Adam Bagg, MD
Emeritus Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact InformationHospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
Division of Hematopathology
7.055 E. Gates Building
3400 Spruce Street
Philadelphia, PA 19104
Tel: 215-662-4280
Fax: 215-615-3931
Email: adambagg@pennmedicine.upenn.edu
Specialty Division
Hematopathology
Research Expertise
Molecular genetics and pathology of Leukemias and Lymphomas; Myelodysplastic syndromes; Castleman disease; Hodgkin lymphoma
Clinical Expertise
Laboratory Hematology; Laboratory Evaluation of Hematologic Diseases; Leukemias; Lymphomas; Myelodysplastic Syndromes; Myeloma; Molecular Pathology; Myeloma; Hodgkin lymphoma
Itmat Expertise
Dr. Bagg studies: (1) the diagnostic molecular pathology of hematologic neoplasms, with the development of novel assays to facilitate their diagnosis; and (2) unraveling the biology and improving the laboratory diagnosis of the myelodysplastic syndromes.
Other Expertise
Postgraduate education on Hematologic Neoplasms
Education
MBBCh (summa cum laude), University of the Witwatersrand, South Africa, Top 1% of graduating class, 1981
Specialty Certification
Hematology/Hematopathology, South African Medical and Dental Council, 1988
Clinical Pathology, American Board of Pathology, 1992
Hematology/Hematopathology, American Board of Pathology, 1999
Postgraduate Training
Intern in Internal Medicine and General Surgery, Johannesburg Hospital,
University of the Witwatersrand, Johannesburg, South Africa, 1982
Medical Officer in Internal Medicine, 1 Military Hospital, Pretoria, South Africa, 1983-84
Resident in Hematology/Hematopathology, University of the Witwatersrand and the
South African Institute for Medical Research, Johannesburg, 1985-88
Chief Resident in Pathology, School of Pathology, University of the Witwatersrand and the
South African Institute for Medical Research, 1987-88
Resident, Clinical Pathology, Georgetown University, Washington, D.C, 1989-92
Fellow, Hematopathology, Georgetown University, Washington, D.C, 1992-93
Awards and Honors
Alan Rubensohn Memorial Award, Most Distinguished 1st Year Medical Student, 1976
Isaac Kushlick Memorial Prize, Most Distinguished Student in Physics, 1976
Arthur Aitken Scholarship for Academic Merit, 1977-79
A.H. Wadee Memorial Medal, Most Distinguished Student in Anatomy, 1977
Convocation Merit Scholarship for Academic Achievement, 1977
Hajee Suliman Ebrahim Memorial Trust Gold Medal, Most Distinguished Student in Physiology, 1978
S.L. Sive Prize, Best Performance in Clinical Pathology, 1979
Dallas MacKenzie Prize, Most Distinguished Student in Community Pediatrics, 1981
Samuel and Sylvia Schnaid Scholarship for Academic Excellence, 1986-88
James Gear Prize, Most Distinguished Graduate Resident of the School of Pathology, University of the Witwatersrand & South African Institute for Medical Research, 1988
Cecil John Adams Memorial Trust Fellowship, 1989-91
South African Medical Research Council Overseas Post-Doctoral Scholarship, 1989-91
Watkins Pitchford Memorial Prize for Best Published Paper, South African Institute for Medical Research, 1989
Phyllis Knocker/Bradlow Award for Exceptional Performance in the National Specialty Board Examinatio, with subsequent contributions to basic or clinical research, College of Medicine of South Africa, 1991
Washington Society of Pathologists Award, Oral Presentation at Annual Meeting, 1991
Special Fellowship of the Leukemia Society of America, 1992-95
Golden Apple Award Nomination, Class of 1995, Georgetown University Medical School, 1993
Visiting Professorship, University of Iowa, 1995
Golden Apple Award Nomination, Class of 1998, Georgetown University Medical School, 1996
Teacher of the Year Award, Department of Pathology, Georgetown University, 1997
Golden Apple Award Nomination, Class of 2000, Georgetown University Medical School, 1998
Osler Institute (National Board Review) Teaching Award, Pathology Course Lecture - White Cell Disorders (for 1995, awarded 1998), 1998
Golden Apple Award Nomination, Class of 2001, Georgetown University Medical School, 1999
