PEOPLE

Douglas B. Cines, MD

Professor of Pathology and Laboratory Medicine
Professor of Medicine
Perelman School of Medicine at the University of Pennsylvania 

Attending Physician, Coagulation Laboratory

Contact InformationPerelman School of Medicine at the University of Pennsylvania
Department of Pathology and Laboratory Medicine
Stellar-Chance Laboratories, Rm. 513A
422 Curie Blvd.
Philadelphia, PA 19104
Email: dcines@pennmedicine.upenn.edu

Specialty Division

Laboratory Medicine, Cancer and Immunobiology

Research Expertise

Thrombosis, fibrinolysis, vascular biology, immunohematology

Clinical Expertise

Coagulation, immune hematological disorders

Itmat Expertise

Dr. Cines works on the delivery of plasminogen activators, among other therapeutics, for the prevention and treatment of thrombotic disorders.

Education

AB (History, Pre-Med), New York University, 1968
MD (Medicine), New York University School of Medicine, 1972

Specialty Certification

Internal Medicine, American Board of Internal Medicine, 1975
Hematology, American Board of Internal Medicine, 1980

Postgraduate Training

Intern, Medicine, N.C. Memorial Hospital, Chapel Hill, NC, 1972-73
Resident, Medicine, N.C. Memorial Hospital, Chapel Hill, NC, 1973-75
Fellow, Hematology-Oncology, Hospital of the University of Pennsylvania, 1975-78

Awards and Honors

Phi Beta Kappa , Alpha Omega Alpha, New York University Scholar, 1968
NIH Research Career Development Award, 1979
American Federation for Clinical Research, 1986
American Society of Clinical Investigation, 1986
Academy of Clinical Laboratory Physicians and Scientists, 1990
Visiting Scientist, Roche Institute Molecular Biology, 1990-1992
John Morgan Society, 1995
American Association of University Pathologists, 1995
Association of American Physicians, 1995
Biennial Award for Contributions to Hemostasis Research (BACH), International Society on Thrombosis and Haemostasis (ISTH), 2017
Platelet Disorder Support Association Robert C McMillan Award, 2021

Memberships and Professional Organizations

American Society of Hematology, 1980-present
American Association for the Advancement of Science, 1980-present
American Federation for Clinical Research, 1980-present
Immunology Graduate Group (IGG), University of Pennsylvania, 1984-94
Medical Faculty Senate, University of Pennsylvania
-------- Steering Committee, 1985-88
-------- Chairman, 1986-87
American Society of Hematology, 1986-91
Cell Biology Graduate Group, University of Pennsylvania, 1986-2000
Lupus Foundation of Philadelphia/Delaware Valley, Medical Advisory Board, 1986-2006
American Society of Hematology, 1986-present
-------- Scientific Subcommittee, Immunohematology, 1986-91
-------- Practice Guidelines Subcommittee – ITP, 1992-93
-------- Scientific Committee, Laboratory Medicine, Chair, 1999-2002
-------- ASH Small Meetings Oversight Committee, 2010-present
-------- Consult a Colleague Program, 2012-present
-------- ITP Guideline Panel, 2015-present
-------- HIT Guideline Panel, 2015-present
University Senate, Executive Council, University of Pennsylvania, 1988-90
Philadelphia Hematology Society, 1992-2000
-------- President, 1996
Anticoagulation Task Force, Hospital of the University of Pennsylvania, 2000-present
International Society on Thrombosis and Haemostasis, 2000-06, 2007-12
-------- Scientific & Standardization Committee, Platelet Immunology, 2000-06; Chair, 2006
-------- Platelet Program Subcommittee, 2007-12
Federation of Clinical Immunology Societies, Immunohematology Subcommittee, Chair, 2002-present
American Association of Immunologists, 2004-present
Platelet Disorder Support Association, Medical Advisory Board, 2004-present
US Food and Drug Administration, Ad Hoc Consultant, 2004-05
US Department of Justice, Vaccine Division, Ad Hoc Consultant, 2011-12
American Society Hematology Thrombocytopenia, Education Committee, 2019-present

Web Links


Selected Publications

Packaging of supplemented urokinase into naked alpha-granules of in vitro -grown megakaryocytes for targeted therapeutic delivery

Poncz M, Zaitsev SV, Ahn H, Kowalska MA, Bdeir K, Camire RM, Cines DB, Stepanova V. bioRxiv [Preprint]. 2023 Dec 5:2023.12.05.570278. doi: 10.1101/2023.12.05.570278. PMID: 38106191; PMCID: PMC10723305.

