Douglas B. Cines, MD
Professor of Pathology and Laboratory Medicine
Professor of Medicine
Perelman School of Medicine at the University of Pennsylvania
Attending Physician, Coagulation Laboratory
Contact InformationPerelman School of Medicine at the University of Pennsylvania
Department of Pathology and Laboratory Medicine
Stellar-Chance Laboratories, Rm. 513A
422 Curie Blvd.
Philadelphia, PA 19104
Email: dcines@pennmedicine.upenn.edu
Specialty Division
Laboratory Medicine, Cancer and Immunobiology
Research Expertise
Thrombosis, fibrinolysis, vascular biology, immunohematology
Clinical Expertise
Coagulation, immune hematological disorders
Itmat Expertise
Dr. Cines works on the delivery of plasminogen activators, among other therapeutics, for the prevention and treatment of thrombotic disorders.
Education
AB (History, Pre-Med), New York University, 1968
MD (Medicine), New York University School of Medicine, 1972
Specialty Certification
Internal Medicine, American Board of Internal Medicine, 1975
Hematology, American Board of Internal Medicine, 1980
Postgraduate Training
Intern, Medicine, N.C. Memorial Hospital, Chapel Hill, NC, 1972-73
Resident, Medicine, N.C. Memorial Hospital, Chapel Hill, NC, 1973-75
Fellow, Hematology-Oncology, Hospital of the University of Pennsylvania, 1975-78
Awards and Honors
Phi Beta Kappa , Alpha Omega Alpha, New York University Scholar, 1968
NIH Research Career Development Award, 1979
American Society of Clinical Investigation, 1986
American Federation for Clinical Research, 1986
Visiting Scientist, Roche Institute Molecular Biology, 1990-1992
Academy of Clinical Laboratory Physicians and Scientists, 1990
Association of American Physicians, 1995
American Association of University Pathologists, 1995
John Morgan Society, 1995
Biennial Award for Contributions to Hemostasis Research (BACH), International Society on Thrombosis and Haemostasis (ISTH), 2017
Platelet Disorder Support Association Robert C McMillan Award, 2021
Henry Stratton Medal (basic sciences) American Society of Hematology, 2024
Memberships and Professional Organizations
American Society of Hematology, 1980-present
American Association for the Advancement of Science, 1980-present
American Federation for Clinical Research, 1980-present
Immunology Graduate Group (IGG), University of Pennsylvania, 1984-94
Medical Faculty Senate, University of Pennsylvania
-------- Steering Committee, 1985-88
-------- Chairman, 1986-87
American Society of Hematology, 1986-91
Cell Biology Graduate Group, University of Pennsylvania, 1986-2000
Lupus Foundation of Philadelphia/Delaware Valley, Medical Advisory Board, 1986-2006
American Society of Hematology, 1986-present
-------- Scientific Subcommittee, Immunohematology, 1986-91
-------- Practice Guidelines Subcommittee – ITP, 1992-93
-------- Scientific Committee, Laboratory Medicine, Chair, 1999-2002
-------- ASH Small Meetings Oversight Committee, 2010-present
-------- Consult a Colleague Program, 2012-present
-------- ITP Guideline Panel, 2015-present
-------- HIT Guideline Panel, 2015-present
University Senate, Executive Council, University of Pennsylvania, 1988-90
Philadelphia Hematology Society, 1992-2000
-------- President, 1996
Anticoagulation Task Force, Hospital of the University of Pennsylvania, 2000-present
International Society on Thrombosis and Haemostasis, 2000-06, 2007-12
-------- Scientific & Standardization Committee, Platelet Immunology, 2000-06; Chair, 2006
-------- Platelet Program Subcommittee, 2007-12
Federation of Clinical Immunology Societies, Immunohematology Subcommittee, Chair, 2002-present
American Association of Immunologists, 2004-present
Platelet Disorder Support Association, Medical Advisory Board, 2004-present
US Food and Drug Administration, Ad Hoc Consultant, 2004-05
US Department of Justice, Vaccine Division, Ad Hoc Consultant, 2011-12
American Society Hematology Thrombocytopenia, Education Committee, 2019-present
Web Links
Selected Publications
Packaging of supplemented urokinase into naked alpha-granules of in vitro -grown megakaryocytes for targeted therapeutic delivery
Poncz M, Zaitsev SV, Ahn H, Kowalska MA, Bdeir K, Camire RM, Cines DB, Stepanova V. bioRxiv [Preprint]. 2023 Dec 5:2023.12.05.570278. doi: 10.1101/2023.12.05.570278. PMID: 38106191; PMCID: PMC10723305.
Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury
Ngo AT, Skidmore A, Oberg J, Yarovoi I, Sarkar A, Levine N, Bochenek V, Zhao G, Rauova L, Kowalska MA, Eckart K, Mangalmurti NS, Rux A, Cines DB, Poncz M, Gollomp K. JCI Insight 8(22):e171054, Nov 2023. doi: 10.1172/jci.insight.171054. PMID: 37991024; PMCID: PMC10721321.
Pathogenesis of refractory ITP: Overview
Cines DB. Br J Haematol 203(1):10-16, Oct 2023. doi: 10.1111/bjh.19083. PMID: 37735546; PMCID: PMC10539016.
PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hypertension
Kudryashova TV, Zaitsev S, Jiang L, Buckley BJ, McGuckin JP, Goncharov D, Zhyvylo I, Lin D, Newcomb G, Piper B, Bogamuwa S, Saiyed A, Teos L, Ranson M, Wolters PJ, Kelso MJ, Poncz M, DeLisser HM, Cines DB, Goncharova EA, Farkas L, Stepanova V. bioRxiv [Preprint]. 2023 Sep 22:2023.09.21.558893. doi: 10.1101/2023.09.21.558893. PMID: 37790328; PMCID: PMC10542168.
Management of Primary Immune Thrombocytopenia in Pregnancy
Bussel JB, Hou M, Cines DB. N Engl J Med 389(6):540-548, Aug 2023. doi: 10.1056/NEJMra2214617. PMID: 37590449.
Treatment of thrombocytopenia and thrombosis in HIT in mice using deglycosylated KKO: a novel therapeutic?
Sarkar A, Khandelwal S, Koma GT, Kim H, Gruel Y, Rollin J, Passam F, Wool GD, Arepally GM, Cines DB, Rauova L, Poncz M. Blood Adv 7(15):4112-4123, Aug 2023. doi: 10.1182/bloodadvances.2023009661. PMID: 37196641; PMCID: PMC10388731.
Vaccine-induced immune thrombotic thrombocytopenia
Cines DB, Greinacher A. Blood 141(14):1659-1665, Apr 2023. doi: 10.1182/blood.2022017696. PMID: 36669155; PMCID: PMC9870607.
Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia
Cai Z, Bdeir K, Yarovoi SV, Rauova L, Arepally GM, Khandelwal S, Rollin J, Gruel Y, Zaitsev S, Poncz M, Greene MI, Cines DB. J Thromb Haemost 21(3):652-666, Mar 2023. doi: 10.1016/j.jtha.2022.11.043. Epub 2022 Dec 22. PMID: 36696211.
Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury
Ngo ATP, Sarkar A, Yarovoi I, Levine ND, Bochenek V, Zhao G, Rauova L, Kowalska MA, Eckart K, Mangalmurti NS, Rux A, Cines DB, Poncz M, Gollomp K. bioRxiv [Preprint]. 2023 Jan 9:2023.01.09.522931. doi: 10.1101/2023.01.09.522931. Update in: JCI Insight. 2023 Nov 22;8(22): PMID: 36711969; PMCID: PMC9881987.
Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts
Le HT, Golla K, Karimi R, Hughes MR, Lakschevitz F, Cines DB, Kowalska MA, Poncz M, McNagny KM, Häkkinen L, Kim H. Sci Rep 12(1):18636, Nov 2022. doi: 10.1038/s41598-022-19850-w. PMID: 36329090; PMCID: PMC9633774.