Callender-Binford Lectureship, Armed Forces Institute of Pathology, 1999
Kevin E. Salhany Resident Teaching Award, Dept. of Pathology & Laboratory Medicine, University of Pennsylvania, 2000
Research Recognition Award, Leukemia and Lymphoma Society of America, 2002
Teaching Award for National Board Review Course, Osler Institute, 2003
Senior Author on Poster for "Pathologist-In-Training" Award to Sindhu Cherian, Society of Hematopathology, USCAP Annual Meeting, 2004
"Outstanding Faculty," Dean’s Report, University of Pennsylvania School of Medicine, 2005
International Union Against Cancer (UICC, Geneva Switzerland) Award (NIH funded) to teach in China, 2006
Senior Author on Platform Presentation for the ”Paul E. Standjord Young Investigator Award for 2006” at the Annual Meeting of the Academy of Clinical Physicians and Scientists To Michele Roullet, MD, 2006
Faculty Sponsor for College of American Pathologists Foundation Advanced Training Grant to Kun Ru, MD, PhD, 2006
Visiting Professor, Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY, 2007
Teaching Award for National Board Review Course, Osler Institute, 2008
Annual Resident Lecture Award, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 2009
Senior Author on Presentation accepted/nominated for the Stowell Orbison Award at the Annual Meeting of the United States and Canadian Academy of Pathology, to Rebecca King, MD, 2009
Visiting Professor, University of New Mexico, 2009
America’s Top Doctors for Cancer, Castle Connolly, 2009
Top Doctor in Philadelphia, Philadelphia Magazine, 2010
America’s Top Doctors, Castle Connolly, 2010
Kevin E. Salhany Resident Teaching Award, Dept. of Pathology & Laboratory Medicine, University of Pennsylvania, 2010
America’s Top Doctors for Cancer, Castle Connolly, 2010
Top Doctor in Philadelphia, Philadelphia Magazine, 2011
America’s Top Doctors for Cancer, Castle Connolly, 2011
Top Doctor in Philadelphia, Philadelphia Magazine, 2012
Top 1% of Doctors in the United States, US News and World Report, 2012
Co-author on a top scoring abstract (platform presentation) at the Annual Meeting of the International Society for Laboratory Hematology, Nice, France, 2012
Visiting Professorship, Emory University, 2012
Co-author on the most downloaded manuscript in Science Translational Medicine in 2011, 2012
Co-Author on American Society of Hematology Abstract Achievement Award for a trainee presenter, 54th ASH Annual Meeting, Atlanta, GA, to Grant Nybakken, 2012
Visiting Professor, Stanford University, 2013
Top Doctor in America, US News and World Report, 2013
Visiting Professor, University of California, San Diego, 2013
Top Doctor in Philadelphia, Philadelphia Magazine, 2013
Outstanding Speaker Award, American Association of Clinical Chemistry, 2013
America’s Top Doctors for Cancer, Castle Connolly, 2014
First Prize in Pathology category, British Medical Association Book Award, for Knowles Neoplastic Hematopathology (in which I senior authored a chapter), 2014
Top Doctor in Philadelphia, Philadelphia Magazine, 2014
America’s Top Doctors, Castle Connolly, 2014
America's Top Doctors, Newsweek Magazine, 2015
Top Doctor in Philadelphia, Philadelphia Magazine, 2015
America’s Top Doctors, Castle Connolly, 2015
America’s Top Doctors for Cancer, Castle Connolly, 2015
Top Doctor in Philadelphia, Philadelphia Magazine, 2016
Top Doctor in Philadelphia, Philadelphia Magazine, 2017
Annual Resident Lecture Award, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 2017
A. James French Lectureship, University of Michigan, 2017
Visiting Professor, Brigham and Women’s Hospital, Harvard Medical School, 2018
Top Doctor in Philadelphia, Philadelphia Magazine, 2018
Annual Grand Rounds Lecture and Visiting Professor, Georgetown University Medical Center, 2019
Top Doctor in Philadelphia (only Hematopathologist in Philadelphia so recognized, 10th year in a row), Philadelphia Magazine, 2019
Visiting Professor, Yale University, 2019
Top Doctor in Philadelphia, Philadelphia Magazine, 2020
Keynote Speaker, Roderick Ross Research Day, St. Michael’s Hospital, University of Toronto, 2021
