Medical Student Achievement Award in Endocrinology, 2015
Award for Distinguished Contributions by a Resident, 2017
Transfusion Medicine Research T32 Training grant, 2018-2021
Memberships and Professional Organizations
Engineers Without Borders, 2006 - 2009
American Medical Student Association, 2008 - 2015
American Society for Virology, 2012 - 2013
Association for Molecular Pathology, 2016 - 2017
College of American Pathologists, 2018 - Present
American Society for Clinical Pathology, 2018 - Present
American Society for Histocompatibility and Immunogenetics, 2022 - Present
American Society of Transplantation, 2025 - Present
Web Links
Selected Publications
Haplotypic resolution of the challenging genomic regions of MHC and KIR using a combination of targeted sequencing and a novel assembly pipeline
Mosbruger, Timothy; Dinou, Amalia; Duke, Jamie; Ferriola, Deborah; Li, Yang; Hayeck, Tristan; Monos, Dimitri, Nucleic Acids Research 53(): , 2025, PMID:40464686
Cars pick up another passenger: Organ transplantation.
Georgia F Papadaki, Yang Li, Dimitri S Monos, Vijay G Bhoj, Human Immunology 86(): , 2025, PMID:39591915
Both Low Eplet Mismatch and Low Indirect T-Cell Recognition Scores Are StrongPrognosticators of Reduced Alloimmune Rejection in Pediatric Kidney Transplants
Yang Li, Timothy Mosbruger, Deborah Ferriola, Jamie Duke, Sarah Morris, Brooke Marcellus, Dimitri Monos, Benjamin Laskin, Sandra Amaral, World Transplant Congress 2025, 2025
Targeted and complete genomic sequencing of the major histocompatibility complex in haplotypic form of individual heterozygous samples
Taishan Hu, Timothy L Mosbruger, Nikolaos G Tairis, Amalia Dinou, Pushkala Jayaraman, Mahdi Sarmady, Kingham Brewster, Yang Li, Tristan J Hayeck, Jamie L Duke, Dimitri S Monos, Genome Research 34(): 1500-1513, 2024, PMID:39327030
The impact of patterns in linkage disequilibrium and sequencing quality on the imprint of balancing selection.
Hayeck, T. J., Li, Y., Mosbruger, T. L., Bradfield, J. P., Gleason, A. G., Damianos, G. L., Shaw, G. T., Duke, J. L., Conlin, L. K., Turner, T. N., Fernández-Viña, M. A., Sarmady, & M., Monos, D. S., Genome Biology and Evolution, 16(2): , 2024, PMID:38302106
Hi-C analysis using self-reference provides a more informative MHC chromatin interaction map.
Li, Y., Mosbruger, T. L., Hayeck, T. J., Wells, A. D., Grant, S. F. A., & Monos, D., ASHI 48th Annual Meeting: P98., 2022
Mobilization‐based transplantation of young‐donor hematopoietic stem cells extends lifespan in mice.
Guderyon, M. J., Chen, C., Bhattacharjee, A., Ge, G., Fernandez, R. A., Gelfond, J. A. L., Gorena, K. M., Cheng, C. J., Li, Y., Nelson, J. F., Strong, R. J., Hornsby, P. J., Clark, R. A., & Li, S., Aging Cell 19(3): , 2020, PMID:32012439
Non-toxic HSC Transplantation-Based Macrophage/Microglia-Mediated GDNF Delivery for Parkinson’s Disease.
Chen, C., Guderyon, M. J., Li, Y., Ge, G., Bhattacharjee, A., Ballard, C., He, Z., Masliah, E., Clark, R. A., O’Connor, J. C., & Li, S., Molecular Therapy - Methods & Clinical Development 17(): 83-98, 2020, PMID:31890743
Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals.
Henry, C., Zheng, N. Y., Huang, M., Cabanov, A., Rojas, K. T., Kaur, K., Andrews, S. F., Palm, A. E., Chen, Y. Q., Li, Y., Hoskova, K., Utset, H. A., Vieira, M. C., Wrammert, J., Ahmed, R., Holden-Wiltse, J., Topham, D. J., Treanor, J. J., Ertl, H. C., Schmader K.E, Cobey S., Krammer F., Hensley S. E, Greenberg H., He X.S., Wilson, P. C., Cell Host & Microbe 25(3): 357-366, 2019
Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia.
Balcerek, J., Jiang, J., Li, Y., Jiang, Q., Holdreith, N., Singh, B., Chandra, V., Lv, K., Ren, J., Rozenova, K., Li, W., Greenberg, R. A., & Tong, W., Nature Communications 9(1): 3915, 2018, PMID:30254368
