Nicole Alyse Aqui, MD
Associate Professor of Clinical Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Director, Pathology Residency Training Program
Chief of Transfusion and Apheresis Services
Contact Information3 White Building
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-4344
Fax: 215-662-6891
Specialty Division
Transfusion Medicine & Therapeutic Pathology
Research Expertise
Immune assessment, immune recovery
Clinical Expertise
Transfusion medicine, apheresis, blood banking, hematopoietic stem cell collection/processing
Education
B.S. (Cellular and Molecular Biology), University of Maryland College Park, 1996
M.D. (Medicine), University of Pennsylvania School of Medicine, 2001
Specialty Certification
Clinical Pathology, 2004
Postgraduate Training
Student Fellowship, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 1999-2000
Resident, Clinical Pathology, Hospital of the University of Pennsylvania, 2001-2004
Fellow, Patient Oriented Training Program, University of Pennsylvania, 2003-2004
Fellow, Division of Transfusion Medicine
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 2004-2005
Postdoctoral Research Fellow, University of Pennsylvania, 2005-2006
Awards and Honors
Medical Society of Eastern Pennsylvania Medical Student Award for Leadership and Community Service, 1999-1999
American Association of University Women Selected Professions Fellowship, 2000-2001
Charles Drew Award, University of Pennsylvania, 2001-2001
Helen O. Dickens Award, Perelman School of Medicine, 2001-2001
American Association of Blood Banks-Baxter Transfusion Medicine Fellow Award, 2004-2004
Multiple Myeloma Research Foundation Fellow's Award, 2004-2005
Best Abstract, International Society for Cellular Therapy Annual Meeting, 2009-2009
Gift of Life Award, Ree Wynn Foundation, 2015
Philadelphia Living Legend, Council of the City of Philadelphia, 2016
Memberships and Professional Organizations
College of American Pathologists, 2001 - 2010
International Society of Cellular Therapy, 2003 - Present
AABB (formerly the American Association of Blood Banks), 2004 - Present
American Society for Hematology, 2007 - Present
International Society for Biological Therapy of Cancer, 2009 - 2012
American Society for Apheresis, 2010 - present
American Red Cross, Penn-Jersey Blood Services Region, 2016 - present
Web Links
Selected Publications
Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma.
Rapoport Aaron P, Aqui Nicole A, Stadtmauer Edward A, Vogl Dan T, Fang Hong-Bin, Cai Ling, Janofsky Stephen, Chew Anne, Storek Jan, Akpek Gorgun, Badros Ashraf, Yanovich Saul, Tan Ming T, Veloso Elizabeth, Pasetti Marcela F, Cross Alan, Philip Sunita, Murphy Heather, Bhagat Rita, Zheng Zhaohui, Milliron Todd, Cotte Julio, Cannon Andrea, Levine Bruce L, Vonderheide Robert H, June Carl H, Blood 117(3): 788-97, 2011, PMID:21030558
Transfer of influenza vaccine-primed costimulated autologous T cells after stem cell transplantation for multiple myeloma leads to reconstitution of influenza immunity: results of a randomized clinical trial.
Stadtmauer Edward A, Vogl Dan T, Luning Prak Eline, Boyer Jean, Aqui Nicole A, Rapoport Aaron P, McDonald Kenyetta R, Hou Xiaoling, Murphy Heather, Bhagat Rita, Mangan Patricia A, Chew Anne, Veloso Elizabeth A, Levine Bruce L, Vonderheide Robert H, Jawad Abbas F, June Carl H, Sullivan Kathleen E, Blood 117(1): 63-71, 2011, PMID:20864577
Changes in regulatory T-cells in responding and non-responding patients with indolent B-cell or mantle cell lymphomas during treatment with lenalidomide, dexamethasone, and rituximab
N. Aqui, L. Leinbach, E. A. Chong, T. Ahmadi, J. Svoboda, A. Gordon, L. H. Downs, S. Nasta, S. J. Schuster, J Clin Oncol 28(suppl; abstr 8085): 7s, 2010
Rapid immune recovery and graft-versus-host disease-like engraftment syndrome following adoptive transfer of Costimulated autologous T cells.
Rapoport Aaron P, Stadtmauer Edward A, Aqui Nicole, Vogl Dan, Chew Anne, Fang Hong-Bin, Janofsky Stephen, Yager Kelly, Veloso Elizabeth, Zheng Zhaohui, Milliron Todd, Westphal Sandra, Cotte Julio, Huynh Hong, Cannon Andrea, Yanovich Saul, Akpek Gorgun, Tan Ming, Virts Kristen, Ruehle Kathleen, Harris Carolynn, Philip Sunita, Vonderheide Robert H, Levine Bruce L, June Carl H, Clinical Cancer Research 15(13): 4499-507, 2009, PMID:19509133
Post-transplant adoptive T-cell immunotherapy
Aqui NA, June CH, Best Pract Res Clin Haematol 21(3): 503-519, 2008, PMID:18790452
CD28 Costimulation is essential for human T regulatory expansion and function
Golovina T, Mikheeva T, Suhoski MM, Aqui NA, Tai VC, Shan X, Liu R, Balcarcel RR, Fisher N, Levine BL, Carroll RG, Blazar BR, June CH, Riley JL, Journal of Immunology 181(4): 2855-2868, 2008, PMID:18684977
Engineering artificial antigen presenting cells to express a diverse array of costimulatory molecules
Suhoski M, Golovina T, Aqui NA, Tai V, Varela-Rohena A, Milone MC, Carroll RG, Riley J, June CH, Molecular Therapy 15(5): 981-988, 2007, PMID:17375070
Posttransplant lymphoproliferative disorder in liver transplant recipients: A report of seventeen cases
Patel H, Vogl DT, Aqui N, Shaked A, Olthoff K, Markmann J, Reddy R, Stadtmauer EA, Schuster SJ, Tsai DE, Leukemia and Lymphoma 48(5): 885-891, 2007, PMID:17487731
Treatment of PTLD with rituximab or chemotherapy
Elstrom RL, Andreadis C, Aqui NA, Ahya VN, Bloom RD, Brozena SC, Olthoff KM, Schuster SJ, Nasta SD, Stadtmauer EA, Tsai DE, American Journal of Transplantation 6(3): 569-576, 2006, PMID:16468968
Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer
Rapoport AP*, Stadtmauer EA*, Aqui NA*, Badros A, Cotte J, Chrisley L, Veloso E, Zheng Z, Westphal S, Mair R, Chi N, Ratterree B, Pochran MF, Natt S, Hinkle J, Sickles C, Sohal A, Ruehle K, Lynch C, Zhang L, Porter DL, Luger S, Guo C, Fang HB, Blackwelder W, Hankey K, Mann D, Edelman R, Frasch C, Levine BL, Cross A, June CH, Nature Medicine 11(11): 1230-1237, 2005, PMID:16227990