Grand Rounds, Society of Hematopathology, Inaugural Year, 2021
Top Doctor in Philadelphia, Philadelphia Magazine, 2021
Visiting Professor, Mayo Clinic, 2022
Top Doctor in Philadelphia, Philadelphia Magazine, 2022
Top Doctor in Philadelphia (only Hematopathologist in Philadelphia so recognized, 14th year in a row), Philadelphia Magazine, 2023
Grand Rounds, UCLA, 2023
Memberships and Professional Organizations
Society of Hematopathology, 1991-present
American Association for Cancer Research, 1993-99
American Society of Hematology, 1993-present
Clinical Immunology Society, 1994-99
--- Clinical Laboratory Immunology Committee, 1996-97
Association for Molecular Pathology, 1995-present
--- Hematopathology Representative on Clinical Practice Committee, 1996-97
--- Annual Meeting Program Committee, ad hoc 1998-present
--- Chair-Elect of Hematopathology Section, 1999
--- Chair of Hematopathology Section, 2000
--- Hematopathology Representative on Nominations Committee, 2001
--- BCR-ABL Reporting Subcommittee of Clinical Practice Committee, 2003-present
United States and Canadian Academy of Pathology, 1997-present
--- Education Committee, 2006-10
--- Steven Vogel Award Committee, 2007-10, 2016-18
--- Chair of Steven Vogel Award Committee, 2009-10
--- Benjamin Castleman Award Committee, 2010-12
--- Chair of Benjamin Castleman Award Committee, 2011-12
--- Stowell-Orbison Award Committee, 2010
--- Council/Board of Directors, 2011-14
College of American Pathologists, Local Laboratory Inspector, 1997-98, 2002
Inspector, Boca Raton Regional Hospital (Boca Raton, FL), Reviewer, 2005
National Institutes of Health, Expert Panel on Molecular Testing in Chronic Myelogenous Leukemia, 2005
America Society for Investigative Pathology, 2006-08
Amgen, Inc., International Advisory Panel on Hematologic Safety of a Novel Therapeutic Agent, 2006
Medical University of South Carolina (Charleston, SC), Academic Reviewer, 2008
Celgene and Genzyme Genetics, Round Table on Genetic Testing in High Risk Myeloma, 2009
Paroxysmal Nocturnal Hemoglobinuria Diagnostic Testing Advisory Board, 2010
Johns Hopkins University, Advisory Panel on Lymphoma and Myelodysplastic Syndrome Diagnosis and Therapy, 2010
Bone Marrow Pathology Group (Founding Member), 2011-present
Food and Drug Administration, Panelist in Workshop on Minimal Residue Disease as a Surrogate Endpoint in Acute Lymphoblastic Leukemia, 2012
ASCP-CAP-ASH Joint Guideline Development, Recommendations for the Work-up of Lymphoma Expert Panel, 2017-21
European Bone Marrow Working Group, 2019-present
International Consensus Classification of Lymphoid and Myeloid Neoplasms, Clinical Advisory Committee, 2021-present
Web Links
Selected Publications
Molecular Pathology of Hematologic Neoplasms
Duncavage E, Caponetti GC, Bagg A. Jaffe (ed): Hematopathology, 3rd Edition. Elsevier 2023.
Treatment consistent with idiopathic multicentric Castleman disease guidelines is associated with improved outcomes
Pierson SK, Lim MS, Srkalovic G, Brandstadter JD, Sarmiento Bustamante M, Shyamsundar S, Mango N, Lavery C, Austin B, Alapat D, Lechowicz MJ, Bagg A, Li H, Casper C, van Rhee F, Fajgenbaum DC. Blood Adv 7(21):6652-6664, Nov 2023. doi: 10.1182/bloodadvances.2023010745. PMID: 37656441; PMCID: PMC10637880.
Guide to the Diagnosis of Myeloid Neoplasms: A Bone Marrow Pathology Group Approach
Foucar K, Bagg A, Bueso-Ramos CE, George T, Hasserjian RP, Hsi ED, Orazi A, Tam W, Wang SA, Weinberg OK, Arber DA. Am J Clin Pathol 160(4):365-393, Oct 2023. doi: 10.1093/ajcp/aqad069. PMID: 37391178
VEXAS'd by lymphadenopathy: an unusual case of extramedullary hematopoiesis
Fenu EM, Bagg A. Blood 141(22):2784, Jun 2023. doi: 10.1182/blood.2023020012. PMID: 37261849.
TP53 in AML and MDS: The new (old) kid on the block
Marks JA, Wang X, Fenu EM, Bagg A, Lai C. Blood Rev 60:101055, Jul 2023. doi: 10.1016/j.blre.2023.101055. Epub 2023 Feb 14. PMID: 36841672.
Digital image analysis of erythroblastic islands in myelodysplastic syndromes
Zhang R, Drumheller B, Wang LP, Obstfeld AE, Lake JI, Bagg A. Int J Lab Hematol 45(3):289-296, Jun 2023. doi: 10.1111/ijlh.14001. Epub 2023 Mar 22. PMID: 36946202.
