Douglas B. Cines, MD
Professor of Medicine, Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Director, Coagulation Laboratory
Contact InformationDept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012
Email: dcines@pennmedicine.upenn.edu
Specialty Division
Laboratory Medicine, Immunobiology and Experimental Pathology
Research Expertise
Thrombosis, fibrinolysis, vascular biology, immunohematology
Clinical Expertise
Coagulation, immune hematological disorders
Itmat Expertise
Dr. Cines works on the delivery of plasminogen activators, among other therapeutics, for the prevention and treatment of thrombotic disorders.
Education
A.B. (History, PreMed), New York University, 1968
M.D. (Medicine), New York University School of Medicine, 1972
Specialty Certification
American Board of Internal Medicine, 1975
American Board of Internal Medicine (Hematology), 1980
Postgraduate Training
Intern in Medicine, N.C., Memorial Hospital, Chapel Hill, NC, 1972-1973
Resident in Medicine, N.C, Memorial Hospital, Chapel Hill, NC, 1973-1975
Fellow, Hematology-Oncology, Hospital of the University of Pennsylvania, 1975-1978
Awards and Honors
Phi Beta Kappa , Alpha Omega Alpha, New York University Scholar, 1968
NIH Research Career Development Award, 1979
American Federation for Clinical Research, 1986
American Society of Clinical Investigation, 1986
Academy of Clinical Laboratory Physicians and Scientists, 1990
Visiting Scientist, Roche Institute Molecular Biology, 1990-1992
John Morgan Society, 1995
Association of American Physicians, 1995
American Association of University Pathologists, 1995
Biennial Award for Contributions to Hemostasis Research (BACH), International Society on Thrombosis and Haemostasis (ISTH), 2017
Memberships and Professional Organizations
American Federation for Clinical Research, 1980 - Present
American Association for the Advancement of Science, 1980 - Present
American Society of Hematology, 1980 - Present
Lupus Foundation of Philadelphia/Del. Valley, 1986 - 2006
American Society of Hematology, 1986 - 1991
American Society of Hematology, 1992 - 1993
Philadelphia Hematology Society, 1992 - 2000
American Society of Hematology, 1999 - 2002
International Society on Thrombosis and Haemostasis., 2000 - 2006
Federation of Clinical Immunology Societies, 2002 - Present
American Association of Immunologists, 2004 - Present
US Food and Drug Administration, 2004 - 2005
Platelet Disorder Support Association, 2004 - Present
International Society of Thrombosis and Haemostasis., 2007 - 2012
American Society of Hematology, 2010 - 2012
US Department of Justice, Vaccine Division, 2011 - 2012
American Society of Hematology, 2012 - Present
American Society of Hematology, 2015 - Present
American Society of Hematology, 2015 - Present
Am. Soc. Hematol. Thrombocytopenia, 2019 - Present
Web Links
Selected Publications
Thrombocytopenia in pregnancy: Diagnosis and approach to management.
Pishko, A., Levine. L.R. and Cines, D.B., Blood Reviews, 2020
Platelet factor 4-von Willebrand factor complexes are immunogenic and prothrombotic in heparin-induced thrombocytopenia.
250. Johnson, I., Hayes, V., Sarkar, A., Arepally, G.M., Chung, D.W., Lopez, J.A., Cines, D.B., Rauova, L. and Poncz, M, Blood 135(15): 1270-1280, 2020
Opposing effects of HNP1 (α-defensin-1) on plasma cholesterol and atherogenesis.
252. Higazi M, Abdeen S, Abu-Fanne R, Heyman SN, Masarwy A, Bdeir K, Maraga E, Cines DB, Higazi AA, PLOS One 15(4): , 2020
The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli.
Chernysh IN, Nagaswami C, Kosolapova S, Peshkova AD, Cuker A, Cines DB, Cambor CL, Litvinov RI, Weisel JW, Scientific Reports 10(1): 5112, 2020
FcRn augments induction of tissue factor activity by IgG-containing immune complexes.
251. Cines, D.B., Zaitsev, S., Rauova, L., Rux, A., Stepanova, V., Krishnaswamy, S., Sarkar, A., Kowalska, M.A., Zhao, G., Mast, A.E., Blumberg, L.J., McCrae, K.R., Poncz, M. Hubbard, J.J., Pyzik, M., and Blumberg, R.S., Blood, 2020
COVID-ARDS Clarified: A vascular endotype?
114. Vaughan, A.E., Reilly, J.P., Cines, D.B., Meyer, N.J., and Mangalmurti, N.S., American Journal of Respiratory Critical Care Medicine, 2020
Diagnosing HIT: The need for speed
Cuker, A and Cines, DB, Blood, 2020
Effect of Synthetic Inhibitors on HIT Antigenic Complex - Therapeutic Approach Alternative to Anticoagulation.
101. Kizhakkedathu, J.N., La, C., Kalathottukaren, M.T., Yarovoi, S.V., Hayes, V., Koma, G.T., Abbina, S, Morrissey, J.H., Haynes, C.A., Cines, D.B., and Rauova, L., ISTH, 2020
Pathogenesis of heparin-induced thrombocytopenia
113. Arepally, G. and Cines, D.B, Translational Research 14(): , 2020
Urokinase-type plasminogen activator (uPA)-deficient TSC2-null tumor cells are more sensitive to the estrogen antagonist tamoxifen
Zeitsev, S.V., Tsang, J., Krymskata V.P., Cines, D.B. and Stepanova, V., LAM foundation, 2020
