MacLean Nasrallah, MD, PhD
Assistant Professor of Clinical Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Contact InformationHospital of the University of Pennsylvania
FO6.089
3400 Spruce St.
Philadelphia, PA 19104
Specialty Division
Neuropathology
Research Expertise
Brain development
Mouse models
In utero electroporation in mouse models
Molecular biology
Itmat Expertise
Brain tumors
Neuropathology and Genetic/molecular pathology advances
Clinical Expertise
Neuropathology
Molecular pathology of neuropathology
Education
AB (Mathematics), Harvard University, 1997
PhD (Neuroscience), University of Pennsylvania, 2010
MD University of Pennsylvania, 2012
Specialty Certification
Anatomic Pathology and Neuropathology, American Board of Pathology, 2016
Postgraduate Training
Resident in Anatomic Pathology, Hospital of the University of Pennsylvania, 2012-2014
Fellow in Neuropathology, Hospital of the University of Pennsylvania, 2014-2016
Awards and Honors
ASCP Academic Excellence and Achievement in Pathology award, 2012
Memberships and Professional Organizations
Association for Pathology Informatics, 2013 - 2015
American Society for Clinical Pathology, 2013 - 2016
United States and Canadian Academy of Pathology, 2013 - 2016
Association for Molecular Pathology, 2015 - 2017
American Association of Neuropathologists, 2015 - Present
Society for NeuroOncology, 2017 - Present
Web Links
Selected Publications
SETD2 mutations in primary central nervous system tumors.
Viaene AN, Santi M, Rosenbaum J, Li MM, Surrey LF, Nasrallah MP., Acta Neuropathologica Communications, 2018, PMID:30419952
Histopathologic quantification of viable tumor versus treatment effect in surgically resected recurrent glioblastoma.
Bagley SJ, Schwab RD, Nelson E, Viaene AN, Binder ZA, Lustig RA, O'Rourke DM, Brem S, Desai AS, Nasrallah MP., Journal of Neurooncology, 2018, PMID:30446903
Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development.
Binder ZA, Thorne AH, Bakas S, Wileyto EP, Bilello M, Akbari H, Rathore S, Ha SM, Zhang L, Ferguson CJ, Dahiya S, Bi WL, Reardon DA, Idbaih A, Felsberg J, Hentschel B, Weller M, Bagley SJ, Morrissette JJD, Nasrallah MP, Ma J, Zanca C, Scott AM, Orellana L, Davatzikos C, Furnari FB, O'Rourke DM, Cancer Cell, 2018, PMID:29990498
In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature.
Akbari H, Bakas S, Pisapia JM, Nasrallah MP, Rozycki M, Martinez-Lage M, Morrissette JJD, Dahmane N, O'Rourke DM, Davatzikos C., Neuro Oncol, 2018, PMID:29617843
Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1.
Rathore S, Akbari H, Rozycki M, Abdullah KG, Nasrallah MP, Binder ZA, Davuluri RV, Lustig RA, Dahmane N, Bilello M, O'Rourke DM, Davatzikos C, Scientific Reports, 2018
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot JM, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV, Sci Transl Med 9(): 399, 2017, PMID:28724573
The second window ICG technique demonstrates a broad plateau period for near infrared fluorescence tumor contrast in glioblastoma
Zeh R, Sheikh S, Xia L, Pierce J, Newton A, Predina J, Cho S, Nasrallah M, Singhal S, Dorsey J, Lee JYK, PLoS One 12(7): e0182034, 2017, PMID:28738091
Folate Receptor Overexpression in Human and Canine Meningiomas-Immunohistochemistry and Case Report of Intraoperative Molecular Imaging.
Pierce JT, Cho SS, Nag S, Zeh R, Jeon J, Holt D, Durham A, Nasrallah MP, Singhal S, Lee JYK., Neurosurgery, 2018, PMID:30113687
Folate Receptor Near-Infrared Optical Imaging Provides Sensitive and Specific Intraoperative Visualization of Nonfunctional Pituitary Adenomas.