Triple-Negative Primary Myelofibrosis: A Bone Marrow Pathology Group Study
Al-Ghamdi YA, Lake J, Bagg A, Thakral B, Wang SA, Bueso-Ramos C, Masarova L, Verstovsek S, Rogers HJ, Hsi ED, Gralewski JH, Chabot-Richards D, George TI, Rets A, Hasserjian RP, Weinberg OK, Parilla M, Arber DA, Padilla O, Orazi A, Tam W. Mod Pathol 36(3):100016, Mar 2023. doi: 10.1016/j.modpat.2022.100016. Epub 2023 Jan 10. PMID: 36788093.
Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia
Duncavage EJ, Bagg A, Hasserjian RP, DiNardo CD, Godley LA, Iacobucci I, Jaiswal S, Malcovati L, Vannucchi AM, Patel KP, Arber DA, Arcila ME, Bejar R, Berliner N, Borowitz MJ, Branford S, Brown AL, Cargo CA, Döhner H, Falini B, Garcia-Manero G, Haferlach T, Hellström-Lindberg E, Kim AS, Klco JM, Komrokji R, Lee-Cheun Loh M, Loghavi S, Mullighan CG, Ogawa S, Orazi A, Papaemmanuil E, Reiter A, Ross DM, Savona M, Shimamura A, Skoda RC, Solé F, Stone RM, Tefferi A, Walter MJ, Wu D, Ebert BL, Cazzola M. Blood 140(21):2228-2247, Nov 2022. doi: 10.1182/blood.2022015853. PMID: 36130297; PMCID: PMC10488320.
Genomic profiling for clinical decision making in lymphoid neoplasms
de Leval L, Alizadeh AA, Bergsagel PL, Campo E, Davies A, Dogan A, Fitzgibbon J, Horwitz SM, Melnick AM, Morice WG, Morin RD, Nadel B, Pileri SA, Rosenquist R, Rossi D, Salaverria I, Steidl C, Treon SP, Zelenetz AD, Advani RH, Allen CE, Ansell SM, Chan WC, Cook JR, Cook LB, d'Amore F, Dirnhofer S, Dreyling M, Dunleavy K, Feldman AL, Fend F, Gaulard P, Ghia P, Gribben JG, Hermine O, Hodson DJ, Hsi ED, Inghirami G, Jaffe ES, Karube K, Kataoka K, Klapper W, Kim WS, King RL, Ko YH, LaCasce AS, Lenz G, Martin-Subero JI, Piris MA, Pittaluga S, Pasqualucci L, Quintanilla-Martinez L, Rodig SJ, Rosenwald A, Salles GA, San-Miguel J, Savage KJ, Sehn LH, Semenzato G, Staudt LM, Swerdlow SH, Tam CS, Trotman J, Vose JM, Weigert O, Wilson WH, Winter JN, Wu CJ, Zinzani PL, Zucca E, Bagg A, Scott DW. Blood 140(21): 2193-2227, Nov 2022. doi: 10.1182/blood.2022015854. PMID: 36001803; PMCID: PMC9837456.
International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data
Arber DA, Orazi A, Hasserjian RP, Borowitz MJ, Calvo KR, Kvasnicka HM, Wang SA, Bagg A, Barbui T, Branford S, Bueso-Ramos CE, Cortes JE, Dal Cin P, DiNardo CD, Dombret H, Duncavage EJ, Ebert BL, Estey EH, Facchetti F, Foucar K, Gangat N, Gianelli U, Godley LA, Gökbuget N, Gotlib J, Hellström-Lindberg E, Hobbs GS, Hoffman R, Jabbour EJ, Kiladjian JJ, Larson RA, Le Beau MM, Loh ML, Löwenberg B, Macintyre E, Malcovati L, Mullighan CG, Niemeyer C, Odenike OM, Ogawa S, Orfao A, Papaemmanuil E, Passamonti F, Porkka K, Pui CH, Radich JP, Reiter A, Rozman M, Rudelius M, Savona MR, Schiffer CA, Schmitt-Graeff A, Shimamura A, Sierra J, Stock WA, Stone RM, Tallman MS, Thiele J, Tien HF, Tzankov A, Vannucchi AM, Vyas P, Wei AH, Weinberg OK, Wierzbowska A, Cazzola M, Döhner H, Tefferi A. Blood 140(11):1200-1228, Sep 2022. doi: 10.1182/blood.2022015850. PMID: 35767897; PMCID: PMC9479031.
