PEOPLE

Wayne William Hancock, MB.BS, PhD, FRCPA

Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania 

Contact Information916B Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104-4318

Office: 215-590-8709
Fax: 215-590-7384

Email: whancock@pennmedicine.upenn.edu

Specialty Division

Immunobiology and Experimental Pathology

Research Expertise

Research Interests

Transplant immunobiology, inflammation and mechanisms of disease, Treg cells, cancer immunology, therapeutics

Research Summary

New Co-Stimulation Molecules And Their Function In Vivo
The world is currently awash with costimulation molecules. Individual labs tout this or that molecule as being key to T cell activation under specific (often ludicrously specific) conditions, but none of these "insights" have yet led to actual therapeutic agents in clinical use. This reflects several factors. Drug companies make drugs and then try and find an application for them, ideally rheumatoid arthritis, multiple sclerosis, asthma or some other widespread disease involving long-term therapy, but certainly not any of the indications subject to the "too small a market (e.g.

CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention
Myocyte Biology / Heart Failure
Biotechnology / Nanomedicine / Imaging
Thrombosis / Hemostasis

CVI Research Description:
I am interested in immunologic and inflammatory events affecting the cardiovascular system, with particular interest in replacement therapies, whether by manipulation of stem cells or through cardiac transplantation. Optimizing outcomes of cardiac transplantation is another special interest.

Itmat Expertise

Transplantation
Autoimmunity
Tolerance
Epigenetics
Therapeutics
HDAC inhibitors
HAT inhibitors
DNMT inhibitors

Graduate Groups

Immunology

Education

M.B.B.S. (Medicine), Monash University, Clayton, Victoria, Australia, 1977
Ph.D. (Medicine), Monash University, Clayton, Victoria, Australia, 1984
F.R.C.P.A. (Pathology), Royal College of Pathologists of Australasia, 1989

Specialty Certification

Fellow of the Royal College of Pathologists of Australasia, 1989

Postgraduate Training

Intern in Medicine , Alfred Hospital, Mebourne, Australia, 1977-1978
Resident in Medicine, Alfred Hospital , Mebourne, Australia, 1978-1979
Pathology Fellow , Prince Henry's Hospital, Melbourne, Australia, 1980-1983
Research Fellowship, Pathology, Brigham and Women's Hospital, Boston, MA, 1984-1986

Awards and Honors

Australian Kidney Foundation Medical Research Scholarship, 1981
Neil Hamilton Fairley Fellowship, National Health and Medical Research Council of Australia, 1984-1985
Australasian Society of Nephrology Travelling Fellowship, 1984
Fogarty International Research Fellowship (NIH), 1985
Inaugural NIH Basic Science Award for Best Basic Science Abstract, American Society for Transplant Physicians, 1996

Memberships and Professional Organizations

International Society of Nephrology, 1983 - Present
The Transplantation Society, 1983 - Present
American Society of Nephrology, 1984 - Present
The Histochemical Society, 1985 - 1994
American Association of Immunologists, 1986 - Present
Transplantation Society of Australia and New Zealand, 1990 - present
American Society of Transplant Physicians, 1993 - 2001
American Society of Transplant Physicians, 1993 - 2001
American Society for Investigative Pathology, 1994 - 2004
NIH Surgery, Anesthesiology and Trauma (SAT) Study Section, 1995 - 2003
National Kidney Foundation, 1997 - 2001
American Society for Hematology, 1997 - Present
American Society of Transplantation, 2001 - Present
NIH Surgery, Anesthesiology and Trauma (SAT) Study Section, 2003 - 2004
NIH Transplantation, Tolerance & Tumors (TTT) Study Section, 2004 - 2006
British Heart Foundation, 2007 - 2007
National Institutes of Health, 2007 - 2007
The Wellcome Trust, 2008 - 2009
National Institutes of Health, 2008 - 2008
National Institutes of Health, 2008 - 2008
Wessex Medical Research, 2008 - 2008
National Health and Medical Research Council of Australia, 2008 - 2008
University of Pennsylvania, 2008 - Present
National Institutes of Health, 2009 - 2009
National Institutes of Health, 2009 - 2009
Australian National University, 2009 - 2010
International Pancreas and Islet Transplant Association, 2009 - Present
National Institutes of Health, 2010 - 2010
Swiss National Science Foundation, 2010 - 2010
Australian National University, 2010 - 2010
Arthritis Research UK, 2010 - 2010
National Institutes of Health, 2010 - 2010
National Institutes of health, 2011 - 2011
American Association for Cancer Research, 2011 - Present
American Society for Microbiology, 2011 - Present
American Chemical Society, 2011 - Present
Transplant Research Foundation of British Columbia, Canada, 2011 - 2011
National Institutes of Health, 2011 - 2011
National Institutes of Health, 2012 - 2012
National Institutes of Health, 2012 - 2012
Broad Medical Research Program, 2012 - 2012
National Institutes of Health, 2012 - 2019
National Institutes of Health, 2013 - 2013
Children's Hospital of Philadelphia, 2013 - 2013
Austrian Science Fund, 2013 - 2013
National Institutes of Health, 2013 - 2013
Department of Defense, 2013 - 2013
Leukaemia & Lymphoma Research, 2013 - 2013
Medical Research Council (UK), 2013 - 2013
National Institutes of Health, 2013 - 2014
Israel Science Foundation, 2014 - 2014
National Institutes of Health, 2014 - 2014
Department of Defense, 2014 - 2014
National Institutes of Health, 2014 - 2014
International Hand and Composite Tissue Allotransplantation Society, 2014 - present
National Institutes off Health, 2015 - 2015
National Institutes of Health, 2015 - 2015
National Institutes of Health, 2016 - 2016
Veterans Administration, 2016 - 2016
National Institutes of Health, 2016 - 2016
National Institutes of Health, 2016 - 2016
National Institutes of Heath, 2016 - 2016
International Chemical Biology Society, 2017 - Present
National Institutes of Health, 2017 - 2017
National Institutes of Health, 2017 - 2017
American Thoracic Society, 2017 - present
National Institute so fHealth, 2017 - 2017
Children's Hospital of Philadelphia, 2017 - 2017
Society for Immunotherapy of Cancer, 2017 - Present
Trisomy 21 Research Society, 2017 - present
American Society for Biochemistry and Molecular Biology, 2017 - present
National Institutes of Health, 2018 - 2018
National Institutes of Health, 2018 - 2018
National Institutes of Health, 2018 - 2018
Oligonucleotide Therapeutics Society, 2018 - present
National Institutes of Health, 2018 - 2018
National Institutes of Health, 2018 - 2018
National Institutes of Health, 2019 - 2019
National Institutes of Health, 2019 - 2019
National Institutes of Health, 2019 - 2019
American Society of Gene & Cell Therapy, 2019 - present
National Institutes of Health, 2019 - 2019
National Institutes of Health, 2019 - 2019
National Institutes of Health, 2019 - 2019
National Institutes of Health, 2020 - 2020
National Institutes of Health, 2020 - 2020