Cho SS, Zeh R, Pierce JT, Jeon J, Nasrallah M, Adappa ND, Palmer JN, Newman JG, White C, Kharlip J, Snyder P, Low P, Singhal S, Grady MS, Lee JYK., Oper Neurosurg, 2018, PMID:29635300
Lis1 is necessary for normal non-radial migration of inhibitory interneurons
McManus MF, Nasrallah IM, Pancoast MM, Wynshaw-Boris A, Golden JA, Am J Pathol 165(3): 775-84, 2004, PMID:15331402
Non-invasive detection of 2-hydroxyglutarate in IDH-mutated gliomas using two-dimensional localized correlation spectroscopy (2D L-COSY) at 7 Tesla
Verma G, Mohan S, Nasrallah MP, Brem S, Lee JY, Chawla S, Wang S, Nagarajan R, Thomas MA, Poptani H, J Transl Med 14(1): 274, 2016, PMID:27659543
Comparison of chemoradiotherapy with radiotherapy alone for "biopsy only" anaplastic astrocytoma
Wu J, Zou T, Bai HX, Li X, Zhang Z, Xiao B, Nasrallah M, Karakousis G, Cao Y, Zhang PJ, Yang L, Oncotarget 8(40): 69038-69046, 2017, PMID:28978179
Developmental interneuron subtype deficits after targeted loss of Arx
Marsh ED, Nasrallah MP, Walsh C, Murray KA, Nicole Sunnen C, McCoy A, Golden JA, BMC Neurosci 17(1): 35, 2016, PMID:27287386
19-year-old male with headaches and a possible seizure
Nasrallah MP, Nasrallah IM, Prelack MS, Johnson MO, Lewis TB, Rubenstein M, Minturn JE, Desai A, Marcotte P, Santi M, Martinez-Lage M, Brain Pathol 27(4): 557-558, 2017, PMID:28585383
Adult-Onset Myopathy in a Patient with Hypomorphic RAG2 Mutations and Combined Immune Deficiency.
Henrickson SE, Walter JE, Quinn C, Kanakry JA, Bardakjian T, Dimitrova D, Ujhazi B, Csomos K, Bosticardo M, Dobbs K, Nasrallah M, Notarangelo LD, Holland SM, Fadugba O., Journal of Clinical Immunology, 2018, PMID:30159811
Intramedullary recurrence of a thoracic meningioma-presentation of an unusual case and review of the literature
Piazza MA, Ramayya AG, Geiger GA, Alonso-Basanta M, Nasrallah MP, Welch WC, Ozturk AK, World Neurosurg 92(): 588, 2016, PMID:26852709
Perilesional hyperintensity on T1-weighted images in intra-axial brain masses other than cavernous malformations
Nabavizadeh SA, Pechersky D, Schmitt JE, Nasrallah M, Wolf R, Loevner L, Mamourian AC, J Neuroimaging 5(): 531-538, 2017, PMID:28098958
Distinct DNA binding and transcriptional repression characteristics related to different ARX mutations
Cho G, Nasrallah MP, Lim Y, Golden JA, Neurogenetics 13(1): 23-9, 2012, PMID:22252899
Interneuron deficits in patients with the Miller-Dieker syndrome
Pancoast M, Dobyns W, Golden JA, Acta Neuropathol 109(4): 400-4, 2005, PMID:15739099
Analysis of non-radial interneuron migration dynamics and its disruption in Lis1+/- mice
Nasrallah IM, McManus MF, Pancoast MM, Wynshaw-Boris A, Golden JA, J Comp Neurol 496(6): 847-58, 2006, PMID:16628622
Differential effects of a polyalanine tract expansion in Arx on neural development and gene expression
Nasrallah MP, Cho G, Simonet JC, Putt ME, Kitamura K, Golden JA, Hum Mol Genet 21(5): 1090-8, 2012, PMID:22108177
Differentiation of brain infection from necrotic glioblastoma using combined analysis of diffusion and perfusion MRI.
Chawla S, Wang S, Mohan S, Nasrallah M, Verma G, Brem S, O'Rourke DM, Wolf RL, Poptani H, Nabavizadeh SA., J Magn Reson Imaging, 2018, PMID:29676844
