Priti Lal, MD
Associate Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
University of Pennsylvania Perelman School of Medicine
Contact InformationDepartment of Pathology and Laboratory Medicine
Hospital of the University of Pennsylvania
6 Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104-4283
Office: 215-662-6505
Email: priti.lal@pennmedicine.upenn.edu
Specialty Division
Anatomic Pathology
Research Expertise
Application of high through-put technology to gain insights into the biology of human cancers, with focus on urothelial and prostate cancers.
Clinical Expertise
GU Pathology
Education
BS (Genetics), Delhi University, Delhi, India, 1984
MD Maulana Azad Medical College, Delhi, India, 1990
Specialty Certification
American Board of Pathology, 2010
American Board of Pathology, Anatomic Pathology (Recertification), 2020
Postgraduate Training
Fogarty Fellow, National Institutes of Health, Bethesda, MD, 1993-1995
Fellow, Molecular Biology, National Institutes of Health, Bethesda, MD, 1993-1995
Resident, Pathology, UMDNJ-New Jersey Medical School, Newark NJ, 1996-2000
Visiting Fellow, GI and Liver Pathology, Armed Forces Institute of Pathology, Washington, DC, 1999-1999
Fellow, Oncologic Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 2000-2001
Fellow, Diagnostic Molecular Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 2001-2002
Fellow, Research, Memorial Sloan Kettering Cancer Center, New York, NY, 2002-2004
Awards and Honors
Fogarty International Fellowship, NIA, NIH, 1993-1995
Lucien J. Rubinstein Award to mentee for the Best Neuropath-oncology paper at the Annual Meeting of the American Association of Neuropathology., 2009
Poster of Distinction Award to mentee for presentation at the American Transplant Congress. "Immunologic Variances are Associated with the Development of Cardiac Allograft Vasculopathy", 2012
Finalist for the Best Presentation Award to mentee at the Annual meeting of Int Soc of Heart & Lung Transplantation, Nice, France. "Fatal Fulminant Accelerated Rejection in a Cardiac Transplant Recipient With Natural Killer Cell Infiltrate", 2015
Leading Success, University of Pennsylvania, 2017-2018
Innovation Contest Winner, grant by the GU Service Line, Univ of Pennsylvania. "Muscle invasive bladder cancer precision panel for treatment and prognosis: A Penn multidisciplinary initiative towards personalized treatment of bladder cancer", 2019
Awarded title of Scholar, Center for Global Health, Univ of Pennsylvania, 2020
Best Poster Award to mentee at the Digital Pathology Association Annual Meeting. "Digital-image Analysis of Tumor Infiltrating Lymphocytes in Prostate Cancer Using Automated Whole Slide Imaging and Tissue Microarray", 2021
Pilot Award, Philadelphia Prostate cancer Biome Project, Thomas Jefferson Univ, 2021-2022
Memberships and Professional Organizations
Association for Molecular Pathology, 1999 - 2011
Pennsylvania Association of Pathologists, 2008 - Present
Pathology Society of Philadelphia, 2010 - Present
United States and Canadian Academy of Pathologists, 2010 - Present
American Society for Clinical Pathology, 2010 - Present
College of American Pathologists, 2010 - Present
Association for Indian Pathologists of North America, 2011 - Present
Association for Pathologists of North America, 2015 - 2015
American Association for Cancer Research, 2015 - Present
International Society of Urogenital Pathology, 2015 - Present
Molecular Pathology Association of India, 2015 - 2015
American Society of Clinical Oncology, 2018 - 2019
Genitourinary Pathology Society, 2019 - Present
Web Links
GU Pathologist and a student forever! Center for Global Health Scholar, Perelman School of Medicine, University of Pennsylvania
