Douglas B. Cines, MD

Professor of Pathology and Laboratory Medicine
Professor of Medicine
Perelman School of Medicine at the University of Pennsylvania 
Director, Coagulation Laboratory

Contact InformationDept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104

Office: 215-662-3966
Fax: 215-573-2012


Specialty Division

Laboratory Medicine, Immunobiology and Experimental Pathology

Research Expertise

Thrombosis, fibrinolysis, vascular biology, immunohematology

Clinical Expertise

Coagulation, immune hematological disorders

Itmat Expertise

Dr. Cines works on the delivery of plasminogen activators, among other therapeutics, for the prevention and treatment of thrombotic disorders.


A.B. (History, PreMed), New York University, 1968
M.D. (Medicine), New York University School of Medicine, 1972

Specialty Certification

American Board of Internal Medicine, 1975
American Board of Internal Medicine (Hematology), 1980

Postgraduate Training

Intern in Medicine, N.C., Memorial Hospital, Chapel Hill, NC, 1972-1973
Resident in Medicine, N.C, Memorial Hospital, Chapel Hill, NC, 1973-1975
Fellow, Hematology-Oncology, Hospital of the University of Pennsylvania, 1975-1978

Awards and Honors

Phi Beta Kappa , Alpha Omega Alpha, New York University Scholar, 1968
NIH Research Career Development Award, 1979
American Society of Clinical Investigation, 1986
American Federation for Clinical Research, 1986
Academy of Clinical Laboratory Physicians and Scientists, 1990
Visiting Scientist, Roche Institute Molecular Biology, 1990-1992
John Morgan Society, 1995
American Association of University Pathologists, 1995
Association of American Physicians, 1995
Biennial Award for Contributions to Hemostasis Research (BACH), International Society on Thrombosis and Haemostasis (ISTH), 2017

Memberships and Professional Organizations

American Federation for Clinical Research, 1980 - Present
American Association for the Advancement of Science, 1980 - Present
American Society of Hematology, 1980 - Present
Lupus Foundation of Philadelphia/Del. Valley, 1986 - 2006
American Society of Hematology, 1986 - 1991
American Society of Hematology, 1992 - 1993
Philadelphia Hematology Society, 1992 - 2000
American Society of Hematology, 1999 - 2002
International Society on Thrombosis and Haemostasis., 2000 - 2006
Federation of Clinical Immunology Societies, 2002 - Present
Platelet Disorder Support Association, 2004 - Present
US Food and Drug Administration, 2004 - 2005
American Association of Immunologists, 2004 - Present
International Society of Thrombosis and Haemostasis., 2007 - 2012
American Society of Hematology, 2010 - 2012
US Department of Justice, Vaccine Division, 2011 - 2012
American Society of Hematology, 2012 - Present
American Society of Hematology, 2015 - Present
American Society of Hematology, 2015 - Present
Am. Soc. Hematol. Thrombocytopenia, 2019 - Present

Web Links

Selected Publications

Thrombocytopenia in pregnancy: Diagnosis and approach to management.

Pishko, A., Levine. L.R. and Cines, D.B., Blood Reviews, 2020

Platelet factor 4-von Willebrand factor complexes are immunogenic and prothrombotic in heparin-induced thrombocytopenia.

250. Johnson, I., Hayes, V., Sarkar, A., Arepally, G.M., Chung, D.W., Lopez, J.A., Cines, D.B., Rauova, L. and Poncz, M, Blood 135(15): 1270-1280, 2020

Opposing effects of HNP1 (α-defensin-1) on plasma cholesterol and atherogenesis.

252. Higazi M, Abdeen S, Abu-Fanne R, Heyman SN, Masarwy A, Bdeir K, Maraga E, Cines DB, Higazi AA, PLOS One 15(4): , 2020

The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli.

Chernysh IN, Nagaswami C, Kosolapova S, Peshkova AD, Cuker A, Cines DB, Cambor CL, Litvinov RI, Weisel JW, Scientific Reports 10(1): 5112, 2020

FcRn augments induction of tissue factor activity by IgG-containing immune complexes.

251. Cines, D.B., Zaitsev, S., Rauova, L., Rux, A., Stepanova, V., Krishnaswamy, S., Sarkar, A., Kowalska, M.A., Zhao, G., Mast, A.E., Blumberg, L.J., McCrae, K.R., Poncz, M. Hubbard, J.J., Pyzik, M., and Blumberg, R.S., Blood, 2020

COVID-ARDS Clarified: A vascular endotype?

114. Vaughan, A.E., Reilly, J.P., Cines, D.B., Meyer, N.J., and Mangalmurti, N.S., American Journal of Respiratory Critical Care Medicine, 2020

Effect of Synthetic Inhibitors on HIT Antigenic Complex - Therapeutic Approach Alternative to Anticoagulation.

101. Kizhakkedathu, J.N., La, C., Kalathottukaren, M.T., Yarovoi, S.V., Hayes, V., Koma, G.T., Abbina, S, Morrissey, J.H., Haynes, C.A., Cines, D.B., and Rauova, L., ISTH, 2020

Pathogenesis of heparin-induced thrombocytopenia

113. Arepally, G. and Cines, D.B, Translational Research 14(): , 2020

Diagnosing HIT: The need for speed

Cuker, A and Cines, DB, Blood, 2020

Urokinase-type plasminogen activator (uPA)-deficient TSC2-null tumor cells are more sensitive to the estrogen antagonist tamoxifen

Zeitsev, S.V., Tsang, J., Krymskata V.P., Cines, D.B. and Stepanova, V., LAM foundation, 2020