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Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury

Ngo AT, Skidmore A, Oberg J, Yarovoi I, Sarkar A, Levine N, Bochenek V, Zhao G, Rauova L, Kowalska MA, Eckart K, Mangalmurti NS, Rux A, Cines DB, Poncz M, Gollomp K. JCI Insight 8(22):e171054, Nov 2023. doi: 10.1172/jci.insight.171054. PMID: 37991024; PMCID: PMC10721321.

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Pathogenesis of refractory ITP: Overview

Cines DB. Br J Haematol 203(1):10-16, Oct 2023. doi: 10.1111/bjh.19083. PMID: 37735546; PMCID: PMC10539016.

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PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hypertension

Kudryashova TV, Zaitsev S, Jiang L, Buckley BJ, McGuckin JP, Goncharov D, Zhyvylo I, Lin D, Newcomb G, Piper B, Bogamuwa S, Saiyed A, Teos L, Ranson M, Wolters PJ, Kelso MJ, Poncz M, DeLisser HM, Cines DB, Goncharova EA, Farkas L, Stepanova V. bioRxiv [Preprint]. 2023 Sep 22:2023.09.21.558893. doi: 10.1101/2023.09.21.558893. PMID: 37790328; PMCID: PMC10542168.

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Management of Primary Immune Thrombocytopenia in Pregnancy

Bussel JB, Hou M, Cines DB. N Engl J Med 389(6):540-548, Aug 2023. doi: 10.1056/NEJMra2214617. PMID: 37590449.

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Treatment of thrombocytopenia and thrombosis in HIT in mice using deglycosylated KKO: a novel therapeutic?  

Sarkar A, Khandelwal S, Koma GT, Kim H, Gruel Y, Rollin J, Passam F, Wool GD, Arepally GM, Cines DB, Rauova L, Poncz M. Blood Adv 7(15):4112-4123, Aug 2023. doi: 10.1182/bloodadvances.2023009661. PMID: 37196641; PMCID: PMC10388731.

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Vaccine-induced immune thrombotic thrombocytopenia

Cines DB, Greinacher A. Blood 141(14):1659-1665, Apr 2023. doi: 10.1182/blood.2022017696. PMID: 36669155; PMCID: PMC9870607.

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Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia

Cai Z, Bdeir K, Yarovoi SV, Rauova L, Arepally GM, Khandelwal S, Rollin J, Gruel Y, Zaitsev S, Poncz M, Greene MI, Cines DB. J Thromb Haemost 21(3):652-666, Mar 2023. doi: 10.1016/j.jtha.2022.11.043. Epub 2022 Dec 22. PMID: 36696211.

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Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury 

Ngo ATP, Sarkar A, Yarovoi I, Levine ND, Bochenek V, Zhao G, Rauova L, Kowalska MA, Eckart K, Mangalmurti NS, Rux A, Cines DB, Poncz M, Gollomp K. bioRxiv [Preprint]. 2023 Jan 9:2023.01.09.522931. doi: 10.1101/2023.01.09.522931. Update in: JCI Insight. 2023 Nov 22;8(22): PMID: 36711969; PMCID: PMC9881987.

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Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts

Le HT, Golla K, Karimi R, Hughes MR, Lakschevitz F, Cines DB, Kowalska MA, Poncz M, McNagny KM, Häkkinen L, Kim H. Sci Rep 12(1):18636, Nov 2022. doi: 10.1038/s41598-022-19850-w. PMID: 36329090; PMCID: PMC9633774.

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