Charuhas Deshpande, MD

Associate Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania

Contact InformationDepartment of Pathology and Laboratory Medicine
3400 Spruce Street, Founders - 6.039
Philadelphia, PA 19104-4283

Office: (215) 615-6523
Fax: (215) 349-5910


Specialty Division

Anatomic Pathology

Research Expertise

Neoplastic and non-neoplastic diseases of lung, pleura and thymus.

Clinical Expertise

Pulmonary and Mediastinal Pathology,
Cardiovascular Pathology,


MBBS Grant Medical College, Mumbai, India, 1986
MD (Pathology), Tata Memorial Hospital - University of Bombay, Mumbai, India, 1990
MD New York State Education Department, 2009

Specialty Certification

American Board of Pathology, 2008

Postgraduate Training

Resident - Pathology, Anatomic and Clinical, Tata Memorial Hospital, Mumbai, India, 1987-1990
Fellow in Surgical Oncopathology, Tata Memorial Hospital, Mumbai, India, 1991-1992
Research Associate, Rush Cancer Institute, Chicago, IL, 1998-2000
Research Associate, Northwestern University, Chicago, IL, 2000-2003
Resident in Pathology - Anatomic and Clinical, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2003-2004
Resident in Pathology - Anatomic and Clinical, Northwestern Memorial Hospital, Chicago, IL, 2004-2007
Chief Resident - Pathology, Anatomic and Clinical, Northwestern Memorial Hospital, Chicago IL, 2005-2006
Fellow in Oncologic Surgical Pathology, Memorial Sloan-Kettering Cancer Center, 2007-2008
Fellow in Thoracic Pathology, Memorial Sloan-Kettering Cancer Center, 2008-2009

Awards and Honors

The James E. Wheeler, MD Award For Excellence In Anatomic Pathology Resident Training, 2012
The Peter C. Nowell Teaching Award, 2013

Memberships and Professional Organizations

United States and Canadian Academy of Pathology, 2004 - Present
American Society of Clinical Pathologists, 2004 - Present
College of American Pathologists, 2004 - Present
Pulmonary Pathology Society, 2009 - Present
International Association for Study of Lung Cancer, 2010 - Present

Web Links

Selected Publications

Alpha-defensins: risk factor for thrombosis in COVID-19 infection.

Abdeen S, Bdeir K, Abu-Fanne R, Maraga E, Higazi M, Khurram N, Feldman M, Deshpande C, Litzky LA, Heyman SN, Montone KT, Cines DB, Higazi AA., British Journal of Haematology 194(1): 44-52, 2021, PMID:34053084

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Molecular imaging can identify the location to perform a frozen biopsy during intraoperative frozen section consultation.

Bryski MG, Frenzel-Sulyok LG, Delikatny EJ, Deshpande C, Litzky LA, Singhal S., PLoS One 16(6): e0252731, 2021, PMID:34086790

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Neoadjuvant Gene-Mediated Cytotoxic Immunotherapy for Non-Small-Cell Lung Cancer: Safety and Immunologic Activity

Predina JD, Haas AR, Martinez M, O'Brien S, Moon EK, Woodruff P, Stadanlick J, Corbett C, Frenzel-Sulyok L, Bryski MG, Eruslanov E, Deshpande C, Langer C, Aguilar LK, Guzik BW, Manzanera AG, Aguilar-Cordova E, Singhal S, Albelda SM., Molecular Therapy 29(2): 658-670, 2021, PMID:33160076

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Gene signature of antigen processing and presentation machinery predicts response to checkpoint blockade in non-small cell lung cancer (NSCLC) and melanoma

Thompson JC, Davis C, Deshpande C, Hwang WT, Jeffries S, Huang A, Mitchell TC, Langer CJ, Albelda SM., J Immunother Cancer. 8(2): e000974, 2020, PMID:33028693

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Pembrolizumab After Completion of Locally Ablative Therapy for Oligometastatic Non-Small Cell Lung Cancer: A Phase 2 Trial.

Bauml JM, Mick R, Ciunci C, Aggarwal C, Davis C, Evans T, Deshpande C, Miller L, Patel P, Alley E, Knepley C, Mutale F, Cohen RB, Langer CJ., JAMA Oncology 1(2): 1283-1290, 2019, PMID:31294762

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RB constrains lineage fidelity and multiple stages of tumour progression and metastasis.

Walter DM, Yates TJ, Ruiz-Torres M, Kim-Kiselak C, Gudiel AA, Deshpande C, Wang WZ, Cicchini M, Stokes KL, Tobias JW, Buza E, Feldser DM., Nature 569(7756): 423-427, 2019, PMID:31043741

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A clinical trial of intraoperative near-infrared imaging to assess tumor extent and identify residual disease during anterior mediastinal tumor resection.

Predina JD, Keating J, Newton A, Corbett C, Xia L, Shin M, Frenzel Sulyok L, Deshpande C, Litzky L, Nie S, Kucharczuk JC, Singhal S., Cancer 125(5): 807-817, 2019, PMID:30561757

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Localization of Pulmonary Ground-Glass Opacities with Folate Receptor-Targeted Intraoperative Molecular Imaging.

Predina JD, Newton A, Corbett C, Xia L, Sulyok LF, Shin M, Deshpande C, Litzky L, Barbosa E, Low PS, Kucharczuk JC, Singhal S, J Thorac Oncol. 13(7): 1028-1036, 2018, PMID:29626619

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An open label trial of folate receptor-targeted intraoperative molecular imaging to localize pulmonary squamous cell carcinomas.

Predina JD, Newton AD, Xia L, Corbett C, Connolly C, Shin M, Sulyok LF, Litzky L, Deshpande C, Nie S, Kularatne SA, Low PS, Singhal S., Oncotarget 9(17): 13517-13529, 2018, PMID:29568374

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A Phase I Clinical Trial of Targeted Intraoperative Molecular Imaging for Pulmonary Adenocarcinomas.

Predina JD, Newton AD, Keating J, Dunbar A, Connolly C, Baldassari M, Mizelle J, Xia L, Deshpande C, Kucharczuk J, Low PS, Singhal S., Ann Thorac Surg. 105(3): 901-908, 2018, PMID:29397932

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