Paul J. L. Zhang, MD

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Director, Immunohistochemistry Laboratory
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
Division of Anatomic Pathology
Hospital of the University of Pennsylvania
3400 Spruce Street, Six Founders
Philadelphia, PA 19104
Office: 215-662-6503


Specialty Division

Anatomic Pathology

Research Expertise

Various tumor markers in diagnostic and prognositc application. In-situ molecular morphometry in tumor diagnosis and prognosis. Hypoxia in sarcoma. Translational research in sarcoma. Growth factors receptors in breast cancer. Mechanism of lymphangionesis and lymphatic invasion in cancer. The significance and determination of host immunoresponse on surgical specimen in cancer patients' prognosis.

Clinical Expertise

Diagnostic pathology in soft tissue tumor, sarcoma and cancers of breast, GYN tract, pulmonary tract, ENT. Diagnostic immmunohistochemical and in-situ hybridization. Evaluation of tumor markers for personalized treatment in surgical specimen.

Itmat Expertise

Translation research by applying morphologic IHC and in-situ molecular evaluation in animal or human tissue samples. Correlation of various clinical and pathologic parameters to assess or validate hypothesis in clinical setting. Help to develop assay for clinical trials for targeted therapty.


M.D. Guangzhou Medical College, Canton, China, 1983

Specialty Certification

Diplomat of the American Board of Pathology in Combined Anatomic and Clinical Pathology, 1995

Postgraduate Training

Resident in Ophthalmology, The First Municipal Hospital of Canton, China, 1983-1985
Research Fellow at Hematology, UCSF VA Medical Center, San Francisco, CA, 1988-1989
Resident in Pathology (AP/CP), NYU Medical Center, New York, NY, 1989-1993
Fellow of Oncologic Pathology, Sloan-Kettering Memorial Cancer Center, New York, NY, 1993-1994

Awards and Honors

The James E Wheeler MD Award for Excellence in Anatomic Pathology Resident Training. Dept of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA June 14, 2007, 2007-2007

Memberships and Professional Organizations

United States and Canadian Academy of Pathology (USCAP), 1992 - Present
College of American Pathologists, 1993 - 1998
American Society of Clinical Pathologists (ASCP), 1994 - Present
Western New York Pathology Society, 1995 - 1996
Connective Tissue Oncology Society, 1996 - 2001
National Society of Histotechnology, 1997 - 2000
International Society of Bone and Soft Tissue Pathology, 2001 - Present
Pathology Society of Philadelphia, 2001 - 2007
Arthur Purdy Stout Society of Surgical Pathologists, 2001 - Present
American Association for the Advancement of Science, 2002 - 2004
Chinese American Pathologist Association, 2006 - 2010
Committee on Publication Ethics (COPE), 2011 - Present
International Skeletal Society, 2014 - Present

Selected Publications

WT1 is expressed in serous, but not in endometrioid, clear cell or mucinous carcinomas of the peritoneum, fallopian tube, ovaries and endometrium.

Ase G, Parash TL, Zhang PJ., Int J Gyn Pathol 23(): 110-118, 2004

Fibrillin and Other Matrix Proteins in Mitral Valve Prolapse Syndrome.

Nasuti, JF, Zhang PJ, Feldman M, MD, PhD, Pasha TL, Khurana JS, Gorman J, Gorman R, Narula J, and Narula N, Annals of Thoracic Surgery 77(): 532-535, 2004

Proliferation of D2-40-expressing intestinal lymphatic vessels in the lamina propria in inflammatory bowel disease

Fogt F, Pascha TL, Zhang PJ, Gausas RE, Rahemtulla A, Zimmerman RL, Int J Mol Med 13(): 221-214, 2004, PMID:14719125

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C-kit Immunoreactivity in Endometrial Adenocarcinomas and Its Clinicopathologic Significance.

Scobie JV, Acs G, Bandera CA, Blank SV, Wheeler JE, Pasha TL and Zhang PJ., Int J Gyn Pathol 22(2): 149-155, 2003, PMID:12649669

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The Role of Calretinin, Inhibin, Melan-A, BCL-2 and c-kit in differentiating Adrenal Cortical and Medullary Tumors, An Immunohistochemical Study.

PJ Zhang, EM Genega, JE Tomaszewski, TL Pasha, VA LiVolsi., Mod Pathol 16(6): 591-597, 2003

Immunophenotype of Desmoplastic Small Round Cell Tumors as Detected in Cases with EWS-WT1 Gene Fusion Product.

Zhang PJ, Goldblum JR, Pawel BR, Fisher C, Pasha TL, Barr FG., Mod Pathol 16(3): 229-235, 2003, PMID:12640103

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The Role of Different Immunostaining Patterns In Herceptest Interpretation and Their Correlation with Gene Amplification as Determined by Fluorescence in Situ Hybridization

Geza. Acs, Lynn Wang, Puthiyaveettil N. Raghunath, Marilyn A. Salscheider and Paul J. Zhang., Applied Immunohistolochemistry & Molecular Morphology 13(3): 222-229, 2003

Expression of Neurotrophin receptor Trk-C in nevi and melanomas, an immunohistochemical study.

Xu X, Tahan, SR and Zhang PJ., Journal of Cutaneous Pathology 30(5): 318-322, 2003

Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and tis potential role in cervical carcinogenesis and tumor progression.

Acs G, Zhang PJ, McGrath CM, Acs P, McBroom J, Mohyeldin A Liu S, Lu Huasheng and Verma A., Am J Pathol 162(6): 1790-1806, 2003

Various Growth Factors, Growth Factor Recptors in Juvenile Nasopharyngeal Angiofibroma; A Comparative Immunhistochemical Study with Nasal Polyps.

Zhang PJ, Liang HH, Pasha TL, Weber R, LiVolsi VA., Arch Pathol Lab Med. 127(11): 1480-1484, 2003