PEOPLE

Priti Lal, MD

Associate Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
Hospital of the University of Pennsylvania
6 Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104-4283
Office: 215-662-6505

Email: priti.lal@pennmedicine.upenn.edu

Specialty Division

Anatomic Pathology

Research Expertise

Application of high through-put technology to gain insights into the biology of human cancers, with focus on urothelial and prostate cancers.

Clinical Expertise

GU Pathology

Education

BS (Genetics), Delhi University, Delhi, India, 1984
MD Maulana Azad Medical College, Delhi, India, 1990

Specialty Certification

American Board of Pathology, 2010
American Board of Pathology, Anatomic Pathology (Recertification), 2020

Postgraduate Training

Fellow, Molecular Biology, National Institutes of Health, Bethesda, MD, 1993-1995
Fogarty Fellow, National Institutes of Health, Bethesda, MD, 1993-1995
Resident, Pathology, UMDNJ-New Jersey Medical School, Newark NJ, 1996-2000
Visiting Fellow, GI and Liver Pathology, Armed Forces Institute of Pathology, Washington, DC, 1999-1999
Fellow, Oncologic Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 2000-2001
Fellow, Diagnostic Molecular Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 2001-2002
Fellow, Research, Memorial Sloan Kettering Cancer Center, New York, NY, 2002-2004

Awards and Honors

Fogarty International Fellowship, NIA, NIH, 1993-1995
Lucien J. Rubinstein Award to mentee for the Best Neuropath-oncology paper at the Annual Meeting of the American Association of Neuropathology., 2009
Poster of Distinction Award to mentee for presentation at the American Transplant Congress. "Immunologic Variances are Associated with the Development of Cardiac Allograft Vasculopathy", 2012
Finalist for the Best Presentation Award to mentee at the Annual meeting of Int Soc of Heart & Lung Transplantation, Nice, France. "Fatal Fulminant Accelerated Rejection in a Cardiac Transplant Recipient With Natural Killer Cell Infiltrate", 2015
Leading Success, University of Pennsylvania, 2017-2018
Innovation Contest Winner, grant by the GU Service Line, Univ of Pennsylvania. "Muscle invasive bladder cancer precision panel for treatment and prognosis: A Penn multidisciplinary initiative towards personalized treatment of bladder cancer", 2019
Awarded title of Scholar, Center for Global Health, Univ of Pennsylvania, 2020
Pilot Award, Philadelphia Prostate cancer Biome Project, Thomas Jefferson Univ, 2021-2022
Best Poster Award to mentee at the Digital Pathology Association Annual Meeting. "Digital-image Analysis of Tumor Infiltrating Lymphocytes in Prostate Cancer Using Automated Whole Slide Imaging and Tissue Microarray", 2021

Memberships and Professional Organizations

Association for Molecular Pathology, 1999 - 2011
Pennsylvania Association of Pathologists, 2008 - Present
United States and Canadian Academy of Pathologists, 2010 - Present
American Society for Clinical Pathology, 2010 - Present
The Pathology Society of Philadelphia, 2010 - Present
College of American Pathologists, 2010 - Present
American Association for Cancer Research, 2015 - Present
International Society of Urogenital Pathology, 2015 - Present
American Society of Clinical Oncology, 2018 - 2019
Genitourinary Pathology Society, 2019 - Present

Web Links


Selected Publications

PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial

Vivek Narayan, Julie S. Barber-Rotenberg, In-Young Jung, Simon F. Lacey, Andrew J. Rech, Megan M. Davis, Wei-Ting Hwang, Priti Lal, Erica L. Carpenter, Shannon L. Maude, Gabriela Plesa, Neha Vapiwala, Anne Chew, Michael Moniak, Ronnie A. Sebro, Michael D. Farwell, Amy Marshall, Joan Gilmore, Lester Lledo, Karen Dengel, Sarah E. Church, Tyler D. Hether, Jun Xu, Mercy Gohil, Thomas H. Buckingham, Stephanie S. Yee, Vanessa E. Gonzalez, Irina Kulikovskaya, Fang Chen, Lifeng Tian, Kyle Tien, Whitney Gladney, Christopher L. Nobles, Hayley E. Raymond, Prostate Cancer Cellular Therapy Program Investigators, Elizabeth O. Hexner, Donald L. Siegel, Frederic D. Bushman, Carl H. June, Joseph A. Fraietta & Naomi B. Haas, Nature Medicine 4(28): 724-734, 2022, PMID:35314843

