Douglas B. Cines, MD

Professor of Pathology and Laboratory Medicine
Professor of Medicine
Perelman School of Medicine at the University of Pennsylvania 
Director, Coagulation Laboratory

Contact InformationDept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104

Office: 215-662-3966
Fax: 215-573-2012


Specialty Division

Laboratory Medicine, Immunobiology and Experimental Pathology

Research Expertise

Thrombosis, fibrinolysis, vascular biology, immunohematology

Clinical Expertise

Coagulation, immune hematological disorders

Itmat Expertise

Dr. Cines works on the delivery of plasminogen activators, among other therapeutics, for the prevention and treatment of thrombotic disorders.


A.B. (History, PreMed), New York University, 1968
M.D. (Medicine), New York University School of Medicine, 1972

Specialty Certification

American Board of Internal Medicine, 1975
American Board of Internal Medicine (Hematology), 1980

Postgraduate Training

Intern in Medicine, N.C., Memorial Hospital, Chapel Hill, NC, 1972-1973
Resident in Medicine, N.C, Memorial Hospital, Chapel Hill, NC, 1973-1975
Fellow, Hematology-Oncology, Hospital of the University of Pennsylvania, 1975-1978

Awards and Honors

Phi Beta Kappa , Alpha Omega Alpha, New York University Scholar, 1968
NIH Research Career Development Award, 1979
American Society of Clinical Investigation, 1986
American Federation for Clinical Research, 1986
Academy of Clinical Laboratory Physicians and Scientists, 1990
Visiting Scientist, Roche Institute Molecular Biology, 1990-1992
American Association of University Pathologists, 1995
Association of American Physicians, 1995
John Morgan Society, 1995
Biennial Award for Contributions to Hemostasis Research (BACH), International Society on Thrombosis and Haemostasis (ISTH), 2017

Memberships and Professional Organizations

American Society of Hematology, 1980 - Present
American Federation for Clinical Research, 1980 - Present
American Association for the Advancement of Science, 1980 - Present
American Society of Hematology, 1986 - 1991
Lupus Foundation of Philadelphia/Del. Valley, 1986 - 2006
Philadelphia Hematology Society, 1992 - 2000
American Society of Hematology, 1992 - 1993
American Society of Hematology, 1999 - 2002
International Society on Thrombosis and Haemostasis., 2000 - 2006
Federation of Clinical Immunology Societies, 2002 - Present
US Food and Drug Administration, 2004 - 2005
American Association of Immunologists, 2004 - Present
Platelet Disorder Support Association, 2004 - Present
International Society of Thrombosis and Haemostasis., 2007 - 2012
American Society of Hematology, 2010 - 2012
US Department of Justice, Vaccine Division, 2011 - 2012
American Society of Hematology, 2012 - Present
American Society of Hematology, 2015 - Present
American Society of Hematology, 2015 - Present
Am. Soc. Hematol. Thrombocytopenia, 2019 - Present

Web Links

Selected Publications

Divergent impact of tocilizumab and colchicine in COVID-19-associated coagulopathy: The role of alpha-defensins.

Abdeen S, Abu-Fanne R, Bdeir Kh, Marags E, Higazi M, Cines DB, Heyma SN, and Higazi, AA-R., Br J Haematol, 2021

Mesenchymal stromal cells enhance self-assembly of a HUVEC tubular network through uPA-uPAR/VEGFR2/integrin/NOTCH crosstalk.

Beloglazova, I., Stepanova, V., Zubkovaa, E., Dergilev, K., Koptelova, N., Tyurin-Kuzmin, P.A., Dyikanov, D., Plekhanova, O., Cines, D.B., Mazar, A.P., Yelena Parfyonova, Y., BBA-Mol Cell Res. 1869(1): , 2021

Erythrocytes reveal complement activation in patients with COVID-19.

Lam, L.K.M., Reilly, J.P., Rux A.H. Murphy, S.J., Kuri-Cervantes, L., Weisman, A.R., Ittner, C.A.G., Pampena, M.B., Pampena, M.B., Betts., M.R., Wherry, E.J., Song, W.-C., Lambris, J.D., Cines, D.B., Meyer, N.J., Mangalmurti, N.S., American Journal of Physiology-Lung Cellular and Molecular Physiology., 2021

Alpha-defensins: Risk factor for thrombosis in COVID-19 infection.

Abdeen, S., Bdeir, Kh., Abu-Fanne, R., Maraga, E., HigazI, M.,. Khurram, N., Feldman, M., Deshpande, C., Litzky, L.A., Heyman, S.N., Montone, K.T., CineS, D.B., and HigaI, AR., Brit. J. Haematol. 194(1): , 2021

SARS-CoV-2 Vaccine–induced immune thrombotic thrombocytopenia (VITT).

Cines, D.B. and Bussel, J.B., New Eng. J. Med. 384(23): 2254-2256, 2021

Complement mediates binding and procoagulant effects of ultra-large HIT immune complexes.

Khandelwal, S., Rauova, L., Rux, A., Yarovoi S., Zaytsev, S., Myoung, S., Johnson, A, Barnes, A., Lee, G.M., Duarte, M., Poncz, M., Arepally, G.M., Cines,D.B., Blood, 2021

Covid-19 vaccination and immune thrombocytopenia.

Pishko, A., Bussel, J.B. and Cines, D.B., Nature Medicine 27(7): , 2021

Precision targeting of the plasminogen activator inhibitor-1: Mechanism increases efficacy of fibrinolytic therapy.

Florova, G. Girard, R.A., Azghani, A.O., Sarva, K., Buchanan, A., Karandashova, S., DeVera, C.J., Morris, D., Chamiso, M., Koenig, K., Cines, D.B., Idell. S., and Komissarov, A. A., Physiol. Reports 9(9): e14861, 2021

Thrombocytopenia following Pfizer and Moderna SARS/CoV-2 vaccination.

Lee, E.-J., Cines, D.B., Gernsheimer, T., Kessler, C., Michel, M, Tarrantino, M.D., Semple, J.W., Arnold, D. M., Godeau, B., Lambert, M. P., Bussel, J.B., Am. J. Hematol 96(5): 534-537, 2021

Functional NMDA receptors are expressed by human pulmonary artery smooth muscle cells

Na Dong, Y.N., Hsu, F.C., Koziol-White, C. J., Stepanova, V. Jude, J.A., Gritsiuta, A. Rue, R. Mott, R. Coulter, D.A., Panettieri, Jr, R.A., Krymskaya, V.P., Takano, H., Goncharova, E.A., Cines, D.B., and Lynch, D.R., Sci. Reports 11(1): 8205, 2021