Web Links


Selected Publications

Clinically available immunosuppression with tacrolimus combined with basiliximab, rapamycin and CTLA4Ig averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques.

Graham ML, Ramachandran S, Singh A, Moore MEG, Flanagan EB, Azimzadeh A, Burlak C, Mueller KR, Martins K, Anazawa T, Balamurugan AN, Bansal-Pakala P, Murtaugh MP, O’Brien TD, Papas KK, Spizzo T, Schuurman HJ, Hancock WW, Hering BJ., American Journal of Transplantation 22(): 745-760, 2022

The selective estrogen receptor modulator, Raloxifene, is protective against renal ischemia reperfusion injury.

Hernandez P, O’Brien C, Concors SJ, Wang Z, Ge G, Hancock WW, Levine MH., Transplantation In press(): , 2022

Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo.

Siska PJ, Jiao J, Matos C, Singer K, Dettmer K, Oefner PJ, Cully MD, Wang Z, Oliff KN, Wilkins BJ, Christensen LM, Wang L, Hancock WW, Baur JA, Levine MH, Ugele I, Mayr R, Renner K, Zhou L, Kreutz M, Beier UH., EBioMedicine 74(): 103734, 2021

Obesity-related IL-18 impairs Treg function and promotes lung ischemia-reperfusion injury.

Akimova T, Zhang T, Christensen LM, Wang Z, Han R, Negorev D, Samanta A, Sasson IE, Gaddapara T, Jiao J, Wang L, Bhatti TR, Levine MH, Diamond JM, Beier UH, Simmons RA, Cantu E, Wilkes DS, Lederer DJ, Anderson M, Christie JD, Hancock WW., American Journal of Respiratory and Critical Care Medicine 204(): 1060-1074, 2021

A biological circuit involving Mef2c, Mef2d and Hdac9 controls the immunosuppressive functions of CD4+Foxp3+ T-regulatory cells.

Di Giorgio E, Wang L, Xiong Y, Christensen LM, Akimova T, Han R, Samanta A, Trevisanut M, Brancolini C, Beier UH, Hancock WW., Frontiers in Immunology 12(): 703632, 2021

HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury.

Aufhauser DD, Wang Z, Murken DR, Samanta A, Concors SJ, Bhatti TR, Wang Y, Ge G, Wang L, Cheraghlou S, Wagner FH, Holson EB, Kalin JH, Cole PA, Hancock WW, Levine MH., Scientific Reports 11(): 9018, 2021

MEF2D sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity.

Di Giorgio E, Wang L, Xiong Y, Akimova T, Christensen LM, Han R, Samanta A, Trevisanut M, Bhatti TR, Beier UH, Hancock WW., Journal of Clinical Investigation 130(): 6242-6260, 2020

Lactate Limits T Cell Proliferation via the NAD(H) Redox State.

Quinn WJ 3rd, Jiao J, TeSlaa T, Stadanlick J, Wang Z, Wang L, Akimova T, Angelin A, Schäfer PM, Cully MD, Perry C, Kopinski PK, Guo L, Blair IA, Ghanem LR, Leibowitz MS, Hancock WW, Moon EK, Levine MH, Eruslanov EB, Wallace DC, Baur JA, Beier UH., Cell Reports 33(): 108500, 2020

The CCR2/MCP-1 Chemokine Pathway and Lung Adenocarcinoma.

Mittal P, Wang L, Akimova T, Leach CA, Clemente JC, Sender MR, Chen Y, Turunen BJ, Hancock WW., Cancers 12(): 3723, 2020

Limited efficacy of rapamycin monotherapy in vascularized composite allotransplantation.

Xu H, Steinberger Z, Wang L, Han R, Zhang Y, Hancock WW, Levin LS., Transplant Immunology 61(): , 2020

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