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Novel Biomarker Signature That May Predict Aggressive Disease in African American Men With Prostate Cancer

Yamoah K, Johnson MH, Choeurng V, Faisal FA, Yousefi K, Haddad Z, Ross AE, Alshalafa M, Den R, Lal Priti, Feldman M, Dicker AP, Klein EA, Davicioni E, Rebbeck TR, Schaeffer EM, J Clin Oncol 33(25): 2789-96, 2015, PMID:26195723

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Phase 2 trial of the cyclin-dependent kinase 4/6 inhibitor palbociclib in patients with retinoblastoma protein-expressing germ cell tumors

Vaughn DJ, Hwang WT, Lal Priti, Rosen MA, Gallagher M, O'Dwyer PJ, Cancer 121(9): 1463-8, 2015, PMID:25522918

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COX-2 mediates pro-tumorigenic effects of PKCε in prostate cancer

Garg R, Blando JM, Perez CJ, Lal Priti, Feldman MD, Smyth EM, Ricciotti E, Grosser T, Benavides F, Kazanietz MG, Oncogene 37(34): 4735-4749, 2018, PMID:29765153

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Computationally derived image signature of stromal morphology is prognostic of prostate cancer recurrence following prostatectomy in African American patients

Bhargava HK, Leo P, Elliott R, Janowczyk A, Whitney J, Gupta S, Fu P, Yamoah K, Khani F, Robinson BD, Rebbeck TR, Feldman M, Lal Priti, Madabhushi A, Clin Cancer Res 26(8): 1915-1923, 2020, PMID:32139401

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CDK7 inhibition suppresses Castration- Resistant Prostate Cancer through MED1 inactivaion

Rasool RU, Natesan R, Deng Q, Aras S, Lal Priti, Sander Effron S, Mitchell-Velasquez E, Posimo JM, Carskadon S, Baca SC, Pomerantz MM, Siddiqui J, Schwartz LE, Lee DJ, Palanisamy N, Narla G, Den RB, Freedman ML, Brady DC, Asangani IA, Cancer Discov 9(11): 1538-1555, 2019, PMID:31466944

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PDL-1 Expression reveals significant association with squamous differentiation in Upper Tract Urothelial Carcinoma

Arriola AGP, Farahani SJ, Bhargava HK, Guzzo TJ, Brooks JSJ, Lal Priti, Am J Clin Pathol 151(6): 561-573, 2019, PMID:30776071

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Differences in PD-L1 Expressing Macrophages and Immune Micro-environment in Testicular Germ Cell Tumors

Sadigh S, Farahani SJ, Shah A, Vaughn D, Lal Priti, Am J Clin Pathol 153(3): 387-395, 2020, PMID:31802108

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A Phase 1 Clinical Trial of PSMA-directed/TGFβ-insensitive CAR-T cells in Metastatic Castration-Resistant Prostate Cancer

Vivek Narayan, Whitney Gladney, Gabriela Plesa, Neha Vapiwala, Erica Carpenter, Shannon L. Maude, Priti Lal, Simon F. Lacey, Jan Joseph Melenhorst, Ronnie Sebro, Michael Farwell, Wei-Ting Hwang, Michael Moniak, Joan Gilmore, Lester Lledo, Karen Dengel, Amy Marshall, Christina Marie Coughlin, Carl H. June, Naomi B. Haas, Am Soc of Clin Onc 2020. J of Clin Onc, 2020

Tumor Hypoxia Recruits Regulatory T Cells via the CCL28 Chemokine to Promote Immune Tolerance and Angiogenesis

Facciabene A, Peng X, Ian SH , Barchetti A, Balint K, Wang LP, Gilks CB, Lal Priti, Zhang L, Coukos G, Nature 475(7355): 226-230, 2011, PMID:21753853

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