Selected Publications
PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial
Vivek Narayan, Julie S. Barber-Rotenberg, In-Young Jung, Simon F. Lacey, Andrew J. Rech, Megan M. Davis, Wei-Ting Hwang, Priti Lal, Erica L. Carpenter, Shannon L. Maude, Gabriela Plesa, Neha Vapiwala, Anne Chew, Michael Moniak, Ronnie A. Sebro, Michael D. Farwell, Amy Marshall, Joan Gilmore, Lester Lledo, Karen Dengel, Sarah E. Church, Tyler D. Hether, Jun Xu, Mercy Gohil, Thomas H. Buckingham, Stephanie S. Yee, Vanessa E. Gonzalez, Irina Kulikovskaya, Fang Chen, Lifeng Tian, Kyle Tien, Whitney Gladney, Christopher L. Nobles, Hayley E. Raymond, Prostate Cancer Cellular Therapy Program Investigators, Elizabeth O. Hexner, Donald L. Siegel, Frederic D. Bushman, Carl H. June, Joseph A. Fraietta & Naomi B. Haas, Nature Medicine 4(28): 724-734, 2022, PMID:35314843
Novel Biomarker Signature That May Predict Aggressive Disease in African American Men With Prostate Cancer
Yamoah K, Johnson MH, Choeurng V, Faisal FA, Yousefi K, Haddad Z, Ross AE, Alshalafa M, Den R, Lal Priti, Feldman M, Dicker AP, Klein EA, Davicioni E, Rebbeck TR, Schaeffer EM, J Clin Oncol 33(25): 2789-96, 2015, PMID:26195723
Phase 2 trial of the cyclin-dependent kinase 4/6 inhibitor palbociclib in patients with retinoblastoma protein-expressing germ cell tumors
Vaughn DJ, Hwang WT, Lal Priti, Rosen MA, Gallagher M, O'Dwyer PJ, Cancer 121(9): 1463-8, 2015, PMID:25522918
COX-2 mediates pro-tumorigenic effects of PKCε in prostate cancer
Garg R, Blando JM, Perez CJ, Lal Priti, Feldman MD, Smyth EM, Ricciotti E, Grosser T, Benavides F, Kazanietz MG, Oncogene 37(34): 4735-4749, 2018, PMID:29765153
Computationally derived image signature of stromal morphology is prognostic of prostate cancer recurrence following prostatectomy in African American patients
Bhargava HK, Leo P, Elliott R, Janowczyk A, Whitney J, Gupta S, Fu P, Yamoah K, Khani F, Robinson BD, Rebbeck TR, Feldman M, Lal Priti, Madabhushi A, Clin Cancer Res 26(8): 1915-1923, 2020, PMID:32139401
CDK7 inhibition suppresses Castration- Resistant Prostate Cancer through MED1 inactivaion
Rasool RU, Natesan R, Deng Q, Aras S, Lal Priti, Sander Effron S, Mitchell-Velasquez E, Posimo JM, Carskadon S, Baca SC, Pomerantz MM, Siddiqui J, Schwartz LE, Lee DJ, Palanisamy N, Narla G, Den RB, Freedman ML, Brady DC, Asangani IA, Cancer Discov 9(11): 1538-1555, 2019, PMID:31466944
PDL-1 Expression reveals significant association with squamous differentiation in Upper Tract Urothelial Carcinoma
Arriola AGP, Farahani SJ, Bhargava HK, Guzzo TJ, Brooks JSJ, Lal Priti, Am J Clin Pathol 151(6): 561-573, 2019, PMID:30776071
Differences in PD-L1 Expressing Macrophages and Immune Micro-environment in Testicular Germ Cell Tumors
Sadigh S, Farahani SJ, Shah A, Vaughn D, Lal Priti, Am J Clin Pathol 153(3): 387-395, 2020, PMID:31802108
A Phase 1 Clinical Trial of PSMA-directed/TGFβ-insensitive CAR-T cells in Metastatic Castration-Resistant Prostate Cancer
Vivek Narayan, Whitney Gladney, Gabriela Plesa, Neha Vapiwala, Erica Carpenter, Shannon L. Maude, Priti Lal, Simon F. Lacey, Jan Joseph Melenhorst, Ronnie Sebro, Michael Farwell, Wei-Ting Hwang, Michael Moniak, Joan Gilmore, Lester Lledo, Karen Dengel, Amy Marshall, Christina Marie Coughlin, Carl H. June, Naomi B. Haas, Am Soc of Clin Onc 2020. J of Clin Onc, 2020
Tumor Hypoxia Recruits Regulatory T Cells via the CCL28 Chemokine to Promote Immune Tolerance and Angiogenesis
Facciabene A, Peng X, Ian SH , Barchetti A, Balint K, Wang LP, Gilks CB, Lal Priti, Zhang L, Coukos G, Nature 475(7355): 226-230, 2011, PMID:21753853
